Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	121260
Gene name	Solute carrier family 15 member 4
Gene symbol	SLC15A4
Synonyms (NCBI Gene)	FP12591PHT1PTR4
Chromosome	12
Chromosome location	12q24.33

160

Show/Hide all (160)

miRTarBase ID	miRNA	Experiments	Reference
MIRT002585	hsa-miR-124-3p	Microarray	15685193
MIRT002585	hsa-miR-124-3p	Microarray	15685193
MIRT002585	hsa-miR-124-3p	Microarray	18668037
MIRT044921	hsa-miR-186-5p	CLASH	23622248
MIRT038188	hsa-miR-151a-5p	CLASH	23622248
MIRT719400	hsa-miR-548c-3p	HITS-CLIP	19536157
MIRT719399	hsa-miR-4668-3p	HITS-CLIP	19536157
MIRT719398	hsa-miR-302b-5p	HITS-CLIP	19536157
MIRT719397	hsa-miR-302d-5p	HITS-CLIP	19536157
MIRT719400	hsa-miR-548c-3p	HITS-CLIP	19536157
MIRT719399	hsa-miR-4668-3p	HITS-CLIP	19536157
MIRT719398	hsa-miR-302b-5p	HITS-CLIP	19536157
MIRT719397	hsa-miR-302d-5p	HITS-CLIP	19536157
MIRT1352737	hsa-miR-1245b-3p	CLIP-seq
MIRT1352738	hsa-miR-127-5p	CLIP-seq
MIRT1352739	hsa-miR-134	CLIP-seq
MIRT1352740	hsa-miR-141	CLIP-seq
MIRT1352741	hsa-miR-15a	CLIP-seq
MIRT1352742	hsa-miR-15b	CLIP-seq
MIRT1352743	hsa-miR-16	CLIP-seq
MIRT1352744	hsa-miR-186	CLIP-seq
MIRT1352745	hsa-miR-195	CLIP-seq
MIRT1352746	hsa-miR-200a	CLIP-seq
MIRT1352747	hsa-miR-203	CLIP-seq
MIRT1352748	hsa-miR-23a	CLIP-seq
MIRT1352749	hsa-miR-23b	CLIP-seq
MIRT1352750	hsa-miR-23c	CLIP-seq
MIRT1352751	hsa-miR-299-5p	CLIP-seq
MIRT1352752	hsa-miR-3118	CLIP-seq
MIRT1352753	hsa-miR-3164	CLIP-seq
MIRT1352754	hsa-miR-383	CLIP-seq
MIRT1352755	hsa-miR-409-3p	CLIP-seq
MIRT1352756	hsa-miR-424	CLIP-seq
MIRT1352757	hsa-miR-4275	CLIP-seq
MIRT1352758	hsa-miR-4307	CLIP-seq
MIRT1352759	hsa-miR-4474-5p	CLIP-seq
MIRT1352760	hsa-miR-4501	CLIP-seq
MIRT1352761	hsa-miR-4652-3p	CLIP-seq
MIRT1352762	hsa-miR-4772-5p	CLIP-seq
MIRT1352763	hsa-miR-4775	CLIP-seq
MIRT1352764	hsa-miR-487b	CLIP-seq
MIRT1352765	hsa-miR-497	CLIP-seq
MIRT1352766	hsa-miR-548a-5p	CLIP-seq
MIRT1352767	hsa-miR-548ab	CLIP-seq
MIRT1352768	hsa-miR-548ak	CLIP-seq
MIRT1352769	hsa-miR-548b-5p	CLIP-seq
MIRT1352770	hsa-miR-548c-5p	CLIP-seq
MIRT1352771	hsa-miR-548d-5p	CLIP-seq
MIRT1352772	hsa-miR-548h	CLIP-seq
MIRT1352773	hsa-miR-548i	CLIP-seq
MIRT1352774	hsa-miR-548j	CLIP-seq
MIRT1352775	hsa-miR-548n	CLIP-seq
MIRT1352776	hsa-miR-548w	CLIP-seq
MIRT1352777	hsa-miR-548y	CLIP-seq
MIRT1352778	hsa-miR-559	CLIP-seq
MIRT1352779	hsa-miR-582-5p	CLIP-seq
MIRT1352780	hsa-miR-590-3p	CLIP-seq
MIRT1352781	hsa-miR-622	CLIP-seq
MIRT1352782	hsa-miR-922	CLIP-seq
MIRT1352783	hsa-miR-944	CLIP-seq
MIRT2104465	hsa-miR-1261	CLIP-seq
MIRT2104466	hsa-miR-3121-5p	CLIP-seq
MIRT2104467	hsa-miR-4448	CLIP-seq
MIRT1352781	hsa-miR-622	CLIP-seq
MIRT2328858	hsa-miR-101	CLIP-seq
MIRT2328859	hsa-miR-124	CLIP-seq
MIRT2328860	hsa-miR-1264	CLIP-seq
MIRT1352739	hsa-miR-134	CLIP-seq
MIRT1352740	hsa-miR-141	CLIP-seq
MIRT2328861	hsa-miR-144	CLIP-seq
MIRT2328862	hsa-miR-148a	CLIP-seq
MIRT2328863	hsa-miR-148b	CLIP-seq
MIRT2328864	hsa-miR-152	CLIP-seq
MIRT2328865	hsa-miR-18a	CLIP-seq
MIRT2328866	hsa-miR-18b	CLIP-seq
MIRT1352746	hsa-miR-200a	CLIP-seq
MIRT2328867	hsa-miR-2117	CLIP-seq
MIRT2328868	hsa-miR-223	CLIP-seq
MIRT1352748	hsa-miR-23a	CLIP-seq
MIRT1352749	hsa-miR-23b	CLIP-seq
MIRT1352750	hsa-miR-23c	CLIP-seq
MIRT1352752	hsa-miR-3118	CLIP-seq
MIRT1352753	hsa-miR-3164	CLIP-seq
MIRT2328869	hsa-miR-345	CLIP-seq
MIRT2328870	hsa-miR-3611	CLIP-seq
MIRT2328871	hsa-miR-3714	CLIP-seq
MIRT2328872	hsa-miR-3910	CLIP-seq
MIRT2328873	hsa-miR-4264	CLIP-seq
MIRT2328874	hsa-miR-4273	CLIP-seq
MIRT1352757	hsa-miR-4275	CLIP-seq
MIRT2328875	hsa-miR-4276	CLIP-seq
MIRT2328876	hsa-miR-431	CLIP-seq
MIRT2328877	hsa-miR-4323	CLIP-seq
MIRT2328878	hsa-miR-4434	CLIP-seq
MIRT1352760	hsa-miR-4501	CLIP-seq
MIRT2328879	hsa-miR-4516	CLIP-seq
MIRT2328880	hsa-miR-4645-5p	CLIP-seq
MIRT2328881	hsa-miR-4673	CLIP-seq
MIRT2328882	hsa-miR-4735-3p	CLIP-seq
MIRT2328883	hsa-miR-4742-5p	CLIP-seq
MIRT2328884	hsa-miR-4755-3p	CLIP-seq
MIRT2328885	hsa-miR-4768-3p	CLIP-seq
MIRT1352763	hsa-miR-4775	CLIP-seq
MIRT2328886	hsa-miR-4797-3p	CLIP-seq
MIRT2328887	hsa-miR-495	CLIP-seq
MIRT2328888	hsa-miR-506	CLIP-seq
MIRT2328889	hsa-miR-548l	CLIP-seq
MIRT1352775	hsa-miR-548n	CLIP-seq
MIRT1352779	hsa-miR-582-5p	CLIP-seq
MIRT1352780	hsa-miR-590-3p	CLIP-seq
MIRT2328890	hsa-miR-665	CLIP-seq
MIRT2328891	hsa-miR-802	CLIP-seq
MIRT2328892	hsa-miR-935	CLIP-seq
MIRT1352783	hsa-miR-944	CLIP-seq
MIRT2623257	hsa-miR-1184	CLIP-seq
MIRT2623258	hsa-miR-1205	CLIP-seq
MIRT2328859	hsa-miR-124	CLIP-seq
MIRT2104465	hsa-miR-1261	CLIP-seq
MIRT2623259	hsa-miR-1301	CLIP-seq
MIRT1352751	hsa-miR-299-5p	CLIP-seq
MIRT2104466	hsa-miR-3121-5p	CLIP-seq
MIRT2623260	hsa-miR-3158-5p	CLIP-seq
MIRT2623261	hsa-miR-3653	CLIP-seq
MIRT2623262	hsa-miR-3658	CLIP-seq
MIRT2623263	hsa-miR-3683	CLIP-seq
MIRT2328871	hsa-miR-3714	CLIP-seq
MIRT2328872	hsa-miR-3910	CLIP-seq
MIRT1352755	hsa-miR-409-3p	CLIP-seq
MIRT2623264	hsa-miR-4279	CLIP-seq
MIRT2623265	hsa-miR-4312	CLIP-seq
MIRT2104467	hsa-miR-4448	CLIP-seq
MIRT2623266	hsa-miR-4522	CLIP-seq
MIRT2623267	hsa-miR-4660	CLIP-seq
MIRT2328884	hsa-miR-4755-3p	CLIP-seq
MIRT2328885	hsa-miR-4768-3p	CLIP-seq
MIRT2623268	hsa-miR-491-3p	CLIP-seq
MIRT2623269	hsa-miR-5047	CLIP-seq
MIRT2328888	hsa-miR-506	CLIP-seq
MIRT2623270	hsa-miR-532-5p	CLIP-seq
MIRT1352766	hsa-miR-548a-5p	CLIP-seq
MIRT1352767	hsa-miR-548ab	CLIP-seq
MIRT1352768	hsa-miR-548ak	CLIP-seq
MIRT1352769	hsa-miR-548b-5p	CLIP-seq
MIRT1352770	hsa-miR-548c-5p	CLIP-seq
MIRT1352771	hsa-miR-548d-5p	CLIP-seq
MIRT1352772	hsa-miR-548h	CLIP-seq
MIRT1352773	hsa-miR-548i	CLIP-seq
MIRT1352774	hsa-miR-548j	CLIP-seq
MIRT1352775	hsa-miR-548n	CLIP-seq
MIRT1352776	hsa-miR-548w	CLIP-seq
MIRT1352777	hsa-miR-548y	CLIP-seq
MIRT1352778	hsa-miR-559	CLIP-seq
MIRT2623271	hsa-miR-586	CLIP-seq
MIRT2328890	hsa-miR-665	CLIP-seq
MIRT2690881	hsa-miR-142-5p	CLIP-seq
MIRT2690882	hsa-miR-369-3p	CLIP-seq
MIRT2690883	hsa-miR-374a	CLIP-seq
MIRT2690884	hsa-miR-374b	CLIP-seq
MIRT2690885	hsa-miR-4633-5p	CLIP-seq
MIRT2690886	hsa-miR-561	CLIP-seq

Show/Hide all (55)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002376	Process	Immune system process	IEA
GO:0005290	Function	L-histidine transmembrane transporter activity	IBA
GO:0005290	Function	L-histidine transmembrane transporter activity	IDA	25238095, 29224352
GO:0005290	Function	L-histidine transmembrane transporter activity	IEA
GO:0005515	Function	Protein binding	IPI	24695226, 28514442, 32433612, 33961781, 35271311
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IDA	25238095, 29224352
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005765	Component	Lysosomal membrane	TAS
GO:0005768	Component	Endosome	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006811	Process	Monoatomic ion transport	TAS
GO:0006857	Process	Oligopeptide transport	IEA
GO:0010008	Component	Endosome membrane	IEA
GO:0015031	Process	Protein transport	IEA
GO:0015293	Function	Symporter activity	IEA
GO:0015333	Function	Peptide:proton symporter activity	IDA	25238095, 29224352
GO:0015333	Function	Peptide:proton symporter activity	IEA
GO:0015333	Function	Peptide:proton symporter activity	TAS
GO:0015647	Function	Peptidoglycan transmembrane transporter activity	IDA	25238095, 29224352
GO:0015817	Process	Histidine transport	IBA
GO:0015833	Process	Peptide transport	IEA
GO:0015835	Process	Peptidoglycan transport	IDA	25238095, 29224352
GO:0015835	Process	Peptidoglycan transport	IEA
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0022857	Function	Transmembrane transporter activity	IEA
GO:0031901	Component	Early endosome membrane	IEA
GO:0033023	Process	Mast cell homeostasis	IEA
GO:0033023	Process	Mast cell homeostasis	ISS
GO:0034157	Process	Positive regulation of toll-like receptor 7 signaling pathway	IEA
GO:0034157	Process	Positive regulation of toll-like receptor 7 signaling pathway	IMP	25238095, 32433612
GO:0034161	Process	Positive regulation of toll-like receptor 8 signaling pathway	IMP	32433612
GO:0034165	Process	Positive regulation of toll-like receptor 9 signaling pathway	IEA
GO:0034165	Process	Positive regulation of toll-like receptor 9 signaling pathway	IMP	25238095
GO:0035579	Component	Specific granule membrane	TAS
GO:0036020	Component	Endolysosome membrane	IDA	32433612
GO:0036020	Component	Endolysosome membrane	TAS
GO:0045087	Process	Innate immune response	IEA
GO:0045089	Process	Positive regulation of innate immune response	IDA	32433612
GO:0048302	Process	Regulation of isotype switching to IgG isotypes	IEA
GO:0048302	Process	Regulation of isotype switching to IgG isotypes	ISS
GO:0055085	Process	Transmembrane transport	IEA
GO:0070424	Process	Regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	IEA
GO:0070424	Process	Regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	ISS
GO:0070430	Process	Positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway	IEA
GO:0070430	Process	Positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway	ISS
GO:0070434	Process	Positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	IEA
GO:0070434	Process	Positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	ISS
GO:0071916	Function	Dipeptide transmembrane transporter activity	IBA
GO:0071916	Function	Dipeptide transmembrane transporter activity	IDA	29224352, 31073693
GO:0089708	Process	L-histidine transmembrane export from vacuole	IEA
GO:0140206	Process	Dipeptide import across plasma membrane	IBA
GO:0140206	Process	Dipeptide import across plasma membrane	IDA	29224352, 31073693
GO:1902600	Process	Proton transmembrane transport	IEA

MIM	HGNC	e!Ensembl
615806	23090	ENSG00000139370

Q8N697

Protein name

Solute carrier family 15 member 4 (Peptide transporter 4) (Peptide/histidine transporter 1) (hPHT1)

Protein function

Proton-coupled amino-acid transporter that mediates the transmembrane transport of L-histidine and some di- and tripeptides from inside the lysosome to the cytosol, and plays a key role in innate immune response (PubMed:16289537, PubMed:25238095

PDB

8JZR , 8JZS , 8JZU , 8JZX , 8P6A , 8QSK , 8QSL , 8QSM , 8QSN , 8WX3 , 8WX4 , 8WX5

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00854	PTR2	103 → 518	POT family	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in skeletal muscle. Moderately expressed in kidney, liver, and heart. Weakly expressed in colon and brain. Expressed in low levels throughout the gastrointestinal tract and in Caco-2 cells. Expressed in retinal fragmen

Sequence

MEGSGGGAGERAPLLGARRAAAAAAAAGAFAGRRAACGAVLLTELLERAAFYGITSNLVL
FLNGAPFCWEGAQASEALLLFMGLTYLGSPFGGWLADARLGRARAILLSLALYLLGMLAF
PLLAAPATRAALCGSARLLNCTAPGPDAAARCCSPATFAGLVLVGLGVATVKANITPFGA
DQVKDRGPEATRRFFNWFYWSINLGAILSLGGIAYIQQNVSFVTGYAIPTVCVGLAFVVF
LCGQSVFITKPPDGSAFTDMFKILTYSCCSQKRSGERQSNGEGIGVFQQSSKQSLFDSCK
MSHGGPFTEEKVEDVKALVKIVPVFLALIPYWTVYFQMQTTYVLQSLHLRIPEISNITTT
PHTLPAAWLTMFDAVLILLLIPLKDKLVDPILRRHGLLPSSLKRIAVGMFFVMCSAFAAG
ILESKRLNLVKEKTINQTIGNVVYHAADLSLWWQVPQYLLIGISEIFASIAGLEFAYSAA
PKSMQSAIMGLFFFFSGVGSFVGSGLLALVSIKAIGWMSSHTDFGNINGCYLNYYFFLLA
AIQGATLLLFLIISVKYDHHRDHQRSRANGVPTSRRA

Sequence length

577

Interactions

View interactions

	Reactome
			Proton/oligopeptide cotransporters Neutrophil degranulation

SLC15A4 (solute carrier family 15 member 4)