Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	121256
Gene name Gene Name - the full gene name approved by the HGNC.	Transmembrane protein 132D
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TMEM132D
Synonyms (NCBI Gene) Gene synonyms aliases	MOLT, PPP1R153
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12q24.33

Show/Hide all(88)

miRTarBase ID	miRNA	Experiments
MIRT1430751	hsa-miR-1273f	CLIP-seq
MIRT1430752	hsa-miR-1287	CLIP-seq
MIRT1430753	hsa-miR-1343	CLIP-seq
MIRT1430754	hsa-miR-143	CLIP-seq
MIRT1430755	hsa-miR-185	CLIP-seq
MIRT1430756	hsa-miR-2116	CLIP-seq
MIRT1430757	hsa-miR-3074-5p	CLIP-seq
MIRT1430758	hsa-miR-3124-3p	CLIP-seq
MIRT1430759	hsa-miR-3125	CLIP-seq
MIRT1430760	hsa-miR-3135b	CLIP-seq
MIRT1430761	hsa-miR-3150b-3p	CLIP-seq
MIRT1430762	hsa-miR-3173-3p	CLIP-seq
MIRT1430763	hsa-miR-3690	CLIP-seq
MIRT1430764	hsa-miR-370	CLIP-seq
MIRT1430765	hsa-miR-378g	CLIP-seq
MIRT1430766	hsa-miR-3916	CLIP-seq
MIRT1430767	hsa-miR-4252	CLIP-seq
MIRT1430768	hsa-miR-4254	CLIP-seq
MIRT1430769	hsa-miR-4270	CLIP-seq
MIRT1430770	hsa-miR-4306	CLIP-seq
MIRT1430771	hsa-miR-4441	CLIP-seq
MIRT1430772	hsa-miR-4463	CLIP-seq
MIRT1430773	hsa-miR-4534	CLIP-seq
MIRT1430774	hsa-miR-4644	CLIP-seq
MIRT1430775	hsa-miR-4677-5p	CLIP-seq
MIRT1430776	hsa-miR-4687-3p	CLIP-seq
MIRT1430777	hsa-miR-4699-3p	CLIP-seq
MIRT1430778	hsa-miR-4708-5p	CLIP-seq
MIRT1430779	hsa-miR-4770	CLIP-seq
MIRT1430780	hsa-miR-4784	CLIP-seq
MIRT1430781	hsa-miR-4797-5p	CLIP-seq
MIRT1430782	hsa-miR-516a-3p	CLIP-seq
MIRT1430783	hsa-miR-765	CLIP-seq
MIRT1430784	hsa-miR-875-3p	CLIP-seq
MIRT1430751	hsa-miR-1273f	CLIP-seq
MIRT1430752	hsa-miR-1287	CLIP-seq
MIRT1430754	hsa-miR-143	CLIP-seq
MIRT1430755	hsa-miR-185	CLIP-seq
MIRT2129170	hsa-miR-2110	CLIP-seq
MIRT2129171	hsa-miR-2355-3p	CLIP-seq
MIRT2129172	hsa-miR-2392	CLIP-seq
MIRT1430757	hsa-miR-3074-5p	CLIP-seq
MIRT1430760	hsa-miR-3135b	CLIP-seq
MIRT2129173	hsa-miR-3150a-3p	CLIP-seq
MIRT2129174	hsa-miR-3175	CLIP-seq
MIRT2129175	hsa-miR-3605-5p	CLIP-seq
MIRT1430764	hsa-miR-370	CLIP-seq
MIRT1430765	hsa-miR-378g	CLIP-seq
MIRT2129176	hsa-miR-4260	CLIP-seq
MIRT1430770	hsa-miR-4306	CLIP-seq
MIRT1430774	hsa-miR-4644	CLIP-seq
MIRT2129177	hsa-miR-4646-3p	CLIP-seq
MIRT1430778	hsa-miR-4708-5p	CLIP-seq
MIRT1430779	hsa-miR-4770	CLIP-seq
MIRT1430781	hsa-miR-4797-5p	CLIP-seq
MIRT1430782	hsa-miR-516a-3p	CLIP-seq
MIRT2129178	hsa-miR-676	CLIP-seq
MIRT2129179	hsa-miR-939	CLIP-seq
MIRT1430752	hsa-miR-1287	CLIP-seq
MIRT2350753	hsa-miR-146a	CLIP-seq
MIRT2350754	hsa-miR-146b-5p	CLIP-seq
MIRT2129170	hsa-miR-2110	CLIP-seq
MIRT2129172	hsa-miR-2392	CLIP-seq
MIRT1430757	hsa-miR-3074-5p	CLIP-seq
MIRT1430760	hsa-miR-3135b	CLIP-seq
MIRT2129173	hsa-miR-3150a-3p	CLIP-seq
MIRT2129174	hsa-miR-3175	CLIP-seq
MIRT2129175	hsa-miR-3605-5p	CLIP-seq
MIRT1430764	hsa-miR-370	CLIP-seq
MIRT1430765	hsa-miR-378g	CLIP-seq
MIRT2350755	hsa-miR-3929	CLIP-seq
MIRT2129176	hsa-miR-4260	CLIP-seq
MIRT2350756	hsa-miR-4419b	CLIP-seq
MIRT2350757	hsa-miR-4478	CLIP-seq
MIRT2350758	hsa-miR-4484	CLIP-seq
MIRT2350759	hsa-miR-4765	CLIP-seq
MIRT2350760	hsa-miR-4766-5p	CLIP-seq
MIRT2350761	hsa-miR-488	CLIP-seq
MIRT1430782	hsa-miR-516a-3p	CLIP-seq
MIRT2350762	hsa-miR-548an	CLIP-seq
MIRT2350763	hsa-miR-589	CLIP-seq
MIRT2129179	hsa-miR-939	CLIP-seq
MIRT1430752	hsa-miR-1287	CLIP-seq
MIRT1430757	hsa-miR-3074-5p	CLIP-seq
MIRT1430760	hsa-miR-3135b	CLIP-seq
MIRT1430764	hsa-miR-370	CLIP-seq
MIRT1430765	hsa-miR-378g	CLIP-seq
MIRT1430782	hsa-miR-516a-3p	CLIP-seq

Show/Hide all(3)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	19389623
GO:0010923	Process	Negative regulation of phosphatase activity	IDA	19389623
GO:0016021	Component	Integral component of membrane	NAS	12966072

MIM	HGNC	e!Ensembl
611257	29411	ENSG00000151952

Protein

UniProt ID

Q14C87

Protein name

Transmembrane protein 132D (Mature oligodendrocytes transmembrane protein) (Mature OL transmembrane protein)

Protein function

Regulate neuronals morphology via inhibition of the WAVE regulatory complex (WCR), a complex that controls F-actin cytoskeletal dynamics.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15705	TMEM132D_N	49 → 179	Mature oligodendrocyte transmembrane protein, TMEM132D, N-term	Family
PF16070	TMEM132	436 → 779	Transmembrane protein family 132	Family
PF15706	TMEM132D_C	886 → 972	Mature oligodendrocyte transmembrane protein, TMEM132D, C-term	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in mature oligodendrocytes. Detected in the brain, lung, pancreas and testis (PubMed:12966072). Highly expressed in mature neurons of the adult nervous system (PubMed:33726789). {ECO:0000269|PubMed:12966072, ECO:0000269|PubMe

Sequence

MCPSEMGTLWHHWSPVLISLAALFSKVTEGRGILESIQRFSLLPTYLPVTYHINNADVSF
FLKEANQDIMRNSSLQSRVESFLIYKSRRLPVLNASYGPFSIEQVVPQDLMLPSNPFGFT
NKFSLNWKLKAHILRDKVYLSRPKVQVLFHIMGRDWDDRSAGEKLPCLRVFAFRETREVR
GSCRLQGDLGLCVAELELLSSWFSPPTVVAGRRKSVDQPEGTPVELYYTVHPGGERGDCV
REDARRSNGIRTGHSDIDESGPPLQRIGSIFLYQTHRKPSLRELRLDNSVAIHYIPKTVR
KGDVLTFPVSISRNSTEDRFTLRAKVKKGVNIIGVRASSPSIWDVKERTDYTGKYAPAVI
VCQKKAAGSENSADGASYEVMQIDVEVEEPGDLPATQLVTWQVEYPGEITSDLGVSKIYV
SPKDLIGVVPLAMEAEILNTAILTGKTVAVPVKVVSVEDDGTVTELLESVECRSSDEDVI
KVSDRCDYVFVNGKEMKGKVNVVVNFTYQHLSSPLEMTVWVPRLPLQIEVSDTELNQIKG
WRVPIVSSRRPAGDSEEEEDDERRGRGCTLQYQHAMVRVLTQFVAEAAGPGGHLAHLLGS
DWQVDITELINDFMQVEEPRIAKLQGGQILMGQELGMTTIQILSPLSDTILAEKTITVLD
EKVTITDLGVQLVTGLSLSLQLSPGSNRAIFATAVAQELLQRPKQEAAISCWVQFSDGSV
TPLDIYDGKDFSLMATSLDEKVVSIHQDPKFKWPIIAAETEGQGTLVKVEMVISESCQKS
KRKSVLAVGTANIKVKFGQNDANPNTSDSRHTGAGVHMENNVSDRRPKKPSQEWGSQEGQ
YYGSSSMGLMEGRGTTTDRSILQKKKGQESLLDDNSHLQTIPSDLTSFPAQVDLPRSNGE
MDGNDLMQASKGLSDLEIGMYALLGVFCLAILVFLINCVTFALKYRHKQVPFEEQEGMSH
SHDWVGLSNRTELLENHINFASSQDEQITAIDRGMDFEESKYLLSTNSQKSINGQLFKPL
GPIIIDGKDQKSEPPTSPTSKRKRVKFTTFTAVSSDDEYPTRNSIVMSSEDDIKWVCQDL
DPGDCKELHNYMERLHENV

Sequence length

1099

Interactions

View interactions

Show/Hide Causal Diseases (3)

Disease term	Disease name	dbSNP ID	References
Causal
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297	27903959
Lung carcinoma	Small cell carcinoma of lung	rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355 View all (44 more)	22941189
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	21926974

Show/Hide Unknown Diseases (4)

Disease term	Disease name	Source
Unknown
Mental retardation	intellectual disability	GenCC
Asthma	Asthma	GWAS
Diabetes	Diabetes	GWAS
Dementia	Dementia	GWAS

Show/Hide Text Mining Associations (9)

Disease Name	Relationship Type	References
Associations from Text Mining
Anxiety	Associate	27318301
Bipolar Disorder	Associate	27112568
Colorectal Neoplasms	Associate	24951259
Frontotemporal Dementia	Associate	32576262
Neoplasm Metastasis	Associate	25863124
Neoplasms	Associate	25863124, 26448945
Ovarian Neoplasms	Associate	26448945
Retinal Detachment	Associate	37695605
Small Cell Lung Carcinoma	Associate	25863124

TMEM132D (transmembrane protein 132D)