Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	121256
Gene name	Transmembrane protein 132D
Gene symbol	TMEM132D
Synonyms (NCBI Gene)	MOLTPPP1R153
Chromosome	12
Chromosome location	12q24.33

Show/Hide all (88)

miRTarBase ID	miRNA	Experiments
MIRT1430751	hsa-miR-1273f	CLIP-seq
MIRT1430752	hsa-miR-1287	CLIP-seq
MIRT1430753	hsa-miR-1343	CLIP-seq
MIRT1430754	hsa-miR-143	CLIP-seq
MIRT1430755	hsa-miR-185	CLIP-seq
MIRT1430756	hsa-miR-2116	CLIP-seq
MIRT1430757	hsa-miR-3074-5p	CLIP-seq
MIRT1430758	hsa-miR-3124-3p	CLIP-seq
MIRT1430759	hsa-miR-3125	CLIP-seq
MIRT1430760	hsa-miR-3135b	CLIP-seq
MIRT1430761	hsa-miR-3150b-3p	CLIP-seq
MIRT1430762	hsa-miR-3173-3p	CLIP-seq
MIRT1430763	hsa-miR-3690	CLIP-seq
MIRT1430764	hsa-miR-370	CLIP-seq
MIRT1430765	hsa-miR-378g	CLIP-seq
MIRT1430766	hsa-miR-3916	CLIP-seq
MIRT1430767	hsa-miR-4252	CLIP-seq
MIRT1430768	hsa-miR-4254	CLIP-seq
MIRT1430769	hsa-miR-4270	CLIP-seq
MIRT1430770	hsa-miR-4306	CLIP-seq
MIRT1430771	hsa-miR-4441	CLIP-seq
MIRT1430772	hsa-miR-4463	CLIP-seq
MIRT1430773	hsa-miR-4534	CLIP-seq
MIRT1430774	hsa-miR-4644	CLIP-seq
MIRT1430775	hsa-miR-4677-5p	CLIP-seq
MIRT1430776	hsa-miR-4687-3p	CLIP-seq
MIRT1430777	hsa-miR-4699-3p	CLIP-seq
MIRT1430778	hsa-miR-4708-5p	CLIP-seq
MIRT1430779	hsa-miR-4770	CLIP-seq
MIRT1430780	hsa-miR-4784	CLIP-seq
MIRT1430781	hsa-miR-4797-5p	CLIP-seq
MIRT1430782	hsa-miR-516a-3p	CLIP-seq
MIRT1430783	hsa-miR-765	CLIP-seq
MIRT1430784	hsa-miR-875-3p	CLIP-seq
MIRT1430751	hsa-miR-1273f	CLIP-seq
MIRT1430752	hsa-miR-1287	CLIP-seq
MIRT1430754	hsa-miR-143	CLIP-seq
MIRT1430755	hsa-miR-185	CLIP-seq
MIRT2129170	hsa-miR-2110	CLIP-seq
MIRT2129171	hsa-miR-2355-3p	CLIP-seq
MIRT2129172	hsa-miR-2392	CLIP-seq
MIRT1430757	hsa-miR-3074-5p	CLIP-seq
MIRT1430760	hsa-miR-3135b	CLIP-seq
MIRT2129173	hsa-miR-3150a-3p	CLIP-seq
MIRT2129174	hsa-miR-3175	CLIP-seq
MIRT2129175	hsa-miR-3605-5p	CLIP-seq
MIRT1430764	hsa-miR-370	CLIP-seq
MIRT1430765	hsa-miR-378g	CLIP-seq
MIRT2129176	hsa-miR-4260	CLIP-seq
MIRT1430770	hsa-miR-4306	CLIP-seq
MIRT1430774	hsa-miR-4644	CLIP-seq
MIRT2129177	hsa-miR-4646-3p	CLIP-seq
MIRT1430778	hsa-miR-4708-5p	CLIP-seq
MIRT1430779	hsa-miR-4770	CLIP-seq
MIRT1430781	hsa-miR-4797-5p	CLIP-seq
MIRT1430782	hsa-miR-516a-3p	CLIP-seq
MIRT2129178	hsa-miR-676	CLIP-seq
MIRT2129179	hsa-miR-939	CLIP-seq
MIRT1430752	hsa-miR-1287	CLIP-seq
MIRT2350753	hsa-miR-146a	CLIP-seq
MIRT2350754	hsa-miR-146b-5p	CLIP-seq
MIRT2129170	hsa-miR-2110	CLIP-seq
MIRT2129172	hsa-miR-2392	CLIP-seq
MIRT1430757	hsa-miR-3074-5p	CLIP-seq
MIRT1430760	hsa-miR-3135b	CLIP-seq
MIRT2129173	hsa-miR-3150a-3p	CLIP-seq
MIRT2129174	hsa-miR-3175	CLIP-seq
MIRT2129175	hsa-miR-3605-5p	CLIP-seq
MIRT1430764	hsa-miR-370	CLIP-seq
MIRT1430765	hsa-miR-378g	CLIP-seq
MIRT2350755	hsa-miR-3929	CLIP-seq
MIRT2129176	hsa-miR-4260	CLIP-seq
MIRT2350756	hsa-miR-4419b	CLIP-seq
MIRT2350757	hsa-miR-4478	CLIP-seq
MIRT2350758	hsa-miR-4484	CLIP-seq
MIRT2350759	hsa-miR-4765	CLIP-seq
MIRT2350760	hsa-miR-4766-5p	CLIP-seq
MIRT2350761	hsa-miR-488	CLIP-seq
MIRT1430782	hsa-miR-516a-3p	CLIP-seq
MIRT2350762	hsa-miR-548an	CLIP-seq
MIRT2350763	hsa-miR-589	CLIP-seq
MIRT2129179	hsa-miR-939	CLIP-seq
MIRT1430752	hsa-miR-1287	CLIP-seq
MIRT1430757	hsa-miR-3074-5p	CLIP-seq
MIRT1430760	hsa-miR-3135b	CLIP-seq
MIRT1430764	hsa-miR-370	CLIP-seq
MIRT1430765	hsa-miR-378g	CLIP-seq
MIRT1430782	hsa-miR-516a-3p	CLIP-seq

Show/Hide all (3)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	19389623, 33726789
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	NAS	12966072

MIM	HGNC	e!Ensembl
611257	29411	ENSG00000151952

Q14C87

Protein name

Transmembrane protein 132D (Mature oligodendrocytes transmembrane protein) (Mature OL transmembrane protein)

Protein function

Regulate neuronals morphology via inhibition of the WAVE regulatory complex (WCR), a complex that controls F-actin cytoskeletal dynamics.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15705	TMEM132D_N	49 → 179	Mature oligodendrocyte transmembrane protein, TMEM132D, N-term	Family
PF16070	TMEM132	436 → 779	Transmembrane protein family 132	Family
PF15706	TMEM132D_C	886 → 972	Mature oligodendrocyte transmembrane protein, TMEM132D, C-term	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in mature oligodendrocytes. Detected in the brain, lung, pancreas and testis (PubMed:12966072). Highly expressed in mature neurons of the adult nervous system (PubMed:33726789). {ECO:0000269|PubMed:12966072, ECO:0000269|PubMe

Sequence

MCPSEMGTLWHHWSPVLISLAALFSKVTEGRGILESIQRFSLLPTYLPVTYHINNADVSF
FLKEANQDIMRNSSLQSRVESFLIYKSRRLPVLNASYGPFSIEQVVPQDLMLPSNPFGFT
NKFSLNWKLKAHILRDKVYLSRPKVQVLFHIMGRDWDDRSAGEKLPCLRVFAFRETREVR
GSCRLQGDLGLCVAELELLSSWFSPPTVVAGRRKSVDQPEGTPVELYYTVHPGGERGDCV
REDARRSNGIRTGHSDIDESGPPLQRIGSIFLYQTHRKPSLRELRLDNSVAIHYIPKTVR
KGDVLTFPVSISRNSTEDRFTLRAKVKKGVNIIGVRASSPSIWDVKERTDYTGKYAPAVI
VCQKKAAGSENSADGASYEVMQIDVEVEEPGDLPATQLVTWQVEYPGEITSDLGVSKIYV
SPKDLIGVVPLAMEAEILNTAILTGKTVAVPVKVVSVEDDGTVTELLESVECRSSDEDVI
KVSDRCDYVFVNGKEMKGKVNVVVNFTYQHLSSPLEMTVWVPRLPLQIEVSDTELNQIKG
WRVPIVSSRRPAGDSEEEEDDERRGRGCTLQYQHAMVRVLTQFVAEAAGPGGHLAHLLGS
DWQVDITELINDFMQVEEPRIAKLQGGQILMGQELGMTTIQILSPLSDTILAEKTITVLD
EKVTITDLGVQLVTGLSLSLQLSPGSNRAIFATAVAQELLQRPKQEAAISCWVQFSDGSV
TPLDIYDGKDFSLMATSLDEKVVSIHQDPKFKWPIIAAETEGQGTLVKVEMVISESCQKS
KRKSVLAVGTANIKVKFGQNDANPNTSDSRHTGAGVHMENNVSDRRPKKPSQEWGSQEGQ
YYGSSSMGLMEGRGTTTDRSILQKKKGQESLLDDNSHLQTIPSDLTSFPAQVDLPRSNGE
MDGNDLMQASKGLSDLEIGMYALLGVFCLAILVFLINCVTFALKYRHKQVPFEEQEGMSH
SHDWVGLSNRTELLENHINFASSQDEQITAIDRGMDFEESKYLLSTNSQKSINGQLFKPL
GPIIIDGKDQKSEPPTSPTSKRKRVKFTTFTAVSSDDEYPTRNSIVMSSEDDIKWVCQDL
DPGDCKELHNYMERLHENV

Sequence length

1099

Interactions

View interactions

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
TMEM132D-related disorder	Likely benign; Benign	rs144926631, rs762639339, rs149686713, rs73159540, rs555131, rs10773594, rs753420447, rs150964423, rs757602371, rs143257185, rs184778944, rs150876325, rs372463803, rs758753338, rs199691995 View all (10 more)	RCV003954220 RCV003907033 RCV003904219 RCV003979751 RCV003979805 RCV003982521 RCV003904105 RCV003973945 RCV003977055 RCV003951909 RCV003964188 RCV003929422 RCV003951694 RCV003959272 RCV003947146 RCV003954746 RCV003961933 RCV003924188 RCV003976870 RCV003976873 RCV003976974 RCV003971638 RCV003969177 RCV003969198 RCV003916042
Vascular endothelial growth factor (VEGF) inhibitor response	association	rs155370	RCV002254035

Show/Hide Text Mining Associations (9)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Anxiety	Associate	27318301
Bipolar Disorder	Associate	27112568
Colorectal Neoplasms	Associate	24951259
Frontotemporal Dementia	Associate	32576262
Neoplasm Metastasis	Associate	25863124
Neoplasms	Associate	25863124, 26448945
Ovarian Neoplasms	Associate	26448945
Retinal Detachment	Associate	37695605
Small Cell Lung Carcinoma	Associate	25863124

TMEM132D (transmembrane protein 132D)