LRIG3 (leucine rich repeats and immunoglobulin like domains 3)

Gene
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
121227
Gene name Gene Name - the full gene name approved by the HGNC.
Leucine rich repeats and immunoglobulin like domains 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
LRIG3
Synonyms (NCBI Gene) Gene synonyms aliases
LIG3
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q14.1
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(248)
miRTarBase ID miRNA Experiments Reference
MIRT016034 hsa-miR-374b-5p Sequencing 20371350
MIRT031125 hsa-miR-19b-3p Sequencing 20371350
MIRT051405 hsa-let-7f-5p CLASH 23622248
MIRT050669 hsa-miR-18a-5p CLASH 23622248
MIRT048604 hsa-miR-99a-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(8)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 23723069, 30429017
GO:0005615 Component Extracellular space HDA 22664934
GO:0005615 Component Extracellular space IBA 21873635
GO:0005886 Component Plasma membrane IEA
GO:0016021 Component Integral component of membrane IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
608870 30991 ENSG00000139263
Protein
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Q6UXM1
Protein name Leucine-rich repeats and immunoglobulin-like domains protein 3 (LIG-3)
Protein function May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13855 LRR_8 121 → 179 Leucine rich repeat Repeat
PF13855 LRR_8 167 → 227 Leucine rich repeat Repeat
PF13855 LRR_8 215 → 275 Leucine rich repeat Repeat
PF13855 LRR_8 263 → 323 Leucine rich repeat Repeat
PF13855 LRR_8 311 → 371 Leucine rich repeat Repeat
PF13855 LRR_8 375 → 446 Leucine rich repeat Repeat
PF13927 Ig_3 498 → 585 Domain
PF07679 I-set 603 → 693 Immunoglobulin I-set domain Domain
PF07679 I-set 697 → 784 Immunoglobulin I-set domain Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:15203213}.
Sequence 
MSAPSLRARAAGLGLLLCAVLGRAGRSDSGGRGELGQPSGVAAERPCPTTCRCLGDLLDC
SRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS
ANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVT
SMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGA
LKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAIN
RISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSS
LKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDN
AIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKG
RSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNEL
LHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVN
MLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDV
FFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIA
GGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNV
RLSVIPTPTCDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDC
SITNTDETNLPADIPSYLSSQGTLADRQDGYVSSESGSHHQFVTSSGAGFFLPQHDSSGT
CHIDNSSEADVEAATDLFLCPFLGSTGPMYLKGNVYGSDPFETYHTGCSPDPRTVLMDHY
EPSYIKKKECYPCSHPSEESCERSFSNISWPSHVRKLLNTSYSHNEGPGMKNLCLNKSSL
DFSANPEPASVASSNSFMGTFGKALRRPHLDAYSSFGQPSDCQPRAFYLKAHSSPDLDSG
SEEDGKERTDFQEENHICTFKQTLENYRTPNFQSYDLDT
Sequence length 1119
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (1)
Unknown
Disease term Disease name Evidence References Source
Heart Failure Heart Failure GWAS
Show/Hide Text Mining Associations (11)
Associations from Text Mining
Disease Name Relationship Type References
Calcinosis Cutis Inhibit 32107843
Carcinoma Non Small Cell Lung Associate 21170350
Charcot Marie Tooth Disease Associate 26517670
Colorectal Neoplasms Inhibit 32107843
Glioma Associate 19448407, 36639372
Leukemia Lymphocytic Chronic B Cell Associate 35501457
Neoplasms Inhibit 19448407, 36639372
Neoplasms Associate 24998916
Papillomavirus Infections Associate 24998916
Uterine Cervical Dysplasia Associate 24998916