LRIG3 (leucine rich repeats and immunoglobulin like domains 3)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID 121227
Gene name Leucine rich repeats and immunoglobulin like domains 3
Gene symbol LRIG3
Synonyms (NCBI Gene)
LIG3
Chromosome 12
Chromosome location 12q14.1
miRNA miRNA information provided by mirtarbase database.
248
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (248)
miRTarBase ID miRNA Experiments Reference
MIRT016034 hsa-miR-374b-5p Sequencing 20371350
MIRT031125 hsa-miR-19b-3p Sequencing 20371350
MIRT051405 hsa-let-7f-5p CLASH 23622248
MIRT050669 hsa-miR-18a-5p CLASH 23622248
MIRT048604 hsa-miR-99a-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
10
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (10)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 23723069, 30429017, 33961781
GO:0005615 Component Extracellular space HDA 22664934
GO:0005886 Component Plasma membrane IBA
GO:0005886 Component Plasma membrane IEA
GO:0007605 Process Sensory perception of sound IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
608870 30991 ENSG00000139263
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q6UXM1
Protein name Leucine-rich repeats and immunoglobulin-like domains protein 3 (LIG-3)
Protein function May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13855 LRR_8 121 → 179 Leucine rich repeat Repeat
PF13855 LRR_8 167 → 227 Leucine rich repeat Repeat
PF13855 LRR_8 215 → 275 Leucine rich repeat Repeat
PF13855 LRR_8 263 → 323 Leucine rich repeat Repeat
PF13855 LRR_8 311 → 371 Leucine rich repeat Repeat
PF13855 LRR_8 375 → 446 Leucine rich repeat Repeat
PF13927 Ig_3 498 → 585 Domain
PF07679 I-set 603 → 693 Immunoglobulin I-set domain Domain
PF07679 I-set 697 → 784 Immunoglobulin I-set domain Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:15203213}.
Sequence 
MSAPSLRARAAGLGLLLCAVLGRAGRSDSGGRGELGQPSGVAAERPCPTTCRCLGDLLDC
SRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS
ANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVT
SMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGA
LKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAIN
RISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSS
LKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDN
AIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKG
RSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNEL
LHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVN
MLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDV
FFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIA
GGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNV
RLSVIPTPTCDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDC
SITNTDETNLPADIPSYLSSQGTLADRQDGYVSSESGSHHQFVTSSGAGFFLPQHDSSGT
CHIDNSSEADVEAATDLFLCPFLGSTGPMYLKGNVYGSDPFETYHTGCSPDPRTVLMDHY
EPSYIKKKECYPCSHPSEESCERSFSNISWPSHVRKLLNTSYSHNEGPGMKNLCLNKSSL
DFSANPEPASVASSNSFMGTFGKALRRPHLDAYSSFGQPSDCQPRAFYLKAHSSPDLDSG
SEEDGKERTDFQEENHICTFKQTLENYRTPNFQSYDLDT
Sequence length 1119
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
2
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (2)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Familial cancer of breast Likely benign rs138577440 RCV005904722
Melanoma Likely benign rs138577440 RCV005904723
Show/Hide Text Mining Associations (11)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Calcinosis Cutis Inhibit 32107843
Carcinoma Non Small Cell Lung Associate 21170350
Charcot Marie Tooth Disease Associate 26517670
Colorectal Neoplasms Inhibit 32107843
Glioma Associate 19448407, 36639372
Leukemia Lymphocytic Chronic B Cell Associate 35501457
Neoplasms Inhibit 19448407, 36639372
Neoplasms Associate 24998916
Papillomavirus Infections Associate 24998916
Uterine Cervical Dysplasia Associate 24998916