Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	1212
Gene name	Clathrin light chain B
Gene symbol	CLTB
Synonyms (NCBI Gene)	LCB
Chromosome	5
Chromosome location	5q35.2
Summary	Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytos

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miRTarBase ID	miRNA	Experiments	Reference
MIRT025306	hsa-miR-34a-5p	Proteomics	21566225
MIRT495214	hsa-miR-330-3p	PAR-CLIP	23708386
MIRT495213	hsa-miR-329-3p	PAR-CLIP	23708386
MIRT495212	hsa-miR-362-3p	PAR-CLIP	23708386
MIRT495211	hsa-miR-4503	PAR-CLIP	23708386
MIRT495214	hsa-miR-330-3p	PAR-CLIP	23708386
MIRT495213	hsa-miR-329-3p	PAR-CLIP	23708386
MIRT495212	hsa-miR-362-3p	PAR-CLIP	23708386
MIRT495211	hsa-miR-4503	PAR-CLIP	23708386
MIRT898053	hsa-miR-1254	CLIP-seq
MIRT898054	hsa-miR-1270	CLIP-seq
MIRT898055	hsa-miR-1273f	CLIP-seq
MIRT898056	hsa-miR-296-5p	CLIP-seq
MIRT898057	hsa-miR-3116	CLIP-seq
MIRT898058	hsa-miR-3150a-3p	CLIP-seq
MIRT898059	hsa-miR-3175	CLIP-seq
MIRT898060	hsa-miR-342-5p	CLIP-seq
MIRT898061	hsa-miR-3616-3p	CLIP-seq
MIRT898062	hsa-miR-4254	CLIP-seq
MIRT898063	hsa-miR-4419a	CLIP-seq
MIRT898064	hsa-miR-4459	CLIP-seq
MIRT898065	hsa-miR-4510	CLIP-seq
MIRT898066	hsa-miR-4651	CLIP-seq
MIRT898067	hsa-miR-4664-5p	CLIP-seq
MIRT898068	hsa-miR-4683	CLIP-seq
MIRT898069	hsa-miR-4710	CLIP-seq
MIRT898070	hsa-miR-4721	CLIP-seq
MIRT898071	hsa-miR-4738-5p	CLIP-seq
MIRT898072	hsa-miR-4779	CLIP-seq
MIRT898073	hsa-miR-608	CLIP-seq
MIRT898074	hsa-miR-620	CLIP-seq
MIRT898075	hsa-miR-765	CLIP-seq
MIRT898076	hsa-miR-939	CLIP-seq
MIRT898064	hsa-miR-4459	CLIP-seq
MIRT898064	hsa-miR-4459	CLIP-seq
MIRT898053	hsa-miR-1254	CLIP-seq
MIRT898054	hsa-miR-1270	CLIP-seq
MIRT2505093	hsa-miR-151-3p	CLIP-seq
MIRT898056	hsa-miR-296-5p	CLIP-seq
MIRT898057	hsa-miR-3116	CLIP-seq
MIRT2505094	hsa-miR-3184	CLIP-seq
MIRT898060	hsa-miR-342-5p	CLIP-seq
MIRT898061	hsa-miR-3616-3p	CLIP-seq
MIRT2505095	hsa-miR-3619-3p	CLIP-seq
MIRT2505096	hsa-miR-3652	CLIP-seq
MIRT2505097	hsa-miR-411	CLIP-seq
MIRT2505098	hsa-miR-423-5p	CLIP-seq
MIRT898062	hsa-miR-4254	CLIP-seq
MIRT898063	hsa-miR-4419a	CLIP-seq
MIRT2505099	hsa-miR-4430	CLIP-seq
MIRT898064	hsa-miR-4459	CLIP-seq
MIRT2505100	hsa-miR-4463	CLIP-seq
MIRT2505101	hsa-miR-4492	CLIP-seq
MIRT2505102	hsa-miR-4498	CLIP-seq
MIRT2505103	hsa-miR-4499	CLIP-seq
MIRT898065	hsa-miR-4510	CLIP-seq
MIRT2505104	hsa-miR-4640-5p	CLIP-seq
MIRT898066	hsa-miR-4651	CLIP-seq
MIRT898067	hsa-miR-4664-5p	CLIP-seq
MIRT898068	hsa-miR-4683	CLIP-seq
MIRT2505105	hsa-miR-4695-5p	CLIP-seq
MIRT898069	hsa-miR-4710	CLIP-seq
MIRT898070	hsa-miR-4721	CLIP-seq
MIRT2505106	hsa-miR-4726-5p	CLIP-seq
MIRT898071	hsa-miR-4738-5p	CLIP-seq
MIRT2505107	hsa-miR-4776-5p	CLIP-seq
MIRT898072	hsa-miR-4779	CLIP-seq
MIRT898073	hsa-miR-608	CLIP-seq
MIRT898074	hsa-miR-620	CLIP-seq
MIRT2505108	hsa-miR-665	CLIP-seq
MIRT2505109	hsa-miR-762	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005198	Function	Structural molecule activity	IEA
GO:0005515	Function	Protein binding	IPI	11889126
GO:0005802	Component	Trans-Golgi network	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005905	Component	Clathrin-coated pit	IEA
GO:0006886	Process	Intracellular protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016192	Process	Vesicle-mediated transport	IEA
GO:0030118	Component	Clathrin coat	IEA
GO:0030118	Component	Clathrin coat	ISS
GO:0030118	Component	Clathrin coat	NAS	3267234
GO:0030125	Component	Clathrin vesicle coat	IBA
GO:0030130	Component	Clathrin coat of trans-Golgi network vesicle	IEA
GO:0030132	Component	Clathrin coat of coated pit	IEA
GO:0030659	Component	Cytoplasmic vesicle membrane	IEA
GO:0030672	Component	Synaptic vesicle membrane	IBA
GO:0030672	Component	Synaptic vesicle membrane	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0032050	Function	Clathrin heavy chain binding	IBA
GO:0042277	Function	Peptide binding	IEA
GO:0045334	Component	Clathrin-coated endocytic vesicle	NAS	25898166
GO:0048488	Process	Synaptic vesicle endocytosis	IEA
GO:0060170	Component	Ciliary membrane	IEA
GO:0072583	Process	Clathrin-dependent endocytosis	IBA
GO:0098835	Component	Presynaptic endocytic zone membrane	IEA

MIM	HGNC	e!Ensembl
118970	2091	ENSG00000175416

P09497

Protein name

Clathrin light chain B (Lcb)

Protein function

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01086	Clathrin_lg_ch	1 → 228	Clathrin light chain	Family

Sequence

MADDFGFFSSSESGAPEAAEEDPAAAFLAQQESEIAGIENDEGFGAPAGSHAAPAQPGPT
SGAGSEDMGTTVNGDVFQEANGPADGYAAIAQADRLTQEPESIRKWREEQRKRLQELDAA
SKVTEQEWREKAKKDLEEWNQRQSEQVEKNKINNRIADKAFYQQPDADIIGYVASEEAFV
KESKEETPGTEWEKVAQLCDFNPKSSKQCKDVSRLRSVLMSLKQTPLSR

Sequence length

229

Interactions

View interactions

	KEGG		Reactome
	Lysosome Endocytosis Synaptic vesicle cycle Endocrine and other factor-regulated calcium reabsorption Huntington disease Bacterial invasion of epithelial cells		Gap junction degradation Formation of annular gap junctions EPH-ephrin mediated repulsion of cells Lysosome Vesicle Biogenesis WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis

CLTB (clathrin light chain B)