Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
120526
Gene name Gene Name - the full gene name approved by the HGNC.
DnaJ heat shock protein family (Hsp40) member C24
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
DNAJC24
Synonyms (NCBI Gene) Gene synonyms aliases
DPH4, JJJ3, ZCSL3
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11p13
Summary Summary of gene provided in NCBI Entrez Gene.
Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT572135 hsa-miR-490-3p PAR-CLIP 20371350
MIRT572134 hsa-miR-619-3p PAR-CLIP 20371350
MIRT572133 hsa-miR-4716-3p PAR-CLIP 20371350
MIRT572132 hsa-miR-6794-5p PAR-CLIP 20371350
MIRT572131 hsa-miR-6744-5p PAR-CLIP 20371350
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001671 Function ATPase activator activity IBA 21873635
GO:0001671 Function ATPase activator activity IDA 22367199
GO:0005737 Component Cytoplasm IEA
GO:0005856 Component Cytoskeleton IEA
GO:0008198 Function Ferrous iron binding IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
611072 26979 ENSG00000170946
Protein
UniProt ID Q6P3W2
Protein name DnaJ homolog subfamily C member 24 (CSL-type zinc finger-containing protein 3) (Diphthamide biosynthesis protein 4)
Protein function Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron-bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translation
PDB 2L6L
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00226 DnaJ 11 79 DnaJ domain Domain
PF05207 zf-CSL 95 148 CSL zinc finger Domain
Sequence
Sequence length 149
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Synthesis of diphthamide-EEF2
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
Glaucoma Glaucoma rs121918355, rs1566660365, rs1566635134, rs121918356, rs1566634475, rs28936700, rs55771538, rs28936701, rs104893622, rs55989760, rs72549387, rs104893628, rs2125316417, rs104893629, rs74315328
View all (29 more)
25027321
Unknown
Disease term Disease name Evidence References Source
Gout Gout GWAS
Insomnia Insomnia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Carcinoma Hepatocellular Associate 35606363
Hypoxia Stimulate 35606363
Neoplasms Inhibit 35606363