CALHM3 (calcium homeostasis modulator 3)

Gene

• Entrez ID: 119395
• Gene name: Calcium homeostasis modulator 3
• Gene symbol: CALHM3
• Synonyms (NCBI Gene): FAM26A, bA225H22.7
• Chromosome: 10
• Chromosome location: 10q24.33

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018398	hsa-miR-335-5p	Microarray	18185580

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005244	Function	Voltage-gated monoatomic ion channel activity	IEA
GO:0005244	Function	Voltage-gated monoatomic ion channel activity	ISS
GO:0005261	Function	Monoatomic cation channel activity	IBA
GO:0005262	Function	Calcium channel activity	IEA
GO:0005515	Function	Protein binding	IPI	30126976
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006816	Process	Calcium ion transport	IEA
GO:0015867	Process	ATP transport	IEA
GO:0015867	Process	ATP transport	ISS
GO:0016020	Component	Membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	ISS
GO:0022832	Function	Voltage-gated channel activity	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0050909	Process	Sensory perception of taste	IEA
GO:0050909	Process	Sensory perception of taste	ISS
GO:0051291	Process	Protein heterooligomerization	IEA
GO:0051291	Process	Protein heterooligomerization	ISS
GO:0070588	Process	Calcium ion transmembrane transport	IEA
GO:1904669	Process	ATP export	IEA

Other IDs

• MIM: 618263
• HGNC: 23458
• e!Ensembl: ENSG00000183128

Protein

• UniProt ID: Q86XJ0
• Protein name: Calcium homeostasis modulator protein 3 (Protein A)
• Protein function: Pore-forming subunit of gustatory voltage-gated ion channels required for sensory perception of sweet, bitter and umami tastes. With CALHM1 forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells, ATP acting as a neu
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF14798	Ca_hom_mod	1 → 252	Calcium homeostasis modulator	Family

• Tissue specificity: TISSUE SPECIFICITY: Specifically expressed in circumvallate taste bud cells. {ECO:0000269|PubMed:19997627}.
• Sequence:

  MDKFRMLFQHFQSSSESVMNGICLLLAAVTVKLYSSFDFNCPCLVHYNALYGLGLLLTPP
  LALFLCGLLANRQSVVMVEEWRRPAGHRRKDPGIIRYMCSSVLQRALAAPLVWILLALLD
  GKCFVCAFSSSVDPEKFLDFANMTPSQVQLFLAKVPCKEDELVRDSPARKAVSRYLRCLS
  QAIGWSVTLLLIIAAFLARCLRPCFDQTVFLQRRYWSNYVDLEQKLFDETCCEHARDFAH
  RCVLHFFASMRSELQARGLRRGNAGRRLELPAVPEPPEGLDSGSGKAHLRAISSREQVDR
  LLSTWYSSKPPLDLAASPGLCGGGLSHRAPTLALGTRLSQHTDV

• Sequence length: 344