Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein
Entrez ID	1192
Gene name	Chloride intracellular channel 1
Gene symbol	CLIC1
Synonyms (NCBI Gene)	CL1C1CLCNL1G6NCC27
Chromosome	6
Chromosome location	6p21.33
Summary	Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracel

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miRTarBase ID	miRNA	Experiments	Reference
MIRT004124	hsa-miR-192-5p	Microarray	16822819
MIRT004186	hsa-miR-197-3p	Microarray	16822819
MIRT050364	hsa-miR-25-3p	CLASH	23622248
MIRT049437	hsa-miR-92a-3p	CLASH	23622248
MIRT046924	hsa-miR-221-3p	CLASH	23622248
MIRT038667	hsa-miR-183-3p	CLASH	23622248
MIRT038595	hsa-miR-106b-3p	CLASH	23622248
MIRT896218	hsa-miR-122	CLIP-seq
MIRT896219	hsa-miR-1224-3p	CLIP-seq
MIRT896220	hsa-miR-1225-5p	CLIP-seq
MIRT896221	hsa-miR-1260	CLIP-seq
MIRT896222	hsa-miR-1260b	CLIP-seq
MIRT896223	hsa-miR-1280	CLIP-seq
MIRT896224	hsa-miR-2355-3p	CLIP-seq
MIRT896225	hsa-miR-3132	CLIP-seq
MIRT896226	hsa-miR-3198	CLIP-seq
MIRT896227	hsa-miR-3657	CLIP-seq
MIRT896228	hsa-miR-3908	CLIP-seq
MIRT896229	hsa-miR-3942-5p	CLIP-seq
MIRT896230	hsa-miR-4309	CLIP-seq
MIRT896231	hsa-miR-4434	CLIP-seq
MIRT896232	hsa-miR-4516	CLIP-seq
MIRT896233	hsa-miR-4531	CLIP-seq
MIRT896234	hsa-miR-4669	CLIP-seq
MIRT896235	hsa-miR-4694-3p	CLIP-seq
MIRT896236	hsa-miR-4703-5p	CLIP-seq
MIRT896237	hsa-miR-4752	CLIP-seq
MIRT896238	hsa-miR-4766-3p	CLIP-seq
MIRT896239	hsa-miR-4781-3p	CLIP-seq
MIRT896240	hsa-miR-4802-5p	CLIP-seq
MIRT896241	hsa-miR-574-5p	CLIP-seq
MIRT896242	hsa-miR-676	CLIP-seq
MIRT896220	hsa-miR-1225-5p	CLIP-seq
MIRT1965718	hsa-miR-3126-5p	CLIP-seq
MIRT896225	hsa-miR-3132	CLIP-seq
MIRT1965719	hsa-miR-3190	CLIP-seq
MIRT896228	hsa-miR-3908	CLIP-seq
MIRT1965720	hsa-miR-3918	CLIP-seq
MIRT896229	hsa-miR-3942-5p	CLIP-seq
MIRT1965721	hsa-miR-4261	CLIP-seq
MIRT1965722	hsa-miR-4419a	CLIP-seq
MIRT896231	hsa-miR-4434	CLIP-seq
MIRT1965723	hsa-miR-4491	CLIP-seq
MIRT1965724	hsa-miR-4510	CLIP-seq
MIRT1965725	hsa-miR-4512	CLIP-seq
MIRT896232	hsa-miR-4516	CLIP-seq
MIRT896233	hsa-miR-4531	CLIP-seq
MIRT1965726	hsa-miR-4657	CLIP-seq
MIRT1965727	hsa-miR-4685-5p	CLIP-seq
MIRT896235	hsa-miR-4694-3p	CLIP-seq
MIRT896236	hsa-miR-4703-5p	CLIP-seq
MIRT1965728	hsa-miR-4733-3p	CLIP-seq
MIRT896237	hsa-miR-4752	CLIP-seq
MIRT896238	hsa-miR-4766-3p	CLIP-seq
MIRT896240	hsa-miR-4802-5p	CLIP-seq
MIRT896218	hsa-miR-122	CLIP-seq
MIRT896220	hsa-miR-1225-5p	CLIP-seq
MIRT2201638	hsa-miR-1236	CLIP-seq
MIRT896225	hsa-miR-3132	CLIP-seq
MIRT1965719	hsa-miR-3190	CLIP-seq
MIRT896227	hsa-miR-3657	CLIP-seq
MIRT896228	hsa-miR-3908	CLIP-seq
MIRT1965720	hsa-miR-3918	CLIP-seq
MIRT896229	hsa-miR-3942-5p	CLIP-seq
MIRT1965721	hsa-miR-4261	CLIP-seq
MIRT896231	hsa-miR-4434	CLIP-seq
MIRT1965723	hsa-miR-4491	CLIP-seq
MIRT1965725	hsa-miR-4512	CLIP-seq
MIRT896232	hsa-miR-4516	CLIP-seq
MIRT896233	hsa-miR-4531	CLIP-seq
MIRT1965726	hsa-miR-4657	CLIP-seq
MIRT896234	hsa-miR-4669	CLIP-seq
MIRT1965727	hsa-miR-4685-5p	CLIP-seq
MIRT896235	hsa-miR-4694-3p	CLIP-seq
MIRT896236	hsa-miR-4703-5p	CLIP-seq
MIRT1965728	hsa-miR-4733-3p	CLIP-seq
MIRT896237	hsa-miR-4752	CLIP-seq
MIRT896238	hsa-miR-4766-3p	CLIP-seq
MIRT896240	hsa-miR-4802-5p	CLIP-seq
MIRT896241	hsa-miR-574-5p	CLIP-seq
MIRT2201639	hsa-miR-665	CLIP-seq
MIRT896218	hsa-miR-122	CLIP-seq
MIRT896219	hsa-miR-1224-3p	CLIP-seq
MIRT896220	hsa-miR-1225-5p	CLIP-seq
MIRT2201638	hsa-miR-1236	CLIP-seq
MIRT896221	hsa-miR-1260	CLIP-seq
MIRT896222	hsa-miR-1260b	CLIP-seq
MIRT896223	hsa-miR-1280	CLIP-seq
MIRT2504523	hsa-miR-193a-3p	CLIP-seq
MIRT2504524	hsa-miR-193b	CLIP-seq
MIRT896224	hsa-miR-2355-3p	CLIP-seq
MIRT2504525	hsa-miR-302a	CLIP-seq
MIRT2504526	hsa-miR-302b	CLIP-seq
MIRT2504527	hsa-miR-302c	CLIP-seq
MIRT2504528	hsa-miR-302d	CLIP-seq
MIRT2504529	hsa-miR-302e	CLIP-seq
MIRT2504530	hsa-miR-3124-3p	CLIP-seq
MIRT896225	hsa-miR-3132	CLIP-seq
MIRT2504531	hsa-miR-3187-3p	CLIP-seq
MIRT1965719	hsa-miR-3190	CLIP-seq
MIRT896226	hsa-miR-3198	CLIP-seq
MIRT896227	hsa-miR-3657	CLIP-seq
MIRT2504532	hsa-miR-372	CLIP-seq
MIRT2504533	hsa-miR-373	CLIP-seq
MIRT896228	hsa-miR-3908	CLIP-seq
MIRT1965720	hsa-miR-3918	CLIP-seq
MIRT2504534	hsa-miR-3938	CLIP-seq
MIRT896229	hsa-miR-3942-5p	CLIP-seq
MIRT1965721	hsa-miR-4261	CLIP-seq
MIRT896230	hsa-miR-4309	CLIP-seq
MIRT896231	hsa-miR-4434	CLIP-seq
MIRT2504535	hsa-miR-4446-5p	CLIP-seq
MIRT1965723	hsa-miR-4491	CLIP-seq
MIRT1965725	hsa-miR-4512	CLIP-seq
MIRT896232	hsa-miR-4516	CLIP-seq
MIRT2504536	hsa-miR-4529-5p	CLIP-seq
MIRT896233	hsa-miR-4531	CLIP-seq
MIRT1965726	hsa-miR-4657	CLIP-seq
MIRT896234	hsa-miR-4669	CLIP-seq
MIRT1965727	hsa-miR-4685-5p	CLIP-seq
MIRT896236	hsa-miR-4703-5p	CLIP-seq
MIRT1965728	hsa-miR-4733-3p	CLIP-seq
MIRT896237	hsa-miR-4752	CLIP-seq
MIRT2504537	hsa-miR-4755-5p	CLIP-seq
MIRT896238	hsa-miR-4766-3p	CLIP-seq
MIRT896239	hsa-miR-4781-3p	CLIP-seq
MIRT2504538	hsa-miR-520a-3p	CLIP-seq
MIRT2504539	hsa-miR-520b	CLIP-seq
MIRT2504540	hsa-miR-520c-3p	CLIP-seq
MIRT2504541	hsa-miR-520d-3p	CLIP-seq
MIRT2504542	hsa-miR-520e	CLIP-seq
MIRT896241	hsa-miR-574-5p	CLIP-seq
MIRT2504543	hsa-miR-642a	CLIP-seq
MIRT2201639	hsa-miR-665	CLIP-seq
MIRT2504544	hsa-miR-670	CLIP-seq
MIRT896242	hsa-miR-676	CLIP-seq
MIRT896218	hsa-miR-122	CLIP-seq
MIRT896220	hsa-miR-1225-5p	CLIP-seq
MIRT2201638	hsa-miR-1236	CLIP-seq
MIRT2504523	hsa-miR-193a-3p	CLIP-seq
MIRT2504524	hsa-miR-193b	CLIP-seq
MIRT2504525	hsa-miR-302a	CLIP-seq
MIRT2504526	hsa-miR-302b	CLIP-seq
MIRT2504527	hsa-miR-302c	CLIP-seq
MIRT2504528	hsa-miR-302d	CLIP-seq
MIRT2504529	hsa-miR-302e	CLIP-seq
MIRT2504530	hsa-miR-3124-3p	CLIP-seq
MIRT896225	hsa-miR-3132	CLIP-seq
MIRT2504531	hsa-miR-3187-3p	CLIP-seq
MIRT1965719	hsa-miR-3190	CLIP-seq
MIRT896226	hsa-miR-3198	CLIP-seq
MIRT896227	hsa-miR-3657	CLIP-seq
MIRT2504532	hsa-miR-372	CLIP-seq
MIRT2504533	hsa-miR-373	CLIP-seq
MIRT896228	hsa-miR-3908	CLIP-seq
MIRT1965720	hsa-miR-3918	CLIP-seq
MIRT2504534	hsa-miR-3938	CLIP-seq
MIRT896229	hsa-miR-3942-5p	CLIP-seq
MIRT1965721	hsa-miR-4261	CLIP-seq
MIRT896230	hsa-miR-4309	CLIP-seq
MIRT896231	hsa-miR-4434	CLIP-seq
MIRT2504535	hsa-miR-4446-5p	CLIP-seq
MIRT1965723	hsa-miR-4491	CLIP-seq
MIRT1965725	hsa-miR-4512	CLIP-seq
MIRT896232	hsa-miR-4516	CLIP-seq
MIRT2504536	hsa-miR-4529-5p	CLIP-seq
MIRT896233	hsa-miR-4531	CLIP-seq
MIRT1965726	hsa-miR-4657	CLIP-seq
MIRT896234	hsa-miR-4669	CLIP-seq
MIRT1965727	hsa-miR-4685-5p	CLIP-seq
MIRT896235	hsa-miR-4694-3p	CLIP-seq
MIRT896236	hsa-miR-4703-5p	CLIP-seq
MIRT1965728	hsa-miR-4733-3p	CLIP-seq
MIRT896237	hsa-miR-4752	CLIP-seq
MIRT2504537	hsa-miR-4755-5p	CLIP-seq
MIRT896238	hsa-miR-4766-3p	CLIP-seq
MIRT896240	hsa-miR-4802-5p	CLIP-seq
MIRT2504538	hsa-miR-520a-3p	CLIP-seq
MIRT2504539	hsa-miR-520b	CLIP-seq
MIRT2504540	hsa-miR-520c-3p	CLIP-seq
MIRT2504541	hsa-miR-520d-3p	CLIP-seq
MIRT2504542	hsa-miR-520e	CLIP-seq
MIRT896241	hsa-miR-574-5p	CLIP-seq
MIRT2504543	hsa-miR-642a	CLIP-seq
MIRT2201639	hsa-miR-665	CLIP-seq
MIRT2504544	hsa-miR-670	CLIP-seq

Show/Hide all (40)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005254	Function	Chloride channel activity	IBA
GO:0005254	Function	Chloride channel activity	IDA	9139710
GO:0005254	Function	Chloride channel activity	IEA
GO:0005515	Function	Protein binding	IPI	12163479, 12681486, 14667819, 24338975, 26618866, 28514442, 29924966, 31324722, 32296183, 35156780, 36012204
GO:0005615	Component	Extracellular space	HDA	22664934
GO:0005634	Component	Nucleus	HDA	16791210
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	16130169
GO:0005635	Component	Nuclear envelope	IDA	9139710
GO:0005737	Component	Cytoplasm	HDA	16791210
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	10793131
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005903	Component	Brush border	TAS	10793131
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006821	Process	Chloride transport	IBA
GO:0006821	Process	Chloride transport	IDA	9139710
GO:0006821	Process	Chloride transport	IEA
GO:0007165	Process	Signal transduction	TAS	16130169
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0031965	Component	Nuclear membrane	IEA
GO:0031982	Component	Vesicle	HDA	19190083
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0034702	Component	Monoatomic ion channel complex	IEA
GO:0034707	Component	Chloride channel complex	IEA
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0045669	Process	Positive regulation of osteoblast differentiation	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	12681486
GO:0051881	Process	Regulation of mitochondrial membrane potential	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337, 23533145
GO:0070062	Component	Extracellular exosome	IDA	15326289
GO:0070527	Process	Platelet aggregation	HMP	23382103
GO:0072562	Component	Blood microparticle	HDA	22516433
GO:1902476	Process	Chloride transmembrane transport	IEA

MIM	HGNC	e!Ensembl
602872	2062	ENSG00000213719

O00299

Protein name

Chloride intracellular channel protein 1 (Chloride channel ABP) (Glutaredoxin-like oxidoreductase CLIC1) (EC 1.8.-.-) (Glutathione-dependent dehydroascorbate reductase CLIC1) (EC 1.8.5.1) (Nuclear chloride ion channel 27) (NCC27) (Regulatory nuclear chlor

Protein function

In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Reduces selenite and dehydroascorbate and may act as an antioxidant during oxidative stress response (PubMed:2558102

PDB

1K0M , 1K0N , 1K0O , 1RK4 , 3O3T , 3P8W , 3P90 , 3QR6 , 3SWL , 3TGZ , 3UVH , 4IQA , 4JZQ , 4K0G , 4K0N , 7F8R , 7FBQ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13409	GST_N_2	23 → 87	Glutathione S-transferase, N-terminal domain	Domain
PF13410	GST_C_2	123 → 211		Domain

Tissue specificity

TISSUE SPECIFICITY: Expression is prominent in heart, placenta, liver, kidney and pancreas. {ECO:0000269|PubMed:10793131}.

Sequence

MAEEQPQVELFVKAGSDGAKIGNCPFSQRLFMVLWLKGVTFNVTTVDTKRRTETVQKLCP
GGQLPFLLYGTEVHTDTNKIEEFLEAVLCPPRYPKLAALNPESNTAGLDIFAKFSAYIKN
SNPALNDNLEKGLLKALKVLDNYLTSPLPEEVDETSAEDEGVSQRKFLDGNELTLADCNL
LPKLHIVQVVCKKYRGFTIPEAFRGVHRYLSNAYAREEFASTCPDDEEIELAYEQVAKAL
K

Sequence length

241

Interactions

View interactions

CLIC1 (chloride intracellular channel 1)