Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	1192
Gene name Gene Name - the full gene name approved by the HGNC.	Chloride intracellular channel 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CLIC1
Synonyms (NCBI Gene) Gene synonyms aliases	CL1C1, CLCNL1, G6, NCC27
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6p21.33
Summary Summary of gene provided in NCBI Entrez Gene.	Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracel

Show/Hide all(186)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004124	hsa-miR-192-5p	Microarray	16822819
MIRT004186	hsa-miR-197-3p	Microarray	16822819
MIRT050364	hsa-miR-25-3p	CLASH	23622248
MIRT049437	hsa-miR-92a-3p	CLASH	23622248
MIRT046924	hsa-miR-221-3p	CLASH	23622248
MIRT038667	hsa-miR-183-3p	CLASH	23622248
MIRT038595	hsa-miR-106b-3p	CLASH	23622248
MIRT896218	hsa-miR-122	CLIP-seq
MIRT896219	hsa-miR-1224-3p	CLIP-seq
MIRT896220	hsa-miR-1225-5p	CLIP-seq
MIRT896221	hsa-miR-1260	CLIP-seq
MIRT896222	hsa-miR-1260b	CLIP-seq
MIRT896223	hsa-miR-1280	CLIP-seq
MIRT896224	hsa-miR-2355-3p	CLIP-seq
MIRT896225	hsa-miR-3132	CLIP-seq
MIRT896226	hsa-miR-3198	CLIP-seq
MIRT896227	hsa-miR-3657	CLIP-seq
MIRT896228	hsa-miR-3908	CLIP-seq
MIRT896229	hsa-miR-3942-5p	CLIP-seq
MIRT896230	hsa-miR-4309	CLIP-seq
MIRT896231	hsa-miR-4434	CLIP-seq
MIRT896232	hsa-miR-4516	CLIP-seq
MIRT896233	hsa-miR-4531	CLIP-seq
MIRT896234	hsa-miR-4669	CLIP-seq
MIRT896235	hsa-miR-4694-3p	CLIP-seq
MIRT896236	hsa-miR-4703-5p	CLIP-seq
MIRT896237	hsa-miR-4752	CLIP-seq
MIRT896238	hsa-miR-4766-3p	CLIP-seq
MIRT896239	hsa-miR-4781-3p	CLIP-seq
MIRT896240	hsa-miR-4802-5p	CLIP-seq
MIRT896241	hsa-miR-574-5p	CLIP-seq
MIRT896242	hsa-miR-676	CLIP-seq
MIRT896220	hsa-miR-1225-5p	CLIP-seq
MIRT1965718	hsa-miR-3126-5p	CLIP-seq
MIRT896225	hsa-miR-3132	CLIP-seq
MIRT1965719	hsa-miR-3190	CLIP-seq
MIRT896228	hsa-miR-3908	CLIP-seq
MIRT1965720	hsa-miR-3918	CLIP-seq
MIRT896229	hsa-miR-3942-5p	CLIP-seq
MIRT1965721	hsa-miR-4261	CLIP-seq
MIRT1965722	hsa-miR-4419a	CLIP-seq
MIRT896231	hsa-miR-4434	CLIP-seq
MIRT1965723	hsa-miR-4491	CLIP-seq
MIRT1965724	hsa-miR-4510	CLIP-seq
MIRT1965725	hsa-miR-4512	CLIP-seq
MIRT896232	hsa-miR-4516	CLIP-seq
MIRT896233	hsa-miR-4531	CLIP-seq
MIRT1965726	hsa-miR-4657	CLIP-seq
MIRT1965727	hsa-miR-4685-5p	CLIP-seq
MIRT896235	hsa-miR-4694-3p	CLIP-seq
MIRT896236	hsa-miR-4703-5p	CLIP-seq
MIRT1965728	hsa-miR-4733-3p	CLIP-seq
MIRT896237	hsa-miR-4752	CLIP-seq
MIRT896238	hsa-miR-4766-3p	CLIP-seq
MIRT896240	hsa-miR-4802-5p	CLIP-seq
MIRT896218	hsa-miR-122	CLIP-seq
MIRT896220	hsa-miR-1225-5p	CLIP-seq
MIRT2201638	hsa-miR-1236	CLIP-seq
MIRT896225	hsa-miR-3132	CLIP-seq
MIRT1965719	hsa-miR-3190	CLIP-seq
MIRT896227	hsa-miR-3657	CLIP-seq
MIRT896228	hsa-miR-3908	CLIP-seq
MIRT1965720	hsa-miR-3918	CLIP-seq
MIRT896229	hsa-miR-3942-5p	CLIP-seq
MIRT1965721	hsa-miR-4261	CLIP-seq
MIRT896231	hsa-miR-4434	CLIP-seq
MIRT1965723	hsa-miR-4491	CLIP-seq
MIRT1965725	hsa-miR-4512	CLIP-seq
MIRT896232	hsa-miR-4516	CLIP-seq
MIRT896233	hsa-miR-4531	CLIP-seq
MIRT1965726	hsa-miR-4657	CLIP-seq
MIRT896234	hsa-miR-4669	CLIP-seq
MIRT1965727	hsa-miR-4685-5p	CLIP-seq
MIRT896235	hsa-miR-4694-3p	CLIP-seq
MIRT896236	hsa-miR-4703-5p	CLIP-seq
MIRT1965728	hsa-miR-4733-3p	CLIP-seq
MIRT896237	hsa-miR-4752	CLIP-seq
MIRT896238	hsa-miR-4766-3p	CLIP-seq
MIRT896240	hsa-miR-4802-5p	CLIP-seq
MIRT896241	hsa-miR-574-5p	CLIP-seq
MIRT2201639	hsa-miR-665	CLIP-seq
MIRT896218	hsa-miR-122	CLIP-seq
MIRT896219	hsa-miR-1224-3p	CLIP-seq
MIRT896220	hsa-miR-1225-5p	CLIP-seq
MIRT2201638	hsa-miR-1236	CLIP-seq
MIRT896221	hsa-miR-1260	CLIP-seq
MIRT896222	hsa-miR-1260b	CLIP-seq
MIRT896223	hsa-miR-1280	CLIP-seq
MIRT2504523	hsa-miR-193a-3p	CLIP-seq
MIRT2504524	hsa-miR-193b	CLIP-seq
MIRT896224	hsa-miR-2355-3p	CLIP-seq
MIRT2504525	hsa-miR-302a	CLIP-seq
MIRT2504526	hsa-miR-302b	CLIP-seq
MIRT2504527	hsa-miR-302c	CLIP-seq
MIRT2504528	hsa-miR-302d	CLIP-seq
MIRT2504529	hsa-miR-302e	CLIP-seq
MIRT2504530	hsa-miR-3124-3p	CLIP-seq
MIRT896225	hsa-miR-3132	CLIP-seq
MIRT2504531	hsa-miR-3187-3p	CLIP-seq
MIRT1965719	hsa-miR-3190	CLIP-seq
MIRT896226	hsa-miR-3198	CLIP-seq
MIRT896227	hsa-miR-3657	CLIP-seq
MIRT2504532	hsa-miR-372	CLIP-seq
MIRT2504533	hsa-miR-373	CLIP-seq
MIRT896228	hsa-miR-3908	CLIP-seq
MIRT1965720	hsa-miR-3918	CLIP-seq
MIRT2504534	hsa-miR-3938	CLIP-seq
MIRT896229	hsa-miR-3942-5p	CLIP-seq
MIRT1965721	hsa-miR-4261	CLIP-seq
MIRT896230	hsa-miR-4309	CLIP-seq
MIRT896231	hsa-miR-4434	CLIP-seq
MIRT2504535	hsa-miR-4446-5p	CLIP-seq
MIRT1965723	hsa-miR-4491	CLIP-seq
MIRT1965725	hsa-miR-4512	CLIP-seq
MIRT896232	hsa-miR-4516	CLIP-seq
MIRT2504536	hsa-miR-4529-5p	CLIP-seq
MIRT896233	hsa-miR-4531	CLIP-seq
MIRT1965726	hsa-miR-4657	CLIP-seq
MIRT896234	hsa-miR-4669	CLIP-seq
MIRT1965727	hsa-miR-4685-5p	CLIP-seq
MIRT896236	hsa-miR-4703-5p	CLIP-seq
MIRT1965728	hsa-miR-4733-3p	CLIP-seq
MIRT896237	hsa-miR-4752	CLIP-seq
MIRT2504537	hsa-miR-4755-5p	CLIP-seq
MIRT896238	hsa-miR-4766-3p	CLIP-seq
MIRT896239	hsa-miR-4781-3p	CLIP-seq
MIRT2504538	hsa-miR-520a-3p	CLIP-seq
MIRT2504539	hsa-miR-520b	CLIP-seq
MIRT2504540	hsa-miR-520c-3p	CLIP-seq
MIRT2504541	hsa-miR-520d-3p	CLIP-seq
MIRT2504542	hsa-miR-520e	CLIP-seq
MIRT896241	hsa-miR-574-5p	CLIP-seq
MIRT2504543	hsa-miR-642a	CLIP-seq
MIRT2201639	hsa-miR-665	CLIP-seq
MIRT2504544	hsa-miR-670	CLIP-seq
MIRT896242	hsa-miR-676	CLIP-seq
MIRT896218	hsa-miR-122	CLIP-seq
MIRT896220	hsa-miR-1225-5p	CLIP-seq
MIRT2201638	hsa-miR-1236	CLIP-seq
MIRT2504523	hsa-miR-193a-3p	CLIP-seq
MIRT2504524	hsa-miR-193b	CLIP-seq
MIRT2504525	hsa-miR-302a	CLIP-seq
MIRT2504526	hsa-miR-302b	CLIP-seq
MIRT2504527	hsa-miR-302c	CLIP-seq
MIRT2504528	hsa-miR-302d	CLIP-seq
MIRT2504529	hsa-miR-302e	CLIP-seq
MIRT2504530	hsa-miR-3124-3p	CLIP-seq
MIRT896225	hsa-miR-3132	CLIP-seq
MIRT2504531	hsa-miR-3187-3p	CLIP-seq
MIRT1965719	hsa-miR-3190	CLIP-seq
MIRT896226	hsa-miR-3198	CLIP-seq
MIRT896227	hsa-miR-3657	CLIP-seq
MIRT2504532	hsa-miR-372	CLIP-seq
MIRT2504533	hsa-miR-373	CLIP-seq
MIRT896228	hsa-miR-3908	CLIP-seq
MIRT1965720	hsa-miR-3918	CLIP-seq
MIRT2504534	hsa-miR-3938	CLIP-seq
MIRT896229	hsa-miR-3942-5p	CLIP-seq
MIRT1965721	hsa-miR-4261	CLIP-seq
MIRT896230	hsa-miR-4309	CLIP-seq
MIRT896231	hsa-miR-4434	CLIP-seq
MIRT2504535	hsa-miR-4446-5p	CLIP-seq
MIRT1965723	hsa-miR-4491	CLIP-seq
MIRT1965725	hsa-miR-4512	CLIP-seq
MIRT896232	hsa-miR-4516	CLIP-seq
MIRT2504536	hsa-miR-4529-5p	CLIP-seq
MIRT896233	hsa-miR-4531	CLIP-seq
MIRT1965726	hsa-miR-4657	CLIP-seq
MIRT896234	hsa-miR-4669	CLIP-seq
MIRT1965727	hsa-miR-4685-5p	CLIP-seq
MIRT896235	hsa-miR-4694-3p	CLIP-seq
MIRT896236	hsa-miR-4703-5p	CLIP-seq
MIRT1965728	hsa-miR-4733-3p	CLIP-seq
MIRT896237	hsa-miR-4752	CLIP-seq
MIRT2504537	hsa-miR-4755-5p	CLIP-seq
MIRT896238	hsa-miR-4766-3p	CLIP-seq
MIRT896240	hsa-miR-4802-5p	CLIP-seq
MIRT2504538	hsa-miR-520a-3p	CLIP-seq
MIRT2504539	hsa-miR-520b	CLIP-seq
MIRT2504540	hsa-miR-520c-3p	CLIP-seq
MIRT2504541	hsa-miR-520d-3p	CLIP-seq
MIRT2504542	hsa-miR-520e	CLIP-seq
MIRT896241	hsa-miR-574-5p	CLIP-seq
MIRT2504543	hsa-miR-642a	CLIP-seq
MIRT2201639	hsa-miR-665	CLIP-seq
MIRT2504544	hsa-miR-670	CLIP-seq

Show/Hide all(32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005244	Function	Voltage-gated ion channel activity	IEA
GO:0005254	Function	Chloride channel activity	IBA	21873635
GO:0005254	Function	Chloride channel activity	IDA	9139710
GO:0005515	Function	Protein binding	IPI	12163479, 12681486, 14667819, 24338975, 28514442, 32296183
GO:0005615	Component	Extracellular space	HDA	22664934
GO:0005634	Component	Nucleus	HDA	16791210
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	TAS	16130169
GO:0005635	Component	Nuclear envelope	IDA	9139710
GO:0005737	Component	Cytoplasm	HDA	16791210
GO:0005737	Component	Cytoplasm	IDA	10793131
GO:0005739	Component	Mitochondrion	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005903	Component	Brush border	TAS	10793131
GO:0006749	Process	Glutathione metabolic process	IEA
GO:0006821	Process	Chloride transport	IDA	9139710
GO:0007165	Process	Signal transduction	TAS	16130169
GO:0016020	Component	Membrane	HDA	19946888
GO:0031965	Component	Nuclear membrane	IEA
GO:0031982	Component	Vesicle	HDA	19190083
GO:0034707	Component	Chloride channel complex	IEA
GO:0034765	Process	Regulation of ion transmembrane transport	IEA
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0045669	Process	Positive regulation of osteoblast differentiation	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	12681486
GO:0051726	Process	Regulation of cell cycle	IEA
GO:0051881	Process	Regulation of mitochondrial membrane potential	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337, 23533145
GO:0070062	Component	Extracellular exosome	IDA	15326289
GO:0070527	Process	Platelet aggregation	HMP	23382103
GO:0072562	Component	Blood microparticle	HDA	22516433
GO:1902476	Process	Chloride transmembrane transport	IEA

MIM	HGNC	e!Ensembl
602872	2062	ENSG00000213719

Protein

UniProt ID

O00299

Protein name

Chloride intracellular channel protein 1 (Chloride channel ABP) (Glutaredoxin-like oxidoreductase CLIC1) (EC 1.8.-.-) (Glutathione-dependent dehydroascorbate reductase CLIC1) (EC 1.8.5.1) (Nuclear chloride ion channel 27) (NCC27) (Regulatory nuclear chlor

Protein function

In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Reduces selenite and dehydroascorbate and may act as an antioxidant during oxidative stress response (PubMed:2558102

PDB

1K0M , 1K0N , 1K0O , 1RK4 , 3O3T , 3P8W , 3P90 , 3QR6 , 3SWL , 3TGZ , 3UVH , 4IQA , 4JZQ , 4K0G , 4K0N , 7F8R , 7FBQ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13409	GST_N_2	23 → 87	Glutathione S-transferase, N-terminal domain	Domain
PF13410	GST_C_2	123 → 211		Domain

Tissue specificity

TISSUE SPECIFICITY: Expression is prominent in heart, placenta, liver, kidney and pancreas. {ECO:0000269|PubMed:10793131}.

Sequence

MAEEQPQVELFVKAGSDGAKIGNCPFSQRLFMVLWLKGVTFNVTTVDTKRRTETVQKLCP
GGQLPFLLYGTEVHTDTNKIEEFLEAVLCPPRYPKLAALNPESNTAGLDIFAKFSAYIKN
SNPALNDNLEKGLLKALKVLDNYLTSPLPEEVDETSAEDEGVSQRKFLDGNELTLADCNL
LPKLHIVQVVCKKYRGFTIPEAFRGVHRYLSNAYAREEFASTCPDDEEIELAYEQVAKAL
K

Sequence length

241

Interactions

View interactions

Show/Hide Causal Diseases (6)

Disease term	Disease name	dbSNP ID	References
Causal
Arthritis	Degenerative polyarthritis	rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470	18784066
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158 View all (309 more)	20562527
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451 View all (71 more)	20562527
Esophagus neoplasm	Squamous cell carcinoma of esophagus	rs28934578, rs121918714, rs1567556006, rs1575166666	21517111
Marfan syndrome	Mammary Carcinoma, Human	rs137854456, rs137854457, rs267606796, rs137854458, rs137854459, rs137854460, rs137854470, rs137854471, rs267606797, rs137854461, rs137854462, rs137854463, rs869025419, rs137854464, rs137854465 View all (942 more)	20562527
Rheumatoid arthritis	Rheumatoid Arthritis	rs587776843	21156761

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Neuroticism	Neuroticism			GWAS

Show/Hide Text Mining Associations (51)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma of Lung	Associate	21858536, 36181109
Arthritis	Associate	34410943
Arthritis Psoriatic	Associate	34410943
Arthritis Rheumatoid	Associate	34177888
Atrial Fibrillation	Associate	39864423
Bile Duct Neoplasms	Associate	31106658
Breast Neoplasms	Associate	20005186
Capillary Malformation Arteriovenous Malformation	Associate	35722791
Carcinogenesis	Associate	27461670, 30229897
Carcinoma Hepatocellular	Associate	31364737, 34766585
Carcinoma Hepatocellular	Stimulate	35722791
Carcinoma Merkel Cell	Stimulate	29462791
Carcinoma Ovarian Epithelial	Associate	25582317
Carcinoma Ovarian Epithelial	Stimulate	30282979
Carcinoma Pancreatic Ductal	Associate	27461670
Carcinoma Renal Cell	Associate	31243111
Cerebrovascular Disorders	Associate	27716384
Choriocarcinoma	Associate	21330840
Colorectal Neoplasms	Associate	24587680, 25227665
Drug Related Side Effects and Adverse Reactions	Associate	28093084
Endometrial Neoplasms	Associate	22415234
Esophageal Squamous Cell Carcinoma	Associate	34148879
Gallbladder Neoplasms	Associate	25227665, 28378944, 29516682
Glioblastoma	Associate	35135603
Glioma	Associate	22578365, 35135603
Glomerulonephritis IGA	Associate	33754492
Hydatidiform Mole	Associate	21330840
IgA Vasculitis	Associate	34410943
Inflammation	Associate	34410943
Influenza Human	Associate	38257829
Leukemia Lymphocytic Chronic B Cell	Stimulate	32841520
Leukemia Lymphocytic Chronic B Cell	Associate	32841520
Liver Cirrhosis	Associate	37924785
Lung Neoplasms	Associate	31316050
Lymphatic Metastasis	Associate	36181109
Mitochondrial Diseases	Associate	36264759
Mohr Tranebjaerg syndrome	Stimulate	37104099
Neoplasm Metastasis	Associate	25205595, 31106658, 31243111, 35260554, 36181109
Neoplasm Metastasis	Stimulate	25582317, 32841520
Neoplasms	Associate	21858536, 26497050, 27461670, 27716384, 30282979, 31243111, 31316050, 32841520, 34766585, 35135603, 36181109, 36264759
Neoplasms	Stimulate	22578365, 25205595
Neoplasms Cystic Mucinous and Serous	Associate	30282979
Ovarian Neoplasms	Stimulate	25582317
Pancreatitis	Associate	36671463
Peritonitis	Associate	25582317
Personality Disorders	Associate	22578365
Pre Eclampsia	Associate	40244094
Pulmonary Arterial Hypertension	Associate	36264759
Stomach Neoplasms	Associate	22791942, 25227665, 26497050, 35260554, 37104099
Vascular Malformations	Associate	27716384
Vasculitis	Associate	34410943

CLIC1 (chloride intracellular channel 1)