PSTK (phosphoseryl-tRNA kinase)

Gene

• Entrez ID: 118672
• Gene name: Phosphoseryl-tRNA kinase
• Gene symbol: PSTK
• Synonyms (NCBI Gene): C10orf89
• Chromosome: 10
• Chromosome location: 10q26.13

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT441596	hsa-miR-4255	PAR-CLIP	22100165
MIRT441595	hsa-miR-3137	PAR-CLIP	22100165
MIRT441594	hsa-miR-20b-3p	PAR-CLIP	22100165
MIRT441593	hsa-miR-6073	PAR-CLIP	22100165
MIRT441592	hsa-miR-142-3p	PAR-CLIP	22100165
MIRT441592	hsa-miR-142-3p	PAR-CLIP	22100165
MIRT441591	hsa-miR-192-3p	PAR-CLIP	22100165
MIRT441590	hsa-miR-4776-3p	PAR-CLIP	22100165
MIRT441596	hsa-miR-4255	PAR-CLIP	22100165
MIRT441595	hsa-miR-3137	PAR-CLIP	22100165
MIRT441594	hsa-miR-20b-3p	PAR-CLIP	22100165
MIRT441593	hsa-miR-6073	PAR-CLIP	22100165
MIRT441592	hsa-miR-142-3p	PAR-CLIP	22100165
MIRT441592	hsa-miR-142-3p	PAR-CLIP	22100165
MIRT441591	hsa-miR-192-3p	PAR-CLIP	22100165
MIRT441590	hsa-miR-4776-3p	PAR-CLIP	22100165
MIRT1271204	hsa-miR-2053	CLIP-seq
MIRT1271205	hsa-miR-3182	CLIP-seq
MIRT1271206	hsa-miR-338-5p	CLIP-seq
MIRT1271207	hsa-miR-3682-5p	CLIP-seq
MIRT1271208	hsa-miR-3686	CLIP-seq
MIRT1271209	hsa-miR-3913-3p	CLIP-seq
MIRT1271210	hsa-miR-4490	CLIP-seq
MIRT1271211	hsa-miR-4659a-3p	CLIP-seq
MIRT1271212	hsa-miR-4659b-3p	CLIP-seq
MIRT1271213	hsa-miR-4774-5p	CLIP-seq
MIRT1271214	hsa-miR-489	CLIP-seq
MIRT1271215	hsa-miR-502-5p	CLIP-seq
MIRT1271216	hsa-miR-548ae	CLIP-seq
MIRT1271217	hsa-miR-548aj	CLIP-seq
MIRT1271218	hsa-miR-548am	CLIP-seq
MIRT1271219	hsa-miR-548x	CLIP-seq
MIRT1271220	hsa-miR-656	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000049	Function	TRNA binding	IBA
GO:0000166	Function	Nucleotide binding	IEA
GO:0005524	Function	ATP binding	IEA
GO:0006412	Process	Translation	IEA
GO:0016301	Function	Kinase activity	IBA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0043915	Function	L-seryl-tRNA(Sec) kinase activity	IEA

Other IDs

• MIM: 611310
• HGNC: 28578
• e!Ensembl: ENSG00000179988

Protein

• UniProt ID: Q8IV42
• Protein name: L-seryl-tRNA(Sec) kinase (EC 2.7.1.164) (O-phosphoseryl-tRNA(Sec) kinase)
• Protein function: Specifically phosphorylates seryl-tRNA(Sec) to O-phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08433	KTI12	130 → 319	Chromatin associated protein KTI12	Domain

• Sequence:

  MKTAENIRGTGSDGPRKRGLCVLCGLPAAGKSTFARALAHRLQQEQGWAIGVVAYDDVMP
  DAFLAGARARPAPSQWKLLRQELLKYLEYFLMAVINGCQMSVPPNRTEAMWEDFITCLKD
  QDLIFSAAFEAQSCYLLTKTAVSRPLFLVLDDNFYYQSMRYEVYQLARKYSLGFCQLFLD
  CPLETCLQRNGQRPQALPPETIHLMGRKLEKPNPEKNAWEHNSLTIPSPACASEASLEVT
  DLLLTALENPVKYAEDNMEQKDTDRIICSTNILHKTDQTLRRIVSQTMKEAKGNQEAFSE
  MTFKQRWVRANHAAIWRIILGNEHIKCRSAKVGWLQCCRIEKRPLSTG

• Sequence length: 348

Pathways

KEGG:

Selenocompound metabolism
Aminoacyl-tRNA biosynthesis

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
MIGRAINE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations