CLCN6 (chloride voltage-gated channel 6)
Gene | |
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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1185 |
Gene name
Gene Name - the full gene name approved by the HGNC.
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Chloride voltage-gated channel 6 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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CLCN6 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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CLC-6, CONRIBA |
Chromosome
Chromosome number
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1 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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1p36.22 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a member of the voltage-dependent chloride channel protein family. Members of this family can function as either chloride channels or antiporters. This protein is primarily localized to late endosomes and functions as a chloride/proton a |
miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein | |||||||||||||||||||||
UniProt ID | P51797 | ||||||||||||||||||||
Protein name | H(+)/Cl(-) exchange transporter 6 (Chloride channel protein 6) (ClC-6) (Chloride transport protein 6) | ||||||||||||||||||||
Protein function | Voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the late endosome lumen. The CLC channel family contains both chloride channels and proton-coupled ani | ||||||||||||||||||||
PDB | 8JPJ , 8JPO , 8JPR | ||||||||||||||||||||
Family and domains |
Pfam
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Tissue specificity | TISSUE SPECIFICITY: Testis, ovary, small intestine, brain and skeletal muscle. Low level expression in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Isoform 3 is only detected in kidney. {ECO:0000269|PubMed:10198195, ECO: | ||||||||||||||||||||
Sequence |
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Sequence length | 869 | ||||||||||||||||||||
Interactions | View interactions |
Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease information provided by ClinVar, GenCC, and GWAS databases.
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