OLFM3 (olfactomedin 3)

Gene

• Entrez ID: 118427
• Gene name: Olfactomedin 3
• Gene symbol: OLFM3
• Synonyms (NCBI Gene): NOE3, NOELIN3, OPTIMEDIN
• Chromosome: 1
• Chromosome location: 1p21.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT439119	hsa-miR-10b-5p	3'LIFE	25074381
MIRT439119	hsa-miR-10b-5p	3'LIFE	25074381
MIRT1203100	hsa-miR-4662a-5p	CLIP-seq
MIRT2058633	hsa-miR-1208	CLIP-seq
MIRT2058634	hsa-miR-3127-5p	CLIP-seq
MIRT2058635	hsa-miR-452	CLIP-seq
MIRT2058636	hsa-miR-4676-3p	CLIP-seq
MIRT2058634	hsa-miR-3127-5p	CLIP-seq
MIRT2585169	hsa-miR-190	CLIP-seq
MIRT2585170	hsa-miR-190b	CLIP-seq
MIRT2585171	hsa-miR-4645-3p	CLIP-seq
MIRT2585172	hsa-miR-4802-5p	CLIP-seq
MIRT2585173	hsa-miR-548p	CLIP-seq
MIRT2585169	hsa-miR-190	CLIP-seq
MIRT2585170	hsa-miR-190b	CLIP-seq
MIRT2585171	hsa-miR-4645-3p	CLIP-seq
MIRT2585172	hsa-miR-4802-5p	CLIP-seq
MIRT2585173	hsa-miR-548p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	12019210, 25416956, 31515488, 32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0007165	Process	Signal transduction	IBA
GO:0032281	Component	AMPA glutamate receptor complex	IEA
GO:0042462	Process	Eye photoreceptor cell development	IEA
GO:0045202	Component	Synapse	IEA

Other IDs

• MIM: 607567
• HGNC: 17990
• e!Ensembl: ENSG00000118733

Protein

• UniProt ID: Q96PB7
• Protein name: Noelin-3 (Olfactomedin-3) (Optimedin)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12308	Noelin-1	46 → 145	Neurogenesis glycoprotein	Family
  PF02191	OLF	222 → 468	Olfactomedin-like domain	Family

• Tissue specificity: TISSUE SPECIFICITY: In the eye, expressed in trabecular meshwork and neural retina; in non-ocular tissues, expressed in brain and lung. {ECO:0000269|PubMed:12019210}.
• Sequence:

  MSPPLLKLGAVLSTMAMISNWMSQTLPSLVGLNTTRLSTPDTLTQISPKEGWQVYSSAQD
  PDGRCICTVVAPEQNLCSRDAKSRQLRQLLEKVQNMSQSIEVLNLRTQRDFQYVLKMETQ
  MKGLKAKFRQIEDDRKTLMTKHFQELKEKMDELLPLIPVLEQYKTDAKLITQFKEEIRNL
  SAVLTGIQEEIGAYDYEELHQRVLSLETRLRDCMKKLTCGKLMKITGPVTVKTSGTRFGA
  WMTDPLASEKNNRVWYMDSYTNNKIVREYKSIADFVSGAESRTYNLPFKWAGTNHVVYNG
  SLYFNKYQSNIIIKYSFDMGRVLAQRSLEYAGFHNVYPYTWGGFSDIDLMADEIGLWAVY
  ATNQNAGNIVISQLNQDTLEVMKSWSTGYPKRSAGESFMICGTLYVTNSHLTGAKVYYSY
  STKTSTYEYTDIPFHNQYFHISMLDYNARDRALYAWNNGHQVLFNVTLFHIIKTEDDT

• Sequence length: 478

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARPAL TUNNEL SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DISEASE OF PERITONEUM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG ADENOCARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OPEN-ANGLE GLAUCOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Strabismus, susceptibility to	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TREATMENT-RESISTANT HYPERTENSION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Alzheimer Disease	Associate	32711556	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Multiple Sclerosis	Associate	24511991	★☆☆☆☆ Found in Text Mining only
Obesity	Associate	37800791	★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Associate	24511991	★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Associate	37800791	★☆☆☆☆ Found in Text Mining only