Gene Gene information from NCBI Gene database.
Entrez ID 117608
Gene name Zinc finger protein 354B
Gene symbol ZNF354B
Synonyms (NCBI Gene)
KID2
Chromosome 5
Chromosome location 5q35.3
miRNA miRNA information provided by mirtarbase database.
1064
miRTarBase ID miRNA Experiments Reference
MIRT026090 hsa-miR-196a-5p Sequencing 20371350
MIRT032151 hsa-let-7d-5p Sequencing 20371350
MIRT483963 hsa-miR-5588-3p HITS-CLIP 21572407
MIRT483962 hsa-miR-2114-5p HITS-CLIP 21572407
MIRT483960 hsa-miR-7852-3p HITS-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
15
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0000122 Process Negative regulation of transcription by RNA polymerase II ISS
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA
GO:0003677 Function DNA binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
HGNC N/A HGNC
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96LW1
Protein name Zinc finger protein 354B
Protein function Transcriptional repressor that binds DNA upon activation by RAS proteins signal transduction to initiate transcriptional silencing through the recruitment of additional DNA-binding proteins, multisubunit complexes and chromatin-modifying activit
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01352 KRAB 13 54 KRAB box Family
PF00096 zf-C2H2 214 236 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 242 264 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 270 292 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 298 320 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 354 376 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 382 404 Zinc finger, C2H2 type Domain
PF16622 zf-C2H2_11 407 432 zinc-finger C2H2-type Domain
PF00096 zf-C2H2 438 460 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 466 488 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 494 516 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 522 544 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 550 572 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 578 600 Zinc finger, C2H2 type Domain
Sequence
MAAGQREARPQVSLTFEDVAVLFTWDEWRKLAPSQRNLYRDVMLENYRNLVSLGLSFTKP
KVISLLQQGEDPWEVEKDSSGVSSLGCKSTPKMTKSTQTQDSFQEQIRKRLKRDEPWNFI
SERSCIYEEKLKKQQDKNENLQIISVAHTKILTVDRSHKNVEFGQNFYLKSVFIKQQRFA
KEKTPSKCEIQRNSFKQNSNLLNQSKIKTAEKRYKCSTCEKAFIHNSSLRKHQKNHTGEK
LFKCKECLKAFSQSSALIQHQRTHTGEKPYICKECGKAFSHSASLCKHLRTHTVEKCYRC
KECGKSFSRRSGLFIHQKIH
AQENPHKYNPGRKASSYSTSLSGSQKIHLRKKSYLCNECG
NTFKSSSSLRYHQRIH
TGEKPFKCSECGRAFSQSASLIQHERIHTGEKPYRCNECGKGFT
SISRLNRHRIIH
TGEKLYNCNECGKALSSHSTLIIHERIHTGEKPCKCKVCGKAFRQSSA
LIQHQRMH
TGERPYKCNECDKTFRCNSSLSNHQRIHTGEKPYRCLECGMSFGQSAALIQH
QRIH
TGEKPFKCNTCGKTFRQSSSLIAHQRIHTGEKPYECNACGKLFSQRSSLTNHYKIH
IEEDSLKADLHV
Sequence length 612
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Generic Transcription Pathway
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ASTROCYTOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BILIARY ATRESIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations