Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
117583
Gene name Gene Name - the full gene name approved by the HGNC.
Par-3 family cell polarity regulator beta
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PARD3B
Synonyms (NCBI Gene) Gene synonyms aliases
ALS2CR19, PAR3B, PAR3L, PAR3beta
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q33.3
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT709221 hsa-miR-4267 HITS-CLIP 19536157
MIRT709220 hsa-miR-3688-5p HITS-CLIP 19536157
MIRT709219 hsa-miR-891a-3p HITS-CLIP 19536157
MIRT709218 hsa-miR-6512-3p HITS-CLIP 19536157
MIRT709217 hsa-miR-6720-5p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000226 Process Microtubule cytoskeleton organization IBA 21873635
GO:0005515 Function Protein binding IPI 16458856
GO:0005912 Component Adherens junction IBA 21873635
GO:0005923 Component Bicellular tight junction IEA
GO:0005938 Component Cell cortex IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
619353 14446 ENSG00000116117
Protein
UniProt ID Q8TEW8
Protein name Partitioning defective 3 homolog B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein) (PAR3-beta) (Partitioning defective 3-like protein) (PAR3-L protein)
Protein function Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12053 Par3_HAL_N_term 1 83 N-terminal of Par3 and HAL proteins Family
PF00595 PDZ 382 467 PDZ domain Domain
PF00595 PDZ 498 589 PDZ domain Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in kidney, lung and skeletal muscle. Expressed at intermediate levels in brain, heart, placenta, liver and pancreas. Isoform 1 is predominant, while isoform 2 and isoform 3 are expressed at lower levels.
Sequence
MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGYWVKIHHLEYTDGGILD
PDDVLADVVEDKDKLIAVFEEQE
PLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGG
EIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVL
NGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS
RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSV
IGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGG
KPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGA
AIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIA
RQEGHFLPRELKG
EPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFK
DGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVIL
RRPERPMEDPA
ECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPT
PHSALGLGLEDYSHSSGVDSAVYFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKV
HSLAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNES
FRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEK
EKKKEKGKLKVKEKKRKEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGL
REEELEKMKEERERIGAKHQELREKQARGLLDYATGAIGSVYDMDDDEMDPNYARVNHFR
EPCTSANVFRSPSPPRAGPFGYPRDGHPLSPERDHLEGLYAKVNKPYHPLVPADSGRPTG
GSTDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWVPGRGPDGNAHNLRFEGMER
QYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHPPKGSYPRPTELRVADLRYP
QHYPPPPAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPRGGSPDQYPYRTQDSRQKNP
MTAAV
Sequence length 1205
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Autism Autistic Disorder rs121964908, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699
View all (8 more)
22843504
Leukemia Leukemia, Myelocytic, Acute rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297 27903959
Neurodevelopmental disorders Neurodevelopmental Disorders rs869312846, rs869312840, rs869312848, rs869312849, rs869312845, rs886041956, rs1064795110, rs1555762734, rs1555764992, rs1568512728, rs1568532361, rs1595472741, rs1595472764, rs1595476797, rs1016320330
View all (2 more)
28191889
Unknown
Disease term Disease name Evidence References Source
Asthma Asthma 25918132 ClinVar
Intracranial Aneurysm Intracranial Aneurysm GWAS
Diabetes Diabetes GWAS
Attention Deficit Hyperactivity Disorder Attention Deficit Hyperactivity Disorder GWAS
Associations from Text Mining
Disease Name Relationship Type References
Acquired Immunodeficiency Syndrome Associate 21502085, 24240316, 29641325
Colorectal Neoplasms Stimulate 28443499
HIV Infections Associate 29641325
Neoplasms Stimulate 28443499
Osteoarthritis Associate 24825461
Reticular dysgenesis Associate 40064387