TAGAP (T cell activation RhoGTPase activating protein)

Gene

• Entrez ID: 117289
• Gene name: T cell activation RhoGTPase activating protein
• Gene symbol: TAGAP
• Synonyms (NCBI Gene): ARHGAP47, FKSG15, IDDM21, TAGAP1
• Chromosome: 6
• Chromosome location: 6q25.3
• Summary: This gene encodes a member of the Rho GTPase-activator protein superfamily. The encoded protein may function as a Rho GTPase-activating protein. Alterations in this gene may be associated with several diseases, including rheumatoid arthritis, celiac disea

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT439486	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT439486	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT1410049	hsa-miR-106a	CLIP-seq
MIRT1410050	hsa-miR-106b	CLIP-seq
MIRT1410051	hsa-miR-139-5p	CLIP-seq
MIRT1410052	hsa-miR-17	CLIP-seq
MIRT1410053	hsa-miR-20a	CLIP-seq
MIRT1410054	hsa-miR-20b	CLIP-seq
MIRT1410055	hsa-miR-2682	CLIP-seq
MIRT1410056	hsa-miR-3189-5p	CLIP-seq
MIRT1410057	hsa-miR-371b-3p	CLIP-seq
MIRT1410058	hsa-miR-4438	CLIP-seq
MIRT1410059	hsa-miR-449c	CLIP-seq
MIRT1410060	hsa-miR-4514	CLIP-seq
MIRT1410061	hsa-miR-4692	CLIP-seq
MIRT1410062	hsa-miR-4758-3p	CLIP-seq
MIRT1410063	hsa-miR-5095	CLIP-seq
MIRT1410064	hsa-miR-519d	CLIP-seq
MIRT1410065	hsa-miR-548ac	CLIP-seq
MIRT1410066	hsa-miR-548ae	CLIP-seq
MIRT1410067	hsa-miR-548aj	CLIP-seq
MIRT1410068	hsa-miR-548am	CLIP-seq
MIRT1410069	hsa-miR-548d-3p	CLIP-seq
MIRT1410070	hsa-miR-548t	CLIP-seq
MIRT1410071	hsa-miR-548x	CLIP-seq
MIRT1410072	hsa-miR-548z	CLIP-seq
MIRT1410073	hsa-miR-93	CLIP-seq
MIRT1410051	hsa-miR-139-5p	CLIP-seq
MIRT1410055	hsa-miR-2682	CLIP-seq
MIRT1410074	hsa-miR-374c	CLIP-seq
MIRT1410075	hsa-miR-4277	CLIP-seq
MIRT1410058	hsa-miR-4438	CLIP-seq
MIRT1410059	hsa-miR-449c	CLIP-seq
MIRT1410060	hsa-miR-4514	CLIP-seq
MIRT1410061	hsa-miR-4692	CLIP-seq
MIRT1410063	hsa-miR-5095	CLIP-seq
MIRT1410076	hsa-miR-655	CLIP-seq
MIRT2122887	hsa-miR-21	CLIP-seq
MIRT2122888	hsa-miR-28-5p	CLIP-seq
MIRT2122889	hsa-miR-3139	CLIP-seq
MIRT2122890	hsa-miR-4272	CLIP-seq
MIRT2122891	hsa-miR-513c	CLIP-seq
MIRT2122892	hsa-miR-514b-5p	CLIP-seq
MIRT2122893	hsa-miR-590-5p	CLIP-seq
MIRT2122894	hsa-miR-708	CLIP-seq
MIRT2461117	hsa-miR-1323	CLIP-seq
MIRT2461118	hsa-miR-2276	CLIP-seq
MIRT2461119	hsa-miR-4420	CLIP-seq
MIRT2461120	hsa-miR-548o	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005096	Function	GTPase activator activity	IBA
GO:0005096	Function	GTPase activator activity	IEA
GO:0005096	Function	GTPase activator activity	TAS
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005829	Component	Cytosol	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0035023	Process	Regulation of Rho protein signal transduction	IEA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS

Other IDs

• MIM: 609667
• HGNC: 15669
• e!Ensembl: ENSG00000164691

Protein

• UniProt ID: Q8N103
• Protein name: T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein)
• Protein function: May function as a GTPase-activating protein and may play important roles during T-cell activation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00620	RhoGAP	101 → 250	RhoGAP domain	Domain

• Sequence:

  MKLRSSHNASKTLNANNMETLIECQSEGDIKEHPLLASCESEDSICQLIEVKKRKKVLSW
  PFLMRRLSPASDFSGALETDLKASLFDQPLSIICGDSDTLPRPIQDILTILCLKGPSTEG
  IFRRAANEKARKELKEELNSGDAVDLERLPVHLLAVVFKDFLRSIPRKLLSSDLFEEWMG
  ALEMQDEEDRIEALKQVADKLPRPNLLLLKHLVYVLHLISKNSEVNRMDSSNLAICIGPN
  MLTLENDQSLSFEAQKDLNNKVKTLVEFLIDNCFEIFGENIPVHSSITSDDSLEHTDSSD
  VSTLQNDSAYDSNDPDVESNSSSGISSPSRQPQVPMATAAGLDSAGPQDAREVSPEPIVS
  TVARLKSSLAQPDRRYSEPSMPSSQECLESRVTNQTLTKSEGDFPVPRVGSRLESEEAED
  PFPEEVFPAVQGKTKRPVDLKIKNLAPGSVLPRALVLKAFSSSSLDASSDSSPVASPSSP
  KRNFFSRHQSFTTKTEKGKPSREIKKHSMSFTFAPHKKVLTKNLSAGSGKSQDFTRDHVP
  RGVRKESQLAGRIVQENGCETHNQTARGFCLRPHALSVDDVFQGADWERPGSPPSYEEAM
  QGPAARLVASESQTVGSMTVGSMRARMLEAHCLLPPLPPAHHVEDSRHRGSKEPLPGHGL
  SPLPERWKQSRTVHASGDSLGHVSGPGRPELLPLRTVSESVQRNKRDCLVRRCSQPVFEA
  DQFQYAKESYI

• Sequence length: 731

Pathways

Reactome:

Rho GTPase cycle