Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	117289
Gene name Gene Name - the full gene name approved by the HGNC.	T cell activation RhoGTPase activating protein
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TAGAP
Synonyms (NCBI Gene) Gene synonyms aliases	ARHGAP47, FKSG15, IDDM21, TAGAP1
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6q25.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the Rho GTPase-activator protein superfamily. The encoded protein may function as a Rho GTPase-activating protein. Alterations in this gene may be associated with several diseases, including rheumatoid arthritis, celiac disea

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miRTarBase ID	miRNA	Experiments	Reference
MIRT439486	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT439486	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT1410049	hsa-miR-106a	CLIP-seq
MIRT1410050	hsa-miR-106b	CLIP-seq
MIRT1410051	hsa-miR-139-5p	CLIP-seq
MIRT1410052	hsa-miR-17	CLIP-seq
MIRT1410053	hsa-miR-20a	CLIP-seq
MIRT1410054	hsa-miR-20b	CLIP-seq
MIRT1410055	hsa-miR-2682	CLIP-seq
MIRT1410056	hsa-miR-3189-5p	CLIP-seq
MIRT1410057	hsa-miR-371b-3p	CLIP-seq
MIRT1410058	hsa-miR-4438	CLIP-seq
MIRT1410059	hsa-miR-449c	CLIP-seq
MIRT1410060	hsa-miR-4514	CLIP-seq
MIRT1410061	hsa-miR-4692	CLIP-seq
MIRT1410062	hsa-miR-4758-3p	CLIP-seq
MIRT1410063	hsa-miR-5095	CLIP-seq
MIRT1410064	hsa-miR-519d	CLIP-seq
MIRT1410065	hsa-miR-548ac	CLIP-seq
MIRT1410066	hsa-miR-548ae	CLIP-seq
MIRT1410067	hsa-miR-548aj	CLIP-seq
MIRT1410068	hsa-miR-548am	CLIP-seq
MIRT1410069	hsa-miR-548d-3p	CLIP-seq
MIRT1410070	hsa-miR-548t	CLIP-seq
MIRT1410071	hsa-miR-548x	CLIP-seq
MIRT1410072	hsa-miR-548z	CLIP-seq
MIRT1410073	hsa-miR-93	CLIP-seq
MIRT1410051	hsa-miR-139-5p	CLIP-seq
MIRT1410055	hsa-miR-2682	CLIP-seq
MIRT1410074	hsa-miR-374c	CLIP-seq
MIRT1410075	hsa-miR-4277	CLIP-seq
MIRT1410058	hsa-miR-4438	CLIP-seq
MIRT1410059	hsa-miR-449c	CLIP-seq
MIRT1410060	hsa-miR-4514	CLIP-seq
MIRT1410061	hsa-miR-4692	CLIP-seq
MIRT1410063	hsa-miR-5095	CLIP-seq
MIRT1410076	hsa-miR-655	CLIP-seq
MIRT2122887	hsa-miR-21	CLIP-seq
MIRT2122888	hsa-miR-28-5p	CLIP-seq
MIRT2122889	hsa-miR-3139	CLIP-seq
MIRT2122890	hsa-miR-4272	CLIP-seq
MIRT2122891	hsa-miR-513c	CLIP-seq
MIRT2122892	hsa-miR-514b-5p	CLIP-seq
MIRT2122893	hsa-miR-590-5p	CLIP-seq
MIRT2122894	hsa-miR-708	CLIP-seq
MIRT2461117	hsa-miR-1323	CLIP-seq
MIRT2461118	hsa-miR-2276	CLIP-seq
MIRT2461119	hsa-miR-4420	CLIP-seq
MIRT2461120	hsa-miR-548o	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005096	Function	GTPase activator activity	IBA
GO:0005096	Function	GTPase activator activity	IEA
GO:0005096	Function	GTPase activator activity	TAS
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005829	Component	Cytosol	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0035023	Process	Regulation of Rho protein signal transduction	IEA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS

MIM	HGNC	e!Ensembl
609667	15669	ENSG00000164691

Protein

UniProt ID

Q8N103

Protein name

T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein)

Protein function

May function as a GTPase-activating protein and may play important roles during T-cell activation.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00620	RhoGAP	101 → 250	RhoGAP domain	Domain

Sequence

MKLRSSHNASKTLNANNMETLIECQSEGDIKEHPLLASCESEDSICQLIEVKKRKKVLSW
PFLMRRLSPASDFSGALETDLKASLFDQPLSIICGDSDTLPRPIQDILTILCLKGPSTEG
IFRRAANEKARKELKEELNSGDAVDLERLPVHLLAVVFKDFLRSIPRKLLSSDLFEEWMG
ALEMQDEEDRIEALKQVADKLPRPNLLLLKHLVYVLHLISKNSEVNRMDSSNLAICIGPN
MLTLENDQSLSFEAQKDLNNKVKTLVEFLIDNCFEIFGENIPVHSSITSDDSLEHTDSSD
VSTLQNDSAYDSNDPDVESNSSSGISSPSRQPQVPMATAAGLDSAGPQDAREVSPEPIVS
TVARLKSSLAQPDRRYSEPSMPSSQECLESRVTNQTLTKSEGDFPVPRVGSRLESEEAED
PFPEEVFPAVQGKTKRPVDLKIKNLAPGSVLPRALVLKAFSSSSLDASSDSSPVASPSSP
KRNFFSRHQSFTTKTEKGKPSREIKKHSMSFTFAPHKKVLTKNLSAGSGKSQDFTRDHVP
RGVRKESQLAGRIVQENGCETHNQTARGFCLRPHALSVDDVFQGADWERPGSPPSYEEAM
QGPAARLVASESQTVGSMTVGSMRARMLEAHCLLPPLPPAHHVEDSRHRGSKEPLPGHGL
SPLPERWKQSRTVHASGDSLGHVSGPGRPELLPLRTVSESVQRNKRDCLVRRCSQPVFEA
DQFQYAKESYI

Sequence length

731

Interactions

View interactions

	Reactome
			Rho GTPase cycle

Show/Hide Unknown Diseases (12)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Celiac disease	Celiac disease	N/A	N/A	GWAS
Crohn Disease	Crohn's disease	N/A	N/A	GWAS
Dermatitis	Atopic dermatitis	N/A	N/A	GWAS
Eczema	Eczema	N/A	N/A	GWAS
Hypothyroidism	Hypothyroidism	N/A	N/A	GWAS
Inflammatory Bowel Disease	Inflammatory bowel disease	N/A	N/A	GWAS
Multiple Sclerosis	Multiple sclerosis	N/A	N/A	GWAS
Psoriasis	Psoriasis	N/A	N/A	GWAS
Psoriasis vulgaris	Psoriasis vulgaris	N/A	N/A	GWAS
Rheumatoid arthritis	Rheumatoid arthritis	N/A	N/A	GWAS
Systemic lupus erythematosus	Systemic lupus erythematosus	N/A	N/A	GWAS
Vitiligo	Vitiligo	N/A	N/A	GWAS

Show/Hide Text Mining Associations (15)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma	Associate	30720096
Adenocarcinoma of Lung	Associate	32337264
Arthritis Rheumatoid	Associate	19898481, 20854658, 21390051, 22127930, 23242182, 29329296, 32398702
Autoimmune Diseases	Associate	20854658, 29329296
Carcinoma Intraductal Noninfiltrating	Associate	38615592
Carcinoma Renal Cell	Associate	35739510
Celiac Disease	Associate	19073967, 21390051, 22087237, 26859134, 27015091
Diabetes Mellitus Type 1	Associate	19073967, 20854658, 21390051
Disease	Associate	20854658
Hereditary Breast and Ovarian Cancer Syndrome	Inhibit	38615592
Immune System Diseases	Associate	19898481
Lymphoma Follicular	Associate	35030632
Multiple Sclerosis	Associate	26765264, 29329296
Neoplasms	Associate	30720096
Triple Negative Breast Neoplasms	Associate	37963845

TAGAP (T cell activation RhoGTPase activating protein)