Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	117155
Gene name Gene Name - the full gene name approved by the HGNC.	Cation channel sperm associated 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CATSPER2
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	15q15.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of a family of cation channel proteins that localize to the flagellum of spermatozoa. Defects at this locus causes male infertility. Alternatively spliced transcript variants have been observed at this locus. Readthrough transcr

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miRTarBase ID	miRNA	Experiments
MIRT1956220	hsa-miR-106a	CLIP-seq
MIRT1956221	hsa-miR-106b	CLIP-seq
MIRT1956222	hsa-miR-17	CLIP-seq
MIRT1956223	hsa-miR-20a	CLIP-seq
MIRT1956224	hsa-miR-20b	CLIP-seq
MIRT1956225	hsa-miR-302a	CLIP-seq
MIRT1956226	hsa-miR-302b	CLIP-seq
MIRT1956227	hsa-miR-302c	CLIP-seq
MIRT1956228	hsa-miR-302d	CLIP-seq
MIRT1956229	hsa-miR-302e	CLIP-seq
MIRT1956230	hsa-miR-372	CLIP-seq
MIRT1956231	hsa-miR-373	CLIP-seq
MIRT1956232	hsa-miR-4438	CLIP-seq
MIRT1956233	hsa-miR-4638-5p	CLIP-seq
MIRT1956234	hsa-miR-4731-5p	CLIP-seq
MIRT1956235	hsa-miR-4797-3p	CLIP-seq
MIRT1956236	hsa-miR-5095	CLIP-seq
MIRT1956237	hsa-miR-512-3p	CLIP-seq
MIRT1956238	hsa-miR-519a	CLIP-seq
MIRT1956239	hsa-miR-519b-3p	CLIP-seq
MIRT1956240	hsa-miR-519c-3p	CLIP-seq
MIRT1956241	hsa-miR-519d	CLIP-seq
MIRT1956242	hsa-miR-520a-3p	CLIP-seq
MIRT1956243	hsa-miR-520b	CLIP-seq
MIRT1956244	hsa-miR-520c-3p	CLIP-seq
MIRT1956245	hsa-miR-520d-3p	CLIP-seq
MIRT1956246	hsa-miR-520e	CLIP-seq
MIRT1956247	hsa-miR-520g	CLIP-seq
MIRT1956248	hsa-miR-520h	CLIP-seq
MIRT1956249	hsa-miR-93	CLIP-seq
MIRT1956220	hsa-miR-106a	CLIP-seq
MIRT1956221	hsa-miR-106b	CLIP-seq
MIRT1956222	hsa-miR-17	CLIP-seq
MIRT1956223	hsa-miR-20a	CLIP-seq
MIRT1956224	hsa-miR-20b	CLIP-seq
MIRT1956225	hsa-miR-302a	CLIP-seq
MIRT1956226	hsa-miR-302b	CLIP-seq
MIRT1956227	hsa-miR-302c	CLIP-seq
MIRT1956228	hsa-miR-302d	CLIP-seq
MIRT1956229	hsa-miR-302e	CLIP-seq
MIRT1956230	hsa-miR-372	CLIP-seq
MIRT1956231	hsa-miR-373	CLIP-seq
MIRT1956232	hsa-miR-4438	CLIP-seq
MIRT1956233	hsa-miR-4638-5p	CLIP-seq
MIRT1956234	hsa-miR-4731-5p	CLIP-seq
MIRT1956236	hsa-miR-5095	CLIP-seq
MIRT1956237	hsa-miR-512-3p	CLIP-seq
MIRT1956241	hsa-miR-519d	CLIP-seq
MIRT1956242	hsa-miR-520a-3p	CLIP-seq
MIRT1956243	hsa-miR-520b	CLIP-seq
MIRT1956244	hsa-miR-520c-3p	CLIP-seq
MIRT1956245	hsa-miR-520d-3p	CLIP-seq
MIRT1956246	hsa-miR-520e	CLIP-seq
MIRT1956247	hsa-miR-520g	CLIP-seq
MIRT1956248	hsa-miR-520h	CLIP-seq
MIRT1956249	hsa-miR-93	CLIP-seq
MIRT2446243	hsa-miR-1976	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005216	Function	Monoatomic ion channel activity	IEA
GO:0005227	Function	Calcium-activated cation channel activity	IEA
GO:0005245	Function	Voltage-gated calcium channel activity	IDA	21412338
GO:0005245	Function	Voltage-gated calcium channel activity	IEA
GO:0005262	Function	Calcium channel activity	IEA
GO:0005515	Function	Protein binding	IPI	16740636
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005929	Component	Cilium	IEA
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006816	Process	Calcium ion transport	IDA	21412338
GO:0006816	Process	Calcium ion transport	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0009566	Process	Fertilization	IBA
GO:0016020	Component	Membrane	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0030317	Process	Flagellated sperm motility	IBA
GO:0030317	Process	Flagellated sperm motility	IEA
GO:0031514	Component	Motile cilium	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0034702	Component	Monoatomic ion channel complex	IEA
GO:0036128	Component	CatSper complex	IBA
GO:0036128	Component	CatSper complex	IEA
GO:0036128	Component	CatSper complex	ISS
GO:0042995	Component	Cell projection	IEA
GO:0048240	Process	Sperm capacitation	IBA
GO:0055085	Process	Transmembrane transport	IEA
GO:0070588	Process	Calcium ion transmembrane transport	IEA

MIM	HGNC	e!Ensembl
607249	18810	ENSG00000166762

Protein

UniProt ID

Q96P56

Protein name

Cation channel sperm-associated protein 2 (CatSper2)

Protein function

Pore-forming subunit of the CatSper complex, a sperm-specific voltage-gated calcium channel, that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome r

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00520	Ion_trans	107 → 352	Ion transport protein	Family

Tissue specificity

TISSUE SPECIFICITY: Testis-specific. {ECO:0000269|PubMed:11675491, ECO:0000269|PubMed:17347248}.

Sequence

MAAYQQEEQMQLPRADAIRSRLIDTFSLIEHLQGLSQAVPRHTIRELLDPSRQKKLVLGD
QHQLVRFSIKPQRIEQISHAQRLLSRLHVRCSQRPPLSLWAGWVLECPLFKNFIIFLVFL
NTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLSNFSVFWKSAWNVF
DFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKS
MTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWY
ALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREV
QLKADMFKRQIIQRRKNMSHEALTSSHSKIEDSSRGASQQRESLDLSEVSEVESNYGATE
EDLITSASKTEETLSKKREYQSSSCVSSTSSSYSSSSESRFSESIGRLDWETLVHENLPG
LMEMDQDDRVWPRDSLFRYFELLEKLQYNLEERKKLQEFAVQALMNLEDK

Sequence length

530

Interactions

View interactions

	Reactome
			Sperm Motility And Taxes

CATSPER2 (cation channel sperm associated 2)