Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	116987
Gene name	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
Gene symbol	AGAP1
Synonyms (NCBI Gene)	AGAP-1CENTG2GGAP1cnt-g2
Chromosome	2
Chromosome location	2q37.2
Summary	This gene encodes a member of an ADP-ribosylation factor GTPase-activating protein family involved in membrane trafficking and cytoskeleton dynamics. This gene functions as a direct regulator of the adaptor-related protein complex 3 on endosomes. Multiple

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Show/Hide all (214)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024193	hsa-miR-221-3p	Sequencing	20371350
MIRT043133	hsa-miR-324-5p	CLASH	23622248
MIRT036541	hsa-miR-1225-3p	CLASH	23622248
MIRT689071	hsa-miR-181d-3p	HITS-CLIP	23313552
MIRT689070	hsa-miR-5193	HITS-CLIP	23313552
MIRT689069	hsa-miR-4638-5p	HITS-CLIP	23313552
MIRT689068	hsa-miR-6869-3p	HITS-CLIP	23313552
MIRT689067	hsa-miR-3648	HITS-CLIP	23313552
MIRT648246	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT648245	hsa-miR-4643	HITS-CLIP	23824327
MIRT648244	hsa-miR-3941	HITS-CLIP	23824327
MIRT648243	hsa-miR-4672	HITS-CLIP	23824327
MIRT648242	hsa-miR-466	HITS-CLIP	23824327
MIRT648241	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT648240	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT648239	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT648238	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT513155	hsa-miR-498	PAR-CLIP	23446348
MIRT442222	hsa-miR-21-3p	PAR-CLIP	22291592
MIRT442221	hsa-miR-3591-3p	PAR-CLIP	22291592
MIRT442220	hsa-miR-3681-5p	PAR-CLIP	22291592
MIRT442219	hsa-miR-6849-5p	PAR-CLIP	22291592
MIRT442217	hsa-miR-6080	PAR-CLIP	22291592
MIRT442222	hsa-miR-21-3p	PAR-CLIP	22291592
MIRT442221	hsa-miR-3591-3p	PAR-CLIP	22291592
MIRT442220	hsa-miR-3681-5p	PAR-CLIP	22291592
MIRT442219	hsa-miR-6849-5p	PAR-CLIP	22291592
MIRT442217	hsa-miR-6080	PAR-CLIP	22291592
MIRT442222	hsa-miR-21-3p	PAR-CLIP	23708386
MIRT442221	hsa-miR-3591-3p	PAR-CLIP	23708386
MIRT442220	hsa-miR-3681-5p	PAR-CLIP	23708386
MIRT442219	hsa-miR-6849-5p	PAR-CLIP	23708386
MIRT442217	hsa-miR-6080	PAR-CLIP	23708386
MIRT459543	hsa-miR-4798-3p	PAR-CLIP	23592263
MIRT459541	hsa-miR-6873-5p	PAR-CLIP	23592263
MIRT459542	hsa-miR-4733-3p	PAR-CLIP	23592263
MIRT459540	hsa-miR-6077	PAR-CLIP	23592263
MIRT442222	hsa-miR-21-3p	PAR-CLIP	22100165
MIRT442221	hsa-miR-3591-3p	PAR-CLIP	22100165
MIRT442220	hsa-miR-3681-5p	PAR-CLIP	22100165
MIRT442219	hsa-miR-6849-5p	PAR-CLIP	22100165
MIRT442217	hsa-miR-6080	PAR-CLIP	22100165
MIRT443587	hsa-miR-8078	PAR-CLIP	22100165
MIRT442222	hsa-miR-21-3p	PAR-CLIP	22100165
MIRT442221	hsa-miR-3591-3p	PAR-CLIP	22100165
MIRT442220	hsa-miR-3681-5p	PAR-CLIP	22100165
MIRT442219	hsa-miR-6849-5p	PAR-CLIP	22100165
MIRT442217	hsa-miR-6080	PAR-CLIP	22100165
MIRT459542	hsa-miR-4733-3p	PAR-CLIP	26701625
MIRT459542	hsa-miR-4733-3p	PAR-CLIP	26701625
MIRT689071	hsa-miR-181d-3p	HITS-CLIP	23313552
MIRT689070	hsa-miR-5193	HITS-CLIP	23313552
MIRT689069	hsa-miR-4638-5p	HITS-CLIP	23313552
MIRT689068	hsa-miR-6869-3p	HITS-CLIP	23313552
MIRT689067	hsa-miR-3648	HITS-CLIP	23313552
MIRT648246	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT648245	hsa-miR-4643	HITS-CLIP	23824327
MIRT648244	hsa-miR-3941	HITS-CLIP	23824327
MIRT648243	hsa-miR-4672	HITS-CLIP	23824327
MIRT648242	hsa-miR-466	HITS-CLIP	23824327
MIRT648241	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT648240	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT648239	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT648238	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT513155	hsa-miR-498	PAR-CLIP	23446348
MIRT442222	hsa-miR-21-3p	PAR-CLIP	22291592
MIRT442221	hsa-miR-3591-3p	PAR-CLIP	22291592
MIRT442220	hsa-miR-3681-5p	PAR-CLIP	22291592
MIRT442219	hsa-miR-6849-5p	PAR-CLIP	22291592
MIRT442217	hsa-miR-6080	PAR-CLIP	22291592
MIRT442222	hsa-miR-21-3p	PAR-CLIP	22291592
MIRT442221	hsa-miR-3591-3p	PAR-CLIP	22291592
MIRT442220	hsa-miR-3681-5p	PAR-CLIP	22291592
MIRT442219	hsa-miR-6849-5p	PAR-CLIP	22291592
MIRT442217	hsa-miR-6080	PAR-CLIP	22291592
MIRT442222	hsa-miR-21-3p	PAR-CLIP	23708386
MIRT442221	hsa-miR-3591-3p	PAR-CLIP	23708386
MIRT442220	hsa-miR-3681-5p	PAR-CLIP	23708386
MIRT442219	hsa-miR-6849-5p	PAR-CLIP	23708386
MIRT442217	hsa-miR-6080	PAR-CLIP	23708386
MIRT459543	hsa-miR-4798-3p	PAR-CLIP	23592263
MIRT459541	hsa-miR-6873-5p	PAR-CLIP	23592263
MIRT459542	hsa-miR-4733-3p	PAR-CLIP	23592263
MIRT459540	hsa-miR-6077	PAR-CLIP	23592263
MIRT442222	hsa-miR-21-3p	PAR-CLIP	22100165
MIRT442221	hsa-miR-3591-3p	PAR-CLIP	22100165
MIRT442220	hsa-miR-3681-5p	PAR-CLIP	22100165
MIRT442219	hsa-miR-6849-5p	PAR-CLIP	22100165
MIRT442217	hsa-miR-6080	PAR-CLIP	22100165
MIRT443587	hsa-miR-8078	PAR-CLIP	22100165
MIRT442222	hsa-miR-21-3p	PAR-CLIP	22100165
MIRT442221	hsa-miR-3591-3p	PAR-CLIP	22100165
MIRT442220	hsa-miR-3681-5p	PAR-CLIP	22100165
MIRT442219	hsa-miR-6849-5p	PAR-CLIP	22100165
MIRT442217	hsa-miR-6080	PAR-CLIP	22100165
MIRT771569	hsa-miR-1227	CLIP-seq
MIRT771570	hsa-miR-1231	CLIP-seq
MIRT771571	hsa-miR-1238	CLIP-seq
MIRT771572	hsa-miR-1269	CLIP-seq
MIRT771573	hsa-miR-1269b	CLIP-seq
MIRT771574	hsa-miR-1272	CLIP-seq
MIRT771575	hsa-miR-1288	CLIP-seq
MIRT771576	hsa-miR-1303	CLIP-seq
MIRT771577	hsa-miR-188-5p	CLIP-seq
MIRT771578	hsa-miR-2113	CLIP-seq
MIRT771579	hsa-miR-3133	CLIP-seq
MIRT771580	hsa-miR-3148	CLIP-seq
MIRT771581	hsa-miR-3158-3p	CLIP-seq
MIRT771582	hsa-miR-3183	CLIP-seq
MIRT771583	hsa-miR-3192	CLIP-seq
MIRT771584	hsa-miR-3646	CLIP-seq
MIRT771585	hsa-miR-3675-3p	CLIP-seq
MIRT771586	hsa-miR-3907	CLIP-seq
MIRT771587	hsa-miR-4314	CLIP-seq
MIRT771588	hsa-miR-4436a	CLIP-seq
MIRT771589	hsa-miR-4515	CLIP-seq
MIRT771590	hsa-miR-4517	CLIP-seq
MIRT771591	hsa-miR-4520b-3p	CLIP-seq
MIRT771592	hsa-miR-4529-3p	CLIP-seq
MIRT771593	hsa-miR-4645-3p	CLIP-seq
MIRT771594	hsa-miR-4646-5p	CLIP-seq
MIRT771595	hsa-miR-4715-3p	CLIP-seq
MIRT771596	hsa-miR-4716-5p	CLIP-seq
MIRT771597	hsa-miR-4721	CLIP-seq
MIRT771598	hsa-miR-4723-3p	CLIP-seq
MIRT771599	hsa-miR-4731-5p	CLIP-seq
MIRT771600	hsa-miR-4740-5p	CLIP-seq
MIRT771601	hsa-miR-4753-3p	CLIP-seq
MIRT771602	hsa-miR-4780	CLIP-seq
MIRT771603	hsa-miR-488	CLIP-seq
MIRT771604	hsa-miR-582-5p	CLIP-seq
MIRT771605	hsa-miR-587	CLIP-seq
MIRT771606	hsa-miR-599	CLIP-seq
MIRT771607	hsa-miR-600	CLIP-seq
MIRT771608	hsa-miR-623	CLIP-seq
MIRT771609	hsa-miR-654-3p	CLIP-seq
MIRT771610	hsa-miR-9	CLIP-seq
MIRT771571	hsa-miR-1238	CLIP-seq
MIRT771572	hsa-miR-1269	CLIP-seq
MIRT771573	hsa-miR-1269b	CLIP-seq
MIRT771575	hsa-miR-1288	CLIP-seq
MIRT771582	hsa-miR-3183	CLIP-seq
MIRT771584	hsa-miR-3646	CLIP-seq
MIRT771589	hsa-miR-4515	CLIP-seq
MIRT771591	hsa-miR-4520b-3p	CLIP-seq
MIRT771592	hsa-miR-4529-3p	CLIP-seq
MIRT771598	hsa-miR-4723-3p	CLIP-seq
MIRT771600	hsa-miR-4740-5p	CLIP-seq
MIRT771601	hsa-miR-4753-3p	CLIP-seq
MIRT771610	hsa-miR-9	CLIP-seq
MIRT1545180	hsa-miR-1915	CLIP-seq
MIRT1545181	hsa-miR-4285	CLIP-seq
MIRT1545182	hsa-miR-4726-3p	CLIP-seq
MIRT1545183	hsa-miR-485-5p	CLIP-seq
MIRT1545184	hsa-miR-764	CLIP-seq
MIRT1927667	hsa-miR-1184	CLIP-seq
MIRT1927668	hsa-miR-1205	CLIP-seq
MIRT1927669	hsa-miR-1253	CLIP-seq
MIRT771574	hsa-miR-1272	CLIP-seq
MIRT1927670	hsa-miR-1273f	CLIP-seq
MIRT1927671	hsa-miR-1307	CLIP-seq
MIRT1927672	hsa-miR-134	CLIP-seq
MIRT1927673	hsa-miR-1468	CLIP-seq
MIRT1927674	hsa-miR-3118	CLIP-seq
MIRT771580	hsa-miR-3148	CLIP-seq
MIRT1927675	hsa-miR-3158-5p	CLIP-seq
MIRT1927676	hsa-miR-3160-5p	CLIP-seq
MIRT1927677	hsa-miR-3164	CLIP-seq
MIRT1927678	hsa-miR-34b	CLIP-seq
MIRT1927679	hsa-miR-3529	CLIP-seq
MIRT771584	hsa-miR-3646	CLIP-seq
MIRT1927680	hsa-miR-3671	CLIP-seq
MIRT771585	hsa-miR-3675-3p	CLIP-seq
MIRT1927681	hsa-miR-3690	CLIP-seq
MIRT1927682	hsa-miR-3691-3p	CLIP-seq
MIRT1927683	hsa-miR-379	CLIP-seq
MIRT1927684	hsa-miR-3913-3p	CLIP-seq
MIRT1927685	hsa-miR-3919	CLIP-seq
MIRT1927686	hsa-miR-4255	CLIP-seq
MIRT1927687	hsa-miR-4268	CLIP-seq
MIRT1545181	hsa-miR-4285	CLIP-seq
MIRT1927688	hsa-miR-4287	CLIP-seq
MIRT1927689	hsa-miR-4292	CLIP-seq
MIRT1927690	hsa-miR-4308	CLIP-seq
MIRT1927691	hsa-miR-4451	CLIP-seq
MIRT1927692	hsa-miR-4469	CLIP-seq
MIRT771590	hsa-miR-4517	CLIP-seq
MIRT1927693	hsa-miR-4520a-3p	CLIP-seq
MIRT1927694	hsa-miR-455-5p	CLIP-seq
MIRT1927695	hsa-miR-4638-3p	CLIP-seq
MIRT771593	hsa-miR-4645-3p	CLIP-seq
MIRT1927696	hsa-miR-4650-3p	CLIP-seq
MIRT1927697	hsa-miR-4659a-3p	CLIP-seq
MIRT1927698	hsa-miR-4659b-3p	CLIP-seq
MIRT1927699	hsa-miR-4676-5p	CLIP-seq
MIRT1927700	hsa-miR-4685-3p	CLIP-seq
MIRT1927701	hsa-miR-4713-5p	CLIP-seq
MIRT1927702	hsa-miR-4756-3p	CLIP-seq
MIRT1927703	hsa-miR-4762-3p	CLIP-seq
MIRT1927704	hsa-miR-4786-3p	CLIP-seq
MIRT1927705	hsa-miR-544	CLIP-seq
MIRT1927706	hsa-miR-575	CLIP-seq
MIRT771604	hsa-miR-582-5p	CLIP-seq
MIRT771607	hsa-miR-600	CLIP-seq
MIRT1927707	hsa-miR-630	CLIP-seq
MIRT1927708	hsa-miR-942	CLIP-seq
MIRT1927678	hsa-miR-34b	CLIP-seq
MIRT2168486	hsa-miR-3664-5p	CLIP-seq
MIRT1927680	hsa-miR-3671	CLIP-seq
MIRT1927684	hsa-miR-3913-3p	CLIP-seq
MIRT771590	hsa-miR-4517	CLIP-seq
MIRT1927699	hsa-miR-4676-5p	CLIP-seq
MIRT1927704	hsa-miR-4786-3p	CLIP-seq
MIRT1927706	hsa-miR-575	CLIP-seq

Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003924	Function	GTPase activity	IBA
GO:0003924	Function	GTPase activity	IEA
GO:0005096	Function	GTPase activator activity	IBA
GO:0005096	Function	GTPase activator activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005525	Function	GTP binding	IEA
GO:0005543	Function	Phospholipid binding	IDA	18954304
GO:0005737	Component	Cytoplasm	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0015031	Process	Protein transport	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0098845	Component	Postsynaptic endosome	IEA
GO:0099159	Process	Regulation of modification of postsynaptic structure	IEA

MIM	HGNC	e!Ensembl
608651	16922	ENSG00000157985

Q9UPQ3

Protein name

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 (AGAP-1) (Centaurin-gamma-2) (Cnt-g2) (GTP-binding and GTPase-activating protein 1) (GGAP1)

Protein function

GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system.

PDB

7EB6

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00071	Ras	73 → 231	Ras family	Domain
PF01412	ArfGap	609 → 725	Putative GTPase activating protein for Arf	Domain
PF12796	Ank_2	736 → 830	Ankyrin repeats (3 copies)	Repeat

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:12388557, ECO:0000269|PubMed:12640130, ECO:0000269|PubMed:15381706, ECO:0000269|PubMed:16079295}.

Sequence

MNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDAFVNS
QEWTLSRSVPELKVGIVGNLASGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLL
LIRDEGGPPEAQFAMWVDAVIFVFSLEDEISFQTVYHYYSRMANYRNTSEIPLVLVGTQD
AISSANPRVIDDARARKLSNDLKRCTYYETCATYGLNVERVFQDVAQKIVATRKKQQLSI
GPCKSLPNSPSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVPPT
ANTPTPVRKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQGMLLKRSGKS
LNKEWKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSACAPI
SSPKTNGLSKDMSSLHISPNSGNVTSASGSQMASGISLVSFNSRPDGMHQRSYSVSSADQ
WSEATVIANSAISSDTGLGDSVCSSPSISSTTSPKLDPPPSPHANRKKHRRKKSTSNFKA
DGLSGTAEEQEENFEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSCESSKNK
SRLTSQSEAMALQSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSR
VRSLDLDDWPVELIKVMSSIGNELANSVWEESSQGRTKPSVDSTREEKERWIRAKYEQKL
FLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKG
NVVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQYGCPDERFVLMATPNLS
RRNNNRNNSSGRVPTII

Sequence length

857

Interactions

View interactions

	KEGG
	Endocytosis

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Cholangiocarcinoma	Likely benign	rs199745326	RCV005934787
Clear cell carcinoma of kidney	Uncertain significance	rs753970882	RCV005928467
Hepatocellular carcinoma	Benign	rs2278884	RCV005926980
Malignant lymphoma, large B-cell, diffuse	Benign	rs2278884	RCV005926981
Malignant tumor of esophagus	Uncertain significance	rs200114461	RCV005928453
Thyroid cancer, nonmedullary, 1	Uncertain significance	rs761131808	RCV005927249

Show/Hide Text Mining Associations (3)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Autistic Disorder	Associate	15892143
Cleft Palate	Associate	34382870
Ovarian Neoplasms	Associate	37577760

AGAP1 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 1)