Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	116984
Gene name	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
Gene symbol	ARAP2
Synonyms (NCBI Gene)	CENTD1PARX
Chromosome	4
Chromosome location	4p14
Summary	The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted ca

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miRTarBase ID	miRNA	Experiments	Reference
MIRT027376	hsa-miR-101-3p	Sequencing	20371350
MIRT030346	hsa-miR-26b-5p	Microarray	19088304
MIRT624684	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT624683	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT624681	hsa-miR-4699-3p	HITS-CLIP	23824327
MIRT624682	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT624679	hsa-miR-3682-5p	HITS-CLIP	23824327
MIRT624680	hsa-miR-6883-3p	HITS-CLIP	23824327
MIRT624678	hsa-miR-623	HITS-CLIP	23824327
MIRT624677	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT624676	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT660562	hsa-miR-1305	HITS-CLIP	23824327
MIRT624675	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT669520	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT624684	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT624683	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT624681	hsa-miR-4699-3p	HITS-CLIP	23824327
MIRT624682	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT624679	hsa-miR-3682-5p	HITS-CLIP	23824327
MIRT624678	hsa-miR-623	HITS-CLIP	23824327
MIRT624677	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT624676	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT660562	hsa-miR-1305	HITS-CLIP	23824327
MIRT624675	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT624684	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT624683	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT624681	hsa-miR-4699-3p	HITS-CLIP	23824327
MIRT624682	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT624679	hsa-miR-3682-5p	HITS-CLIP	23824327
MIRT624680	hsa-miR-6883-3p	HITS-CLIP	23824327
MIRT624678	hsa-miR-623	HITS-CLIP	23824327
MIRT624677	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT624676	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT624675	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT027376	hsa-miR-101-3p	PAR-CLIP	23592263
MIRT481681	hsa-miR-144-3p	PAR-CLIP	23592263
MIRT027376	hsa-miR-101-3p	PAR-CLIP	23592263
MIRT481680	hsa-miR-381-3p	PAR-CLIP	23592263
MIRT481679	hsa-miR-300	PAR-CLIP	23592263
MIRT481678	hsa-miR-338-5p	PAR-CLIP	23592263
MIRT481677	hsa-miR-1255b-2-3p	PAR-CLIP	23592263
MIRT481676	hsa-miR-4666a-3p	PAR-CLIP	23592263
MIRT481675	hsa-miR-767-3p	PAR-CLIP	23592263
MIRT481674	hsa-miR-5186	PAR-CLIP	23592263
MIRT481673	hsa-miR-6847-3p	PAR-CLIP	23592263
MIRT481672	hsa-miR-582-5p	PAR-CLIP	23592263
MIRT481671	hsa-let-7a-3p	PAR-CLIP	23592263
MIRT481670	hsa-let-7b-3p	PAR-CLIP	23592263
MIRT481669	hsa-let-7f-1-3p	PAR-CLIP	23592263
MIRT481668	hsa-miR-98-3p	PAR-CLIP	23592263
MIRT481667	hsa-miR-4789-5p	PAR-CLIP	23592263
MIRT481666	hsa-let-7f-2-3p	PAR-CLIP	23592263
MIRT481665	hsa-miR-1185-1-3p	PAR-CLIP	23592263
MIRT481664	hsa-miR-1185-2-3p	PAR-CLIP	23592263
MIRT481663	hsa-miR-3144-3p	PAR-CLIP	23592263
MIRT481662	hsa-miR-6828-3p	PAR-CLIP	23592263
MIRT481661	hsa-miR-6071	PAR-CLIP	23592263
MIRT481660	hsa-miR-544a	PAR-CLIP	23592263
MIRT481659	hsa-miR-6738-3p	PAR-CLIP	23592263
MIRT481658	hsa-miR-4703-5p	PAR-CLIP	23592263
MIRT441212	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT441213	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT441212	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT728322	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT728321	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT728320	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT728319	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT728318	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT728317	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT441213	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT624684	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT624683	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT624681	hsa-miR-4699-3p	HITS-CLIP	23824327
MIRT624682	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT624679	hsa-miR-3682-5p	HITS-CLIP	23824327
MIRT624680	hsa-miR-6883-3p	HITS-CLIP	23824327
MIRT624678	hsa-miR-623	HITS-CLIP	23824327
MIRT624677	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT624676	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT660562	hsa-miR-1305	HITS-CLIP	23824327
MIRT624675	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT669520	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT624684	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT624683	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT624681	hsa-miR-4699-3p	HITS-CLIP	23824327
MIRT624682	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT624679	hsa-miR-3682-5p	HITS-CLIP	23824327
MIRT624678	hsa-miR-623	HITS-CLIP	23824327
MIRT624677	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT624676	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT660562	hsa-miR-1305	HITS-CLIP	23824327
MIRT624675	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT624684	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT624683	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT624681	hsa-miR-4699-3p	HITS-CLIP	23824327
MIRT624682	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT624679	hsa-miR-3682-5p	HITS-CLIP	23824327
MIRT624680	hsa-miR-6883-3p	HITS-CLIP	23824327
MIRT624678	hsa-miR-623	HITS-CLIP	23824327
MIRT624677	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT624676	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT624675	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT027376	hsa-miR-101-3p	PAR-CLIP	23592263
MIRT481681	hsa-miR-144-3p	PAR-CLIP	23592263
MIRT027376	hsa-miR-101-3p	PAR-CLIP	23592263
MIRT481680	hsa-miR-381-3p	PAR-CLIP	23592263
MIRT481679	hsa-miR-300	PAR-CLIP	23592263
MIRT481678	hsa-miR-338-5p	PAR-CLIP	23592263
MIRT481677	hsa-miR-1255b-2-3p	PAR-CLIP	23592263
MIRT481676	hsa-miR-4666a-3p	PAR-CLIP	23592263
MIRT481675	hsa-miR-767-3p	PAR-CLIP	23592263
MIRT481674	hsa-miR-5186	PAR-CLIP	23592263
MIRT481673	hsa-miR-6847-3p	PAR-CLIP	23592263
MIRT481672	hsa-miR-582-5p	PAR-CLIP	23592263
MIRT481671	hsa-let-7a-3p	PAR-CLIP	23592263
MIRT481670	hsa-let-7b-3p	PAR-CLIP	23592263
MIRT481669	hsa-let-7f-1-3p	PAR-CLIP	23592263
MIRT481668	hsa-miR-98-3p	PAR-CLIP	23592263
MIRT481667	hsa-miR-4789-5p	PAR-CLIP	23592263
MIRT481666	hsa-let-7f-2-3p	PAR-CLIP	23592263
MIRT481665	hsa-miR-1185-1-3p	PAR-CLIP	23592263
MIRT481664	hsa-miR-1185-2-3p	PAR-CLIP	23592263
MIRT481663	hsa-miR-3144-3p	PAR-CLIP	23592263
MIRT481662	hsa-miR-6828-3p	PAR-CLIP	23592263
MIRT481661	hsa-miR-6071	PAR-CLIP	23592263
MIRT481660	hsa-miR-544a	PAR-CLIP	23592263
MIRT481659	hsa-miR-6738-3p	PAR-CLIP	23592263
MIRT481658	hsa-miR-4703-5p	PAR-CLIP	23592263
MIRT791631	hsa-miR-106a	CLIP-seq
MIRT791632	hsa-miR-106b	CLIP-seq
MIRT791633	hsa-miR-1257	CLIP-seq
MIRT791634	hsa-miR-1267	CLIP-seq
MIRT791635	hsa-miR-130a	CLIP-seq
MIRT791636	hsa-miR-130b	CLIP-seq
MIRT791637	hsa-miR-141	CLIP-seq
MIRT791638	hsa-miR-17	CLIP-seq
MIRT791639	hsa-miR-181a	CLIP-seq
MIRT791640	hsa-miR-181b	CLIP-seq
MIRT791641	hsa-miR-181c	CLIP-seq
MIRT791642	hsa-miR-181d	CLIP-seq
MIRT791643	hsa-miR-186	CLIP-seq
MIRT791644	hsa-miR-19a	CLIP-seq
MIRT791645	hsa-miR-19b	CLIP-seq
MIRT791646	hsa-miR-200a	CLIP-seq
MIRT791647	hsa-miR-20a	CLIP-seq
MIRT791648	hsa-miR-20b	CLIP-seq
MIRT791649	hsa-miR-2861	CLIP-seq
MIRT791650	hsa-miR-301a	CLIP-seq
MIRT791651	hsa-miR-301b	CLIP-seq
MIRT791652	hsa-miR-30a	CLIP-seq
MIRT791653	hsa-miR-30b	CLIP-seq
MIRT791654	hsa-miR-30c	CLIP-seq
MIRT791655	hsa-miR-30d	CLIP-seq
MIRT791656	hsa-miR-30e	CLIP-seq
MIRT791657	hsa-miR-3133	CLIP-seq
MIRT791658	hsa-miR-3134	CLIP-seq
MIRT791659	hsa-miR-3136-5p	CLIP-seq
MIRT791660	hsa-miR-3148	CLIP-seq
MIRT791661	hsa-miR-3182	CLIP-seq
MIRT791662	hsa-miR-3607-3p	CLIP-seq
MIRT791663	hsa-miR-3654	CLIP-seq
MIRT791664	hsa-miR-3666	CLIP-seq
MIRT791665	hsa-miR-3686	CLIP-seq
MIRT791666	hsa-miR-3688-3p	CLIP-seq
MIRT791667	hsa-miR-3692	CLIP-seq
MIRT791668	hsa-miR-371-5p	CLIP-seq
MIRT791669	hsa-miR-371b-5p	CLIP-seq
MIRT791670	hsa-miR-378	CLIP-seq
MIRT791671	hsa-miR-378b	CLIP-seq
MIRT791672	hsa-miR-378c	CLIP-seq
MIRT791673	hsa-miR-378d	CLIP-seq
MIRT791674	hsa-miR-378e	CLIP-seq
MIRT791675	hsa-miR-378f	CLIP-seq
MIRT791676	hsa-miR-378h	CLIP-seq
MIRT791677	hsa-miR-378i	CLIP-seq
MIRT791678	hsa-miR-381	CLIP-seq
MIRT791679	hsa-miR-3927	CLIP-seq
MIRT791680	hsa-miR-3973	CLIP-seq
MIRT791681	hsa-miR-422a	CLIP-seq
MIRT791682	hsa-miR-4262	CLIP-seq
MIRT791683	hsa-miR-4268	CLIP-seq
MIRT791684	hsa-miR-4295	CLIP-seq
MIRT791685	hsa-miR-4436b-5p	CLIP-seq
MIRT791686	hsa-miR-4439	CLIP-seq
MIRT791687	hsa-miR-4448	CLIP-seq
MIRT791688	hsa-miR-4473	CLIP-seq
MIRT791689	hsa-miR-4513	CLIP-seq
MIRT791690	hsa-miR-4534	CLIP-seq
MIRT791691	hsa-miR-454	CLIP-seq
MIRT791692	hsa-miR-4650-3p	CLIP-seq
MIRT791693	hsa-miR-4704-3p	CLIP-seq
MIRT791694	hsa-miR-4738-3p	CLIP-seq
MIRT791695	hsa-miR-4777-5p	CLIP-seq
MIRT791696	hsa-miR-4795-3p	CLIP-seq
MIRT791697	hsa-miR-512-3p	CLIP-seq
MIRT791698	hsa-miR-513c	CLIP-seq
MIRT791699	hsa-miR-514b-5p	CLIP-seq
MIRT791700	hsa-miR-519a	CLIP-seq
MIRT791701	hsa-miR-519b-3p	CLIP-seq
MIRT791702	hsa-miR-519c-3p	CLIP-seq
MIRT791703	hsa-miR-519d	CLIP-seq
MIRT791704	hsa-miR-520f	CLIP-seq
MIRT791705	hsa-miR-520g	CLIP-seq
MIRT791706	hsa-miR-520h	CLIP-seq
MIRT791707	hsa-miR-548ag	CLIP-seq
MIRT791708	hsa-miR-548ai	CLIP-seq
MIRT791709	hsa-miR-549	CLIP-seq
MIRT791710	hsa-miR-600	CLIP-seq
MIRT791711	hsa-miR-606	CLIP-seq
MIRT791712	hsa-miR-618	CLIP-seq
MIRT791713	hsa-miR-624	CLIP-seq
MIRT791714	hsa-miR-93	CLIP-seq
MIRT1933584	hsa-miR-3942-3p	CLIP-seq
MIRT1933585	hsa-miR-4310	CLIP-seq
MIRT1933586	hsa-miR-4666-3p	CLIP-seq
MIRT1933587	hsa-miR-4729	CLIP-seq
MIRT1933588	hsa-miR-548ac	CLIP-seq
MIRT1933589	hsa-miR-548ae	CLIP-seq
MIRT1933590	hsa-miR-548aj	CLIP-seq
MIRT1933591	hsa-miR-548am	CLIP-seq
MIRT1933592	hsa-miR-548d-3p	CLIP-seq
MIRT1933593	hsa-miR-548x	CLIP-seq
MIRT1933594	hsa-miR-548z	CLIP-seq
MIRT1933595	hsa-miR-579	CLIP-seq
MIRT791635	hsa-miR-130a	CLIP-seq
MIRT791636	hsa-miR-130b	CLIP-seq
MIRT791650	hsa-miR-301a	CLIP-seq
MIRT791651	hsa-miR-301b	CLIP-seq
MIRT791664	hsa-miR-3666	CLIP-seq
MIRT791668	hsa-miR-371-5p	CLIP-seq
MIRT791684	hsa-miR-4295	CLIP-seq
MIRT791691	hsa-miR-454	CLIP-seq
MIRT791667	hsa-miR-3692	CLIP-seq
MIRT2443846	hsa-miR-4775	CLIP-seq

Show/Hide all (11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005096	Function	GTPase activator activity	IBA
GO:0005096	Function	GTPase activator activity	IEA
GO:0005547	Function	Phosphatidylinositol-3,4,5-trisphosphate binding	IBA
GO:0005547	Function	Phosphatidylinositol-3,4,5-trisphosphate binding	IDA	11804589
GO:0005547	Function	Phosphatidylinositol-3,4,5-trisphosphate binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0032956	Process	Regulation of actin cytoskeleton organization	IBA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
606645	16924	ENSG00000047365

Q8WZ64

Protein name

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 (Centaurin-delta-1) (Cnt-d1) (Protein PARX)

Protein function

Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) bindin

PDB

1X40 , 2COD

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00536	SAM_1	8 → 67	SAM domain (Sterile alpha motif)	Domain
PF00169	PH	483 → 574	PH domain	Domain
PF00169	PH	588 → 679	PH domain	Domain
PF01412	ArfGap	685 → 803	Putative GTPase activating protein for Arf	Domain
PF00169	PH	879 → 1001	PH domain	Domain
PF00620	RhoGAP	1129 → 1282	RhoGAP domain	Domain
PF00788	RA	1326 → 1418	Ras association (RalGDS/AF-6) domain	Domain
PF00169	PH	1435 → 1537	PH domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Detected in brain, thymus, lymph node, thyroid, spinal cord, trachea, heart, skeletal muscle, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. {ECO:0000269|PubMed:11804590}.

Sequence

MSSVSEVNVDIKDFLMSINLEQYLLHFHESGFTTVKDCAAINDSLLQKIGISPTGHRRRI
LKQLQIILSKMQDIPIYANVHKTKKNDDPSKDYHVPSSDQNICIELSNSGSVQTSSPPQL
ETVRKNLEDSDASVERSQYPQSDDKLSPPKRDFPTAEEPHLNLGSLNDSLFGSDNIKIES
LITKKTVDHTVEEQQTEKVKLITENLSKLPNADSECLSFVGCSTSGTNSGNGTNGLLEGS
PPSPFFKFQGEMIVNDLYVPSSPILAPVRSRSKLVSRPSRSFLLRHRPVPEIPGSTKGVS
GSYFRERRNVATSTEKSVAWQNSNEENSSSIFPYGETFLFQRLENSKKRSIKNEFLTQGE
ALKGEAATATNSFIIKSSIYDNRKEKISEDKVEDIWIPREDKNNFLIDTASESEYSTVEE
CFQSLRRKNSKASKSRTQKALILDSVNRHSYPLSSTSGNADSSAVSSQAISPYACFYGAS
AKKVKSGWLDKLSPQGKRMFQKRWVKFDGLSISYYNNEKEMYSKGIIPLSAISTVRVQGD
NKFEVVTTQRTFVFRVEKEEERNDWISILLNALKSQSLTSQSQAVVTPEKCGYLELRGYK
AKIFTVLSGNSVWLCKNEQDFKSGLGITIIPMNVANVKQVDRTVKQSFEIITPYRSFSFT
AETEKEKQDWIEAVQQSIAETLSDYEVAEKIWFNESNRSCADCKAPDPDWASINLCVVIC
KKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIGNKRANDFWAGNLQKDEELHMD
SPVEKRKNFITQKYKEGKFRKTLLASLTKEELNKALCAAVVKPDVLETMALLFSGADVMC
ATGDPVHSTPYLLAKKAGQSLQMEFLYHNKFSDFPQHDIHSEGVLSQESSQSTFLCDFLY
QAPSAASKLSSEKKLLEETNKKWCVLEGGFLSYYENDKSTTPNGTININEVICLAIHKED
FYLNTGPIFIFEIYLPSERVFLFGAETSQAQRKWTEAIAKHFVPLFAENLTEADYDLIGQ
LFYKDCHALDQWRKGWFAMDKSSLHFCLQMQEVQGDRMHLRRLQELTISTMVQNGEKLDV
LLLVEKGRTLYIHGHTKLDFTVWHTAIEKAAGTDGNALQDQQLSKNDVPIIVNSCIAFVT
QYGLGCKYIYQKNGDPLHISELLESFKKDARSFKLRAGKHQLEDVTAVLKSFLSDIDDAL
LTKELYPYWISALDTQDDKERIKKYGAFIRSLPGVNRATLAAIIEHLYRVQKCSEINHMN
AHNLALVFSSCLFQTKGQTSEEVNVIEDLINNYVEIFEVKEDQVKQMDIENSFITKWKDT
QVSQAGDLLIEVYVERKEPDCSIIIRISPVMEAEELTNDILAIKNIIPTKGDIWATFEVI
ENEELERPLHYKENVLEQVLRWSSLAEPGSAYLVVKRFLTADTIKHCSDRSTLGSIKEGI
LKIKEEPSKILSGNKFQDRYFVLRDGFLFLYKDVKSSKHDKMFSLSSMKFYRGVKKKMKP
PTSWGLTAYSEKHHWHLCCDSSRTQTEWMTSIFIAQHEYDIWPPAGKERKRSITKNPKIG
GLPLIPIQHEGNATLARKNIESARAELERLRLSEKCDKESVDSSLKERASMVAHCLEHKD
DKLRNRPRKHRSFNCLEDTEPEAPLGQPKGHKGLKTLRKTEDRNSKATLDSDHKLPSRVI
EELNVVLQRSRTLPKELQDEQILK

Sequence length

1704

Interactions

View interactions

	KEGG		Reactome
	Endocytosis		Rho GTPase cycle

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Ovarian serous cystadenocarcinoma	Uncertain significance	rs1383340649	RCV005932713
Sarcoma	Likely benign	rs147255071	RCV005927354

Show/Hide Text Mining Associations (4)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Breast Neoplasms	Associate	32734521
Esophageal Squamous Cell Carcinoma	Associate	35842667
Neoplasm Metastasis	Inhibit	35842667
Neoplasms	Associate	35842667, 36366450

ARAP2 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2)