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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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116984
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Gene name
Gene Name - the full gene name approved by the HGNC.
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ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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ARAP2 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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CENTD1, PARX |
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Chromosome
Chromosome number
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4 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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4p14 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted ca |
| UniProt ID |
Q8WZ64
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| Protein name |
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 (Centaurin-delta-1) (Cnt-d1) (Protein PARX) |
| Protein function |
Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) bindin |
| PDB |
1X40
,
2COD
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| Family and domains |
Pfam
| Accession |
ID |
Position in sequence |
Description |
Type |
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PF00536
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SAM_1 |
8 → 67 |
SAM domain (Sterile alpha motif) |
Domain |
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PF00169
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PH |
483 → 574 |
PH domain |
Domain |
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PF00169
|
PH |
588 → 679 |
PH domain |
Domain |
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PF01412
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ArfGap |
685 → 803 |
Putative GTPase activating protein for Arf |
Domain |
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PF00169
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PH |
879 → 1001 |
PH domain |
Domain |
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PF00620
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RhoGAP |
1129 → 1282 |
RhoGAP domain |
Domain |
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PF00788
|
RA |
1326 → 1418 |
Ras association (RalGDS/AF-6) domain |
Domain |
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PF00169
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PH |
1435 → 1537 |
PH domain |
Domain |
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| Tissue specificity |
TISSUE SPECIFICITY: Detected in brain, thymus, lymph node, thyroid, spinal cord, trachea, heart, skeletal muscle, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. {ECO:0000269|PubMed:11804590}. |
| Sequence |
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| Sequence length |
1704 |
| Interactions |
View interactions
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