MED12L (mediator complex subunit 12L)

Gene

• Entrez ID: 116931
• Gene name: Mediator complex subunit 12L
• Gene symbol: MED12L
• Synonyms (NCBI Gene): NIZIDS, NOPAR, TNRC11L, TRALP, TRALPUSH
• Chromosome: 3
• Chromosome location: 3q25.1
• Summary: The protein encoded by this gene is part of the Mediator complex, which is involved in transcriptional coactivation of nearly all RNA polymerase II-dependent genes. The Mediator complex links gene-specific transcriptional activators with the basal transcr

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs1559855453	->C	Pathogenic	Genic upstream transcript variant, frameshift variant, non coding transcript variant, coding sequence variant
rs1560115921	C>T	Pathogenic	Stop gained, genic downstream transcript variant, coding sequence variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT028147	hsa-miR-93-5p	Sequencing	20371350
MIRT042329	hsa-miR-484	CLASH	23622248
MIRT208722	hsa-miR-19a-3p	PAR-CLIP	20371350
MIRT208723	hsa-miR-19b-3p	PAR-CLIP	20371350
MIRT208731	hsa-miR-3662	PAR-CLIP	20371350
MIRT305596	hsa-miR-6750-3p	PAR-CLIP	20371350
MIRT208724	hsa-miR-580-5p	PAR-CLIP	20371350
MIRT506589	hsa-miR-32-3p	PAR-CLIP	20371350
MIRT208733	hsa-miR-4698	PAR-CLIP	20371350
MIRT506588	hsa-miR-3607-5p	PAR-CLIP	20371350
MIRT208732	hsa-miR-548aj-5p	PAR-CLIP	20371350
MIRT208726	hsa-miR-548f-5p	PAR-CLIP	20371350
MIRT208727	hsa-miR-548g-5p	PAR-CLIP	20371350
MIRT208729	hsa-miR-548x-5p	PAR-CLIP	20371350
MIRT208725	hsa-miR-1468-3p	PAR-CLIP	20371350
MIRT506587	hsa-miR-4764-3p	PAR-CLIP	20371350
MIRT506586	hsa-miR-6516-3p	PAR-CLIP	20371350
MIRT208734	hsa-miR-548aw	PAR-CLIP	20371350
MIRT208722	hsa-miR-19a-3p	PAR-CLIP	20371350
MIRT208723	hsa-miR-19b-3p	PAR-CLIP	20371350
MIRT208731	hsa-miR-3662	PAR-CLIP	20371350
MIRT305596	hsa-miR-6750-3p	PAR-CLIP	20371350
MIRT208724	hsa-miR-580-5p	PAR-CLIP	20371350
MIRT506589	hsa-miR-32-3p	PAR-CLIP	20371350
MIRT208733	hsa-miR-4698	PAR-CLIP	20371350
MIRT506588	hsa-miR-3607-5p	PAR-CLIP	20371350
MIRT506587	hsa-miR-4764-3p	PAR-CLIP	20371350
MIRT506586	hsa-miR-6516-3p	PAR-CLIP	20371350
MIRT208722	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT208723	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT208731	hsa-miR-3662	PAR-CLIP	21572407
MIRT305596	hsa-miR-6750-3p	PAR-CLIP	21572407
MIRT208724	hsa-miR-580-5p	PAR-CLIP	21572407
MIRT506589	hsa-miR-32-3p	PAR-CLIP	21572407
MIRT208733	hsa-miR-4698	PAR-CLIP	21572407
MIRT556146	hsa-miR-1306-5p	PAR-CLIP	21572407
MIRT506588	hsa-miR-3607-5p	PAR-CLIP	21572407
MIRT556145	hsa-miR-4772-3p	PAR-CLIP	21572407
MIRT556144	hsa-miR-2276-3p	PAR-CLIP	21572407
MIRT208732	hsa-miR-548aj-5p	PAR-CLIP	21572407
MIRT208726	hsa-miR-548f-5p	PAR-CLIP	21572407
MIRT208727	hsa-miR-548g-5p	PAR-CLIP	21572407
MIRT208729	hsa-miR-548x-5p	PAR-CLIP	21572407
MIRT208725	hsa-miR-1468-3p	PAR-CLIP	21572407
MIRT506587	hsa-miR-4764-3p	PAR-CLIP	21572407
MIRT506586	hsa-miR-6516-3p	PAR-CLIP	21572407
MIRT208734	hsa-miR-548aw	PAR-CLIP	21572407
MIRT208722	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT208723	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT208731	hsa-miR-3662	PAR-CLIP	21572407
MIRT305596	hsa-miR-6750-3p	PAR-CLIP	21572407
MIRT208724	hsa-miR-580-5p	PAR-CLIP	21572407
MIRT506589	hsa-miR-32-3p	PAR-CLIP	21572407
MIRT208733	hsa-miR-4698	PAR-CLIP	21572407
MIRT506588	hsa-miR-3607-5p	PAR-CLIP	21572407
MIRT208732	hsa-miR-548aj-5p	PAR-CLIP	21572407
MIRT208726	hsa-miR-548f-5p	PAR-CLIP	21572407
MIRT208727	hsa-miR-548g-5p	PAR-CLIP	21572407
MIRT208729	hsa-miR-548x-5p	PAR-CLIP	21572407
MIRT208725	hsa-miR-1468-3p	PAR-CLIP	21572407
MIRT506587	hsa-miR-4764-3p	PAR-CLIP	21572407
MIRT506586	hsa-miR-6516-3p	PAR-CLIP	21572407
MIRT208734	hsa-miR-548aw	PAR-CLIP	21572407
MIRT208722	hsa-miR-19a-3p	PAR-CLIP	23446348
MIRT208723	hsa-miR-19b-3p	PAR-CLIP	23446348
MIRT208731	hsa-miR-3662	PAR-CLIP	23446348
MIRT305596	hsa-miR-6750-3p	PAR-CLIP	23446348
MIRT208724	hsa-miR-580-5p	PAR-CLIP	23446348
MIRT506589	hsa-miR-32-3p	PAR-CLIP	23446348
MIRT208733	hsa-miR-4698	PAR-CLIP	23446348
MIRT506588	hsa-miR-3607-5p	PAR-CLIP	23446348
MIRT208732	hsa-miR-548aj-5p	PAR-CLIP	23446348
MIRT208726	hsa-miR-548f-5p	PAR-CLIP	23446348
MIRT208727	hsa-miR-548g-5p	PAR-CLIP	23446348
MIRT208729	hsa-miR-548x-5p	PAR-CLIP	23446348
MIRT208725	hsa-miR-1468-3p	PAR-CLIP	23446348
MIRT506587	hsa-miR-4764-3p	PAR-CLIP	23446348
MIRT506586	hsa-miR-6516-3p	PAR-CLIP	23446348
MIRT208734	hsa-miR-548aw	PAR-CLIP	23446348
MIRT208722	hsa-miR-19a-3p	PAR-CLIP	20371350
MIRT208723	hsa-miR-19b-3p	PAR-CLIP	20371350
MIRT208731	hsa-miR-3662	PAR-CLIP	20371350
MIRT305596	hsa-miR-6750-3p	PAR-CLIP	20371350
MIRT208724	hsa-miR-580-5p	PAR-CLIP	20371350
MIRT506589	hsa-miR-32-3p	PAR-CLIP	20371350
MIRT208733	hsa-miR-4698	PAR-CLIP	20371350
MIRT506588	hsa-miR-3607-5p	PAR-CLIP	20371350
MIRT208732	hsa-miR-548aj-5p	PAR-CLIP	20371350
MIRT208726	hsa-miR-548f-5p	PAR-CLIP	20371350
MIRT208727	hsa-miR-548g-5p	PAR-CLIP	20371350
MIRT208729	hsa-miR-548x-5p	PAR-CLIP	20371350
MIRT208725	hsa-miR-1468-3p	PAR-CLIP	20371350
MIRT506587	hsa-miR-4764-3p	PAR-CLIP	20371350
MIRT506586	hsa-miR-6516-3p	PAR-CLIP	20371350
MIRT208734	hsa-miR-548aw	PAR-CLIP	20371350
MIRT208722	hsa-miR-19a-3p	PAR-CLIP	20371350
MIRT208723	hsa-miR-19b-3p	PAR-CLIP	20371350
MIRT208731	hsa-miR-3662	PAR-CLIP	20371350
MIRT305596	hsa-miR-6750-3p	PAR-CLIP	20371350
MIRT208724	hsa-miR-580-5p	PAR-CLIP	20371350
MIRT506589	hsa-miR-32-3p	PAR-CLIP	20371350
MIRT208733	hsa-miR-4698	PAR-CLIP	20371350
MIRT506588	hsa-miR-3607-5p	PAR-CLIP	20371350
MIRT506587	hsa-miR-4764-3p	PAR-CLIP	20371350
MIRT506586	hsa-miR-6516-3p	PAR-CLIP	20371350
MIRT208722	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT208723	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT208731	hsa-miR-3662	PAR-CLIP	21572407
MIRT305596	hsa-miR-6750-3p	PAR-CLIP	21572407
MIRT208724	hsa-miR-580-5p	PAR-CLIP	21572407
MIRT506589	hsa-miR-32-3p	PAR-CLIP	21572407
MIRT208733	hsa-miR-4698	PAR-CLIP	21572407
MIRT556146	hsa-miR-1306-5p	PAR-CLIP	21572407
MIRT506588	hsa-miR-3607-5p	PAR-CLIP	21572407
MIRT556145	hsa-miR-4772-3p	PAR-CLIP	21572407
MIRT556144	hsa-miR-2276-3p	PAR-CLIP	21572407
MIRT208732	hsa-miR-548aj-5p	PAR-CLIP	21572407
MIRT208726	hsa-miR-548f-5p	PAR-CLIP	21572407
MIRT208727	hsa-miR-548g-5p	PAR-CLIP	21572407
MIRT208729	hsa-miR-548x-5p	PAR-CLIP	21572407
MIRT208725	hsa-miR-1468-3p	PAR-CLIP	21572407
MIRT506587	hsa-miR-4764-3p	PAR-CLIP	21572407
MIRT506586	hsa-miR-6516-3p	PAR-CLIP	21572407
MIRT208734	hsa-miR-548aw	PAR-CLIP	21572407
MIRT208722	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT208723	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT208731	hsa-miR-3662	PAR-CLIP	21572407
MIRT305596	hsa-miR-6750-3p	PAR-CLIP	21572407
MIRT208724	hsa-miR-580-5p	PAR-CLIP	21572407
MIRT506589	hsa-miR-32-3p	PAR-CLIP	21572407
MIRT208733	hsa-miR-4698	PAR-CLIP	21572407
MIRT506588	hsa-miR-3607-5p	PAR-CLIP	21572407
MIRT208732	hsa-miR-548aj-5p	PAR-CLIP	21572407
MIRT208726	hsa-miR-548f-5p	PAR-CLIP	21572407
MIRT208727	hsa-miR-548g-5p	PAR-CLIP	21572407
MIRT208729	hsa-miR-548x-5p	PAR-CLIP	21572407
MIRT208725	hsa-miR-1468-3p	PAR-CLIP	21572407
MIRT506587	hsa-miR-4764-3p	PAR-CLIP	21572407
MIRT506586	hsa-miR-6516-3p	PAR-CLIP	21572407
MIRT208734	hsa-miR-548aw	PAR-CLIP	21572407
MIRT208722	hsa-miR-19a-3p	PAR-CLIP	23446348
MIRT208723	hsa-miR-19b-3p	PAR-CLIP	23446348
MIRT208731	hsa-miR-3662	PAR-CLIP	23446348
MIRT305596	hsa-miR-6750-3p	PAR-CLIP	23446348
MIRT208724	hsa-miR-580-5p	PAR-CLIP	23446348
MIRT506589	hsa-miR-32-3p	PAR-CLIP	23446348
MIRT208733	hsa-miR-4698	PAR-CLIP	23446348
MIRT506588	hsa-miR-3607-5p	PAR-CLIP	23446348
MIRT208732	hsa-miR-548aj-5p	PAR-CLIP	23446348
MIRT208726	hsa-miR-548f-5p	PAR-CLIP	23446348
MIRT208727	hsa-miR-548g-5p	PAR-CLIP	23446348
MIRT208729	hsa-miR-548x-5p	PAR-CLIP	23446348
MIRT208725	hsa-miR-1468-3p	PAR-CLIP	23446348
MIRT506587	hsa-miR-4764-3p	PAR-CLIP	23446348
MIRT506586	hsa-miR-6516-3p	PAR-CLIP	23446348
MIRT208734	hsa-miR-548aw	PAR-CLIP	23446348
MIRT1140330	hsa-miR-105	CLIP-seq
MIRT1140331	hsa-miR-106a	CLIP-seq
MIRT1140332	hsa-miR-106b	CLIP-seq
MIRT1140333	hsa-miR-10a	CLIP-seq
MIRT1140334	hsa-miR-10b	CLIP-seq
MIRT1140335	hsa-miR-1182	CLIP-seq
MIRT1140336	hsa-miR-122	CLIP-seq
MIRT1140337	hsa-miR-1237	CLIP-seq
MIRT1140338	hsa-miR-1249	CLIP-seq
MIRT1140339	hsa-miR-1264	CLIP-seq
MIRT1140340	hsa-miR-1271	CLIP-seq
MIRT1140341	hsa-miR-128	CLIP-seq
MIRT1140342	hsa-miR-129-5p	CLIP-seq
MIRT1140343	hsa-miR-1296	CLIP-seq
MIRT1140344	hsa-miR-1299	CLIP-seq
MIRT1140345	hsa-miR-130a	CLIP-seq
MIRT1140346	hsa-miR-130b	CLIP-seq
MIRT1140347	hsa-miR-139-5p	CLIP-seq
MIRT1140348	hsa-miR-142-5p	CLIP-seq
MIRT1140349	hsa-miR-148a	CLIP-seq
MIRT1140350	hsa-miR-148b	CLIP-seq
MIRT1140351	hsa-miR-152	CLIP-seq
MIRT1140352	hsa-miR-17	CLIP-seq
MIRT1140353	hsa-miR-181a	CLIP-seq
MIRT1140354	hsa-miR-181b	CLIP-seq
MIRT1140355	hsa-miR-181c	CLIP-seq
MIRT1140356	hsa-miR-181d	CLIP-seq
MIRT1140357	hsa-miR-182	CLIP-seq
MIRT1140358	hsa-miR-186	CLIP-seq
MIRT1140359	hsa-miR-19a	CLIP-seq
MIRT1140360	hsa-miR-19b	CLIP-seq
MIRT1140361	hsa-miR-2052	CLIP-seq
MIRT1140362	hsa-miR-20a	CLIP-seq
MIRT1140363	hsa-miR-20b	CLIP-seq
MIRT1140364	hsa-miR-23a	CLIP-seq
MIRT1140365	hsa-miR-23b	CLIP-seq
MIRT1140366	hsa-miR-23c	CLIP-seq
MIRT1140367	hsa-miR-27a	CLIP-seq
MIRT1140368	hsa-miR-27b	CLIP-seq
MIRT1140369	hsa-miR-2909	CLIP-seq
MIRT1140370	hsa-miR-299-5p	CLIP-seq
MIRT1140371	hsa-miR-301a	CLIP-seq
MIRT1140372	hsa-miR-301b	CLIP-seq
MIRT1140373	hsa-miR-302a	CLIP-seq
MIRT1140374	hsa-miR-302b	CLIP-seq
MIRT1140375	hsa-miR-302c	CLIP-seq
MIRT1140376	hsa-miR-302d	CLIP-seq
MIRT1140377	hsa-miR-302e	CLIP-seq
MIRT1140378	hsa-miR-30a	CLIP-seq
MIRT1140379	hsa-miR-30b	CLIP-seq
MIRT1140380	hsa-miR-30c	CLIP-seq
MIRT1140381	hsa-miR-30d	CLIP-seq
MIRT1140382	hsa-miR-30e	CLIP-seq
MIRT1140383	hsa-miR-3134	CLIP-seq
MIRT1140384	hsa-miR-3135b	CLIP-seq
MIRT1140385	hsa-miR-3136-5p	CLIP-seq
MIRT1140386	hsa-miR-3141	CLIP-seq
MIRT1140387	hsa-miR-3159	CLIP-seq
MIRT1140388	hsa-miR-3177-5p	CLIP-seq
MIRT1140389	hsa-miR-3180-5p	CLIP-seq
MIRT1140390	hsa-miR-3185	CLIP-seq
MIRT1140391	hsa-miR-3190	CLIP-seq
MIRT1140392	hsa-miR-330-3p	CLIP-seq
MIRT1140393	hsa-miR-340	CLIP-seq
MIRT1140394	hsa-miR-3545-5p	CLIP-seq
MIRT1140395	hsa-miR-3609	CLIP-seq
MIRT1140396	hsa-miR-3613-5p	CLIP-seq
MIRT1140397	hsa-miR-3622a-5p	CLIP-seq
MIRT1140398	hsa-miR-3652	CLIP-seq
MIRT1140399	hsa-miR-3653	CLIP-seq
MIRT1140400	hsa-miR-3658	CLIP-seq
MIRT1140401	hsa-miR-3666	CLIP-seq
MIRT1140402	hsa-miR-3672	CLIP-seq
MIRT1140403	hsa-miR-3680	CLIP-seq
MIRT1140404	hsa-miR-3689a-3p	CLIP-seq
MIRT1140405	hsa-miR-3689c	CLIP-seq
MIRT1140406	hsa-miR-371-5p	CLIP-seq
MIRT1140407	hsa-miR-371b-5p	CLIP-seq
MIRT1140408	hsa-miR-372	CLIP-seq
MIRT1140409	hsa-miR-373	CLIP-seq
MIRT1140410	hsa-miR-378	CLIP-seq
MIRT1140411	hsa-miR-378b	CLIP-seq
MIRT1140412	hsa-miR-378c	CLIP-seq
MIRT1140413	hsa-miR-378d	CLIP-seq
MIRT1140414	hsa-miR-378e	CLIP-seq
MIRT1140415	hsa-miR-378f	CLIP-seq
MIRT1140416	hsa-miR-378h	CLIP-seq
MIRT1140417	hsa-miR-378i	CLIP-seq
MIRT1140418	hsa-miR-409-3p	CLIP-seq
MIRT1140419	hsa-miR-422a	CLIP-seq
MIRT1140420	hsa-miR-4260	CLIP-seq
MIRT1140421	hsa-miR-4262	CLIP-seq
MIRT1140422	hsa-miR-4264	CLIP-seq
MIRT1140423	hsa-miR-4276	CLIP-seq
MIRT1140424	hsa-miR-4295	CLIP-seq
MIRT1140425	hsa-miR-4307	CLIP-seq
MIRT1140426	hsa-miR-4423-3p	CLIP-seq
MIRT1140427	hsa-miR-4430	CLIP-seq
MIRT1140428	hsa-miR-4439	CLIP-seq
MIRT1140429	hsa-miR-4470	CLIP-seq
MIRT1140430	hsa-miR-4474-3p	CLIP-seq
MIRT1140431	hsa-miR-4477a	CLIP-seq
MIRT1140432	hsa-miR-4491	CLIP-seq
MIRT1140433	hsa-miR-4505	CLIP-seq
MIRT1140434	hsa-miR-450b-5p	CLIP-seq
MIRT1140435	hsa-miR-4513	CLIP-seq
MIRT1140436	hsa-miR-4534	CLIP-seq
MIRT1140437	hsa-miR-454	CLIP-seq
MIRT1140438	hsa-miR-4638-3p	CLIP-seq
MIRT1140439	hsa-miR-4640-5p	CLIP-seq
MIRT1140440	hsa-miR-4652-3p	CLIP-seq
MIRT1140441	hsa-miR-4657	CLIP-seq
MIRT1140442	hsa-miR-4666-5p	CLIP-seq
MIRT1140443	hsa-miR-4695-3p	CLIP-seq
MIRT1140444	hsa-miR-4712-3p	CLIP-seq
MIRT1140445	hsa-miR-4717-3p	CLIP-seq
MIRT1140446	hsa-miR-4724-3p	CLIP-seq
MIRT1140447	hsa-miR-4726-5p	CLIP-seq
MIRT1140448	hsa-miR-4728-5p	CLIP-seq
MIRT1140449	hsa-miR-4764-5p	CLIP-seq
MIRT1140450	hsa-miR-4782-5p	CLIP-seq
MIRT1140451	hsa-miR-4795-5p	CLIP-seq
MIRT1140452	hsa-miR-4796-3p	CLIP-seq
MIRT1140453	hsa-miR-4797-3p	CLIP-seq
MIRT1140454	hsa-miR-4802-3p	CLIP-seq
MIRT1140455	hsa-miR-4803	CLIP-seq
MIRT1140456	hsa-miR-490-5p	CLIP-seq
MIRT1140457	hsa-miR-5096	CLIP-seq
MIRT1140458	hsa-miR-513a-5p	CLIP-seq
MIRT1140459	hsa-miR-513b	CLIP-seq
MIRT1140460	hsa-miR-516b	CLIP-seq
MIRT1140461	hsa-miR-519d	CLIP-seq
MIRT1140462	hsa-miR-520a-3p	CLIP-seq
MIRT1140463	hsa-miR-520b	CLIP-seq
MIRT1140464	hsa-miR-520c-3p	CLIP-seq
MIRT1140465	hsa-miR-520d-3p	CLIP-seq
MIRT1140466	hsa-miR-520d-5p	CLIP-seq
MIRT1140467	hsa-miR-520e	CLIP-seq
MIRT1140468	hsa-miR-520f	CLIP-seq
MIRT1140469	hsa-miR-524-5p	CLIP-seq
MIRT1140470	hsa-miR-543	CLIP-seq
MIRT1140471	hsa-miR-548ah	CLIP-seq
MIRT1140472	hsa-miR-561	CLIP-seq
MIRT1140473	hsa-miR-601	CLIP-seq
MIRT1140474	hsa-miR-651	CLIP-seq
MIRT1140475	hsa-miR-7	CLIP-seq
MIRT1140476	hsa-miR-93	CLIP-seq
MIRT1140477	hsa-miR-96	CLIP-seq
MIRT2039818	hsa-miR-101	CLIP-seq
MIRT1140337	hsa-miR-1237	CLIP-seq
MIRT2039819	hsa-miR-1276	CLIP-seq
MIRT1140344	hsa-miR-1299	CLIP-seq
MIRT2039820	hsa-miR-144	CLIP-seq
MIRT1140353	hsa-miR-181a	CLIP-seq
MIRT1140354	hsa-miR-181b	CLIP-seq
MIRT1140355	hsa-miR-181c	CLIP-seq
MIRT1140356	hsa-miR-181d	CLIP-seq
MIRT2039821	hsa-miR-1972	CLIP-seq
MIRT1140364	hsa-miR-23a	CLIP-seq
MIRT1140365	hsa-miR-23b	CLIP-seq
MIRT1140366	hsa-miR-23c	CLIP-seq
MIRT2039822	hsa-miR-3065-5p	CLIP-seq
MIRT2039823	hsa-miR-3117-5p	CLIP-seq
MIRT1140391	hsa-miR-3190	CLIP-seq
MIRT1140393	hsa-miR-340	CLIP-seq
MIRT2039824	hsa-miR-3660	CLIP-seq
MIRT1140402	hsa-miR-3672	CLIP-seq
MIRT1140410	hsa-miR-378	CLIP-seq
MIRT1140411	hsa-miR-378b	CLIP-seq
MIRT1140412	hsa-miR-378c	CLIP-seq
MIRT1140413	hsa-miR-378d	CLIP-seq
MIRT1140414	hsa-miR-378e	CLIP-seq
MIRT1140415	hsa-miR-378f	CLIP-seq
MIRT1140416	hsa-miR-378h	CLIP-seq
MIRT1140417	hsa-miR-378i	CLIP-seq
MIRT1140419	hsa-miR-422a	CLIP-seq
MIRT1140420	hsa-miR-4260	CLIP-seq
MIRT1140421	hsa-miR-4262	CLIP-seq
MIRT2039825	hsa-miR-4272	CLIP-seq
MIRT2039826	hsa-miR-4279	CLIP-seq
MIRT1140432	hsa-miR-4491	CLIP-seq
MIRT2039827	hsa-miR-4499	CLIP-seq
MIRT1140434	hsa-miR-450b-5p	CLIP-seq
MIRT1140435	hsa-miR-4513	CLIP-seq
MIRT2039828	hsa-miR-4526	CLIP-seq
MIRT1140438	hsa-miR-4638-3p	CLIP-seq
MIRT1140439	hsa-miR-4640-5p	CLIP-seq
MIRT2039829	hsa-miR-4645-3p	CLIP-seq
MIRT1140441	hsa-miR-4657	CLIP-seq
MIRT1140442	hsa-miR-4666-5p	CLIP-seq
MIRT2039830	hsa-miR-4699-3p	CLIP-seq
MIRT1140447	hsa-miR-4726-5p	CLIP-seq
MIRT2039831	hsa-miR-4731-3p	CLIP-seq
MIRT1140450	hsa-miR-4782-5p	CLIP-seq
MIRT2039832	hsa-miR-4801	CLIP-seq
MIRT1140460	hsa-miR-516b	CLIP-seq
MIRT2039833	hsa-miR-545	CLIP-seq
MIRT2039834	hsa-miR-579	CLIP-seq
MIRT2269773	hsa-miR-1272	CLIP-seq
MIRT1140341	hsa-miR-128	CLIP-seq
MIRT1140345	hsa-miR-130a	CLIP-seq
MIRT1140346	hsa-miR-130b	CLIP-seq
MIRT2269774	hsa-miR-1322	CLIP-seq
MIRT2039820	hsa-miR-144	CLIP-seq
MIRT1140349	hsa-miR-148a	CLIP-seq
MIRT1140350	hsa-miR-148b	CLIP-seq
MIRT1140351	hsa-miR-152	CLIP-seq
MIRT1140353	hsa-miR-181a	CLIP-seq
MIRT1140354	hsa-miR-181b	CLIP-seq
MIRT1140355	hsa-miR-181c	CLIP-seq
MIRT1140356	hsa-miR-181d	CLIP-seq
MIRT1140359	hsa-miR-19a	CLIP-seq
MIRT1140360	hsa-miR-19b	CLIP-seq
MIRT2269775	hsa-miR-2276	CLIP-seq
MIRT1140364	hsa-miR-23a	CLIP-seq
MIRT1140365	hsa-miR-23b	CLIP-seq
MIRT1140366	hsa-miR-23c	CLIP-seq
MIRT1140367	hsa-miR-27a	CLIP-seq
MIRT1140368	hsa-miR-27b	CLIP-seq
MIRT1140371	hsa-miR-301a	CLIP-seq
MIRT1140372	hsa-miR-301b	CLIP-seq
MIRT2039822	hsa-miR-3065-5p	CLIP-seq
MIRT2269776	hsa-miR-3153	CLIP-seq
MIRT2269777	hsa-miR-3646	CLIP-seq
MIRT2039824	hsa-miR-3660	CLIP-seq
MIRT1140401	hsa-miR-3666	CLIP-seq
MIRT1140421	hsa-miR-4262	CLIP-seq
MIRT1140423	hsa-miR-4276	CLIP-seq
MIRT1140424	hsa-miR-4295	CLIP-seq
MIRT2269778	hsa-miR-4495	CLIP-seq
MIRT2039828	hsa-miR-4526	CLIP-seq
MIRT2269779	hsa-miR-4528	CLIP-seq
MIRT1140437	hsa-miR-454	CLIP-seq
MIRT2039829	hsa-miR-4645-3p	CLIP-seq
MIRT1140440	hsa-miR-4652-3p	CLIP-seq
MIRT2269780	hsa-miR-4668-5p	CLIP-seq
MIRT1140455	hsa-miR-4803	CLIP-seq
MIRT1140458	hsa-miR-513a-5p	CLIP-seq
MIRT2390764	hsa-miR-1290	CLIP-seq
MIRT2390765	hsa-miR-3127-3p	CLIP-seq
MIRT2390766	hsa-miR-3167	CLIP-seq
MIRT1140396	hsa-miR-3613-5p	CLIP-seq
MIRT2390767	hsa-miR-3679-3p	CLIP-seq
MIRT2390768	hsa-miR-4446-5p	CLIP-seq
MIRT2390769	hsa-miR-876-5p	CLIP-seq
MIRT2453889	hsa-miR-136	CLIP-seq
MIRT2453890	hsa-miR-345	CLIP-seq
MIRT2453891	hsa-miR-4761-5p	CLIP-seq
MIRT2453892	hsa-miR-498	CLIP-seq
MIRT2453889	hsa-miR-136	CLIP-seq
MIRT2453890	hsa-miR-345	CLIP-seq
MIRT2453891	hsa-miR-4761-5p	CLIP-seq
MIRT2453892	hsa-miR-498	CLIP-seq
MIRT1140330	hsa-miR-105	CLIP-seq
MIRT2453889	hsa-miR-136	CLIP-seq
MIRT1140347	hsa-miR-139-5p	CLIP-seq
MIRT2568851	hsa-miR-2110	CLIP-seq
MIRT2568852	hsa-miR-217	CLIP-seq
MIRT2568853	hsa-miR-3155	CLIP-seq
MIRT2568854	hsa-miR-3155b	CLIP-seq
MIRT2568855	hsa-miR-3647-3p	CLIP-seq
MIRT1140399	hsa-miR-3653	CLIP-seq
MIRT2568856	hsa-miR-3655	CLIP-seq
MIRT1140400	hsa-miR-3658	CLIP-seq
MIRT2568857	hsa-miR-3936	CLIP-seq
MIRT2568858	hsa-miR-4271	CLIP-seq
MIRT2568859	hsa-miR-4282	CLIP-seq
MIRT2568860	hsa-miR-4284	CLIP-seq
MIRT2568861	hsa-miR-4300	CLIP-seq
MIRT1140425	hsa-miR-4307	CLIP-seq
MIRT1140431	hsa-miR-4477a	CLIP-seq
MIRT2568862	hsa-miR-4477b	CLIP-seq
MIRT2568863	hsa-miR-4487	CLIP-seq
MIRT2568864	hsa-miR-4668-3p	CLIP-seq
MIRT2568865	hsa-miR-4725-3p	CLIP-seq
MIRT2568866	hsa-miR-4731-5p	CLIP-seq
MIRT2568867	hsa-miR-4738-3p	CLIP-seq
MIRT2453891	hsa-miR-4761-5p	CLIP-seq
MIRT2453892	hsa-miR-498	CLIP-seq
MIRT2568868	hsa-miR-511	CLIP-seq
MIRT2568869	hsa-miR-548c-3p	CLIP-seq
MIRT2568870	hsa-miR-615-5p	CLIP-seq
MIRT2568871	hsa-miR-720	CLIP-seq
MIRT2568872	hsa-miR-920	CLIP-seq
MIRT2568873	hsa-miR-939	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003712	Function	Transcription coregulator activity	IEA
GO:0003713	Function	Transcription coactivator activity	IBA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0008013	Function	Beta-catenin binding	IEA
GO:0016592	Component	Mediator complex	IBA
GO:0016592	Component	Mediator complex	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA

Other IDs

• MIM: 611318
• HGNC: 16050
• e!Ensembl: ENSG00000144893

Protein

• UniProt ID: Q86YW9
• Protein name: Mediator of RNA polymerase II transcription subunit 12-like protein (Mediator complex subunit 12-like protein) (Thyroid hormone receptor-associated-like protein) (Trinucleotide repeat-containing gene 11 protein-like)
• Protein function: May be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF09497	Med12	105 → 161	Transcription mediator complex subunit Med12	Domain
  PF12145	Med12-LCEWAV	283 → 730	Eukaryotic Mediator 12 subunit domain	Domain
  PF12144	Med12-PQL	1802 → 2019	Eukaryotic Mediator 12 catenin-binding domain	Domain

• Sequence:

  MAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSAR
  NIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDL
  AGNKPLSILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQA
  PDPNLEWTQISTRYLREQLAKISDFYHMASSTGDGPVPVPPEVEQAMKQWEYNEKLAFHM
  FQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCAR
  RLSLLLSDSPNLLAAHSPHMMIGPNNSSIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPL
  VYGLSCMLQTVTLCCPSALVWNYSTNENKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQV
  RARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSM
  ETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIE
  AERCGESEVLDEKESISSSSLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLV
  LLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPVGENADEHYSKDHDVKMEIFSP
  MPGESCENANTSLGRRMSVNCEKLVKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSS
  HECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGVGDEGQKARKNKQETF
  PTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPA
  LNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQ
  TAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQT
  IYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCM
  GHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSF
  HDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQ
  ACFLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLK
  NDDFTMRGLRCDGNADDIWTASQNPKSCGKSISIETANLREYARYVLRTICQQEWVGEHC
  LKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQ
  WTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNSSNSGMSL
  FNPNSIGSADTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKG
  QHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNW
  REERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHT
  NNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDK
  VRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQ
  KNPAPLSWAWFGTVRVDRRVIKYEEQHHLLLYHTHPMPKPRSYYLQPLPLPPEEEEEEPT
  SPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPIS
  SQMMHHPQSTLWGYNLVGQPQQPGFFLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQR
  RSGAMMQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQGQPGDQAALFAAQAR
  PSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTSQQQAGSVVLSPSYNSRAYPAAHSNPV
  LMERLRQIQQQPSGYVQQQASPYLQPLTGSQRLNHQALQQSPLVGGGIDAVLTSAHPNLP
  SVPLPQDPMRPRQPQVRQQQRLLQMQQPQQPQPQQPPQPQQSSQSQSQTLGLQAMQPQQP
  LFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF

• Sequence length: 2145

Pathways

KEGG:

Thyroid hormone signaling pathway

Associated diseases

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Intellectual disability	Pathogenic	rs1560115921, rs1560108090, rs1560103306, rs1559855453	RCV000779622 RCV000779623 RCV000779624 RCV000779625
Nizon-Isidor syndrome	Likely pathogenic; Pathogenic	rs878982061, rs2149096532, rs1724263784, rs2473572861, rs2474008510, rs2473757315, rs2474225919, rs2473757305, rs1560069336, rs2530392269, rs1560108090, rs1723551652, rs1711989766	RCV001537880 RCV001724765 RCV002272608 RCV002283789 RCV002468850 RCV003147873 RCV003335899 RCV003387613 RCV003444083 RCV003492904 RCV001090066 RCV001090064 RCV001090065

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Acute myeloid leukemia	Likely benign	rs771092834, rs186287395	RCV005926965 RCV005939021
Developmental disorder	Likely benign; Uncertain significance	rs1237286376, rs2473957992, rs1723870830	RCV003127995 RCV003127996 RCV003764465
MED12L-related disorder	Uncertain significance; Likely benign; Conflicting classifications of pathogenicity	rs761030969, rs138249004, rs199730852, rs748555256, rs2474209969, rs1714002662, rs2474224895, rs2473681844, rs1713987552, rs2473613799, rs1755452288, rs768984130, rs753466604, rs1380964632, rs369982334, rs2474028154, rs2473854687, rs146070871, rs2531038489, rs1713678593, rs186287395, rs768221380, rs139235145, rs541572659, rs1324159323, rs149086875	RCV003418431 RCV003900915 RCV003963794 RCV003402482 RCV003404211 RCV003417157 RCV003402372 RCV003416726 RCV003412520 RCV003421192 RCV003420723 RCV003400023 RCV003402750 RCV003410785 RCV003921455 RCV003981474 RCV003981669 RCV003911950 RCV003899316 RCV003901365 RCV003941758 RCV003959571 RCV003949862 RCV003969254 RCV003971584 RCV003962309
MED12L-related neurodevelopmental disorder	Uncertain significance	rs2473537987, rs150905004	RCV002467382 RCV001270761
Neurodevelopmental disorder	Uncertain significance	rs772844769, rs1416139284	RCV002277683 RCV001262859
See cases	Uncertain significance; Conflicting classifications of pathogenicity	rs2108204276, rs564510830	RCV002252909 RCV002252589

Associations from Text Mining
Disease Name	Relationship Type	References
Agenesis of Corpus Callosum	Associate	31155615
Autism Spectrum Disorder	Associate	31155615
Congenital Abnormalities	Associate	31155615
Developmental Disabilities	Associate	31155615
Epilepsy	Associate	35175489
Intellectual Disability	Associate	31155615
Myocardial Infarction	Associate	30143348
Prostatic Neoplasms	Associate	28067867
Prostatic Neoplasms Castration Resistant	Associate	28067867
Pulmonary Atelectasis	Associate	34089082
Speech Disorders	Associate	31155615
Stomach Neoplasms	Associate	34034702