Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	1164
Gene name	CDC28 protein kinase regulatory subunit 2
Gene symbol	CKS2
Synonyms (NCBI Gene)	CKSHS2
Chromosome	9
Chromosome location	9q22.2
Summary	CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS2 mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects specialized role

242

Show/Hide all (242)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022264	hsa-miR-124-3p	Microarray	18668037
MIRT052270	hsa-let-7b-5p	CLASH	23622248
MIRT053077	hsa-miR-26a-5p	FlowWestern blot	23861775
MIRT325435	hsa-miR-548ae-3p	HITS-CLIP	19536157
MIRT325436	hsa-miR-548ah-3p	HITS-CLIP	19536157
MIRT325437	hsa-miR-548aj-3p	HITS-CLIP	19536157
MIRT325438	hsa-miR-548am-3p	HITS-CLIP	19536157
MIRT325439	hsa-miR-548aq-3p	HITS-CLIP	19536157
MIRT325429	hsa-miR-548j-3p	HITS-CLIP	19536157
MIRT325432	hsa-miR-548x-3p	HITS-CLIP	19536157
MIRT325425	hsa-miR-548a-3p	HITS-CLIP	19536157
MIRT325440	hsa-miR-548ar-3p	HITS-CLIP	19536157
MIRT325441	hsa-miR-548az-3p	HITS-CLIP	19536157
MIRT325428	hsa-miR-548e-3p	HITS-CLIP	19536157
MIRT325430	hsa-miR-548f-3p	HITS-CLIP	19536157
MIRT723705	hsa-miR-4511	HITS-CLIP	19536157
MIRT723704	hsa-miR-200a-5p	HITS-CLIP	19536157
MIRT723703	hsa-miR-200b-5p	HITS-CLIP	19536157
MIRT723702	hsa-miR-4269	HITS-CLIP	19536157
MIRT723701	hsa-miR-6715b-5p	HITS-CLIP	19536157
MIRT723700	hsa-miR-302a-5p	HITS-CLIP	19536157
MIRT723699	hsa-miR-7-5p	HITS-CLIP	19536157
MIRT723698	hsa-miR-6077	HITS-CLIP	19536157
MIRT479232	hsa-miR-493-5p	PAR-CLIP	20371350
MIRT479231	hsa-miR-1246	PAR-CLIP	20371350
MIRT479229	hsa-miR-6744-5p	PAR-CLIP	20371350
MIRT479228	hsa-miR-1255a	PAR-CLIP	20371350
MIRT479227	hsa-miR-1255b-5p	PAR-CLIP	20371350
MIRT479221	hsa-let-7c-3p	PAR-CLIP	20371350
MIRT479220	hsa-let-7a-2-3p	PAR-CLIP	20371350
MIRT479219	hsa-let-7g-3p	PAR-CLIP	20371350
MIRT479218	hsa-miR-574-3p	PAR-CLIP	20371350
MIRT479232	hsa-miR-493-5p	PAR-CLIP	20371350
MIRT479231	hsa-miR-1246	PAR-CLIP	20371350
MIRT479229	hsa-miR-6744-5p	PAR-CLIP	20371350
MIRT479228	hsa-miR-1255a	PAR-CLIP	20371350
MIRT479227	hsa-miR-1255b-5p	PAR-CLIP	20371350
MIRT479221	hsa-let-7c-3p	PAR-CLIP	20371350
MIRT479220	hsa-let-7a-2-3p	PAR-CLIP	20371350
MIRT479219	hsa-let-7g-3p	PAR-CLIP	20371350
MIRT479218	hsa-miR-574-3p	PAR-CLIP	20371350
MIRT479232	hsa-miR-493-5p	PAR-CLIP	20371350
MIRT479231	hsa-miR-1246	PAR-CLIP	20371350
MIRT479229	hsa-miR-6744-5p	PAR-CLIP	20371350
MIRT479228	hsa-miR-1255a	PAR-CLIP	20371350
MIRT479227	hsa-miR-1255b-5p	PAR-CLIP	20371350
MIRT479221	hsa-let-7c-3p	PAR-CLIP	20371350
MIRT479220	hsa-let-7a-2-3p	PAR-CLIP	20371350
MIRT479219	hsa-let-7g-3p	PAR-CLIP	20371350
MIRT479218	hsa-miR-574-3p	PAR-CLIP	20371350
MIRT479232	hsa-miR-493-5p	PAR-CLIP	23446348
MIRT479231	hsa-miR-1246	PAR-CLIP	23446348
MIRT479229	hsa-miR-6744-5p	PAR-CLIP	23446348
MIRT479228	hsa-miR-1255a	PAR-CLIP	23446348
MIRT479227	hsa-miR-1255b-5p	PAR-CLIP	23446348
MIRT479221	hsa-let-7c-3p	PAR-CLIP	23446348
MIRT479220	hsa-let-7a-2-3p	PAR-CLIP	23446348
MIRT479219	hsa-let-7g-3p	PAR-CLIP	23446348
MIRT479218	hsa-miR-574-3p	PAR-CLIP	23446348
MIRT479232	hsa-miR-493-5p	PAR-CLIP	23446348
MIRT479231	hsa-miR-1246	PAR-CLIP	23446348
MIRT479229	hsa-miR-6744-5p	PAR-CLIP	23446348
MIRT479228	hsa-miR-1255a	PAR-CLIP	23446348
MIRT479227	hsa-miR-1255b-5p	PAR-CLIP	23446348
MIRT479221	hsa-let-7c-3p	PAR-CLIP	23446348
MIRT479220	hsa-let-7a-2-3p	PAR-CLIP	23446348
MIRT479219	hsa-let-7g-3p	PAR-CLIP	23446348
MIRT479218	hsa-miR-574-3p	PAR-CLIP	23446348
MIRT479232	hsa-miR-493-5p	PAR-CLIP	23592263
MIRT479231	hsa-miR-1246	PAR-CLIP	23592263
MIRT479230	hsa-miR-5697	PAR-CLIP	23592263
MIRT365388	hsa-miR-6847-3p	PAR-CLIP	23592263
MIRT479229	hsa-miR-6744-5p	PAR-CLIP	23592263
MIRT479228	hsa-miR-1255a	PAR-CLIP	23592263
MIRT479227	hsa-miR-1255b-5p	PAR-CLIP	23592263
MIRT479226	hsa-miR-1297	PAR-CLIP	23592263
MIRT053077	hsa-miR-26a-5p	PAR-CLIP	23592263
MIRT479225	hsa-miR-26b-5p	PAR-CLIP	23592263
MIRT479223	hsa-miR-4465	PAR-CLIP	23592263
MIRT479224	hsa-miR-513c-5p	PAR-CLIP	23592263
MIRT479222	hsa-miR-514b-5p	PAR-CLIP	23592263
MIRT479221	hsa-let-7c-3p	PAR-CLIP	23592263
MIRT479220	hsa-let-7a-2-3p	PAR-CLIP	23592263
MIRT479219	hsa-let-7g-3p	PAR-CLIP	23592263
MIRT479218	hsa-miR-574-3p	PAR-CLIP	23592263
MIRT479220	hsa-let-7a-2-3p	PAR-CLIP	26701625
MIRT479221	hsa-let-7c-3p	PAR-CLIP	26701625
MIRT479219	hsa-let-7g-3p	PAR-CLIP	26701625
MIRT479231	hsa-miR-1246	PAR-CLIP	26701625
MIRT479228	hsa-miR-1255a	PAR-CLIP	26701625
MIRT479227	hsa-miR-1255b-5p	PAR-CLIP	26701625
MIRT479232	hsa-miR-493-5p	PAR-CLIP	26701625
MIRT479218	hsa-miR-574-3p	PAR-CLIP	26701625
MIRT479229	hsa-miR-6744-5p	PAR-CLIP	26701625
MIRT053077	hsa-miR-26a-5p	Western blottingqRT-PCR	32426838
MIRT325435	hsa-miR-548ae-3p	HITS-CLIP	19536157
MIRT325436	hsa-miR-548ah-3p	HITS-CLIP	19536157
MIRT325437	hsa-miR-548aj-3p	HITS-CLIP	19536157
MIRT325438	hsa-miR-548am-3p	HITS-CLIP	19536157
MIRT325439	hsa-miR-548aq-3p	HITS-CLIP	19536157
MIRT325429	hsa-miR-548j-3p	HITS-CLIP	19536157
MIRT325432	hsa-miR-548x-3p	HITS-CLIP	19536157
MIRT325425	hsa-miR-548a-3p	HITS-CLIP	19536157
MIRT325440	hsa-miR-548ar-3p	HITS-CLIP	19536157
MIRT325441	hsa-miR-548az-3p	HITS-CLIP	19536157
MIRT325428	hsa-miR-548e-3p	HITS-CLIP	19536157
MIRT325430	hsa-miR-548f-3p	HITS-CLIP	19536157
MIRT723705	hsa-miR-4511	HITS-CLIP	19536157
MIRT723704	hsa-miR-200a-5p	HITS-CLIP	19536157
MIRT723703	hsa-miR-200b-5p	HITS-CLIP	19536157
MIRT723702	hsa-miR-4269	HITS-CLIP	19536157
MIRT723701	hsa-miR-6715b-5p	HITS-CLIP	19536157
MIRT723700	hsa-miR-302a-5p	HITS-CLIP	19536157
MIRT723699	hsa-miR-7-5p	HITS-CLIP	19536157
MIRT723698	hsa-miR-6077	HITS-CLIP	19536157
MIRT479232	hsa-miR-493-5p	PAR-CLIP	20371350
MIRT479231	hsa-miR-1246	PAR-CLIP	20371350
MIRT479229	hsa-miR-6744-5p	PAR-CLIP	20371350
MIRT479228	hsa-miR-1255a	PAR-CLIP	20371350
MIRT479227	hsa-miR-1255b-5p	PAR-CLIP	20371350
MIRT479221	hsa-let-7c-3p	PAR-CLIP	20371350
MIRT479220	hsa-let-7a-2-3p	PAR-CLIP	20371350
MIRT479219	hsa-let-7g-3p	PAR-CLIP	20371350
MIRT479218	hsa-miR-574-3p	PAR-CLIP	20371350
MIRT479232	hsa-miR-493-5p	PAR-CLIP	20371350
MIRT479231	hsa-miR-1246	PAR-CLIP	20371350
MIRT479229	hsa-miR-6744-5p	PAR-CLIP	20371350
MIRT479228	hsa-miR-1255a	PAR-CLIP	20371350
MIRT479227	hsa-miR-1255b-5p	PAR-CLIP	20371350
MIRT479221	hsa-let-7c-3p	PAR-CLIP	20371350
MIRT479220	hsa-let-7a-2-3p	PAR-CLIP	20371350
MIRT479219	hsa-let-7g-3p	PAR-CLIP	20371350
MIRT479218	hsa-miR-574-3p	PAR-CLIP	20371350
MIRT479232	hsa-miR-493-5p	PAR-CLIP	20371350
MIRT479231	hsa-miR-1246	PAR-CLIP	20371350
MIRT479229	hsa-miR-6744-5p	PAR-CLIP	20371350
MIRT479228	hsa-miR-1255a	PAR-CLIP	20371350
MIRT479227	hsa-miR-1255b-5p	PAR-CLIP	20371350
MIRT479221	hsa-let-7c-3p	PAR-CLIP	20371350
MIRT479220	hsa-let-7a-2-3p	PAR-CLIP	20371350
MIRT479219	hsa-let-7g-3p	PAR-CLIP	20371350
MIRT479218	hsa-miR-574-3p	PAR-CLIP	20371350
MIRT479232	hsa-miR-493-5p	PAR-CLIP	23446348
MIRT479231	hsa-miR-1246	PAR-CLIP	23446348
MIRT479229	hsa-miR-6744-5p	PAR-CLIP	23446348
MIRT479228	hsa-miR-1255a	PAR-CLIP	23446348
MIRT479227	hsa-miR-1255b-5p	PAR-CLIP	23446348
MIRT479221	hsa-let-7c-3p	PAR-CLIP	23446348
MIRT479220	hsa-let-7a-2-3p	PAR-CLIP	23446348
MIRT479219	hsa-let-7g-3p	PAR-CLIP	23446348
MIRT479218	hsa-miR-574-3p	PAR-CLIP	23446348
MIRT479232	hsa-miR-493-5p	PAR-CLIP	23446348
MIRT479231	hsa-miR-1246	PAR-CLIP	23446348
MIRT479229	hsa-miR-6744-5p	PAR-CLIP	23446348
MIRT479228	hsa-miR-1255a	PAR-CLIP	23446348
MIRT479227	hsa-miR-1255b-5p	PAR-CLIP	23446348
MIRT479221	hsa-let-7c-3p	PAR-CLIP	23446348
MIRT479220	hsa-let-7a-2-3p	PAR-CLIP	23446348
MIRT479219	hsa-let-7g-3p	PAR-CLIP	23446348
MIRT479218	hsa-miR-574-3p	PAR-CLIP	23446348
MIRT479232	hsa-miR-493-5p	PAR-CLIP	23592263
MIRT479231	hsa-miR-1246	PAR-CLIP	23592263
MIRT479230	hsa-miR-5697	PAR-CLIP	23592263
MIRT365388	hsa-miR-6847-3p	PAR-CLIP	23592263
MIRT479229	hsa-miR-6744-5p	PAR-CLIP	23592263
MIRT479228	hsa-miR-1255a	PAR-CLIP	23592263
MIRT479227	hsa-miR-1255b-5p	PAR-CLIP	23592263
MIRT479226	hsa-miR-1297	PAR-CLIP	23592263
MIRT053077	hsa-miR-26a-5p	PAR-CLIP	23592263
MIRT479225	hsa-miR-26b-5p	PAR-CLIP	23592263
MIRT479223	hsa-miR-4465	PAR-CLIP	23592263
MIRT479224	hsa-miR-513c-5p	PAR-CLIP	23592263
MIRT479222	hsa-miR-514b-5p	PAR-CLIP	23592263
MIRT479221	hsa-let-7c-3p	PAR-CLIP	23592263
MIRT479220	hsa-let-7a-2-3p	PAR-CLIP	23592263
MIRT479219	hsa-let-7g-3p	PAR-CLIP	23592263
MIRT479218	hsa-miR-574-3p	PAR-CLIP	23592263
MIRT894285	hsa-miR-101	CLIP-seq
MIRT894286	hsa-miR-1255b	CLIP-seq
MIRT894287	hsa-miR-1267	CLIP-seq
MIRT894288	hsa-miR-144	CLIP-seq
MIRT894289	hsa-miR-2355-5p	CLIP-seq
MIRT894290	hsa-miR-26a	CLIP-seq
MIRT894291	hsa-miR-26b	CLIP-seq
MIRT894292	hsa-miR-3185	CLIP-seq
MIRT894293	hsa-miR-323-3p	CLIP-seq
MIRT894294	hsa-miR-33a	CLIP-seq
MIRT894295	hsa-miR-33b	CLIP-seq
MIRT894296	hsa-miR-3611	CLIP-seq
MIRT894297	hsa-miR-3670	CLIP-seq
MIRT894298	hsa-miR-4420	CLIP-seq
MIRT894299	hsa-miR-4427	CLIP-seq
MIRT894300	hsa-miR-4643	CLIP-seq
MIRT894301	hsa-miR-466	CLIP-seq
MIRT894302	hsa-miR-4789-3p	CLIP-seq
MIRT894303	hsa-miR-4789-5p	CLIP-seq
MIRT894304	hsa-miR-513c	CLIP-seq
MIRT894305	hsa-miR-577	CLIP-seq
MIRT894306	hsa-miR-582-5p	CLIP-seq
MIRT894307	hsa-miR-600	CLIP-seq
MIRT894308	hsa-miR-7	CLIP-seq
MIRT894285	hsa-miR-101	CLIP-seq
MIRT894286	hsa-miR-1255b	CLIP-seq
MIRT894287	hsa-miR-1267	CLIP-seq
MIRT894288	hsa-miR-144	CLIP-seq
MIRT894290	hsa-miR-26a	CLIP-seq
MIRT894291	hsa-miR-26b	CLIP-seq
MIRT894292	hsa-miR-3185	CLIP-seq
MIRT894293	hsa-miR-323-3p	CLIP-seq
MIRT894294	hsa-miR-33a	CLIP-seq
MIRT894295	hsa-miR-33b	CLIP-seq
MIRT894296	hsa-miR-3611	CLIP-seq
MIRT894297	hsa-miR-3670	CLIP-seq
MIRT894298	hsa-miR-4420	CLIP-seq
MIRT894299	hsa-miR-4427	CLIP-seq
MIRT894300	hsa-miR-4643	CLIP-seq
MIRT894301	hsa-miR-466	CLIP-seq
MIRT894302	hsa-miR-4789-3p	CLIP-seq
MIRT894303	hsa-miR-4789-5p	CLIP-seq
MIRT1965166	hsa-miR-513a-3p	CLIP-seq
MIRT894304	hsa-miR-513c	CLIP-seq
MIRT1965167	hsa-miR-548ae	CLIP-seq
MIRT1965168	hsa-miR-548aj	CLIP-seq
MIRT1965169	hsa-miR-548am	CLIP-seq
MIRT1965170	hsa-miR-548e	CLIP-seq
MIRT1965171	hsa-miR-548f	CLIP-seq
MIRT1965172	hsa-miR-548x	CLIP-seq
MIRT894306	hsa-miR-582-5p	CLIP-seq
MIRT894307	hsa-miR-600	CLIP-seq
MIRT894308	hsa-miR-7	CLIP-seq
MIRT894286	hsa-miR-1255b	CLIP-seq
MIRT2201146	hsa-miR-371-5p	CLIP-seq
MIRT1965167	hsa-miR-548ae	CLIP-seq
MIRT1965168	hsa-miR-548aj	CLIP-seq
MIRT1965169	hsa-miR-548am	CLIP-seq
MIRT1965170	hsa-miR-548e	CLIP-seq
MIRT1965171	hsa-miR-548f	CLIP-seq
MIRT1965172	hsa-miR-548x	CLIP-seq
MIRT894308	hsa-miR-7	CLIP-seq
MIRT2201147	hsa-miR-888	CLIP-seq
MIRT894286	hsa-miR-1255b	CLIP-seq
MIRT894292	hsa-miR-3185	CLIP-seq

Show/Hide all (1)

Transcription factor	Regulation	Reference
YBX1	Repression	20596676

Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000307	Component	Cyclin-dependent protein kinase holoenzyme complex	IBA
GO:0003682	Function	Chromatin binding	IEA
GO:0005515	Function	Protein binding	IPI	2227411, 28514442, 32296183, 33961781
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0007127	Process	Meiosis I	IEA
GO:0007346	Process	Regulation of mitotic cell cycle	IBA
GO:0016538	Function	Cyclin-dependent protein serine/threonine kinase regulator activity	IEA
GO:0019005	Component	SCF ubiquitin ligase complex	IBA
GO:0019901	Function	Protein kinase binding	IBA
GO:0042393	Function	Histone binding	IBA
GO:0043130	Function	Ubiquitin binding	IBA
GO:0044772	Process	Mitotic cell cycle phase transition	IEA
GO:0048144	Process	Fibroblast proliferation	IEA
GO:0051301	Process	Cell division	IEA
GO:0061575	Function	Cyclin-dependent protein serine/threonine kinase activator activity	IBA

MIM	HGNC	e!Ensembl
116901	2000	ENSG00000123975

P33552

Protein name

Cyclin-dependent kinases regulatory subunit 2 (CKS-2)

Protein function

Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

PDB

1CKS , 4Y72 , 4YC3 , 5HQ0 , 5LQF , 6GU2 , 6GU3 , 6GU4 , 6GU6 , 6GU7

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01111	CKS	6 → 73	Cyclin-dependent kinase regulatory subunit	Domain

Sequence

MAHKQIYYSDKYFDEHYEYRHVMLPRELSKQVPKTHLMSEEEWRRLGVQQSLGWVHYMIH
EPEPHILLFRRPLPKDQQK

Sequence length

Interactions

View interactions

	KEGG
	Pathways in cancer Small cell lung cancer

CKS2 (CDC28 protein kinase regulatory subunit 2)