Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	116255
Gene name	Monoacylglycerol O-acyltransferase 1
Gene symbol	MOGAT1
Synonyms (NCBI Gene)	DGAT2LDGAT2L1MGAT1
Chromosome	2
Chromosome location	2q36.1
Summary	Acyl-CoA:monoacylglycerol acyltransferase (MOGAT; EC 2.3.1.22) catalyzes the synthesis of diacylglycerols, the precursor of physiologically important lipids such as triacylglycerol and phospholipids (Yen et al., 2002 [PubMed 12077311]).[supplied by OMIM,

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Show/Hide all (141)

miRTarBase ID	miRNA	Experiments	Reference
MIRT723305	hsa-miR-1245a	HITS-CLIP	19536157
MIRT723304	hsa-miR-8079	HITS-CLIP	19536157
MIRT723303	hsa-miR-3140-5p	HITS-CLIP	19536157
MIRT723302	hsa-miR-371b-5p	HITS-CLIP	19536157
MIRT723301	hsa-miR-373-5p	HITS-CLIP	19536157
MIRT723300	hsa-miR-616-5p	HITS-CLIP	19536157
MIRT723299	hsa-miR-371a-5p	HITS-CLIP	19536157
MIRT723298	hsa-miR-372-5p	HITS-CLIP	19536157
MIRT723297	hsa-miR-3653-5p	HITS-CLIP	19536157
MIRT723296	hsa-miR-3663-5p	HITS-CLIP	19536157
MIRT723295	hsa-miR-4795-5p	HITS-CLIP	19536157
MIRT723294	hsa-miR-6131	HITS-CLIP	19536157
MIRT723293	hsa-miR-3616-5p	HITS-CLIP	19536157
MIRT723292	hsa-miR-573	HITS-CLIP	19536157
MIRT723291	hsa-miR-6843-3p	HITS-CLIP	19536157
MIRT723290	hsa-miR-6848-3p	HITS-CLIP	19536157
MIRT718301	hsa-miR-3714	HITS-CLIP	19536157
MIRT718300	hsa-miR-3607-3p	HITS-CLIP	19536157
MIRT718299	hsa-miR-4708-3p	HITS-CLIP	19536157
MIRT718298	hsa-miR-4660	HITS-CLIP	19536157
MIRT718297	hsa-miR-30a-5p	HITS-CLIP	19536157
MIRT718296	hsa-miR-30b-5p	HITS-CLIP	19536157
MIRT718295	hsa-miR-30c-5p	HITS-CLIP	19536157
MIRT718294	hsa-miR-30d-5p	HITS-CLIP	19536157
MIRT718293	hsa-miR-30e-5p	HITS-CLIP	19536157
MIRT718292	hsa-miR-3686	HITS-CLIP	19536157
MIRT702038	hsa-miR-590-3p	HITS-CLIP	23313552
MIRT702037	hsa-miR-4438	HITS-CLIP	23313552
MIRT702036	hsa-miR-455-5p	HITS-CLIP	23313552
MIRT702035	hsa-miR-6504-3p	HITS-CLIP	23313552
MIRT702034	hsa-miR-500b-3p	HITS-CLIP	23313552
MIRT702033	hsa-miR-4735-5p	HITS-CLIP	23313552
MIRT702032	hsa-miR-6128	HITS-CLIP	23313552
MIRT702031	hsa-miR-1227-3p	HITS-CLIP	23313552
MIRT702030	hsa-miR-4775	HITS-CLIP	23313552
MIRT702029	hsa-miR-5095	HITS-CLIP	23313552
MIRT702028	hsa-miR-7151-3p	HITS-CLIP	23313552
MIRT702027	hsa-miR-4715-3p	HITS-CLIP	23313552
MIRT702026	hsa-miR-4701-5p	HITS-CLIP	23313552
MIRT675148	hsa-miR-6499-3p	HITS-CLIP	23313552
MIRT675147	hsa-miR-3194-3p	HITS-CLIP	23313552
MIRT675146	hsa-miR-3135b	HITS-CLIP	23313552
MIRT675145	hsa-miR-504-3p	HITS-CLIP	23313552
MIRT675144	hsa-miR-122-5p	HITS-CLIP	23313552
MIRT675143	hsa-miR-3652	HITS-CLIP	23313552
MIRT675142	hsa-miR-4430	HITS-CLIP	23313552
MIRT675137	hsa-miR-5698	HITS-CLIP	23313552
MIRT675141	hsa-miR-143-5p	HITS-CLIP	23313552
MIRT675140	hsa-miR-5691	HITS-CLIP	23313552
MIRT675139	hsa-miR-6805-3p	HITS-CLIP	23313552
MIRT675149	hsa-miR-432-5p	HITS-CLIP	23824327
MIRT675148	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT675147	hsa-miR-3194-3p	HITS-CLIP	23824327
MIRT675146	hsa-miR-3135b	HITS-CLIP	23824327
MIRT675145	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT675144	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT675143	hsa-miR-3652	HITS-CLIP	23824327
MIRT675142	hsa-miR-4430	HITS-CLIP	23824327
MIRT675141	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT675140	hsa-miR-5691	HITS-CLIP	23824327
MIRT675139	hsa-miR-6805-3p	HITS-CLIP	23824327
MIRT675138	hsa-miR-5004-3p	HITS-CLIP	23824327
MIRT675137	hsa-miR-5698	HITS-CLIP	23824327
MIRT535962	hsa-miR-511-3p	PAR-CLIP	22012620
MIRT535961	hsa-miR-1273g-3p	PAR-CLIP	22012620
MIRT535960	hsa-miR-619-5p	PAR-CLIP	22012620
MIRT535959	hsa-miR-6506-5p	PAR-CLIP	22012620
MIRT535958	hsa-miR-4252	PAR-CLIP	22012620
MIRT535957	hsa-miR-4666a-5p	PAR-CLIP	22012620
MIRT535956	hsa-miR-5089-5p	PAR-CLIP	22012620
MIRT723305	hsa-miR-1245a	HITS-CLIP	19536157
MIRT723304	hsa-miR-8079	HITS-CLIP	19536157
MIRT723303	hsa-miR-3140-5p	HITS-CLIP	19536157
MIRT723302	hsa-miR-371b-5p	HITS-CLIP	19536157
MIRT723301	hsa-miR-373-5p	HITS-CLIP	19536157
MIRT723300	hsa-miR-616-5p	HITS-CLIP	19536157
MIRT723299	hsa-miR-371a-5p	HITS-CLIP	19536157
MIRT723298	hsa-miR-372-5p	HITS-CLIP	19536157
MIRT723297	hsa-miR-3653-5p	HITS-CLIP	19536157
MIRT723296	hsa-miR-3663-5p	HITS-CLIP	19536157
MIRT723295	hsa-miR-4795-5p	HITS-CLIP	19536157
MIRT723294	hsa-miR-6131	HITS-CLIP	19536157
MIRT723293	hsa-miR-3616-5p	HITS-CLIP	19536157
MIRT723292	hsa-miR-573	HITS-CLIP	19536157
MIRT723291	hsa-miR-6843-3p	HITS-CLIP	19536157
MIRT723290	hsa-miR-6848-3p	HITS-CLIP	19536157
MIRT718301	hsa-miR-3714	HITS-CLIP	19536157
MIRT718300	hsa-miR-3607-3p	HITS-CLIP	19536157
MIRT718299	hsa-miR-4708-3p	HITS-CLIP	19536157
MIRT718298	hsa-miR-4660	HITS-CLIP	19536157
MIRT718297	hsa-miR-30a-5p	HITS-CLIP	19536157
MIRT718296	hsa-miR-30b-5p	HITS-CLIP	19536157
MIRT718295	hsa-miR-30c-5p	HITS-CLIP	19536157
MIRT718294	hsa-miR-30d-5p	HITS-CLIP	19536157
MIRT718293	hsa-miR-30e-5p	HITS-CLIP	19536157
MIRT718292	hsa-miR-3686	HITS-CLIP	19536157
MIRT702038	hsa-miR-590-3p	HITS-CLIP	23313552
MIRT702037	hsa-miR-4438	HITS-CLIP	23313552
MIRT702036	hsa-miR-455-5p	HITS-CLIP	23313552
MIRT702035	hsa-miR-6504-3p	HITS-CLIP	23313552
MIRT702034	hsa-miR-500b-3p	HITS-CLIP	23313552
MIRT702033	hsa-miR-4735-5p	HITS-CLIP	23313552
MIRT702032	hsa-miR-6128	HITS-CLIP	23313552
MIRT702031	hsa-miR-1227-3p	HITS-CLIP	23313552
MIRT702030	hsa-miR-4775	HITS-CLIP	23313552
MIRT702029	hsa-miR-5095	HITS-CLIP	23313552
MIRT702028	hsa-miR-7151-3p	HITS-CLIP	23313552
MIRT702027	hsa-miR-4715-3p	HITS-CLIP	23313552
MIRT702026	hsa-miR-4701-5p	HITS-CLIP	23313552
MIRT675148	hsa-miR-6499-3p	HITS-CLIP	23313552
MIRT675147	hsa-miR-3194-3p	HITS-CLIP	23313552
MIRT675146	hsa-miR-3135b	HITS-CLIP	23313552
MIRT675145	hsa-miR-504-3p	HITS-CLIP	23313552
MIRT675144	hsa-miR-122-5p	HITS-CLIP	23313552
MIRT675143	hsa-miR-3652	HITS-CLIP	23313552
MIRT675142	hsa-miR-4430	HITS-CLIP	23313552
MIRT675137	hsa-miR-5698	HITS-CLIP	23313552
MIRT675141	hsa-miR-143-5p	HITS-CLIP	23313552
MIRT675140	hsa-miR-5691	HITS-CLIP	23313552
MIRT675139	hsa-miR-6805-3p	HITS-CLIP	23313552
MIRT675149	hsa-miR-432-5p	HITS-CLIP	23824327
MIRT675148	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT675147	hsa-miR-3194-3p	HITS-CLIP	23824327
MIRT675146	hsa-miR-3135b	HITS-CLIP	23824327
MIRT675145	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT675144	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT675143	hsa-miR-3652	HITS-CLIP	23824327
MIRT675142	hsa-miR-4430	HITS-CLIP	23824327
MIRT675141	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT675140	hsa-miR-5691	HITS-CLIP	23824327
MIRT675139	hsa-miR-6805-3p	HITS-CLIP	23824327
MIRT675138	hsa-miR-5004-3p	HITS-CLIP	23824327
MIRT675137	hsa-miR-5698	HITS-CLIP	23824327
MIRT535962	hsa-miR-511-3p	PAR-CLIP	22012620
MIRT535961	hsa-miR-1273g-3p	PAR-CLIP	22012620
MIRT535960	hsa-miR-619-5p	PAR-CLIP	22012620
MIRT535959	hsa-miR-6506-5p	PAR-CLIP	22012620
MIRT535958	hsa-miR-4252	PAR-CLIP	22012620
MIRT535957	hsa-miR-4666a-5p	PAR-CLIP	22012620
MIRT535956	hsa-miR-5089-5p	PAR-CLIP	22012620
MIRT1155152	hsa-miR-4729	CLIP-seq

Show/Hide all (19)

GO ID	Ontology	Definition	Evidence
GO:0003846	Function	2-acylglycerol O-acyltransferase activity	IEA
GO:0003846	Function	2-acylglycerol O-acyltransferase activity	TAS
GO:0004144	Function	Diacylglycerol O-acyltransferase activity	IBA
GO:0004144	Function	Diacylglycerol O-acyltransferase activity	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IBA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006071	Process	Glycerol metabolic process	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006651	Process	Diacylglycerol biosynthetic process	IBA
GO:0006651	Process	Diacylglycerol biosynthetic process	IEA
GO:0008374	Function	O-acyltransferase activity	IEA
GO:0016020	Component	Membrane	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016746	Function	Acyltransferase activity	IEA
GO:0019432	Process	Triglyceride biosynthetic process	IBA
GO:0019432	Process	Triglyceride biosynthetic process	IEA
GO:0019432	Process	Triglyceride biosynthetic process	TAS

MIM	HGNC	e!Ensembl
610268	18210	ENSG00000124003

Q96PD6

Protein name

2-acylglycerol O-acyltransferase 1 (EC 2.3.1.22) (Acyl-CoA:monoacylglycerol acyltransferase 1) (MGAT1) (Diacylglycerol O-acyltransferase candidate 2) (hDC2) (Diacylglycerol acyltransferase 2-like protein 1) (Monoacylglycerol O-acyltransferase 1)

Protein function

Involved in glycerolipid synthesis and lipid metabolism. Catalyzes the formation of diacylglycerol, the precursor of triacylglycerol, by transferring the acyl chain of a fatty acyl-CoA to a monoacylglycerol, mainly at the sn-1 or sn-3 positions.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03982	DAGAT	40 → 335	Diacylglycerol acyltransferase	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in stomach and liver. {ECO:0000269|PubMed:12621063}.

Sequence

MKVEFAPLNIQLARRLQTVAVLQWVLKYLLLGPMSIGITVMLIIHNYLFLYIPYLMWLYF
DWHTPERGGRRSSWIKNWTLWKHFKDYFPIHLIKTQDLDPSHNYIFGFHPHGIMAVGAFG
NFSVNYSDFKDLFPGFTSYLHVLPLWFWCPVFREYVMSVGLVSVSKKSVSYMVSKEGGGN
ISVIVLGGAKESLDAHPGKFTLFIRQRKGFVKIALTHGASLVPVVSFGENELFKQTDNPE
GSWIRTVQNKLQKIMGFALPLFHARGVFQYNFGLMTYRKAIHTVVGRPIPVRQTLNPTQE
QIEELHQTYMEELRKLFEEHKGKYGIPEHETLVLK

Sequence length

335

Interactions

View interactions

	KEGG		Reactome
	Glycerolipid metabolism Metabolic pathways		Triglyceride biosynthesis

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
UVEAL MELANOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (10)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Breast Neoplasms	Associate	38170155	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Associate	26418287	★★★★★ ★☆☆☆☆ Found in Text Mining only
End Stage Liver Disease	Associate	36293011	★★★★★ ★☆☆☆☆ Found in Text Mining only
Graft vs Host Disease	Associate	18620796	★★★★★ ★☆☆☆☆ Found in Text Mining only
Histiocytosis Langerhans Cell	Associate	36525505	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	18620796, 24870595, 31631566	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Diseases	Associate	32789750	★★★★★ ★☆☆☆☆ Found in Text Mining only
Primary Ovarian Insufficiency	Associate	32789750	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Associate	31631566	★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Associate	38170155	★★★★★ ★☆☆☆☆ Found in Text Mining only

MOGAT1 (monoacylglycerol O-acyltransferase 1)