Gene Gene information from NCBI Gene database.
Entrez ID 116115
Gene name Zinc finger protein 526
Gene symbol ZNF526
Synonyms (NCBI Gene)
DENNED
Chromosome 19
Chromosome location 19q13.2
SNPs SNP information provided by dbSNP.
1
SNP ID Visualize variation Clinical significance Consequence
rs730882205 A>C Likely-pathogenic Coding sequence variant, missense variant
miRNA miRNA information provided by mirtarbase database.
481
miRTarBase ID miRNA Experiments Reference
MIRT032140 hsa-let-7d-5p Sequencing 20371350
MIRT051839 hsa-let-7c-5p CLASH 23622248
MIRT047252 hsa-miR-181b-5p CLASH 23622248
MIRT252857 hsa-miR-3677-5p PAR-CLIP 20371350
MIRT252862 hsa-miR-4712-3p PAR-CLIP 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
5
GO ID Ontology Definition Evidence Reference
GO:0003677 Function DNA binding IEA
GO:0005515 Function Protein binding IPI 32296183, 33961781, 39009827
GO:0005634 Component Nucleus IEA
GO:0008270 Function Zinc ion binding IEA
GO:0046872 Function Metal ion binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
614387 29415 ENSG00000167625
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8TF50
Protein name Zinc finger protein 526
Protein function May be involved in transcriptional regulation.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13912 zf-C2H2_6 331 357 Domain
PF13894 zf-C2H2_4 442 465 Domain
PF00096 zf-C2H2 472 494 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 500 522 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 528 550 Zinc finger, C2H2 type Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:33397746}.
Sequence
MAEVVAEVAEMPTQMSPGAVEMSTPMSAEMMEMSTEVTEMTPGEALASSLFFQHHQFMCS
ECGSLYNTLEEVLSHQEQHMLAVSEEEALTTQNVGLEPELVPGAEGPFQCGECSQLILSP
GELLAHQDAHLRESANQIQYQCWDCQELFPSPELWVAHRKAQHLSATVAEPPVPPPLPPP
TPLPPPSPPSEVKMEPYECPECSTLCATPEEFLEHQGTHFDSLEKEERNGLEEEEEDDEE
DEEDDEEMEDEEAMAEVGDDAVGGDESTAGWAQGCGDCPQHQPSAGARRQHRRTAHSPAS
ATHPFHCSQCQRSFSSANRLQAHGRAHVGGTHECTTCSKVFKKAASLEQHLRLHRGEARY
LCVDCGRGFGTELTLVAHRRAHTANPLHRCRCGKTFSNMTKFLYHRRTHAGKSGAPPTGA
TAPPAPAEPTPPPPPPAPPAQLPCPQCSKSFASASRLSRHRRAVHGPPERRHRCGVCGKG
FKKLIHVRNHLRTH
TGERPFQCHSCGKTFASLANLSRHQLTHTGARPYQCLDCGKRFTQS
SNLQQHRRLH
LRPVAFARAPRLPITGLYNKSPYYCGTCGRWFRAMAGLRLHQRVHARART
LTLQPPRSPSPAPPPPPEPQQTIMCTELGETIAIIETSQPLALEDTLQLCQAALGASEAG
GLLQLDTAFV
Sequence length 670
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
20
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Dentici-Novelli neurodevelopmental syndrome Pathogenic; Likely pathogenic rs754536246, rs2146930042, rs1201644078, rs730882205 RCV002248465
RCV002248466
RCV002248468
RCV002251739
Intellectual disability Likely pathogenic rs730882205 RCV000162109
Noonan-like facies Likely pathogenic rs730882205 RCV000162109
Pulmonic stenosis Likely pathogenic rs730882205 RCV000162109
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Acute myeloid leukemia Benign rs57984044 RCV005889439
Hepatocellular carcinoma Uncertain significance rs146618152 RCV005929141
Ovarian serous cystadenocarcinoma Benign rs57984044 RCV005889440
ZNF526-related disorder Benign; Likely benign; Conflicting classifications of pathogenicity rs3810151, rs367731450, rs148255924, rs755140702, rs370533115, rs138082392, rs145696319, rs200018551 RCV003975063
RCV003917782
RCV003954002
RCV003962120
RCV003954548
RCV003935318
RCV003925497
RCV003935319