Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
116113
Gene name Gene Name - the full gene name approved by the HGNC.
Forkhead box P4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
FOXP4
Synonyms (NCBI Gene) Gene synonyms aliases
hFKHLA
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6p21.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. M
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs1114167294 T>- Likely-pathogenic Non coding transcript variant, coding sequence variant, frameshift variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT021115 hsa-miR-186-5p Sequencing 20371350
MIRT022091 hsa-miR-128-3p Sequencing 20371350
MIRT027329 hsa-miR-101-3p Sequencing 20371350
MIRT028722 hsa-miR-27a-3p Sequencing 20371350
MIRT028722 hsa-miR-27a-3p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0000785 Component Chromatin ISA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific ISA
GO:0001227 Function DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
608924 20842 ENSG00000137166
Protein
UniProt ID Q8IVH2
Protein name Forkhead box protein P4 (Fork head-related protein-like A)
Protein function Transcriptional repressor that represses lung-specific expression.
PDB 6XAT
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF16159 FOXP-CC 303 371 FOXP coiled-coil domain Domain
PF00250 Forkhead 466 547 Forkhead domain Domain
Sequence
MMVESASETIRSAPSGQNGVGSLSGQADGSSGGATGTTASGTGREVTTGADSNGEMSPAE
LLHFQQQQALQVARQFLLQQASGLSSPGNNDSKQSASAVQVPVSVAMMSPQMLTPQQMQQ
ILSPPQLQALLQQQQALMLQQLQEYYKKQQEQLHLQLLTQQQAGKPQPKEALGNKQLAFQ
QQLLQMQQLQQQHLLNLQRQGLVSLQPNQASGPLQTLPQAAVCPTDLPQLWKGEGAPGQP
AEDSVKQEGLDLTGTAATATSFAAPPKVSPPLSHHTLPNGQPTVLTSRRDSSSHEETPGS
HPLYGHGECKWPGCETLCEDLGQFIKHLNTEHALDDRSTAQCRVQMQVVQQLEIQLAKES
ERLQAMMAHLH
MRPSEPKPFSQPLNPVPGSSSFSKVTVSAADSFPDGLVHPPTSAAAPVT
PLRPPGLGSASLHGGGPARRRSSDKFCSPISSELAQNHEFYKNADVRPPFTYASLIRQAI
LETPDRQLTLNEIYNWFTRMFAYFRRNTATWKNAVRHNLSLHKCFVRVENVKGAVWTVDE
REYQKRR
PPKMTGSPTLVKNMISGLSYGALNASYQAALAESSFPLLNSPGMLNPGSASSL
LPLSHDDVGAPVEPLPSNGSSSPPRLSPPQYSHQVQVKEEPAEAEEDRQPGPPLGAPNPS
ASGPPEDRDLEEELPGEELS
Sequence length 680
Interactions View interactions
<
Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Adenocarcinoma Adenocarcinoma N/A N/A GWAS
Alzheimer disease Alzheimer's disease or family history of Alzheimer's disease N/A N/A GWAS
Diabetes Diabetic kidney disease in type 2 diabetes (ESRD vs. no ESRD) N/A N/A GWAS
Lung adenocarcinoma Lung adenocarcinoma, EGFR mutation-positive lung adenocarcinoma N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 27501781
Apraxias Associate 33110267
Breast Neoplasms Associate 35614183
Carcinogenesis Associate 25994569
Carcinoma Hepatocellular Associate 25755720, 32436934, 33604387, 34545456
Carcinoma Non Small Cell Lung Associate 25994569, 34921595
Carcinoma Pancreatic Ductal Associate 31991068
Colorectal Neoplasms Associate 33481661, 33649850, 34622876
Congenital Abnormalities Associate 33110267
COVID 19 Stimulate 35264675