Gene Gene information from NCBI Gene database.
Entrez ID 116113
Gene name Forkhead box P4
Gene symbol FOXP4
Synonyms (NCBI Gene)
hFKHLA
Chromosome 6
Chromosome location 6p21.1
Summary This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. M
SNPs SNP information provided by dbSNP.
1
SNP ID Visualize variation Clinical significance Consequence
rs1114167294 T>- Likely-pathogenic Non coding transcript variant, coding sequence variant, frameshift variant
miRNA miRNA information provided by mirtarbase database.
644
miRTarBase ID miRNA Experiments Reference
MIRT021115 hsa-miR-186-5p Sequencing 20371350
MIRT022091 hsa-miR-128-3p Sequencing 20371350
MIRT027329 hsa-miR-101-3p Sequencing 20371350
MIRT028722 hsa-miR-27a-3p Sequencing 20371350
MIRT028722 hsa-miR-27a-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
17
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0000785 Component Chromatin ISA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific ISA
GO:0001227 Function DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
608924 20842 ENSG00000137166
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8IVH2
Protein name Forkhead box protein P4 (Fork head-related protein-like A)
Protein function Transcriptional repressor that represses lung-specific expression.
PDB 6XAT
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF16159 FOXP-CC 303 371 FOXP coiled-coil domain Domain
PF00250 Forkhead 466 547 Forkhead domain Domain
Sequence
MMVESASETIRSAPSGQNGVGSLSGQADGSSGGATGTTASGTGREVTTGADSNGEMSPAE
LLHFQQQQALQVARQFLLQQASGLSSPGNNDSKQSASAVQVPVSVAMMSPQMLTPQQMQQ
ILSPPQLQALLQQQQALMLQQLQEYYKKQQEQLHLQLLTQQQAGKPQPKEALGNKQLAFQ
QQLLQMQQLQQQHLLNLQRQGLVSLQPNQASGPLQTLPQAAVCPTDLPQLWKGEGAPGQP
AEDSVKQEGLDLTGTAATATSFAAPPKVSPPLSHHTLPNGQPTVLTSRRDSSSHEETPGS
HPLYGHGECKWPGCETLCEDLGQFIKHLNTEHALDDRSTAQCRVQMQVVQQLEIQLAKES
ERLQAMMAHLH
MRPSEPKPFSQPLNPVPGSSSFSKVTVSAADSFPDGLVHPPTSAAAPVT
PLRPPGLGSASLHGGGPARRRSSDKFCSPISSELAQNHEFYKNADVRPPFTYASLIRQAI
LETPDRQLTLNEIYNWFTRMFAYFRRNTATWKNAVRHNLSLHKCFVRVENVKGAVWTVDE
REYQKRR
PPKMTGSPTLVKNMISGLSYGALNASYQAALAESSFPLLNSPGMLNPGSASSL
LPLSHDDVGAPVEPLPSNGSSSPPRLSPPQYSHQVQVKEEPAEAEEDRQPGPPLGAPNPS
ASGPPEDRDLEEELPGEELS
Sequence length 680
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
12
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Developmental Disorder With Language Delay And Congenital Abnormalities not provided rs2532427429 RCV004577701
Feeding difficulties Uncertain significance rs1114167294 RCV000491569
FOXP4-related disorder Uncertain significance rs1380556802, rs1764856579 RCV003405986
RCV003397749
Global developmental delay Uncertain significance rs1114167294 RCV000491569
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 27501781
Apraxias Associate 33110267
Breast Neoplasms Associate 35614183
Carcinogenesis Associate 25994569
Carcinoma Hepatocellular Associate 25755720, 32436934, 33604387, 34545456
Carcinoma Non Small Cell Lung Associate 25994569, 34921595
Carcinoma Pancreatic Ductal Associate 31991068
Colorectal Neoplasms Associate 33481661, 33649850, 34622876
Congenital Abnormalities Associate 33110267
COVID 19 Stimulate 35264675