RMI2 (RecQ mediated genome instability 2)

Gene

• Entrez ID: 116028
• Gene name: RecQ mediated genome instability 2
• Gene symbol: RMI2
• Synonyms (NCBI Gene): BLAP18, C16orf75
• Chromosome: 16
• Chromosome location: 16p13.13
• Summary: RMI2 is a component of the BLM (RECQL3; MIM 604610) complex, which plays a role in homologous recombination-dependent DNA repair and is essential for genome stability (Xu et al., 2008 [PubMed 18923082]).[supplied by OMIM, Nov 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT562773	hsa-miR-548at-5p	PAR-CLIP	20371350
MIRT562772	hsa-miR-4795-5p	PAR-CLIP	20371350
MIRT562771	hsa-miR-3190-3p	PAR-CLIP	20371350
MIRT562770	hsa-miR-3616-5p	PAR-CLIP	20371350
MIRT562769	hsa-miR-573	PAR-CLIP	20371350
MIRT562768	hsa-miR-4480	PAR-CLIP	20371350
MIRT562773	hsa-miR-548at-5p	PAR-CLIP	20371350
MIRT562772	hsa-miR-4795-5p	PAR-CLIP	20371350
MIRT562771	hsa-miR-3190-3p	PAR-CLIP	20371350
MIRT562770	hsa-miR-3616-5p	PAR-CLIP	20371350
MIRT562769	hsa-miR-573	PAR-CLIP	20371350
MIRT562768	hsa-miR-4480	PAR-CLIP	20371350
MIRT1308215	hsa-let-7a	CLIP-seq
MIRT1308216	hsa-let-7b	CLIP-seq
MIRT1308217	hsa-let-7c	CLIP-seq
MIRT1308218	hsa-let-7d	CLIP-seq
MIRT1308219	hsa-let-7e	CLIP-seq
MIRT1308220	hsa-let-7f	CLIP-seq
MIRT1308221	hsa-let-7g	CLIP-seq
MIRT1308222	hsa-let-7i	CLIP-seq
MIRT1308223	hsa-miR-1225-5p	CLIP-seq
MIRT1308224	hsa-miR-1252	CLIP-seq
MIRT1308225	hsa-miR-1253	CLIP-seq
MIRT1308226	hsa-miR-125a-3p	CLIP-seq
MIRT1308227	hsa-miR-1283	CLIP-seq
MIRT1308228	hsa-miR-1323	CLIP-seq
MIRT1308229	hsa-miR-1324	CLIP-seq
MIRT1308230	hsa-miR-181a	CLIP-seq
MIRT1308231	hsa-miR-181b	CLIP-seq
MIRT1308232	hsa-miR-181c	CLIP-seq
MIRT1308233	hsa-miR-181d	CLIP-seq
MIRT1308234	hsa-miR-216a	CLIP-seq
MIRT1308235	hsa-miR-2467-3p	CLIP-seq
MIRT1308236	hsa-miR-2467-5p	CLIP-seq
MIRT1308237	hsa-miR-3120-3p	CLIP-seq
MIRT1308238	hsa-miR-3121-3p	CLIP-seq
MIRT1308239	hsa-miR-3121-5p	CLIP-seq
MIRT1308240	hsa-miR-3123	CLIP-seq
MIRT1308241	hsa-miR-3133	CLIP-seq
MIRT1308242	hsa-miR-3140-3p	CLIP-seq
MIRT1308243	hsa-miR-3145-3p	CLIP-seq
MIRT1308244	hsa-miR-3148	CLIP-seq
MIRT1308245	hsa-miR-3163	CLIP-seq
MIRT1308246	hsa-miR-3166	CLIP-seq
MIRT1308247	hsa-miR-3182	CLIP-seq
MIRT1308248	hsa-miR-3189-3p	CLIP-seq
MIRT1308249	hsa-miR-3190	CLIP-seq
MIRT1308250	hsa-miR-330-3p	CLIP-seq
MIRT1308251	hsa-miR-33a	CLIP-seq
MIRT1308252	hsa-miR-33b	CLIP-seq
MIRT1308253	hsa-miR-34b	CLIP-seq
MIRT1308254	hsa-miR-3613-3p	CLIP-seq
MIRT1308255	hsa-miR-3618	CLIP-seq
MIRT1308256	hsa-miR-3622b-5p	CLIP-seq
MIRT1308257	hsa-miR-3646	CLIP-seq
MIRT1308258	hsa-miR-3647-5p	CLIP-seq
MIRT1308259	hsa-miR-3662	CLIP-seq
MIRT1308260	hsa-miR-3672	CLIP-seq
MIRT1308261	hsa-miR-3685	CLIP-seq
MIRT1308262	hsa-miR-3687	CLIP-seq
MIRT1308263	hsa-miR-3688-3p	CLIP-seq
MIRT1308264	hsa-miR-3713	CLIP-seq
MIRT1308265	hsa-miR-371-5p	CLIP-seq
MIRT1308266	hsa-miR-371b-5p	CLIP-seq
MIRT1308267	hsa-miR-3921	CLIP-seq
MIRT1308268	hsa-miR-3927	CLIP-seq
MIRT1308269	hsa-miR-3978	CLIP-seq
MIRT1308270	hsa-miR-4251	CLIP-seq
MIRT1308271	hsa-miR-4262	CLIP-seq
MIRT1308272	hsa-miR-4269	CLIP-seq
MIRT1308273	hsa-miR-4282	CLIP-seq
MIRT1308274	hsa-miR-4284	CLIP-seq
MIRT1308275	hsa-miR-4329	CLIP-seq
MIRT1308276	hsa-miR-4420	CLIP-seq
MIRT1308277	hsa-miR-4442	CLIP-seq
MIRT1308278	hsa-miR-4458	CLIP-seq
MIRT1308279	hsa-miR-4459	CLIP-seq
MIRT1308280	hsa-miR-4476	CLIP-seq
MIRT1308281	hsa-miR-4500	CLIP-seq
MIRT1308282	hsa-miR-450b-5p	CLIP-seq
MIRT1308283	hsa-miR-4511	CLIP-seq
MIRT1308284	hsa-miR-4514	CLIP-seq
MIRT1308285	hsa-miR-4528	CLIP-seq
MIRT1308286	hsa-miR-4533	CLIP-seq
MIRT1308287	hsa-miR-4650-3p	CLIP-seq
MIRT1308288	hsa-miR-4653-5p	CLIP-seq
MIRT1308289	hsa-miR-4680-5p	CLIP-seq
MIRT1308290	hsa-miR-4686	CLIP-seq
MIRT1308291	hsa-miR-4688	CLIP-seq
MIRT1308292	hsa-miR-4692	CLIP-seq
MIRT1308293	hsa-miR-4695-5p	CLIP-seq
MIRT1308294	hsa-miR-4699-3p	CLIP-seq
MIRT1308295	hsa-miR-4708-3p	CLIP-seq
MIRT1308296	hsa-miR-4711-3p	CLIP-seq
MIRT1308297	hsa-miR-4731-3p	CLIP-seq
MIRT1308298	hsa-miR-4733-3p	CLIP-seq
MIRT1308299	hsa-miR-4742-5p	CLIP-seq
MIRT1308300	hsa-miR-4764-3p	CLIP-seq
MIRT1308301	hsa-miR-4799-5p	CLIP-seq
MIRT1308302	hsa-miR-4801	CLIP-seq
MIRT1308303	hsa-miR-486-3p	CLIP-seq
MIRT1308304	hsa-miR-494	CLIP-seq
MIRT1308305	hsa-miR-507	CLIP-seq
MIRT1308306	hsa-miR-513a-3p	CLIP-seq
MIRT1308307	hsa-miR-520d-5p	CLIP-seq
MIRT1308308	hsa-miR-524-5p	CLIP-seq
MIRT1308309	hsa-miR-543	CLIP-seq
MIRT1308310	hsa-miR-545	CLIP-seq
MIRT1308311	hsa-miR-548aa	CLIP-seq
MIRT1308312	hsa-miR-548c-3p	CLIP-seq
MIRT1308313	hsa-miR-548l	CLIP-seq
MIRT1308314	hsa-miR-548n	CLIP-seq
MIRT1308315	hsa-miR-548o	CLIP-seq
MIRT1308316	hsa-miR-548p	CLIP-seq
MIRT1308317	hsa-miR-548t	CLIP-seq
MIRT1308318	hsa-miR-557	CLIP-seq
MIRT1308319	hsa-miR-587	CLIP-seq
MIRT1308320	hsa-miR-592	CLIP-seq
MIRT1308321	hsa-miR-597	CLIP-seq
MIRT1308322	hsa-miR-618	CLIP-seq
MIRT1308323	hsa-miR-665	CLIP-seq
MIRT1308324	hsa-miR-668	CLIP-seq
MIRT1308325	hsa-miR-877	CLIP-seq
MIRT1308326	hsa-miR-891a	CLIP-seq
MIRT1308327	hsa-miR-922	CLIP-seq
MIRT1308328	hsa-miR-98	CLIP-seq
MIRT1308223	hsa-miR-1225-5p	CLIP-seq
MIRT2091441	hsa-miR-1251	CLIP-seq
MIRT1308228	hsa-miR-1323	CLIP-seq
MIRT1308230	hsa-miR-181a	CLIP-seq
MIRT1308231	hsa-miR-181b	CLIP-seq
MIRT1308232	hsa-miR-181c	CLIP-seq
MIRT1308233	hsa-miR-181d	CLIP-seq
MIRT1308236	hsa-miR-2467-5p	CLIP-seq
MIRT1308237	hsa-miR-3120-3p	CLIP-seq
MIRT1308239	hsa-miR-3121-5p	CLIP-seq
MIRT1308241	hsa-miR-3133	CLIP-seq
MIRT1308243	hsa-miR-3145-3p	CLIP-seq
MIRT2091442	hsa-miR-3185	CLIP-seq
MIRT1308256	hsa-miR-3622b-5p	CLIP-seq
MIRT1308257	hsa-miR-3646	CLIP-seq
MIRT1308258	hsa-miR-3647-5p	CLIP-seq
MIRT1308259	hsa-miR-3662	CLIP-seq
MIRT1308271	hsa-miR-4262	CLIP-seq
MIRT1308272	hsa-miR-4269	CLIP-seq
MIRT1308274	hsa-miR-4284	CLIP-seq
MIRT1308279	hsa-miR-4459	CLIP-seq
MIRT2091443	hsa-miR-4496	CLIP-seq
MIRT1308283	hsa-miR-4511	CLIP-seq
MIRT1308284	hsa-miR-4514	CLIP-seq
MIRT1308289	hsa-miR-4680-5p	CLIP-seq
MIRT1308290	hsa-miR-4686	CLIP-seq
MIRT1308292	hsa-miR-4692	CLIP-seq
MIRT1308293	hsa-miR-4695-5p	CLIP-seq
MIRT1308297	hsa-miR-4731-3p	CLIP-seq
MIRT1308298	hsa-miR-4733-3p	CLIP-seq
MIRT1308299	hsa-miR-4742-5p	CLIP-seq
MIRT1308300	hsa-miR-4764-3p	CLIP-seq
MIRT1308301	hsa-miR-4799-5p	CLIP-seq
MIRT1308302	hsa-miR-4801	CLIP-seq
MIRT1308304	hsa-miR-494	CLIP-seq
MIRT1308307	hsa-miR-520d-5p	CLIP-seq
MIRT1308308	hsa-miR-524-5p	CLIP-seq
MIRT1308309	hsa-miR-543	CLIP-seq
MIRT1308310	hsa-miR-545	CLIP-seq
MIRT1308311	hsa-miR-548aa	CLIP-seq
MIRT1308315	hsa-miR-548o	CLIP-seq
MIRT1308316	hsa-miR-548p	CLIP-seq
MIRT2091444	hsa-miR-558	CLIP-seq
MIRT1308319	hsa-miR-587	CLIP-seq
MIRT1308322	hsa-miR-618	CLIP-seq
MIRT1308323	hsa-miR-665	CLIP-seq
MIRT1308215	hsa-let-7a	CLIP-seq
MIRT1308216	hsa-let-7b	CLIP-seq
MIRT1308217	hsa-let-7c	CLIP-seq
MIRT1308218	hsa-let-7d	CLIP-seq
MIRT1308219	hsa-let-7e	CLIP-seq
MIRT1308220	hsa-let-7f	CLIP-seq
MIRT1308221	hsa-let-7g	CLIP-seq
MIRT1308222	hsa-let-7i	CLIP-seq
MIRT2091441	hsa-miR-1251	CLIP-seq
MIRT1308226	hsa-miR-125a-3p	CLIP-seq
MIRT1308227	hsa-miR-1283	CLIP-seq
MIRT1308229	hsa-miR-1324	CLIP-seq
MIRT1308230	hsa-miR-181a	CLIP-seq
MIRT1308231	hsa-miR-181b	CLIP-seq
MIRT1308232	hsa-miR-181c	CLIP-seq
MIRT1308233	hsa-miR-181d	CLIP-seq
MIRT1308235	hsa-miR-2467-3p	CLIP-seq
MIRT1308236	hsa-miR-2467-5p	CLIP-seq
MIRT1308239	hsa-miR-3121-5p	CLIP-seq
MIRT1308243	hsa-miR-3145-3p	CLIP-seq
MIRT2316051	hsa-miR-3150b-3p	CLIP-seq
MIRT1308246	hsa-miR-3166	CLIP-seq
MIRT2091442	hsa-miR-3185	CLIP-seq
MIRT1308250	hsa-miR-330-3p	CLIP-seq
MIRT1308251	hsa-miR-33a	CLIP-seq
MIRT1308252	hsa-miR-33b	CLIP-seq
MIRT1308253	hsa-miR-34b	CLIP-seq
MIRT1308255	hsa-miR-3618	CLIP-seq
MIRT1308257	hsa-miR-3646	CLIP-seq
MIRT1308259	hsa-miR-3662	CLIP-seq
MIRT1308264	hsa-miR-3713	CLIP-seq
MIRT1308267	hsa-miR-3921	CLIP-seq
MIRT1308268	hsa-miR-3927	CLIP-seq
MIRT1308271	hsa-miR-4262	CLIP-seq
MIRT1308274	hsa-miR-4284	CLIP-seq
MIRT1308276	hsa-miR-4420	CLIP-seq
MIRT1308278	hsa-miR-4458	CLIP-seq
MIRT1308279	hsa-miR-4459	CLIP-seq
MIRT2091443	hsa-miR-4496	CLIP-seq
MIRT1308281	hsa-miR-4500	CLIP-seq
MIRT1308282	hsa-miR-450b-5p	CLIP-seq
MIRT1308283	hsa-miR-4511	CLIP-seq
MIRT1308287	hsa-miR-4650-3p	CLIP-seq
MIRT1308288	hsa-miR-4653-5p	CLIP-seq
MIRT1308289	hsa-miR-4680-5p	CLIP-seq
MIRT2316052	hsa-miR-4684-5p	CLIP-seq
MIRT1308291	hsa-miR-4688	CLIP-seq
MIRT2316053	hsa-miR-4689	CLIP-seq
MIRT1308293	hsa-miR-4695-5p	CLIP-seq
MIRT1308294	hsa-miR-4699-3p	CLIP-seq
MIRT1308298	hsa-miR-4733-3p	CLIP-seq
MIRT1308299	hsa-miR-4742-5p	CLIP-seq
MIRT1308300	hsa-miR-4764-3p	CLIP-seq
MIRT2316054	hsa-miR-4784	CLIP-seq
MIRT1308301	hsa-miR-4799-5p	CLIP-seq
MIRT2316055	hsa-miR-485-5p	CLIP-seq
MIRT1308303	hsa-miR-486-3p	CLIP-seq
MIRT1308304	hsa-miR-494	CLIP-seq
MIRT1308305	hsa-miR-507	CLIP-seq
MIRT1308306	hsa-miR-513a-3p	CLIP-seq
MIRT1308307	hsa-miR-520d-5p	CLIP-seq
MIRT1308308	hsa-miR-524-5p	CLIP-seq
MIRT1308309	hsa-miR-543	CLIP-seq
MIRT1308318	hsa-miR-557	CLIP-seq
MIRT2091444	hsa-miR-558	CLIP-seq
MIRT1308319	hsa-miR-587	CLIP-seq
MIRT1308320	hsa-miR-592	CLIP-seq
MIRT1308321	hsa-miR-597	CLIP-seq
MIRT1308322	hsa-miR-618	CLIP-seq
MIRT1308323	hsa-miR-665	CLIP-seq
MIRT1308324	hsa-miR-668	CLIP-seq
MIRT1308325	hsa-miR-877	CLIP-seq
MIRT1308326	hsa-miR-891a	CLIP-seq
MIRT1308327	hsa-miR-922	CLIP-seq
MIRT2316056	hsa-miR-942	CLIP-seq
MIRT1308328	hsa-miR-98	CLIP-seq
MIRT1308228	hsa-miR-1323	CLIP-seq
MIRT1308237	hsa-miR-3120-3p	CLIP-seq
MIRT1308310	hsa-miR-545	CLIP-seq
MIRT1308311	hsa-miR-548aa	CLIP-seq
MIRT1308315	hsa-miR-548o	CLIP-seq
MIRT1308316	hsa-miR-548p	CLIP-seq
MIRT2316051	hsa-miR-3150b-3p	CLIP-seq
MIRT2091442	hsa-miR-3185	CLIP-seq
MIRT1308251	hsa-miR-33a	CLIP-seq
MIRT1308252	hsa-miR-33b	CLIP-seq
MIRT2458293	hsa-miR-4502	CLIP-seq
MIRT1308282	hsa-miR-450b-5p	CLIP-seq
MIRT2316053	hsa-miR-4689	CLIP-seq
MIRT2316054	hsa-miR-4784	CLIP-seq
MIRT1308305	hsa-miR-507	CLIP-seq
MIRT1308318	hsa-miR-557	CLIP-seq
MIRT2458294	hsa-miR-628-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000724	Process	Double-strand break repair via homologous recombination	IDA	23543748
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	20711169, 20826341, 20826342, 28514442, 29997244, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	23543748
GO:0005654	Component	Nucleoplasm	TAS
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0006260	Process	DNA replication	IEA
GO:0006281	Process	DNA repair	IBA
GO:0016607	Component	Nuclear speck	IBA
GO:0016607	Component	Nuclear speck	IDA
GO:0031422	Component	RecQ family helicase-topoisomerase III complex	IPI	24984776
GO:0033045	Process	Regulation of sister chromatid segregation	IBA
GO:0033045	Process	Regulation of sister chromatid segregation	IMP	27977684
GO:0043007	Process	Maintenance of rDNA	IBA
GO:0071139	Process	Resolution of DNA recombination intermediates	IDA	23543748
GO:2000042	Process	Negative regulation of double-strand break repair via homologous recombination	IBA

Other IDs

• MIM: 612426
• HGNC: 28349
• e!Ensembl: ENSG00000175643

Protein

• UniProt ID: Q96E14
• Protein name: RecQ-mediated genome instability protein 2 (hRMI2) (BLM-associated protein of 18 kDa) (BLAP18)
• Protein function: Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the sta
• PDB: 3MXN, 3NBH, 4DAY
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF16100	RMI2	21 → 143	RecQ-mediated genome instability protein 2	Family

• Sequence:

  MAAAADSFSGGPAGVRLPRSPPLKVLAEQLRRDAEGGPGAWRLSRAAAGRGPLDLAAVWM
  QGRVVMADRGEARLRDPSGDFSVRGLERVPRGRPCLVPGKYVMVMGVVQACSPEPCLQAV
  KMTDLSDNPIHESMWELEVEDLHRNIP

• Sequence length: 147

Pathways

KEGG:

Fanconi anemia pathway

Reactome:

HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint