ADCYAP1 (adenylate cyclase activating polypeptide 1)

Gene

• Entrez ID: 116
• Gene name: Adenylate cyclase activating polypeptide 1
• Gene symbol: ADCYAP1
• Synonyms (NCBI Gene): PACAP
• Chromosome: 18
• Chromosome location: 18p11.32
• Summary: This gene encodes a secreted proprotein that is further processed into multiple mature peptides. These peptides stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the transcriptional activation of target ge

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT712596	hsa-miR-8066	HITS-CLIP	19536157
MIRT712595	hsa-miR-221-5p	HITS-CLIP	19536157
MIRT712594	hsa-miR-8073	HITS-CLIP	19536157
MIRT712593	hsa-miR-3653-5p	HITS-CLIP	19536157
MIRT712592	hsa-miR-1976	HITS-CLIP	19536157
MIRT712591	hsa-miR-6868-5p	HITS-CLIP	19536157
MIRT712590	hsa-miR-4695-3p	HITS-CLIP	19536157
MIRT712589	hsa-miR-885-3p	HITS-CLIP	19536157
MIRT712588	hsa-miR-7641	HITS-CLIP	19536157
MIRT712587	hsa-miR-106a-3p	HITS-CLIP	19536157
MIRT712586	hsa-miR-450b-5p	HITS-CLIP	19536157
MIRT712596	hsa-miR-8066	HITS-CLIP	19536157
MIRT712595	hsa-miR-221-5p	HITS-CLIP	19536157
MIRT712594	hsa-miR-8073	HITS-CLIP	19536157
MIRT712593	hsa-miR-3653-5p	HITS-CLIP	19536157
MIRT712592	hsa-miR-1976	HITS-CLIP	19536157
MIRT712591	hsa-miR-6868-5p	HITS-CLIP	19536157
MIRT712590	hsa-miR-4695-3p	HITS-CLIP	19536157
MIRT712589	hsa-miR-885-3p	HITS-CLIP	19536157
MIRT712588	hsa-miR-7641	HITS-CLIP	19536157
MIRT712587	hsa-miR-106a-3p	HITS-CLIP	19536157
MIRT712586	hsa-miR-450b-5p	HITS-CLIP	19536157
MIRT712596	hsa-miR-8066	HITS-CLIP	19536157
MIRT712595	hsa-miR-221-5p	HITS-CLIP	19536157
MIRT712594	hsa-miR-8073	HITS-CLIP	19536157
MIRT712593	hsa-miR-3653-5p	HITS-CLIP	19536157
MIRT712592	hsa-miR-1976	HITS-CLIP	19536157
MIRT712591	hsa-miR-6868-5p	HITS-CLIP	19536157
MIRT712590	hsa-miR-4695-3p	HITS-CLIP	19536157
MIRT712589	hsa-miR-885-3p	HITS-CLIP	19536157
MIRT712588	hsa-miR-7641	HITS-CLIP	19536157
MIRT712587	hsa-miR-106a-3p	HITS-CLIP	19536157
MIRT712586	hsa-miR-450b-5p	HITS-CLIP	19536157
MIRT508280	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT508279	hsa-miR-6074	HITS-CLIP	21572407
MIRT508277	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT508278	hsa-miR-6083	HITS-CLIP	21572407
MIRT508276	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT508280	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT508279	hsa-miR-6074	HITS-CLIP	23313552
MIRT508277	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT508276	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT508280	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT508279	hsa-miR-6074	HITS-CLIP	23313552
MIRT508277	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT508276	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT508280	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT508279	hsa-miR-6074	HITS-CLIP	23824327
MIRT508277	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT508278	hsa-miR-6083	HITS-CLIP	23824327
MIRT508276	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT639088	hsa-miR-4803	HITS-CLIP	23824327
MIRT639087	hsa-miR-1323	HITS-CLIP	23824327
MIRT639086	hsa-miR-548o-3p	HITS-CLIP	23824327
MIRT639085	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT639084	hsa-miR-452-3p	HITS-CLIP	23824327
MIRT639083	hsa-miR-607	HITS-CLIP	23824327
MIRT639082	hsa-miR-1305	HITS-CLIP	23824327
MIRT639081	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT508280	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT508279	hsa-miR-6074	HITS-CLIP	23824327
MIRT508277	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT508278	hsa-miR-6083	HITS-CLIP	23824327
MIRT508276	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT508280	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT508279	hsa-miR-6074	HITS-CLIP	23824327
MIRT508277	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT508278	hsa-miR-6083	HITS-CLIP	23824327
MIRT508276	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT508280	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT508279	hsa-miR-6074	HITS-CLIP	23824327
MIRT508277	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT508278	hsa-miR-6083	HITS-CLIP	23824327
MIRT508276	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT508280	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT549625	hsa-miR-1284	PAR-CLIP	20371350
MIRT508277	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT508278	hsa-miR-6083	PAR-CLIP	20371350
MIRT508276	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT508280	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT508279	hsa-miR-6074	PAR-CLIP	21572407
MIRT549625	hsa-miR-1284	PAR-CLIP	21572407
MIRT508277	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT508278	hsa-miR-6083	PAR-CLIP	21572407
MIRT508276	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT508280	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT508279	hsa-miR-6074	PAR-CLIP	23446348
MIRT508277	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT508278	hsa-miR-6083	PAR-CLIP	23446348
MIRT508276	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT712596	hsa-miR-8066	HITS-CLIP	19536157
MIRT712595	hsa-miR-221-5p	HITS-CLIP	19536157
MIRT712594	hsa-miR-8073	HITS-CLIP	19536157
MIRT712593	hsa-miR-3653-5p	HITS-CLIP	19536157
MIRT712592	hsa-miR-1976	HITS-CLIP	19536157
MIRT712591	hsa-miR-6868-5p	HITS-CLIP	19536157
MIRT712590	hsa-miR-4695-3p	HITS-CLIP	19536157
MIRT712589	hsa-miR-885-3p	HITS-CLIP	19536157
MIRT712588	hsa-miR-7641	HITS-CLIP	19536157
MIRT712587	hsa-miR-106a-3p	HITS-CLIP	19536157
MIRT712586	hsa-miR-450b-5p	HITS-CLIP	19536157
MIRT712596	hsa-miR-8066	HITS-CLIP	19536157
MIRT712595	hsa-miR-221-5p	HITS-CLIP	19536157
MIRT712594	hsa-miR-8073	HITS-CLIP	19536157
MIRT712593	hsa-miR-3653-5p	HITS-CLIP	19536157
MIRT712592	hsa-miR-1976	HITS-CLIP	19536157
MIRT712591	hsa-miR-6868-5p	HITS-CLIP	19536157
MIRT712590	hsa-miR-4695-3p	HITS-CLIP	19536157
MIRT712589	hsa-miR-885-3p	HITS-CLIP	19536157
MIRT712588	hsa-miR-7641	HITS-CLIP	19536157
MIRT712587	hsa-miR-106a-3p	HITS-CLIP	19536157
MIRT712586	hsa-miR-450b-5p	HITS-CLIP	19536157
MIRT508280	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT508279	hsa-miR-6074	HITS-CLIP	21572407
MIRT508277	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT508278	hsa-miR-6083	HITS-CLIP	21572407
MIRT508276	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT508280	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT508279	hsa-miR-6074	HITS-CLIP	23313552
MIRT508277	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT508276	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT508280	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT508279	hsa-miR-6074	HITS-CLIP	23313552
MIRT508277	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT508276	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT508280	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT508279	hsa-miR-6074	HITS-CLIP	23824327
MIRT508277	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT508278	hsa-miR-6083	HITS-CLIP	23824327
MIRT508276	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT639088	hsa-miR-4803	HITS-CLIP	23824327
MIRT639087	hsa-miR-1323	HITS-CLIP	23824327
MIRT639086	hsa-miR-548o-3p	HITS-CLIP	23824327
MIRT639085	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT639084	hsa-miR-452-3p	HITS-CLIP	23824327
MIRT639083	hsa-miR-607	HITS-CLIP	23824327
MIRT639082	hsa-miR-1305	HITS-CLIP	23824327
MIRT639081	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT508280	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT508279	hsa-miR-6074	HITS-CLIP	23824327
MIRT508277	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT508278	hsa-miR-6083	HITS-CLIP	23824327
MIRT508276	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT508280	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT508279	hsa-miR-6074	HITS-CLIP	23824327
MIRT508277	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT508278	hsa-miR-6083	HITS-CLIP	23824327
MIRT508276	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT508280	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT508279	hsa-miR-6074	HITS-CLIP	23824327
MIRT508277	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT508278	hsa-miR-6083	HITS-CLIP	23824327
MIRT508276	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT508280	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT549625	hsa-miR-1284	PAR-CLIP	20371350
MIRT508277	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT508278	hsa-miR-6083	PAR-CLIP	20371350
MIRT508276	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT508280	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT508279	hsa-miR-6074	PAR-CLIP	21572407
MIRT549625	hsa-miR-1284	PAR-CLIP	21572407
MIRT508277	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT508278	hsa-miR-6083	PAR-CLIP	21572407
MIRT508276	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT508280	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT508279	hsa-miR-6074	PAR-CLIP	23446348
MIRT508277	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT508278	hsa-miR-6083	PAR-CLIP	23446348
MIRT508276	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT768341	hsa-miR-132	CLIP-seq
MIRT768342	hsa-miR-212	CLIP-seq
MIRT768343	hsa-miR-329	CLIP-seq
MIRT768344	hsa-miR-362-3p	CLIP-seq
MIRT768345	hsa-miR-3941	CLIP-seq
MIRT768346	hsa-miR-3973	CLIP-seq
MIRT768347	hsa-miR-410	CLIP-seq
MIRT768348	hsa-miR-4659a-3p	CLIP-seq
MIRT768349	hsa-miR-4659b-3p	CLIP-seq
MIRT768350	hsa-miR-466	CLIP-seq
MIRT768351	hsa-miR-4672	CLIP-seq
MIRT768352	hsa-miR-520g	CLIP-seq
MIRT768353	hsa-miR-520h	CLIP-seq
MIRT768354	hsa-miR-603	CLIP-seq
MIRT768355	hsa-miR-1249	CLIP-seq
MIRT768356	hsa-miR-1302	CLIP-seq
MIRT768357	hsa-miR-3122	CLIP-seq
MIRT768358	hsa-miR-3199	CLIP-seq
MIRT768359	hsa-miR-3619-3p	CLIP-seq
MIRT768360	hsa-miR-3686	CLIP-seq
MIRT768361	hsa-miR-3913-5p	CLIP-seq
MIRT768362	hsa-miR-4298	CLIP-seq
MIRT768363	hsa-miR-4326	CLIP-seq
MIRT768364	hsa-miR-4436a	CLIP-seq
MIRT768365	hsa-miR-4632	CLIP-seq
MIRT768366	hsa-miR-4652-3p	CLIP-seq
MIRT768367	hsa-miR-582-5p	CLIP-seq
MIRT1926651	hsa-miR-1261	CLIP-seq
MIRT768346	hsa-miR-3973	CLIP-seq
MIRT2167600	hsa-miR-1182	CLIP-seq
MIRT768355	hsa-miR-1249	CLIP-seq
MIRT2167601	hsa-miR-1266	CLIP-seq
MIRT2167602	hsa-miR-1267	CLIP-seq
MIRT2167603	hsa-miR-1912	CLIP-seq
MIRT2167604	hsa-miR-3130-5p	CLIP-seq
MIRT2167605	hsa-miR-323b-3p	CLIP-seq
MIRT2167606	hsa-miR-324-5p	CLIP-seq
MIRT2167607	hsa-miR-3664-3p	CLIP-seq
MIRT768360	hsa-miR-3686	CLIP-seq
MIRT768363	hsa-miR-4326	CLIP-seq
MIRT2167608	hsa-miR-4482	CLIP-seq
MIRT2167609	hsa-miR-4518	CLIP-seq
MIRT768366	hsa-miR-4652-3p	CLIP-seq
MIRT2167610	hsa-miR-4738-5p	CLIP-seq
MIRT768367	hsa-miR-582-5p	CLIP-seq
MIRT2426021	hsa-miR-1283	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005102	Function	Signaling receptor binding	IPI
GO:0005179	Function	Hormone activity	IEA
GO:0005184	Function	Neuropeptide hormone activity	IBA
GO:0005184	Function	Neuropeptide hormone activity	IDA	23800469, 35477937, 36385145
GO:0005184	Function	Neuropeptide hormone activity	IEA
GO:0005184	Function	Neuropeptide hormone activity	TAS	2302217
GO:0005515	Function	Protein binding	IPI	17470806, 25451228, 32814053
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IDA	36385145
GO:0007188	Process	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IMP	23800469
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	17110384, 35477937, 36385145
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	9603988, 35477937, 36385145
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP	35477937
GO:0007190	Process	Activation of adenylate cyclase activity	TAS	1730060
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	ISS
GO:0007218	Process	Neuropeptide signaling pathway	IBA
GO:0007218	Process	Neuropeptide signaling pathway	IDA	23800469
GO:0007267	Process	Cell-cell signaling	TAS	2302217
GO:0007399	Process	Nervous system development	IEA
GO:0007565	Process	Female pregnancy	TAS	10698193
GO:0008277	Process	Regulation of G protein-coupled receptor signaling pathway	IDA	11175907
GO:0010628	Process	Positive regulation of gene expression	IEA
GO:0016521	Function	Pituitary adenylate cyclase activating polypeptide activity	IBA
GO:0016521	Function	Pituitary adenylate cyclase activating polypeptide activity	IDA	9603988, 35477937, 36385145
GO:0016521	Function	Pituitary adenylate cyclase activating polypeptide activity	IEA
GO:0030073	Process	Insulin secretion	IEA
GO:0030073	Process	Insulin secretion	ISS
GO:0031175	Process	Neuron projection development	IBA
GO:0031175	Process	Neuron projection development	IDA	23800469
GO:0031891	Function	Type 1 vasoactive intestinal polypeptide receptor binding	IDA	36385145
GO:0031892	Function	Type 2 vasoactive intestinal polypeptide receptor binding	IDA	35477937
GO:0031892	Function	Type 2 vasoactive intestinal polypeptide receptor binding	IMP	35477937
GO:0032880	Process	Regulation of protein localization	IBA
GO:0032880	Process	Regulation of protein localization	IDA	9603988
GO:0032880	Process	Regulation of protein localization	IEA
GO:0043005	Component	Neuron projection	IBA
GO:0043204	Component	Perikaryon	IBA
GO:0043547	Process	Positive regulation of GTPase activity	IDA	23800469
GO:0045786	Process	Negative regulation of cell cycle	IEA
GO:0045860	Process	Positive regulation of protein kinase activity	IDA	23800469
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	23800469
GO:0051428	Function	Peptide hormone receptor binding	IBA
GO:0051428	Function	Peptide hormone receptor binding	IDA	11175907
GO:0051428	Function	Peptide hormone receptor binding	IPI	17470806
GO:0060124	Process	Positive regulation of growth hormone secretion	ISS
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IBA
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IDA	23800469
GO:0071651	Process	Positive regulation of chemokine (C-C motif) ligand 5 production	IDA	24696163
GO:0120162	Process	Positive regulation of cold-induced thermogenesis	IEA
GO:0120162	Process	Positive regulation of cold-induced thermogenesis	ISS	12239106
GO:0141163	Process	Positive regulation of cAMP/PKA signal transduction	IBA

Other IDs

• MIM: 102980
• HGNC: 241
• e!Ensembl: ENSG00000141433

Protein

• UniProt ID: P18509
• Protein name: Pituitary adenylate cyclase-activating polypeptide (PACAP) [Cleaved into: PACAP-related peptide (PRP-48); Pituitary adenylate cyclase-activating polypeptide 27 (PACAP-27) (PACAP27); Pituitary adenylate cyclase-activating polypeptide 38 (PACAP-38) (PACAP38
• Protein function: PACAP is a neuropeptide involved in diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VIPR1), VIP receptor 2 (VIPR2), and PACAP type I receptor (ADCYAP1R1) (P
• PDB: 1GEA, 2D2P, 2JOD, 6LPB, 6M1I, 6P9Y, 6VN7, 7VQX, 7WBJ, 8E3X, 8E3Y
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00123	Hormone_2	83 → 110	Peptide hormone	Family
  PF00123	Hormone_2	132 → 159	Peptide hormone	Family

• Sequence:

  MTMCSGARLALLVYGIIMHSSVYSSPAAAGLRFPGIRPEEEAYGEDGNPLPDFDGSEPPG
  AGSPASAPRAAAAWYRPAGRRDVAHGILNEAYRKVLDQLSAGKHLQSLVARGVGGSLGGG
  AGDDAEPLSKRHSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNKGRRIAYL

• Sequence length: 176

Pathways

KEGG:

cAMP signaling pathway
Neuroactive ligand-receptor interaction
Circadian entrainment
Insulin secretion
Renin secretion

Reactome:

G alpha (s) signalling events
Glucagon-type ligand receptors
ADORA2B mediated anti-inflammatory cytokines production