Gene Gene information from NCBI Gene database.
Entrez ID 115827
Gene name RAB3C, member RAS oncogene family
Gene symbol RAB3C
Synonyms (NCBI Gene)
-
Chromosome 5
Chromosome location 5q11.2
Summary This gene is a member of the RAS oncogene family and encodes a small GTPase. Other similar small GTPases are known to be involved in vesicle trafficking, and the encoded protein was shown to play a role in recycling phagocytosed MHC class 1 complexes to t
miRNA miRNA information provided by mirtarbase database.
354
miRTarBase ID miRNA Experiments Reference
MIRT016896 hsa-miR-335-5p Microarray 18185580
MIRT711419 hsa-miR-532-5p HITS-CLIP 19536157
MIRT711418 hsa-miR-660-3p HITS-CLIP 19536157
MIRT711417 hsa-miR-370-3p HITS-CLIP 19536157
MIRT711416 hsa-miR-6893-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
26
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0003924 Function GTPase activity IBA
GO:0003924 Function GTPase activity IDA 24891604
GO:0003924 Function GTPase activity IEA
GO:0005515 Function Protein binding IPI 24891604, 32296183, 32814053
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
612829 30269 ENSG00000152932
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96E17
Protein name Ras-related protein Rab-3C (EC 3.6.5.2)
Protein function The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to r
PDB 6Y7G
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 32 193 Ras family Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in brain, placenta and lung. {ECO:0000269|PubMed:12296628}.
Sequence
Sequence length 227
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    RAB geranylgeranylation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
5
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BREAST CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM INFECTION GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Adrenal Hyperplasia Congenital Associate 36583008
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Associate 36652260
★☆☆☆☆
Found in Text Mining only