TRMT61A (tRNA methyltransferase 61A)

Gene

• Entrez ID: 115708
• Gene name: TRNA methyltransferase 61A
• Gene symbol: TRMT61A
• Synonyms (NCBI Gene): C14orf172, GCD14, Gcd14p, TRM61, hTRM61
• Chromosome: 14
• Chromosome location: 14q32.33

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT049081	hsa-miR-92a-3p	CLASH	23622248
MIRT043665	hsa-miR-342-3p	CLASH	23622248
MIRT039179	hsa-miR-769-5p	CLASH	23622248
MIRT1456920	hsa-miR-1185	CLIP-seq
MIRT1456921	hsa-miR-1207-3p	CLIP-seq
MIRT1456922	hsa-miR-1207-5p	CLIP-seq
MIRT1456923	hsa-miR-1293	CLIP-seq
MIRT1456924	hsa-miR-149	CLIP-seq
MIRT1456925	hsa-miR-155	CLIP-seq
MIRT1456926	hsa-miR-1972	CLIP-seq
MIRT1456927	hsa-miR-2278	CLIP-seq
MIRT1456928	hsa-miR-3065-5p	CLIP-seq
MIRT1456929	hsa-miR-3126-5p	CLIP-seq
MIRT1456930	hsa-miR-3151	CLIP-seq
MIRT1456931	hsa-miR-3158-3p	CLIP-seq
MIRT1456932	hsa-miR-3175	CLIP-seq
MIRT1456933	hsa-miR-3184	CLIP-seq
MIRT1456934	hsa-miR-342-5p	CLIP-seq
MIRT1456935	hsa-miR-3605-5p	CLIP-seq
MIRT1456936	hsa-miR-3622a-5p	CLIP-seq
MIRT1456937	hsa-miR-3652	CLIP-seq
MIRT1456938	hsa-miR-3679-5p	CLIP-seq
MIRT1456939	hsa-miR-3918	CLIP-seq
MIRT1456940	hsa-miR-423-5p	CLIP-seq
MIRT1456941	hsa-miR-4292	CLIP-seq
MIRT1456942	hsa-miR-4308	CLIP-seq
MIRT1456943	hsa-miR-4314	CLIP-seq
MIRT1456944	hsa-miR-4316	CLIP-seq
MIRT1456945	hsa-miR-4320	CLIP-seq
MIRT1456946	hsa-miR-4323	CLIP-seq
MIRT1456947	hsa-miR-4419a	CLIP-seq
MIRT1456948	hsa-miR-4423-3p	CLIP-seq
MIRT1456949	hsa-miR-4430	CLIP-seq
MIRT1456950	hsa-miR-4433	CLIP-seq
MIRT1456951	hsa-miR-4435	CLIP-seq
MIRT1456952	hsa-miR-4436b-3p	CLIP-seq
MIRT1456953	hsa-miR-4446-3p	CLIP-seq
MIRT1456954	hsa-miR-4447	CLIP-seq
MIRT1456955	hsa-miR-4459	CLIP-seq
MIRT1456956	hsa-miR-4472	CLIP-seq
MIRT1456957	hsa-miR-4481	CLIP-seq
MIRT1456958	hsa-miR-4483	CLIP-seq
MIRT1456959	hsa-miR-4488	CLIP-seq
MIRT1456960	hsa-miR-4492	CLIP-seq
MIRT1456961	hsa-miR-4498	CLIP-seq
MIRT1456962	hsa-miR-4510	CLIP-seq
MIRT1456963	hsa-miR-4520a-3p	CLIP-seq
MIRT1456964	hsa-miR-4638-3p	CLIP-seq
MIRT1456965	hsa-miR-4640-5p	CLIP-seq
MIRT1456966	hsa-miR-4645-5p	CLIP-seq
MIRT1456967	hsa-miR-4649-3p	CLIP-seq
MIRT1456968	hsa-miR-4651	CLIP-seq
MIRT1456969	hsa-miR-4661-3p	CLIP-seq
MIRT1456970	hsa-miR-4664-5p	CLIP-seq
MIRT1456971	hsa-miR-4673	CLIP-seq
MIRT1456972	hsa-miR-4685-5p	CLIP-seq
MIRT1456973	hsa-miR-4688	CLIP-seq
MIRT1456974	hsa-miR-4697-5p	CLIP-seq
MIRT1456975	hsa-miR-4700-3p	CLIP-seq
MIRT1456976	hsa-miR-4710	CLIP-seq
MIRT1456977	hsa-miR-4717-5p	CLIP-seq
MIRT1456978	hsa-miR-4726-5p	CLIP-seq
MIRT1456979	hsa-miR-4745-5p	CLIP-seq
MIRT1456980	hsa-miR-4763-3p	CLIP-seq
MIRT1456981	hsa-miR-4779	CLIP-seq
MIRT1456982	hsa-miR-486-3p	CLIP-seq
MIRT1456983	hsa-miR-495	CLIP-seq
MIRT1456984	hsa-miR-518d-5p	CLIP-seq
MIRT1456985	hsa-miR-519b-5p	CLIP-seq
MIRT1456986	hsa-miR-519c-5p	CLIP-seq
MIRT1456987	hsa-miR-520c-5p	CLIP-seq
MIRT1456988	hsa-miR-526a	CLIP-seq
MIRT1456989	hsa-miR-601	CLIP-seq
MIRT1456990	hsa-miR-608	CLIP-seq
MIRT1456991	hsa-miR-646	CLIP-seq
MIRT1456992	hsa-miR-663b	CLIP-seq
MIRT1456993	hsa-miR-665	CLIP-seq
MIRT1456994	hsa-miR-762	CLIP-seq
MIRT1456921	hsa-miR-1207-3p	CLIP-seq
MIRT2136975	hsa-miR-122	CLIP-seq
MIRT2136976	hsa-miR-1225-3p	CLIP-seq
MIRT2136977	hsa-miR-1234	CLIP-seq
MIRT2136978	hsa-miR-1254	CLIP-seq
MIRT2136979	hsa-miR-1294	CLIP-seq
MIRT2136980	hsa-miR-1304	CLIP-seq
MIRT2136981	hsa-miR-1324	CLIP-seq
MIRT2136982	hsa-miR-151-5p	CLIP-seq
MIRT2136983	hsa-miR-151b	CLIP-seq
MIRT2136984	hsa-miR-182	CLIP-seq
MIRT2136985	hsa-miR-205	CLIP-seq
MIRT2136986	hsa-miR-2467-5p	CLIP-seq
MIRT1456928	hsa-miR-3065-5p	CLIP-seq
MIRT2136987	hsa-miR-3116	CLIP-seq
MIRT2136988	hsa-miR-3117-5p	CLIP-seq
MIRT2136989	hsa-miR-3122	CLIP-seq
MIRT2136990	hsa-miR-3127-5p	CLIP-seq
MIRT2136991	hsa-miR-3141	CLIP-seq
MIRT2136992	hsa-miR-3150b-3p	CLIP-seq
MIRT2136993	hsa-miR-3153	CLIP-seq
MIRT2136994	hsa-miR-3154	CLIP-seq
MIRT2136995	hsa-miR-3176	CLIP-seq
MIRT2136996	hsa-miR-3182	CLIP-seq
MIRT1456933	hsa-miR-3184	CLIP-seq
MIRT2136997	hsa-miR-3188	CLIP-seq
MIRT2136998	hsa-miR-320e	CLIP-seq
MIRT2136999	hsa-miR-361-3p	CLIP-seq
MIRT2137000	hsa-miR-3649	CLIP-seq
MIRT2137001	hsa-miR-365	CLIP-seq
MIRT2137002	hsa-miR-3667-3p	CLIP-seq
MIRT2137003	hsa-miR-3913-5p	CLIP-seq
MIRT2137004	hsa-miR-3922-3p	CLIP-seq
MIRT2137005	hsa-miR-3937	CLIP-seq
MIRT2137006	hsa-miR-3943	CLIP-seq
MIRT2137007	hsa-miR-3975	CLIP-seq
MIRT1456940	hsa-miR-423-5p	CLIP-seq
MIRT2137008	hsa-miR-4254	CLIP-seq
MIRT2137009	hsa-miR-4261	CLIP-seq
MIRT2137010	hsa-miR-4268	CLIP-seq
MIRT2137011	hsa-miR-4269	CLIP-seq
MIRT2137012	hsa-miR-4286	CLIP-seq
MIRT1456944	hsa-miR-4316	CLIP-seq
MIRT2137013	hsa-miR-4318	CLIP-seq
MIRT2137014	hsa-miR-432	CLIP-seq
MIRT1456953	hsa-miR-4446-3p	CLIP-seq
MIRT2137015	hsa-miR-4448	CLIP-seq
MIRT1456955	hsa-miR-4459	CLIP-seq
MIRT1456957	hsa-miR-4481	CLIP-seq
MIRT1456960	hsa-miR-4492	CLIP-seq
MIRT2137016	hsa-miR-4493	CLIP-seq
MIRT1456961	hsa-miR-4498	CLIP-seq
MIRT1456963	hsa-miR-4520a-3p	CLIP-seq
MIRT2137017	hsa-miR-4520b-3p	CLIP-seq
MIRT2137018	hsa-miR-4649-5p	CLIP-seq
MIRT1456968	hsa-miR-4651	CLIP-seq
MIRT2137019	hsa-miR-4668-5p	CLIP-seq
MIRT2137020	hsa-miR-4677-3p	CLIP-seq
MIRT2137021	hsa-miR-4679	CLIP-seq
MIRT1456972	hsa-miR-4685-5p	CLIP-seq
MIRT2137022	hsa-miR-4691-3p	CLIP-seq
MIRT2137023	hsa-miR-4695-5p	CLIP-seq
MIRT2137024	hsa-miR-4733-3p	CLIP-seq
MIRT1456979	hsa-miR-4745-5p	CLIP-seq
MIRT2137025	hsa-miR-4758-5p	CLIP-seq
MIRT2137026	hsa-miR-4767	CLIP-seq
MIRT2137027	hsa-miR-4784	CLIP-seq
MIRT2137028	hsa-miR-4800-5p	CLIP-seq
MIRT2137029	hsa-miR-485-5p	CLIP-seq
MIRT1456983	hsa-miR-495	CLIP-seq
MIRT2137030	hsa-miR-502-5p	CLIP-seq
MIRT2137031	hsa-miR-604	CLIP-seq
MIRT1456990	hsa-miR-608	CLIP-seq
MIRT2137032	hsa-miR-624	CLIP-seq
MIRT2137033	hsa-miR-642b	CLIP-seq
MIRT1456991	hsa-miR-646	CLIP-seq
MIRT2137034	hsa-miR-647	CLIP-seq
MIRT2137035	hsa-miR-661	CLIP-seq
MIRT1456993	hsa-miR-665	CLIP-seq
MIRT2137036	hsa-miR-711	CLIP-seq
MIRT1456994	hsa-miR-762	CLIP-seq
MIRT2137037	hsa-miR-802	CLIP-seq
MIRT2357751	hsa-miR-1178	CLIP-seq
MIRT1456921	hsa-miR-1207-3p	CLIP-seq
MIRT2136978	hsa-miR-1254	CLIP-seq
MIRT2357752	hsa-miR-1279	CLIP-seq
MIRT2136981	hsa-miR-1324	CLIP-seq
MIRT2357753	hsa-miR-137	CLIP-seq
MIRT2136984	hsa-miR-182	CLIP-seq
MIRT2136986	hsa-miR-2467-5p	CLIP-seq
MIRT2357754	hsa-miR-2681	CLIP-seq
MIRT1456928	hsa-miR-3065-5p	CLIP-seq
MIRT2136987	hsa-miR-3116	CLIP-seq
MIRT1456936	hsa-miR-3622a-5p	CLIP-seq
MIRT2137002	hsa-miR-3667-3p	CLIP-seq
MIRT2137008	hsa-miR-4254	CLIP-seq
MIRT2357755	hsa-miR-4270	CLIP-seq
MIRT1456948	hsa-miR-4423-3p	CLIP-seq
MIRT2357756	hsa-miR-4436a	CLIP-seq
MIRT2357757	hsa-miR-4441	CLIP-seq
MIRT1456953	hsa-miR-4446-3p	CLIP-seq
MIRT1456968	hsa-miR-4651	CLIP-seq
MIRT1456972	hsa-miR-4685-5p	CLIP-seq
MIRT2357758	hsa-miR-4720-5p	CLIP-seq
MIRT2357759	hsa-miR-4799-3p	CLIP-seq
MIRT1456983	hsa-miR-495	CLIP-seq
MIRT2137030	hsa-miR-502-5p	CLIP-seq
MIRT1456990	hsa-miR-608	CLIP-seq
MIRT1456991	hsa-miR-646	CLIP-seq
MIRT2137035	hsa-miR-661	CLIP-seq
MIRT2651366	hsa-miR-3922-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16043508, 28514442, 32296183, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	16043508
GO:0005654	Component	Nucleoplasm	TAS
GO:0006396	Process	RNA processing	IEA
GO:0006397	Process	MRNA processing	IDA	29072297, 29107537
GO:0008033	Process	TRNA processing	IEA
GO:0008168	Function	Methyltransferase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030488	Process	TRNA methylation	IBA
GO:0030488	Process	TRNA methylation	IEA
GO:0031515	Component	TRNA (m1A) methyltransferase complex	IBA
GO:0031515	Component	TRNA (m1A) methyltransferase complex	IEA
GO:0031515	Component	TRNA (m1A) methyltransferase complex	IPI	26470919
GO:0032259	Process	Methylation	IEA
GO:0061953	Function	MRNA (adenine-N1-)-methyltransferase activity	IDA	29072297, 29107537
GO:0160107	Function	TRNA (adenine(58)-N1)-methyltransferase activity	IEA

Other IDs

• MIM: 620885
• HGNC: 23790
• e!Ensembl: ENSG00000166166

Protein

• UniProt ID: Q96FX7
• Protein name: tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A (EC 2.1.1.220) (mRNA methyladenosine-N(1)-methyltransferase catalytic subunit TRMT61A) (EC 2.1.1.-) (tRNA(m1A58)-methyltransferase subunit TRMT61A) (tRNA(m1A58)MTase subunit TRMT61A)
• Protein function: Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (PubMed:16043508). Catalytic subunit of mRNA N(1)-methyltransferase complex, whic
• PDB: 5CCB, 5CCX, 5CD1
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08704	GCD14	64 → 286	tRNA methyltransferase complex GCD14 subunit	Family

• Sequence:

  MSFVAYEELIKEGDTAILSLGHGAMVAVRVQRGAQTQTRHGVLRHSVDLIGRPFGSKVTC
  GRGGWVYVLHPTPELWTLNLPHRTQILYSTDIALITMMLELRPGSVVCESGTGSGSVSHA
  IIRTIAPTGHLHTVEFHQQRAEKAREEFQEHRVGRWVTVRTQDVCRSGFGVSHVADAVFL
  DIPSPWEAVGHAWDALKVEGGRFCSFSPCIEQVQRTCQALAARGFSELSTLEVLPQVYNV
  RTVSLPPPDLGTGTDGPAGSDTSPFRSGTPMKEAVGHTGYLTFATKTPG

• Sequence length: 289

Pathways

Reactome:

tRNA modification in the nucleus and cytosol

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BASAL CELL CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BONE FRACTURE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORNELIA DE LANGE SYNDROME	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Carcinoma Hepatocellular	Associate	37170222	★☆☆☆☆ Found in Text Mining only
De Lange Syndrome	Associate	40361155	★☆☆☆☆ Found in Text Mining only
Depressive Disorder Major	Associate	36672180	★☆☆☆☆ Found in Text Mining only
Hearing Loss	Associate	40361155	★☆☆☆☆ Found in Text Mining only
Hepatoblastoma	Associate	37850543	★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Associate	35444240	★☆☆☆☆ Found in Text Mining only