ALPK2 (alpha kinase 2)

Gene

• Entrez ID: 115701
• Gene name: Alpha kinase 2
• Gene symbol: ALPK2
• Synonyms (NCBI Gene): HAK
• Chromosome: 18
• Chromosome location: 18q21.31-q21.32

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT438676	hsa-miR-214-3p	Immunohistochemistry, Immunoprecipitaion, Luciferase reporter assay, qRT-PCR, Western blot	23929716
MIRT438676	hsa-miR-214-3p	Immunohistochemistry, Immunoprecipitaion, Luciferase reporter assay, qRT-PCR, Western blot	23929716
MIRT779032	hsa-miR-1269	CLIP-seq
MIRT779033	hsa-miR-1269b	CLIP-seq
MIRT779034	hsa-miR-1288	CLIP-seq
MIRT779035	hsa-miR-186	CLIP-seq
MIRT779036	hsa-miR-3672	CLIP-seq
MIRT779037	hsa-miR-4515	CLIP-seq
MIRT779038	hsa-miR-4740-5p	CLIP-seq
MIRT779039	hsa-miR-4786-5p	CLIP-seq
MIRT779040	hsa-miR-511	CLIP-seq
MIRT779041	hsa-miR-769-5p	CLIP-seq
MIRT2170727	hsa-miR-4676-5p	CLIP-seq
MIRT2170728	hsa-miR-575	CLIP-seq
MIRT2170729	hsa-miR-621	CLIP-seq
MIRT2473422	hsa-miR-1184	CLIP-seq
MIRT2473423	hsa-miR-1205	CLIP-seq
MIRT2473424	hsa-miR-29a	CLIP-seq
MIRT2473425	hsa-miR-29b	CLIP-seq
MIRT2473426	hsa-miR-29c	CLIP-seq
MIRT2473427	hsa-miR-3065-3p	CLIP-seq
MIRT2473428	hsa-miR-3158-5p	CLIP-seq
MIRT2473429	hsa-miR-4639-3p	CLIP-seq
MIRT2473430	hsa-miR-4645-3p	CLIP-seq
MIRT2473431	hsa-miR-4687-3p	CLIP-seq
MIRT2473432	hsa-miR-4733-3p	CLIP-seq
MIRT2473433	hsa-miR-4747-5p	CLIP-seq
MIRT2473434	hsa-miR-4768-5p	CLIP-seq
MIRT779039	hsa-miR-4786-5p	CLIP-seq
MIRT2473435	hsa-miR-490-3p	CLIP-seq
MIRT2473436	hsa-miR-521	CLIP-seq
MIRT2473437	hsa-miR-647	CLIP-seq
MIRT779041	hsa-miR-769-5p	CLIP-seq
MIRT2473438	hsa-miR-942	CLIP-seq
MIRT2473422	hsa-miR-1184	CLIP-seq
MIRT2473423	hsa-miR-1205	CLIP-seq
MIRT2674913	hsa-miR-125a-3p	CLIP-seq
MIRT2674914	hsa-miR-147	CLIP-seq
MIRT2674915	hsa-miR-1914	CLIP-seq
MIRT2674916	hsa-miR-1976	CLIP-seq
MIRT2674917	hsa-miR-19a	CLIP-seq
MIRT2674918	hsa-miR-19b	CLIP-seq
MIRT2674919	hsa-miR-214	CLIP-seq
MIRT2473424	hsa-miR-29a	CLIP-seq
MIRT2473425	hsa-miR-29b	CLIP-seq
MIRT2473426	hsa-miR-29c	CLIP-seq
MIRT2473427	hsa-miR-3065-3p	CLIP-seq
MIRT2473428	hsa-miR-3158-5p	CLIP-seq
MIRT2674920	hsa-miR-3619-5p	CLIP-seq
MIRT2674921	hsa-miR-3665	CLIP-seq
MIRT2674922	hsa-miR-3911	CLIP-seq
MIRT2674923	hsa-miR-4292	CLIP-seq
MIRT2674924	hsa-miR-4308	CLIP-seq
MIRT2674925	hsa-miR-4330	CLIP-seq
MIRT2674926	hsa-miR-4446-5p	CLIP-seq
MIRT2473429	hsa-miR-4639-3p	CLIP-seq
MIRT2473430	hsa-miR-4645-3p	CLIP-seq
MIRT2674927	hsa-miR-4658	CLIP-seq
MIRT2473431	hsa-miR-4687-3p	CLIP-seq
MIRT2674928	hsa-miR-4719	CLIP-seq
MIRT2674929	hsa-miR-4731-3p	CLIP-seq
MIRT2473432	hsa-miR-4733-3p	CLIP-seq
MIRT2473433	hsa-miR-4747-5p	CLIP-seq
MIRT2674930	hsa-miR-4755-5p	CLIP-seq
MIRT2674931	hsa-miR-4757-5p	CLIP-seq
MIRT2674932	hsa-miR-4758-5p	CLIP-seq
MIRT2674933	hsa-miR-4765	CLIP-seq
MIRT2674934	hsa-miR-4766-5p	CLIP-seq
MIRT2473434	hsa-miR-4768-5p	CLIP-seq
MIRT779039	hsa-miR-4786-5p	CLIP-seq
MIRT2674935	hsa-miR-4789-5p	CLIP-seq
MIRT2674936	hsa-miR-4801	CLIP-seq
MIRT2473435	hsa-miR-490-3p	CLIP-seq
MIRT2473436	hsa-miR-521	CLIP-seq
MIRT2674937	hsa-miR-579	CLIP-seq
MIRT2674938	hsa-miR-629	CLIP-seq
MIRT2674939	hsa-miR-644	CLIP-seq
MIRT2473437	hsa-miR-647	CLIP-seq
MIRT2674940	hsa-miR-663b	CLIP-seq
MIRT2674941	hsa-miR-670	CLIP-seq
MIRT2674942	hsa-miR-761	CLIP-seq
MIRT779041	hsa-miR-769-5p	CLIP-seq
MIRT2473438	hsa-miR-942	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003007	Process	Heart morphogenesis	IMP	29888752
GO:0003308	Process	Negative regulation of Wnt signaling pathway involved in heart development	IMP	29888752
GO:0005524	Function	ATP binding	IEA
GO:0006468	Process	Protein phosphorylation	IEA
GO:0010468	Process	Regulation of gene expression	IMP	22641666
GO:0016323	Component	Basolateral plasma membrane	IMP	28668886
GO:0030010	Process	Establishment of cell polarity	IMP	28668886
GO:0042981	Process	Regulation of apoptotic process	IMP	22641666
GO:0055013	Process	Cardiac muscle cell development	IMP	29888752
GO:0106310	Function	Protein serine kinase activity	IEA
GO:0106311	Function	Protein threonine kinase activity	IEA
GO:1905223	Process	Epicardium morphogenesis	IMP	29888752

Other IDs

• MIM: 619965
• HGNC: 20565
• e!Ensembl: ENSG00000198796

Protein

• UniProt ID: Q86TB3
• Protein name: Alpha-protein kinase 2 (EC 2.7.11.1) (Heart alpha-protein kinase)
• Protein function: Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation (PubMed:10021370). Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-cateni
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07679	I-set	12 → 104	Immunoglobulin I-set domain	Domain
  PF07679	I-set	1791 → 1875	Immunoglobulin I-set domain	Domain
  PF02816	Alpha_kinase	1926 → 2125	Alpha-kinase family	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in developing cardiac tissue and cardiomyocytes (at protein level). {ECO:0000269|PubMed:29888752}.
• Sequence:

  MKDSEGPQRPPLCFLSTLLSQKVPEKSDAVLRCIISGQPKPEVTWYKNGQAIDGSGIISN
  YEFFENQYIHVLHLSCCTKNDAAVYQISAKNSFGMICCSASVEVECSSENPQLSPNLEDD
  RDRGWKHETGTHEEERANQIDEKEHPYKEEESISPGTPRSADSSPSKSNHSLSLQSLGNL
  DISVSSSENPLGVKGTRHTGEAYDPSNTEEIANGLLFLNSSHIYEKQDRCCHKTVHSMAS
  KFTDGDLNNDGPHDEGLRSSQQNPKVQKYISFSLPLSEATAHIYPGDSAVANKQPSPQLS
  SEDSDSDYELCPEITLTYTEEFSDDDLEYLECSDVMTDYSNAVWQRNLLGTEHVFLLESD
  DEEMEFGEHCLGGCEHFLSGMGCGSRVSGDAGPMVATAGFCGHHSQPQEVGVRSSRVSKH
  GPSSPQTGMTLILGPHQDGTSSVTEQGRYKLPTAPEAAENDYPGIQGETRDSHQAREEFA
  SDNLLNMDESVRETEMKLLSGESENSGMSQCWETAADKRVGGKDLWSKRGSRKSARVRQP
  GMKGNPKKPNANLRESTTEGTLHLCSAKESAEPPLTQSDKRETSHTTAAATGRSSHADAR
  ECAISTQAEQEAKTLQTSTDSVSKEGNTNCKGEGMQVNTLFETSQVPDWSDPPQVQVQET
  VRETISCSQMPAFSEPAGEESPFTGTTTISFSNLGGVHKENASLAQHSEVKPCTCGPQHE
  EKQDRDGNIPDNFREDLKYEQSISEANDETMSPGVFSRHLPKDARADFREPVAVSVASPE
  PTDTALTLENVCDEPRDREAVCAMECFEAGDQGTCFDTIDSLVGRPVDKYSPQEICSVDT
  ELAEGQNKVSDLCSSNDKTLEVFFQTQVSETSVSTCKSSKDGNSVMSPLFTSTFTLNISH
  TASEGATGENLAKVENSTYPLASTVHAGQEQPSPSNSGGLDETQLLSSENNPLVQFKEGG
  DKSPSPSAADTTATPASYSSIVSFPWEKPTTLTANNECFQATRETEDTSTVTIATEVHPA
  KYLAVSIPEDKHAGGTEERFPRASHEKVSQFPSQVQLDHILSGATIKSTKELLCRAPSVP
  GVPHHVLQLPEGEGFCSNSPLQVDNLSGDKSQTVDRADFRSYEENFQERGSETKQGVQQQ
  SLSQQGSLSAPDFQQSLPTTSAAQEERNLVPTAHSPASSREGAGQRSGWGTRVSVVAETA
  GEEDSQALSNVPSLSDILLEESKEYRPGNWEAGNKLKIITLEASASEIWPPRQLTNSESK
  ASDGGLIIPDKVWAVPDSLKADAVVPELAPSEIAALAHSPEDAESALADSRESHKGEEPT
  ISVHWRSLSSRGFSQPRLLESSVDPVDEKELSVTDSLSAASETGGKENVNNVSQDQEEKQ
  LKMDHTAFFKKFLTCPKILESSVDPIDEISVIEYTRAGKPEPSETTPQGAREGGQSNDGN
  MGHEAEIQPAILQVPCLQGTILSENRISRSQEGSMKQEAEQIQPEEAKTAIWQVLQPSEG
  GERIPSGCSIGQIQESSDGSLGEAEQSKKDKAELISPTSPLSSCLPIMTHASLGVDTHNS
  TGQIHDVPENDIVEPRKRQYVFPVSQKRGTIENERGKPLPSSPDLTRFPCTSSPEGNVTD
  FLISHKMEEPKIEVLQIGETKPPSSSSSSAKTLAFISGERELEKAPKLLQDPCQKGTLGC
  AKKSREREKSLEARAGKSPGTLTAVTGSEEVKRKPEAPGSGHLAEGVKKKILSRVAALRL
  KLEEKENIRKNSAFLKKMPKLETSLSHTEEKQDPKKPSCKREGRAPVLLKKIQAEMFPEH
  SGNVKLSCQFAEIHEDSTICWTKDSKSIAQVQRSAGDNSTVSFAIVQASPKDQGLYYCCI
  KNSYGKVTAEFNLTAEVLKQLSSRQDTKGCEEIEFSQLIFKEDFLHDSYFGGRLRGQIAT
  EELHFGEGVHRKAFRSTVMHGLMPVFKPGHACVLKVHNAIAYGTRNNDELIQRNYKLAAQ
  ECYVQNTARYYAKIYAAEAQPLEGFGEVPEIIPIFLIHRPENNIPYATVEEELIGEFVKY
  SIRDGKEINFLRRESEAGQKCCTFQHWVYQKTSGCLLVTDMQGVGMKLTDVGIATLAKGY
  KGFKGNCSMTFIDQFKALHQCNKYCKMLGLKSLQNNNQKQKQPSIGKSKVQTNSMTIKKA
  GPETPGEKKT

• Sequence length: 2170

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Alzheimer disease	Alzheimer`s Disease	rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039, rs63750973, rs63749810, rs63750643, rs193922916, rs63750306, rs63750590, rs63750526, rs63751235, rs661, rs63751037, rs63749885, rs63750231, rs63751229, rs63751272, rs63751223, rs63750391, rs63751163, rs281875357, rs63751141, rs63750082, rs121917807, rs63751399, rs63750265, rs63751144, rs63750886, rs63751068, rs121917808, rs63749891, rs63750083, rs63749824, rs63750577, rs267606983, rs63750218, rs63751287, rs63750900, rs63751475, rs63750450, rs63749805, rs63751278, rs63751106, rs63750004, rs63749806, rs63751024, rs63750248, rs63750779, rs63751139, rs63750219, rs63750298, rs63750687, rs63750851, rs1553268799, rs1561901881, rs1561905293, rs866101707, rs1566638673, rs63750009, rs1566656702, rs1566657804, rs1567885728, rs1568339995, rs1566630791, rs1555358260, rs63750964, rs1594998354, rs63751316	30617256

Unknown
Disease term	Disease name	Evidence	References	Source
Multiple Sclerosis	Multiple Sclerosis			GWAS
Dermatitis	Dermatitis			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Carcinogenesis	Associate	20187983, 35813220
Carcinoma Renal Cell	Associate	34705617
Esophageal Neoplasms	Associate	35813220
Hepatitis C	Associate	33705408
Liver Cirrhosis	Associate	33705408
Liver Diseases	Associate	33705408
Neoplasms	Associate	20187983, 34705617
Neoplasms	Stimulate	37284741
Ovarian Neoplasms	Associate	36856946
Schwannomatosis	Associate	32281771
Stomach Neoplasms	Associate	20187983