Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	115701
Gene name	Alpha kinase 2
Gene symbol	ALPK2
Synonyms (NCBI Gene)	HAK
Chromosome	18
Chromosome location	18q21.31-q21.32

Show/Hide all (83)

miRTarBase ID	miRNA	Experiments	Reference
MIRT438676	hsa-miR-214-3p	ImmunohistochemistryImmunoprecipitaionLuciferase reporter assayqRT-PCRWestern blot	23929716
MIRT438676	hsa-miR-214-3p	ImmunohistochemistryImmunoprecipitaionLuciferase reporter assayqRT-PCRWestern blot	23929716
MIRT779032	hsa-miR-1269	CLIP-seq
MIRT779033	hsa-miR-1269b	CLIP-seq
MIRT779034	hsa-miR-1288	CLIP-seq
MIRT779035	hsa-miR-186	CLIP-seq
MIRT779036	hsa-miR-3672	CLIP-seq
MIRT779037	hsa-miR-4515	CLIP-seq
MIRT779038	hsa-miR-4740-5p	CLIP-seq
MIRT779039	hsa-miR-4786-5p	CLIP-seq
MIRT779040	hsa-miR-511	CLIP-seq
MIRT779041	hsa-miR-769-5p	CLIP-seq
MIRT2170727	hsa-miR-4676-5p	CLIP-seq
MIRT2170728	hsa-miR-575	CLIP-seq
MIRT2170729	hsa-miR-621	CLIP-seq
MIRT2473422	hsa-miR-1184	CLIP-seq
MIRT2473423	hsa-miR-1205	CLIP-seq
MIRT2473424	hsa-miR-29a	CLIP-seq
MIRT2473425	hsa-miR-29b	CLIP-seq
MIRT2473426	hsa-miR-29c	CLIP-seq
MIRT2473427	hsa-miR-3065-3p	CLIP-seq
MIRT2473428	hsa-miR-3158-5p	CLIP-seq
MIRT2473429	hsa-miR-4639-3p	CLIP-seq
MIRT2473430	hsa-miR-4645-3p	CLIP-seq
MIRT2473431	hsa-miR-4687-3p	CLIP-seq
MIRT2473432	hsa-miR-4733-3p	CLIP-seq
MIRT2473433	hsa-miR-4747-5p	CLIP-seq
MIRT2473434	hsa-miR-4768-5p	CLIP-seq
MIRT779039	hsa-miR-4786-5p	CLIP-seq
MIRT2473435	hsa-miR-490-3p	CLIP-seq
MIRT2473436	hsa-miR-521	CLIP-seq
MIRT2473437	hsa-miR-647	CLIP-seq
MIRT779041	hsa-miR-769-5p	CLIP-seq
MIRT2473438	hsa-miR-942	CLIP-seq
MIRT2473422	hsa-miR-1184	CLIP-seq
MIRT2473423	hsa-miR-1205	CLIP-seq
MIRT2674913	hsa-miR-125a-3p	CLIP-seq
MIRT2674914	hsa-miR-147	CLIP-seq
MIRT2674915	hsa-miR-1914	CLIP-seq
MIRT2674916	hsa-miR-1976	CLIP-seq
MIRT2674917	hsa-miR-19a	CLIP-seq
MIRT2674918	hsa-miR-19b	CLIP-seq
MIRT2674919	hsa-miR-214	CLIP-seq
MIRT2473424	hsa-miR-29a	CLIP-seq
MIRT2473425	hsa-miR-29b	CLIP-seq
MIRT2473426	hsa-miR-29c	CLIP-seq
MIRT2473427	hsa-miR-3065-3p	CLIP-seq
MIRT2473428	hsa-miR-3158-5p	CLIP-seq
MIRT2674920	hsa-miR-3619-5p	CLIP-seq
MIRT2674921	hsa-miR-3665	CLIP-seq
MIRT2674922	hsa-miR-3911	CLIP-seq
MIRT2674923	hsa-miR-4292	CLIP-seq
MIRT2674924	hsa-miR-4308	CLIP-seq
MIRT2674925	hsa-miR-4330	CLIP-seq
MIRT2674926	hsa-miR-4446-5p	CLIP-seq
MIRT2473429	hsa-miR-4639-3p	CLIP-seq
MIRT2473430	hsa-miR-4645-3p	CLIP-seq
MIRT2674927	hsa-miR-4658	CLIP-seq
MIRT2473431	hsa-miR-4687-3p	CLIP-seq
MIRT2674928	hsa-miR-4719	CLIP-seq
MIRT2674929	hsa-miR-4731-3p	CLIP-seq
MIRT2473432	hsa-miR-4733-3p	CLIP-seq
MIRT2473433	hsa-miR-4747-5p	CLIP-seq
MIRT2674930	hsa-miR-4755-5p	CLIP-seq
MIRT2674931	hsa-miR-4757-5p	CLIP-seq
MIRT2674932	hsa-miR-4758-5p	CLIP-seq
MIRT2674933	hsa-miR-4765	CLIP-seq
MIRT2674934	hsa-miR-4766-5p	CLIP-seq
MIRT2473434	hsa-miR-4768-5p	CLIP-seq
MIRT779039	hsa-miR-4786-5p	CLIP-seq
MIRT2674935	hsa-miR-4789-5p	CLIP-seq
MIRT2674936	hsa-miR-4801	CLIP-seq
MIRT2473435	hsa-miR-490-3p	CLIP-seq
MIRT2473436	hsa-miR-521	CLIP-seq
MIRT2674937	hsa-miR-579	CLIP-seq
MIRT2674938	hsa-miR-629	CLIP-seq
MIRT2674939	hsa-miR-644	CLIP-seq
MIRT2473437	hsa-miR-647	CLIP-seq
MIRT2674940	hsa-miR-663b	CLIP-seq
MIRT2674941	hsa-miR-670	CLIP-seq
MIRT2674942	hsa-miR-761	CLIP-seq
MIRT779041	hsa-miR-769-5p	CLIP-seq
MIRT2473438	hsa-miR-942	CLIP-seq

Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003007	Process	Heart morphogenesis	IEA
GO:0003007	Process	Heart morphogenesis	IMP	29888752
GO:0003308	Process	Negative regulation of Wnt signaling pathway involved in heart development	IMP	29888752
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0010468	Process	Regulation of gene expression	IMP	22641666
GO:0016020	Component	Membrane	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	IMP	28668886
GO:0016740	Function	Transferase activity	IEA
GO:0030010	Process	Establishment of cell polarity	IMP	28668886
GO:0042981	Process	Regulation of apoptotic process	IMP	22641666
GO:0055013	Process	Cardiac muscle cell development	IEA
GO:0055013	Process	Cardiac muscle cell development	IMP	29888752
GO:0106310	Function	Protein serine kinase activity	IEA
GO:1905223	Process	Epicardium morphogenesis	IMP	29888752

MIM	HGNC	e!Ensembl
619965	20565	ENSG00000198796

Q86TB3

Protein name

Alpha-protein kinase 2 (EC 2.7.11.1) (Heart alpha-protein kinase)

Protein function

Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation (PubMed:10021370). Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-cateni

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07679	I-set	12 → 104	Immunoglobulin I-set domain	Domain
PF07679	I-set	1791 → 1875	Immunoglobulin I-set domain	Domain
PF02816	Alpha_kinase	1926 → 2125	Alpha-kinase family	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in developing cardiac tissue and cardiomyocytes (at protein level). {ECO:0000269|PubMed:29888752}.

Sequence

MKDSEGPQRPPLCFLSTLLSQKVPEKSDAVLRCIISGQPKPEVTWYKNGQAIDGSGIISN
YEFFENQYIHVLHLSCCTKNDAAVYQISAKNSFGMICCSASVEVECSSENPQLSPNLEDD
RDRGWKHETGTHEEERANQIDEKEHPYKEEESISPGTPRSADSSPSKSNHSLSLQSLGNL
DISVSSSENPLGVKGTRHTGEAYDPSNTEEIANGLLFLNSSHIYEKQDRCCHKTVHSMAS
KFTDGDLNNDGPHDEGLRSSQQNPKVQKYISFSLPLSEATAHIYPGDSAVANKQPSPQLS
SEDSDSDYELCPEITLTYTEEFSDDDLEYLECSDVMTDYSNAVWQRNLLGTEHVFLLESD
DEEMEFGEHCLGGCEHFLSGMGCGSRVSGDAGPMVATAGFCGHHSQPQEVGVRSSRVSKH
GPSSPQTGMTLILGPHQDGTSSVTEQGRYKLPTAPEAAENDYPGIQGETRDSHQAREEFA
SDNLLNMDESVRETEMKLLSGESENSGMSQCWETAADKRVGGKDLWSKRGSRKSARVRQP
GMKGNPKKPNANLRESTTEGTLHLCSAKESAEPPLTQSDKRETSHTTAAATGRSSHADAR
ECAISTQAEQEAKTLQTSTDSVSKEGNTNCKGEGMQVNTLFETSQVPDWSDPPQVQVQET
VRETISCSQMPAFSEPAGEESPFTGTTTISFSNLGGVHKENASLAQHSEVKPCTCGPQHE
EKQDRDGNIPDNFREDLKYEQSISEANDETMSPGVFSRHLPKDARADFREPVAVSVASPE
PTDTALTLENVCDEPRDREAVCAMECFEAGDQGTCFDTIDSLVGRPVDKYSPQEICSVDT
ELAEGQNKVSDLCSSNDKTLEVFFQTQVSETSVSTCKSSKDGNSVMSPLFTSTFTLNISH
TASEGATGENLAKVENSTYPLASTVHAGQEQPSPSNSGGLDETQLLSSENNPLVQFKEGG
DKSPSPSAADTTATPASYSSIVSFPWEKPTTLTANNECFQATRETEDTSTVTIATEVHPA
KYLAVSIPEDKHAGGTEERFPRASHEKVSQFPSQVQLDHILSGATIKSTKELLCRAPSVP
GVPHHVLQLPEGEGFCSNSPLQVDNLSGDKSQTVDRADFRSYEENFQERGSETKQGVQQQ
SLSQQGSLSAPDFQQSLPTTSAAQEERNLVPTAHSPASSREGAGQRSGWGTRVSVVAETA
GEEDSQALSNVPSLSDILLEESKEYRPGNWEAGNKLKIITLEASASEIWPPRQLTNSESK
ASDGGLIIPDKVWAVPDSLKADAVVPELAPSEIAALAHSPEDAESALADSRESHKGEEPT
ISVHWRSLSSRGFSQPRLLESSVDPVDEKELSVTDSLSAASETGGKENVNNVSQDQEEKQ
LKMDHTAFFKKFLTCPKILESSVDPIDEISVIEYTRAGKPEPSETTPQGAREGGQSNDGN
MGHEAEIQPAILQVPCLQGTILSENRISRSQEGSMKQEAEQIQPEEAKTAIWQVLQPSEG
GERIPSGCSIGQIQESSDGSLGEAEQSKKDKAELISPTSPLSSCLPIMTHASLGVDTHNS
TGQIHDVPENDIVEPRKRQYVFPVSQKRGTIENERGKPLPSSPDLTRFPCTSSPEGNVTD
FLISHKMEEPKIEVLQIGETKPPSSSSSSAKTLAFISGERELEKAPKLLQDPCQKGTLGC
AKKSREREKSLEARAGKSPGTLTAVTGSEEVKRKPEAPGSGHLAEGVKKKILSRVAALRL
KLEEKENIRKNSAFLKKMPKLETSLSHTEEKQDPKKPSCKREGRAPVLLKKIQAEMFPEH
SGNVKLSCQFAEIHEDSTICWTKDSKSIAQVQRSAGDNSTVSFAIVQASPKDQGLYYCCI
KNSYGKVTAEFNLTAEVLKQLSSRQDTKGCEEIEFSQLIFKEDFLHDSYFGGRLRGQIAT
EELHFGEGVHRKAFRSTVMHGLMPVFKPGHACVLKVHNAIAYGTRNNDELIQRNYKLAAQ
ECYVQNTARYYAKIYAAEAQPLEGFGEVPEIIPIFLIHRPENNIPYATVEEELIGEFVKY
SIRDGKEINFLRRESEAGQKCCTFQHWVYQKTSGCLLVTDMQGVGMKLTDVGIATLAKGY
KGFKGNCSMTFIDQFKALHQCNKYCKMLGLKSLQNNNQKQKQPSIGKSKVQTNSMTIKKA
GPETPGEKKT

Sequence length

2170

Interactions

View interactions

Show/Hide Unknown Diseases (9)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
ALPK2-related disorder	Uncertain significance; Likely benign; Benign	rs140442422, rs80083249, rs150887928, rs56323211, rs36075387, rs766688925, rs140972067, rs1420110099, rs61743671, rs138028987, rs371027763, rs753587692, rs56146550, rs145864025, rs75412529 View all (71 more)	RCV003960998 RCV003961000 RCV003943364 RCV003903674 RCV003926373 RCV003903680 RCV003943372 RCV003933761 RCV003903683 RCV003961017 RCV003943374 RCV004757538 RCV003943370 RCV003933756 RCV003973392 RCV003961028 RCV003926385 RCV003943392 RCV003943393 RCV003971296 RCV003961041 RCV003971299 RCV003903705 RCV003973408 RCV003943410 RCV003909343 RCV003974357 RCV003974360 RCV003974517 RCV003974557 RCV003974567 RCV003974589 RCV003974685 RCV003904175 RCV003979548 RCV003979635 RCV003967392 RCV003979807 RCV003979846 RCV003979862 RCV003979877 RCV003984640 RCV003984642 RCV003984662 RCV003982337 RCV003982364 RCV003982456 RCV003982461 RCV003982463 RCV003982478 RCV003979487 RCV003979524 RCV003982259 RCV003984500 RCV003984596 RCV003911414 RCV003961541 RCV003963988 RCV003972010 RCV003972028 RCV003972082 RCV003943834 RCV003914465 RCV003914532 RCV003924516 RCV003939308 RCV003951391 RCV003931954 RCV003979067 RCV003979090 RCV003964311 RCV003981880 RCV003982017 RCV003982118 RCV003982130 RCV003982179 RCV003982180 RCV003976608 RCV003976643 RCV003976710 RCV003978959 RCV003981327 RCV003976330 RCV003933308 RCV003943202 RCV003930564
Clear cell carcinoma of kidney	Likely benign	rs144079055	RCV005931927
Colorectal cancer	Benign	rs33910491	RCV005937139
Hepatocellular carcinoma	Uncertain significance	rs143254374	RCV005931806
Nonpapillary renal cell carcinoma	Likely benign	rs3809981	RCV005931827
Ovarian serous cystadenocarcinoma	Uncertain significance; Likely benign	rs1307195592, rs2518874785, rs2518877247	RCV005931823 RCV005932728 RCV005939435
Pancreatic adenocarcinoma	Benign	rs3809981	RCV005937153
Thyroid cancer, nonmedullary, 1	Likely benign	rs3809981	RCV005931828
Uterine carcinosarcoma	Benign	rs33910491	RCV005937140

Show/Hide Text Mining Associations (11)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Carcinogenesis	Associate	20187983, 35813220
Carcinoma Renal Cell	Associate	34705617
Esophageal Neoplasms	Associate	35813220
Hepatitis C	Associate	33705408
Liver Cirrhosis	Associate	33705408
Liver Diseases	Associate	33705408
Neoplasms	Associate	20187983, 34705617
Neoplasms	Stimulate	37284741
Ovarian Neoplasms	Associate	36856946
Schwannomatosis	Associate	32281771
Stomach Neoplasms	Associate	20187983

ALPK2 (alpha kinase 2)