FCHO2 (FCH and mu domain containing endocytic adaptor 2)

Gene

• Entrez ID: 115548
• Gene name: FCH and mu domain containing endocytic adaptor 2
• Gene symbol: FCHO2
• Synonyms (NCBI Gene): -
• Chromosome: 5
• Chromosome location: 5q13.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT002703	hsa-miR-124-3p	Microarray	15685193
MIRT002703	hsa-miR-124-3p	Microarray	18668037
MIRT002703	hsa-miR-124-3p	Microarray	15685193
MIRT028083	hsa-miR-93-5p	Sequencing	20371350
MIRT041166	hsa-miR-181d-5p	CLASH	23622248
MIRT097132	hsa-miR-20b-5p	PAR-CLIP	21572407
MIRT028083	hsa-miR-93-5p	PAR-CLIP	21572407
MIRT097135	hsa-miR-519d-3p	PAR-CLIP	21572407
MIRT097130	hsa-miR-106a-5p	PAR-CLIP	21572407
MIRT097128	hsa-miR-20a-5p	PAR-CLIP	21572407
MIRT097127	hsa-miR-17-5p	PAR-CLIP	21572407
MIRT097131	hsa-miR-106b-5p	PAR-CLIP	21572407
MIRT097134	hsa-miR-526b-3p	PAR-CLIP	21572407
MIRT557899	hsa-miR-3129-3p	PAR-CLIP	21572407
MIRT557898	hsa-miR-5583-5p	PAR-CLIP	21572407
MIRT097160	hsa-miR-519a-3p	PAR-CLIP	21572407
MIRT097159	hsa-miR-519b-3p	PAR-CLIP	21572407
MIRT097158	hsa-miR-519c-3p	PAR-CLIP	21572407
MIRT314310	hsa-miR-552-5p	PAR-CLIP	21572407
MIRT537401	hsa-miR-548n	PAR-CLIP	22012620
MIRT097138	hsa-miR-548az-5p	PAR-CLIP	22012620
MIRT097136	hsa-miR-548t-5p	PAR-CLIP	22012620
MIRT097133	hsa-miR-409-3p	PAR-CLIP	22012620
MIRT097129	hsa-miR-33a-3p	PAR-CLIP	22012620
MIRT166946	hsa-miR-3680-5p	PAR-CLIP	22012620
MIRT097139	hsa-miR-6736-3p	PAR-CLIP	22012620
MIRT537400	hsa-miR-8068	PAR-CLIP	22012620
MIRT097137	hsa-miR-3674	PAR-CLIP	22012620
MIRT166971	hsa-miR-548c-3p	PAR-CLIP	22100165
MIRT444653	hsa-miR-3163	PAR-CLIP	22100165
MIRT444654	hsa-miR-200a-5p	PAR-CLIP	22100165
MIRT444652	hsa-miR-200b-5p	PAR-CLIP	22100165
MIRT166963	hsa-miR-340-5p	PAR-CLIP	22100165
MIRT444651	hsa-miR-1273e	PAR-CLIP	22100165
MIRT166971	hsa-miR-548c-3p	PAR-CLIP	22100165
MIRT444653	hsa-miR-3163	PAR-CLIP	22100165
MIRT444654	hsa-miR-200a-5p	PAR-CLIP	22100165
MIRT444652	hsa-miR-200b-5p	PAR-CLIP	22100165
MIRT166963	hsa-miR-340-5p	PAR-CLIP	22100165
MIRT444651	hsa-miR-1273e	PAR-CLIP	22100165
MIRT097131	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT097128	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT097131	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT097127	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT097132	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT028083	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT097135	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT097128	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT097148	hsa-miR-92a-3p	HITS-CLIP	22473208
MIRT097151	hsa-miR-92b-3p	HITS-CLIP	22473208
MIRT097147	hsa-miR-32-5p	HITS-CLIP	22473208
MIRT097132	hsa-miR-20b-5p	PAR-CLIP	21572407
MIRT028083	hsa-miR-93-5p	PAR-CLIP	21572407
MIRT097135	hsa-miR-519d-3p	PAR-CLIP	21572407
MIRT097130	hsa-miR-106a-5p	PAR-CLIP	21572407
MIRT097128	hsa-miR-20a-5p	PAR-CLIP	21572407
MIRT097127	hsa-miR-17-5p	PAR-CLIP	21572407
MIRT097131	hsa-miR-106b-5p	PAR-CLIP	21572407
MIRT097134	hsa-miR-526b-3p	PAR-CLIP	21572407
MIRT557899	hsa-miR-3129-3p	PAR-CLIP	21572407
MIRT557898	hsa-miR-5583-5p	PAR-CLIP	21572407
MIRT097160	hsa-miR-519a-3p	PAR-CLIP	21572407
MIRT097159	hsa-miR-519b-3p	PAR-CLIP	21572407
MIRT097158	hsa-miR-519c-3p	PAR-CLIP	21572407
MIRT314310	hsa-miR-552-5p	PAR-CLIP	21572407
MIRT537401	hsa-miR-548n	PAR-CLIP	22012620
MIRT097138	hsa-miR-548az-5p	PAR-CLIP	22012620
MIRT097136	hsa-miR-548t-5p	PAR-CLIP	22012620
MIRT097133	hsa-miR-409-3p	PAR-CLIP	22012620
MIRT097129	hsa-miR-33a-3p	PAR-CLIP	22012620
MIRT166946	hsa-miR-3680-5p	PAR-CLIP	22012620
MIRT097139	hsa-miR-6736-3p	PAR-CLIP	22012620
MIRT537400	hsa-miR-8068	PAR-CLIP	22012620
MIRT097137	hsa-miR-3674	PAR-CLIP	22012620
MIRT166971	hsa-miR-548c-3p	PAR-CLIP	22100165
MIRT444653	hsa-miR-3163	PAR-CLIP	22100165
MIRT444654	hsa-miR-200a-5p	PAR-CLIP	22100165
MIRT444652	hsa-miR-200b-5p	PAR-CLIP	22100165
MIRT166963	hsa-miR-340-5p	PAR-CLIP	22100165
MIRT444651	hsa-miR-1273e	PAR-CLIP	22100165
MIRT166971	hsa-miR-548c-3p	PAR-CLIP	22100165
MIRT444653	hsa-miR-3163	PAR-CLIP	22100165
MIRT444654	hsa-miR-200a-5p	PAR-CLIP	22100165
MIRT444652	hsa-miR-200b-5p	PAR-CLIP	22100165
MIRT166963	hsa-miR-340-5p	PAR-CLIP	22100165
MIRT444651	hsa-miR-1273e	PAR-CLIP	22100165
MIRT993916	hsa-miR-106a	CLIP-seq
MIRT993917	hsa-miR-106b	CLIP-seq
MIRT993918	hsa-miR-1200	CLIP-seq
MIRT993919	hsa-miR-127-5p	CLIP-seq
MIRT993920	hsa-miR-17	CLIP-seq
MIRT993921	hsa-miR-1827	CLIP-seq
MIRT993922	hsa-miR-191	CLIP-seq
MIRT993923	hsa-miR-20a	CLIP-seq
MIRT993924	hsa-miR-20b	CLIP-seq
MIRT993925	hsa-miR-21	CLIP-seq
MIRT993926	hsa-miR-2113	CLIP-seq
MIRT993927	hsa-miR-2115	CLIP-seq
MIRT993928	hsa-miR-218	CLIP-seq
MIRT993929	hsa-miR-25	CLIP-seq
MIRT993930	hsa-miR-298	CLIP-seq
MIRT993931	hsa-miR-30a	CLIP-seq
MIRT993932	hsa-miR-30b	CLIP-seq
MIRT993933	hsa-miR-30c	CLIP-seq
MIRT993934	hsa-miR-30d	CLIP-seq
MIRT993935	hsa-miR-30e	CLIP-seq
MIRT993936	hsa-miR-3140-5p	CLIP-seq
MIRT993937	hsa-miR-3158-5p	CLIP-seq
MIRT993938	hsa-miR-3182	CLIP-seq
MIRT993939	hsa-miR-32	CLIP-seq
MIRT993940	hsa-miR-326	CLIP-seq
MIRT993941	hsa-miR-330-5p	CLIP-seq
MIRT993942	hsa-miR-3607-3p	CLIP-seq
MIRT993943	hsa-miR-3609	CLIP-seq
MIRT993944	hsa-miR-3611	CLIP-seq
MIRT993945	hsa-miR-3622a-5p	CLIP-seq
MIRT993946	hsa-miR-363	CLIP-seq
MIRT993947	hsa-miR-367	CLIP-seq
MIRT993948	hsa-miR-3680	CLIP-seq
MIRT993949	hsa-miR-4316	CLIP-seq
MIRT993950	hsa-miR-4325	CLIP-seq
MIRT993951	hsa-miR-4327	CLIP-seq
MIRT993952	hsa-miR-4423-3p	CLIP-seq
MIRT993953	hsa-miR-4427	CLIP-seq
MIRT993954	hsa-miR-4460	CLIP-seq
MIRT993955	hsa-miR-450b-5p	CLIP-seq
MIRT993956	hsa-miR-4643	CLIP-seq
MIRT993957	hsa-miR-4659a-3p	CLIP-seq
MIRT993958	hsa-miR-4659b-3p	CLIP-seq
MIRT993959	hsa-miR-4680-3p	CLIP-seq
MIRT993960	hsa-miR-4703-3p	CLIP-seq
MIRT993961	hsa-miR-4719	CLIP-seq
MIRT993962	hsa-miR-4727-3p	CLIP-seq
MIRT993963	hsa-miR-4729	CLIP-seq
MIRT993964	hsa-miR-4738-3p	CLIP-seq
MIRT993965	hsa-miR-4766-5p	CLIP-seq
MIRT993966	hsa-miR-4804-3p	CLIP-seq
MIRT993967	hsa-miR-486-5p	CLIP-seq
MIRT993968	hsa-miR-516a-3p	CLIP-seq
MIRT993969	hsa-miR-519d	CLIP-seq
MIRT993970	hsa-miR-548ah	CLIP-seq
MIRT993971	hsa-miR-548t	CLIP-seq
MIRT993972	hsa-miR-568	CLIP-seq
MIRT993973	hsa-miR-579	CLIP-seq
MIRT993974	hsa-miR-580	CLIP-seq
MIRT993975	hsa-miR-590-5p	CLIP-seq
MIRT993976	hsa-miR-593	CLIP-seq
MIRT993977	hsa-miR-616	CLIP-seq
MIRT993978	hsa-miR-626	CLIP-seq
MIRT993979	hsa-miR-636	CLIP-seq
MIRT993980	hsa-miR-92a	CLIP-seq
MIRT993981	hsa-miR-92b	CLIP-seq
MIRT993982	hsa-miR-93	CLIP-seq
MIRT993916	hsa-miR-106a	CLIP-seq
MIRT993917	hsa-miR-106b	CLIP-seq
MIRT993918	hsa-miR-1200	CLIP-seq
MIRT993983	hsa-miR-1208	CLIP-seq
MIRT993920	hsa-miR-17	CLIP-seq
MIRT993923	hsa-miR-20a	CLIP-seq
MIRT993924	hsa-miR-20b	CLIP-seq
MIRT993925	hsa-miR-21	CLIP-seq
MIRT993927	hsa-miR-2115	CLIP-seq
MIRT993928	hsa-miR-218	CLIP-seq
MIRT993929	hsa-miR-25	CLIP-seq
MIRT993930	hsa-miR-298	CLIP-seq
MIRT993931	hsa-miR-30a	CLIP-seq
MIRT993932	hsa-miR-30b	CLIP-seq
MIRT993933	hsa-miR-30c	CLIP-seq
MIRT993934	hsa-miR-30d	CLIP-seq
MIRT993935	hsa-miR-30e	CLIP-seq
MIRT993936	hsa-miR-3140-5p	CLIP-seq
MIRT993939	hsa-miR-32	CLIP-seq
MIRT993942	hsa-miR-3607-3p	CLIP-seq
MIRT993946	hsa-miR-363	CLIP-seq
MIRT993947	hsa-miR-367	CLIP-seq
MIRT993984	hsa-miR-3671	CLIP-seq
MIRT993985	hsa-miR-371-5p	CLIP-seq
MIRT993986	hsa-miR-371b-5p	CLIP-seq
MIRT993987	hsa-miR-4251	CLIP-seq
MIRT993988	hsa-miR-4318	CLIP-seq
MIRT993950	hsa-miR-4325	CLIP-seq
MIRT993953	hsa-miR-4427	CLIP-seq
MIRT993989	hsa-miR-4494	CLIP-seq
MIRT993990	hsa-miR-4499	CLIP-seq
MIRT993955	hsa-miR-450b-5p	CLIP-seq
MIRT993991	hsa-miR-4536	CLIP-seq
MIRT993992	hsa-miR-4539	CLIP-seq
MIRT993956	hsa-miR-4643	CLIP-seq
MIRT993957	hsa-miR-4659a-3p	CLIP-seq
MIRT993958	hsa-miR-4659b-3p	CLIP-seq
MIRT993993	hsa-miR-4699-5p	CLIP-seq
MIRT993960	hsa-miR-4703-3p	CLIP-seq
MIRT993967	hsa-miR-486-5p	CLIP-seq
MIRT993994	hsa-miR-493	CLIP-seq
MIRT993995	hsa-miR-499a-5p	CLIP-seq
MIRT993968	hsa-miR-516a-3p	CLIP-seq
MIRT993996	hsa-miR-519a	CLIP-seq
MIRT993969	hsa-miR-519d	CLIP-seq
MIRT993997	hsa-miR-539	CLIP-seq
MIRT993998	hsa-miR-548ag	CLIP-seq
MIRT993999	hsa-miR-548ai	CLIP-seq
MIRT993971	hsa-miR-548t	CLIP-seq
MIRT993973	hsa-miR-579	CLIP-seq
MIRT993974	hsa-miR-580	CLIP-seq
MIRT993975	hsa-miR-590-5p	CLIP-seq
MIRT993976	hsa-miR-593	CLIP-seq
MIRT993977	hsa-miR-616	CLIP-seq
MIRT993978	hsa-miR-626	CLIP-seq
MIRT993979	hsa-miR-636	CLIP-seq
MIRT994000	hsa-miR-654-3p	CLIP-seq
MIRT993980	hsa-miR-92a	CLIP-seq
MIRT993981	hsa-miR-92b	CLIP-seq
MIRT993982	hsa-miR-93	CLIP-seq
MIRT993955	hsa-miR-450b-5p	CLIP-seq
MIRT993974	hsa-miR-580	CLIP-seq
MIRT993916	hsa-miR-106a	CLIP-seq
MIRT993917	hsa-miR-106b	CLIP-seq
MIRT993920	hsa-miR-17	CLIP-seq
MIRT993923	hsa-miR-20a	CLIP-seq
MIRT993924	hsa-miR-20b	CLIP-seq
MIRT993948	hsa-miR-3680	CLIP-seq
MIRT1994749	hsa-miR-451b	CLIP-seq
MIRT993969	hsa-miR-519d	CLIP-seq
MIRT993971	hsa-miR-548t	CLIP-seq
MIRT993982	hsa-miR-93	CLIP-seq
MIRT2228906	hsa-miR-145	CLIP-seq
MIRT2228907	hsa-miR-3199	CLIP-seq
MIRT2228908	hsa-miR-4475	CLIP-seq
MIRT2228909	hsa-miR-4712-5p	CLIP-seq
MIRT2228910	hsa-miR-548a-3p	CLIP-seq
MIRT2228911	hsa-miR-548e	CLIP-seq
MIRT2228912	hsa-miR-548f	CLIP-seq
MIRT993973	hsa-miR-579	CLIP-seq
MIRT993977	hsa-miR-616	CLIP-seq
MIRT2228913	hsa-miR-770-5p	CLIP-seq
MIRT2387958	hsa-miR-410	CLIP-seq
MIRT2387959	hsa-miR-4773	CLIP-seq
MIRT2387960	hsa-miR-548b-3p	CLIP-seq
MIRT2532441	hsa-miR-1276	CLIP-seq
MIRT993921	hsa-miR-1827	CLIP-seq
MIRT2532442	hsa-miR-23a	CLIP-seq
MIRT2532443	hsa-miR-23b	CLIP-seq
MIRT2532444	hsa-miR-23c	CLIP-seq
MIRT2532445	hsa-miR-4311	CLIP-seq
MIRT993963	hsa-miR-4729	CLIP-seq
MIRT2532446	hsa-miR-520d-5p	CLIP-seq
MIRT2532447	hsa-miR-524-5p	CLIP-seq
MIRT2532448	hsa-miR-583	CLIP-seq
MIRT2532446	hsa-miR-520d-5p	CLIP-seq
MIRT2532447	hsa-miR-524-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001786	Function	Phosphatidylserine binding	IEA
GO:0001786	Function	Phosphatidylserine binding	ISS
GO:0005515	Function	Protein binding	IPI	19380743, 21762413, 22323290, 35271311
GO:0005546	Function	Phosphatidylinositol-4,5-bisphosphate binding	IEA
GO:0005546	Function	Phosphatidylinositol-4,5-bisphosphate binding	ISS
GO:0005737	Component	Cytoplasm	IBA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005905	Component	Clathrin-coated pit	IBA
GO:0005905	Component	Clathrin-coated pit	IDA	21762413, 22484487
GO:0005905	Component	Clathrin-coated pit	IEA
GO:0006897	Process	Endocytosis	IEA
GO:0010324	Process	Membrane invagination	IEA
GO:0010324	Process	Membrane invagination	ISS
GO:0016020	Component	Membrane	IEA
GO:0030136	Component	Clathrin-coated vesicle	IBA
GO:0030136	Component	Clathrin-coated vesicle	IDA	21762413
GO:0030136	Component	Clathrin-coated vesicle	IEA
GO:0035091	Function	Phosphatidylinositol binding	IEA
GO:0035091	Function	Phosphatidylinositol binding	ISS
GO:0042802	Function	Identical protein binding	IEA
GO:0042802	Function	Identical protein binding	IPI	17540576
GO:0045202	Component	Synapse	IEA
GO:0048268	Process	Clathrin coat assembly	IBA
GO:0048268	Process	Clathrin coat assembly	IEA
GO:0048268	Process	Clathrin coat assembly	IMP	20448150
GO:0048488	Process	Synaptic vesicle endocytosis	IBA
GO:0048488	Process	Synaptic vesicle endocytosis	IEA
GO:0072583	Process	Clathrin-dependent endocytosis	IBA
GO:0072583	Process	Clathrin-dependent endocytosis	IEA
GO:0072583	Process	Clathrin-dependent endocytosis	IMP	20448150, 21762413
GO:0072659	Process	Protein localization to plasma membrane	IEA
GO:0072659	Process	Protein localization to plasma membrane	ISS
GO:0098793	Component	Presynapse	IEA

Other IDs

• MIM: 613438
• HGNC: 25180
• e!Ensembl: ENSG00000157107

Protein

• UniProt ID: Q0JRZ9
• Protein name: F-BAR domain only protein 2
• Protein function: Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a pref
• PDB: 2V0O, 7OG1, 7OHO, 7OHZ, 7OI5, 7OIQ, 7OIT
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00611	FCH	17 → 89	Fes/CIP4, and EFC/F-BAR homology domain	Family
  PF10291	muHD	543 → 809	Muniscin C-terminal mu homology domain	Domain

• Sequence:

  MVMAYFVENFWGEKNSGFDVLYHNMKHGQISTKELADFVRERATIEEAYSRSMTKLAKSA
  SNYSQLGTFAPVWDVFKTSTEKLANCHLDLVRKLQELIKEVQKYGEEQVKSHKKTKEEVA
  GTLEAVQTIQSITQALQKSKENYNAKCVEQERLKKEGATQREIEKAAVKSKKATDTYKLY
  VEKYALAKADFEQKMTETAQKFQDIEETHLIHIKEIIGSLSNAIKEIHLQIGQVHEEFIN
  NMANTTVESLIQKFAESKGTGKERPGLIEFEECDTASAVEGIKPRKRKTFALPGIIKKEK
  DAESVECPDADSLNIPDVDEEGYSIKPETNQNDTKENHFYSSSDSDSEDEEPKKYRIEIK
  PMHPNNSHHTMASLDELKVSIGNITLSPAISRHSPVQMNRNLSNEELTKSKPSAPPNEKG
  TSDLLAWDPLFGPSLDSSSSSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGI
  NEIPRPFSPPVTSNTSPPPAAPLARAESSSSISSSASLSAANTPTVGVSRGPSPVSLGNQ
  DTLPVAVALTESVNAYFKGADPTKCIVKITGDMTMSFPSGIIKVFTSNPTPAVLCFRVKN
  ISRLEQILPNAQLVFSDPSQCDSNTKDFWMNMQAVTVYLKKLSEQNPAASYYNVDVLKYQ
  VSSNGIQSTPLNLATYWKCSASTTDLRVDYKYNPEAMVAPSVLSNIQVVVPVDGGVTNMQ
  SLPPAIWNAEQMKAFWKLSSISEKSENGGSGSLRAKFDLSEGPSKPTTLAVQFLSEGSTL
  SGVDFELVGTGYRLSLIKKRFATGRYLADC

• Sequence length: 810

Pathways

Reactome:

Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Thyroid cancer, nonmedullary, 1	Uncertain significance	rs201594850	RCV005937480

Associations from Text Mining
Disease Name	Relationship Type	References
Heart Failure	Associate	32852391
Neoplasms	Inhibit	36077069
Pancreatic Neoplasms	Associate	36077069
Systemic Inflammatory Response Syndrome	Associate	32852391