Gene Gene information from NCBI Gene database.
Entrez ID 115509
Gene name Zinc finger protein 689
Gene symbol ZNF689
Synonyms (NCBI Gene)
TIPUH1
Chromosome 16
Chromosome location 16p11.2
miRNA miRNA information provided by mirtarbase database.
271
miRTarBase ID miRNA Experiments Reference
MIRT050822 hsa-miR-17-5p CLASH 23622248
MIRT043635 hsa-miR-326 CLASH 23622248
MIRT038592 hsa-miR-106b-3p CLASH 23622248
MIRT052788 hsa-miR-3176 CLASH 23622248
MIRT648826 hsa-miR-7851-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
16
GO ID Ontology Definition Evidence Reference
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA
GO:0003677 Function DNA binding IEA
GO:0005515 Function Protein binding IPI 33468658
GO:0005634 Component Nucleus IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
618033 25173 ENSG00000156853
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
C0HLU2
Protein name Transcriptional regulator SEHBP (Short ORF-encoded histone-binding protein) (ZNF689 upstream open reading frame protein)
Protein function Plays a role in transcription regulation.
Family and domains
Sequence

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Sequence length
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96CS4
Protein name Zinc finger protein 689
Protein function May be involved in transcriptional regulation.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01352 KRAB 28 69 KRAB box Family
PF00096 zf-C2H2 177 199 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 205 227 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 233 255 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 261 283 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 289 311 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 317 339 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 373 395 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 401 423 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 429 451 Zinc finger, C2H2 type Domain
Sequence
MAPPSAPLPAQGPGKARPSRKRGRRPRALKFVDVAVYFSPEEWGCLRPAQRALYRDVMRE
TYGHLGALG
CAGPKPALISWLERNTDDWEPAALDPQEYPRGLTVQRKSRTRKKNGEKEVF
PPKEAPRKGKRGRRPSKPRLIPRQTSGGPICPDCGCTFPDHQALESHKCAQNLKKPYPCP
DCGRRFSYPSLLVSHRRAH
SGECPYVCDQCGKRFSQRKNLSQHQVIHTGEKPYHCPDCGR
CFRRSRSLANHRTTH
TGEKPHQCPSCGRRFAYPSLLAIHQRTHTGEKPYTCLECNRRFRQ
RTALVIHQRIH
TGEKPYPCPDCERRFSSSSRLVSHRRVHSGERPYACEHCEARFSQRSTL
LQHQLLHTGEKPYPCPDCGRAFRRSGSLAIHRSTHTEEKLHACDDCGRRFAYPSLLASHR
RVH
SGERPYACDLCSKRFAQWSHLAQHQLLHTGEKPFPCLECGRCFRQRWSLAVHKCSPK
APNCSPRSAIGGSSQRGNAH
Sequence length 500
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Generic Transcription Pathway
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
6
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GASTROESOPHAGEAL REFLUX DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HYPERTENSION GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Alzheimer Disease Associate 36672180
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Brain Diseases Associate 36672180
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Associate 30774308
★☆☆☆☆
Found in Text Mining only
Depressive Disorder Major Associate 36672180
★☆☆☆☆
Found in Text Mining only
Parkinson Disease Associate 36672180
★☆☆☆☆
Found in Text Mining only
Triple Negative Breast Neoplasms Associate 38168642
★☆☆☆☆
Found in Text Mining only