Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	1154
Gene name	Cytokine inducible SH2 containing protein
Gene symbol	CISH
Synonyms (NCBI Gene)	BACTS2CISCIS-1G18SOCS
Chromosome	3
Chromosome location	3p21.2
Summary	The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family

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Show/Hide all (277)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029522	hsa-miR-26b-5p	Microarray	19088304
MIRT054146	hsa-miR-92a-1-5p	MicroarrayqRT-PCR	22660396
MIRT437917	hsa-miR-150-5p	Luciferase reporter assayWestern blot	23723424
MIRT437917	hsa-miR-150-5p	Luciferase reporter assayWestern blottingqRT-PCR	34027272
MIRT893792	hsa-miR-125a-3p	CLIP-seq
MIRT893793	hsa-miR-1266	CLIP-seq
MIRT893794	hsa-miR-1276	CLIP-seq
MIRT893795	hsa-miR-135a	CLIP-seq
MIRT893796	hsa-miR-135b	CLIP-seq
MIRT893797	hsa-miR-181a	CLIP-seq
MIRT893798	hsa-miR-181b	CLIP-seq
MIRT893799	hsa-miR-181c	CLIP-seq
MIRT893800	hsa-miR-181d	CLIP-seq
MIRT893801	hsa-miR-2392	CLIP-seq
MIRT893802	hsa-miR-2467-5p	CLIP-seq
MIRT893803	hsa-miR-27a	CLIP-seq
MIRT893804	hsa-miR-27b	CLIP-seq
MIRT893805	hsa-miR-296-5p	CLIP-seq
MIRT893806	hsa-miR-298	CLIP-seq
MIRT893807	hsa-miR-3138	CLIP-seq
MIRT893808	hsa-miR-3144-5p	CLIP-seq
MIRT893809	hsa-miR-3155	CLIP-seq
MIRT893810	hsa-miR-3155b	CLIP-seq
MIRT893811	hsa-miR-3188	CLIP-seq
MIRT893812	hsa-miR-3191	CLIP-seq
MIRT893813	hsa-miR-3194-3p	CLIP-seq
MIRT893814	hsa-miR-3199	CLIP-seq
MIRT893815	hsa-miR-338-3p	CLIP-seq
MIRT893816	hsa-miR-3652	CLIP-seq
MIRT893817	hsa-miR-3664-3p	CLIP-seq
MIRT893818	hsa-miR-3692	CLIP-seq
MIRT893819	hsa-miR-3975	CLIP-seq
MIRT893820	hsa-miR-4262	CLIP-seq
MIRT893821	hsa-miR-4311	CLIP-seq
MIRT893822	hsa-miR-4312	CLIP-seq
MIRT893823	hsa-miR-4430	CLIP-seq
MIRT893824	hsa-miR-4438	CLIP-seq
MIRT893825	hsa-miR-4488	CLIP-seq
MIRT893826	hsa-miR-4505	CLIP-seq
MIRT893827	hsa-miR-4518	CLIP-seq
MIRT893828	hsa-miR-451b	CLIP-seq
MIRT893829	hsa-miR-4530	CLIP-seq
MIRT893830	hsa-miR-4649-3p	CLIP-seq
MIRT893831	hsa-miR-4652-5p	CLIP-seq
MIRT893832	hsa-miR-4667-5p	CLIP-seq
MIRT893833	hsa-miR-4690-3p	CLIP-seq
MIRT893834	hsa-miR-4693-3p	CLIP-seq
MIRT893835	hsa-miR-4697-5p	CLIP-seq
MIRT893836	hsa-miR-4700-5p	CLIP-seq
MIRT893837	hsa-miR-4731-5p	CLIP-seq
MIRT893838	hsa-miR-4740-5p	CLIP-seq
MIRT893839	hsa-miR-483-5p	CLIP-seq
MIRT893840	hsa-miR-484	CLIP-seq
MIRT893841	hsa-miR-485-5p	CLIP-seq
MIRT893842	hsa-miR-486-3p	CLIP-seq
MIRT893843	hsa-miR-513a-5p	CLIP-seq
MIRT893844	hsa-miR-548b-3p	CLIP-seq
MIRT893845	hsa-miR-548m	CLIP-seq
MIRT893846	hsa-miR-552	CLIP-seq
MIRT893847	hsa-miR-583	CLIP-seq
MIRT893848	hsa-miR-624	CLIP-seq
MIRT893849	hsa-miR-637	CLIP-seq
MIRT893850	hsa-miR-642b	CLIP-seq
MIRT893851	hsa-miR-659	CLIP-seq
MIRT893852	hsa-miR-665	CLIP-seq
MIRT893853	hsa-miR-760	CLIP-seq
MIRT1964976	hsa-miR-1236	CLIP-seq
MIRT1964977	hsa-miR-1254	CLIP-seq
MIRT893793	hsa-miR-1266	CLIP-seq
MIRT893794	hsa-miR-1276	CLIP-seq
MIRT1964978	hsa-miR-1343	CLIP-seq
MIRT893795	hsa-miR-135a	CLIP-seq
MIRT893796	hsa-miR-135b	CLIP-seq
MIRT1964979	hsa-miR-149	CLIP-seq
MIRT1964980	hsa-miR-150	CLIP-seq
MIRT893797	hsa-miR-181a	CLIP-seq
MIRT893798	hsa-miR-181b	CLIP-seq
MIRT893799	hsa-miR-181c	CLIP-seq
MIRT893800	hsa-miR-181d	CLIP-seq
MIRT1964981	hsa-miR-202	CLIP-seq
MIRT1964982	hsa-miR-22	CLIP-seq
MIRT893802	hsa-miR-2467-5p	CLIP-seq
MIRT893803	hsa-miR-27a	CLIP-seq
MIRT893804	hsa-miR-27b	CLIP-seq
MIRT893806	hsa-miR-298	CLIP-seq
MIRT1964983	hsa-miR-3116	CLIP-seq
MIRT1964984	hsa-miR-3126-5p	CLIP-seq
MIRT893807	hsa-miR-3138	CLIP-seq
MIRT1964985	hsa-miR-3163	CLIP-seq
MIRT1964986	hsa-miR-3170	CLIP-seq
MIRT893811	hsa-miR-3188	CLIP-seq
MIRT1964987	hsa-miR-361-5p	CLIP-seq
MIRT893816	hsa-miR-3652	CLIP-seq
MIRT893819	hsa-miR-3975	CLIP-seq
MIRT1964988	hsa-miR-3976	CLIP-seq
MIRT1964989	hsa-miR-4254	CLIP-seq
MIRT1964990	hsa-miR-4257	CLIP-seq
MIRT1964991	hsa-miR-4259	CLIP-seq
MIRT893820	hsa-miR-4262	CLIP-seq
MIRT1964992	hsa-miR-4267	CLIP-seq
MIRT1964993	hsa-miR-4269	CLIP-seq
MIRT893821	hsa-miR-4311	CLIP-seq
MIRT893822	hsa-miR-4312	CLIP-seq
MIRT893823	hsa-miR-4430	CLIP-seq
MIRT1964994	hsa-miR-4436b-3p	CLIP-seq
MIRT893825	hsa-miR-4488	CLIP-seq
MIRT893826	hsa-miR-4505	CLIP-seq
MIRT893827	hsa-miR-4518	CLIP-seq
MIRT1964995	hsa-miR-4685-5p	CLIP-seq
MIRT893834	hsa-miR-4693-3p	CLIP-seq
MIRT893835	hsa-miR-4697-5p	CLIP-seq
MIRT1964996	hsa-miR-4713-5p	CLIP-seq
MIRT893837	hsa-miR-4731-5p	CLIP-seq
MIRT1964997	hsa-miR-4733-3p	CLIP-seq
MIRT1964998	hsa-miR-4779	CLIP-seq
MIRT1964999	hsa-miR-4786-3p	CLIP-seq
MIRT1965000	hsa-miR-4795-3p	CLIP-seq
MIRT893839	hsa-miR-483-5p	CLIP-seq
MIRT893841	hsa-miR-485-5p	CLIP-seq
MIRT893842	hsa-miR-486-3p	CLIP-seq
MIRT893843	hsa-miR-513a-5p	CLIP-seq
MIRT1965001	hsa-miR-532-3p	CLIP-seq
MIRT1965002	hsa-miR-532-5p	CLIP-seq
MIRT893845	hsa-miR-548m	CLIP-seq
MIRT1965003	hsa-miR-571	CLIP-seq
MIRT893847	hsa-miR-583	CLIP-seq
MIRT1965004	hsa-miR-615-5p	CLIP-seq
MIRT893849	hsa-miR-637	CLIP-seq
MIRT893850	hsa-miR-642b	CLIP-seq
MIRT1965005	hsa-miR-661	CLIP-seq
MIRT893853	hsa-miR-760	CLIP-seq
MIRT1965006	hsa-miR-765	CLIP-seq
MIRT2201004	hsa-miR-1200	CLIP-seq
MIRT2201005	hsa-miR-1234	CLIP-seq
MIRT1964976	hsa-miR-1236	CLIP-seq
MIRT893793	hsa-miR-1266	CLIP-seq
MIRT2201006	hsa-miR-1285	CLIP-seq
MIRT1964978	hsa-miR-1343	CLIP-seq
MIRT893795	hsa-miR-135a	CLIP-seq
MIRT893796	hsa-miR-135b	CLIP-seq
MIRT1964979	hsa-miR-149	CLIP-seq
MIRT1964980	hsa-miR-150	CLIP-seq
MIRT893797	hsa-miR-181a	CLIP-seq
MIRT893798	hsa-miR-181b	CLIP-seq
MIRT893799	hsa-miR-181c	CLIP-seq
MIRT893800	hsa-miR-181d	CLIP-seq
MIRT1964982	hsa-miR-22	CLIP-seq
MIRT2201007	hsa-miR-2277-3p	CLIP-seq
MIRT893801	hsa-miR-2392	CLIP-seq
MIRT2201008	hsa-miR-24	CLIP-seq
MIRT893802	hsa-miR-2467-5p	CLIP-seq
MIRT893803	hsa-miR-27a	CLIP-seq
MIRT893804	hsa-miR-27b	CLIP-seq
MIRT893806	hsa-miR-298	CLIP-seq
MIRT2201009	hsa-miR-3065-3p	CLIP-seq
MIRT2201010	hsa-miR-3127-5p	CLIP-seq
MIRT893807	hsa-miR-3138	CLIP-seq
MIRT893808	hsa-miR-3144-5p	CLIP-seq
MIRT1964986	hsa-miR-3170	CLIP-seq
MIRT2201011	hsa-miR-3183	CLIP-seq
MIRT2201012	hsa-miR-3187-5p	CLIP-seq
MIRT893811	hsa-miR-3188	CLIP-seq
MIRT2201013	hsa-miR-3190	CLIP-seq
MIRT893812	hsa-miR-3191	CLIP-seq
MIRT893814	hsa-miR-3199	CLIP-seq
MIRT2201014	hsa-miR-326	CLIP-seq
MIRT2201015	hsa-miR-330-5p	CLIP-seq
MIRT893815	hsa-miR-338-3p	CLIP-seq
MIRT2201016	hsa-miR-3607-5p	CLIP-seq
MIRT1964987	hsa-miR-361-5p	CLIP-seq
MIRT893816	hsa-miR-3652	CLIP-seq
MIRT2201017	hsa-miR-3660	CLIP-seq
MIRT893817	hsa-miR-3664-3p	CLIP-seq
MIRT2201018	hsa-miR-3667-3p	CLIP-seq
MIRT893818	hsa-miR-3692	CLIP-seq
MIRT2201019	hsa-miR-378	CLIP-seq
MIRT2201020	hsa-miR-378b	CLIP-seq
MIRT2201021	hsa-miR-378c	CLIP-seq
MIRT2201022	hsa-miR-378d	CLIP-seq
MIRT2201023	hsa-miR-378e	CLIP-seq
MIRT2201024	hsa-miR-378f	CLIP-seq
MIRT2201025	hsa-miR-378h	CLIP-seq
MIRT2201026	hsa-miR-378i	CLIP-seq
MIRT2201027	hsa-miR-3918	CLIP-seq
MIRT2201028	hsa-miR-3945	CLIP-seq
MIRT893819	hsa-miR-3975	CLIP-seq
MIRT2201029	hsa-miR-422a	CLIP-seq
MIRT1964991	hsa-miR-4259	CLIP-seq
MIRT893820	hsa-miR-4262	CLIP-seq
MIRT2201030	hsa-miR-4264	CLIP-seq
MIRT1964993	hsa-miR-4269	CLIP-seq
MIRT2201031	hsa-miR-4277	CLIP-seq
MIRT2201032	hsa-miR-4279	CLIP-seq
MIRT2201033	hsa-miR-4284	CLIP-seq
MIRT893822	hsa-miR-4312	CLIP-seq
MIRT2201034	hsa-miR-4326	CLIP-seq
MIRT2201035	hsa-miR-4428	CLIP-seq
MIRT893823	hsa-miR-4430	CLIP-seq
MIRT2201036	hsa-miR-4436a	CLIP-seq
MIRT1964994	hsa-miR-4436b-3p	CLIP-seq
MIRT2201037	hsa-miR-4437	CLIP-seq
MIRT893825	hsa-miR-4488	CLIP-seq
MIRT893826	hsa-miR-4505	CLIP-seq
MIRT893827	hsa-miR-4518	CLIP-seq
MIRT893828	hsa-miR-451b	CLIP-seq
MIRT2201038	hsa-miR-4526	CLIP-seq
MIRT893829	hsa-miR-4530	CLIP-seq
MIRT2201039	hsa-miR-4638-3p	CLIP-seq
MIRT2201040	hsa-miR-4640-3p	CLIP-seq
MIRT2201041	hsa-miR-4640-5p	CLIP-seq
MIRT2201042	hsa-miR-4643	CLIP-seq
MIRT893830	hsa-miR-4649-3p	CLIP-seq
MIRT893831	hsa-miR-4652-5p	CLIP-seq
MIRT893832	hsa-miR-4667-5p	CLIP-seq
MIRT1964995	hsa-miR-4685-5p	CLIP-seq
MIRT893834	hsa-miR-4693-3p	CLIP-seq
MIRT893835	hsa-miR-4697-5p	CLIP-seq
MIRT893836	hsa-miR-4700-5p	CLIP-seq
MIRT1964996	hsa-miR-4713-5p	CLIP-seq
MIRT2201043	hsa-miR-4717-3p	CLIP-seq
MIRT2201044	hsa-miR-4723-3p	CLIP-seq
MIRT2201045	hsa-miR-4726-5p	CLIP-seq
MIRT893837	hsa-miR-4731-5p	CLIP-seq
MIRT893838	hsa-miR-4740-5p	CLIP-seq
MIRT2201046	hsa-miR-4761-3p	CLIP-seq
MIRT2201047	hsa-miR-4768-5p	CLIP-seq
MIRT1964999	hsa-miR-4786-3p	CLIP-seq
MIRT2201048	hsa-miR-4793-5p	CLIP-seq
MIRT2201049	hsa-miR-4797-3p	CLIP-seq
MIRT893839	hsa-miR-483-5p	CLIP-seq
MIRT893841	hsa-miR-485-5p	CLIP-seq
MIRT893842	hsa-miR-486-3p	CLIP-seq
MIRT893843	hsa-miR-513a-5p	CLIP-seq
MIRT1965001	hsa-miR-532-3p	CLIP-seq
MIRT1965002	hsa-miR-532-5p	CLIP-seq
MIRT893844	hsa-miR-548b-3p	CLIP-seq
MIRT2201050	hsa-miR-548c-3p	CLIP-seq
MIRT1965003	hsa-miR-571	CLIP-seq
MIRT2201051	hsa-miR-593	CLIP-seq
MIRT2201052	hsa-miR-612	CLIP-seq
MIRT1965004	hsa-miR-615-5p	CLIP-seq
MIRT2201053	hsa-miR-616	CLIP-seq
MIRT893849	hsa-miR-637	CLIP-seq
MIRT893850	hsa-miR-642b	CLIP-seq
MIRT893851	hsa-miR-659	CLIP-seq
MIRT1965005	hsa-miR-661	CLIP-seq
MIRT893852	hsa-miR-665	CLIP-seq
MIRT2201054	hsa-miR-7	CLIP-seq
MIRT893853	hsa-miR-760	CLIP-seq
MIRT1964978	hsa-miR-1343	CLIP-seq
MIRT1964981	hsa-miR-202	CLIP-seq
MIRT1964982	hsa-miR-22	CLIP-seq
MIRT1964986	hsa-miR-3170	CLIP-seq
MIRT1964990	hsa-miR-4257	CLIP-seq
MIRT1964993	hsa-miR-4269	CLIP-seq
MIRT1964997	hsa-miR-4733-3p	CLIP-seq
MIRT2201013	hsa-miR-3190	CLIP-seq
MIRT2201054	hsa-miR-7	CLIP-seq
MIRT2201005	hsa-miR-1234	CLIP-seq
MIRT1964980	hsa-miR-150	CLIP-seq
MIRT2201008	hsa-miR-24	CLIP-seq
MIRT2201033	hsa-miR-4284	CLIP-seq
MIRT893822	hsa-miR-4312	CLIP-seq
MIRT2201035	hsa-miR-4428	CLIP-seq
MIRT893825	hsa-miR-4488	CLIP-seq
MIRT2201042	hsa-miR-4643	CLIP-seq
MIRT893835	hsa-miR-4697-5p	CLIP-seq
MIRT1964996	hsa-miR-4713-5p	CLIP-seq
MIRT2201043	hsa-miR-4717-3p	CLIP-seq
MIRT2678219	hsa-miR-4777-3p	CLIP-seq
MIRT1964999	hsa-miR-4786-3p	CLIP-seq
MIRT2201049	hsa-miR-4797-3p	CLIP-seq
MIRT1965001	hsa-miR-532-3p	CLIP-seq
MIRT1965002	hsa-miR-532-5p	CLIP-seq
MIRT893849	hsa-miR-637	CLIP-seq
MIRT893850	hsa-miR-642b	CLIP-seq
MIRT1965005	hsa-miR-661	CLIP-seq

Show/Hide all (2)

Transcription factor	Regulation	Reference
STAT3	Activation	14630083
STAT6	Unknown	18342537

Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001558	Process	Regulation of cell growth	NAS	9465889
GO:0001960	Process	Negative regulation of cytokine-mediated signaling pathway	IEA
GO:0005126	Function	Cytokine receptor binding	IBA
GO:0005515	Function	Protein binding	IPI	16273093, 24658140, 31980649, 32814053
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IEA
GO:0009968	Process	Negative regulation of signal transduction	IEA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0019221	Process	Cytokine-mediated signaling pathway	IBA
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0035556	Process	Intracellular signal transduction	NAS	10902923
GO:0046426	Process	Negative regulation of receptor signaling pathway via JAK-STAT	IBA

MIM	HGNC	e!Ensembl
602441	1984	ENSG00000114737

Q9NSE2

Protein name

Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Protein G18) (Suppressor of cytokine signaling) (SOCS)

Protein function

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolact

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00017	SH2	82 → 163	SH2 domain	Domain
PF07525	SOCS_box	221 → 254	SOCS box	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in various epithelial tissues. Abundantly expressed in liver and kidney, and to a lesser extent in lung. The tissue distribution of isoforms 1 and 1B is distinct. {ECO:0000269|PubMed:11032736}.

Sequence

MVLCVQGPRPLLAVERTGQRPLWAPSLELPKPVMQPLPAGAFLEEVAEGTPAQTESEPKV
LDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSV
KTTRGPTNVRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASCTADTRSDSPDPAP
TPALPMPKEDAPSDPALPAPPPATAVHLKLVQPFVRRSSARSLQHLCRLVINRLVADVDC
LPLPRRMADYLRQYPFQL

Sequence length

258

Interactions

View interactions

	KEGG		Reactome
	JAK-STAT signaling pathway Prolactin signaling pathway		Interleukin-7 signaling Neddylation

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Bacteremia, susceptibility to, 2	risk factor	rs414171	RCV000023195
CISH-related disorder	Likely benign	rs2471650128, rs199816251, rs148162012	RCV003898982 RCV003924147 RCV003922884
Malaria, susceptibility to	risk factor	rs414171	RCV000007508
Tuberculosis, susceptibility to	risk factor	rs414171	RCV000007507

Show/Hide Text Mining Associations (28)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Alveolar Bone Loss	Inhibit	19026878
Alzheimer Disease	Associate	25286386
Asthma	Associate	30197185
Breast Neoplasms	Associate	12888825, 16446704, 18254957, 25104439, 26625783, 40003884
Carcinoma Hepatocellular	Inhibit	39307915
Carcinoma Intraductal Noninfiltrating	Associate	20712900
Colorectal Neoplasms	Associate	22121102, 25330801
Communicable Diseases	Associate	24964072
Diabetes Mellitus Type 1	Associate	30942443
Glioblastoma	Associate	40071076
Hepatitis B	Associate	24964072
HIV Infections	Associate	21337543
Inflammation	Inhibit	19592657, 32961483
Inflammation	Associate	30197185, 33476981, 34734092
Leukemia	Associate	32531207
Leukemia Myeloid Acute	Associate	15470047, 36050244
Melanoma	Associate	20398276, 21081840
Mouth Neoplasms	Associate	32961483
Neoplasm Metastasis	Associate	31695117
Neoplasms	Associate	12888825, 24131863, 32531207, 36459028
Neuroendocrine Tumors	Associate	39522643
Neutropenia Severe Congenital Autosomal Recessive 3	Associate	15470047
Periapical Granuloma	Associate	19026878
Periapical Periodontitis	Associate	19026878
Squamous Cell Carcinoma of Head and Neck	Associate	32961483
Stomach Neoplasms	Associate	31884511
Thrombocythemia Essential	Associate	24301930
Tuberculosis Pulmonary	Associate	27266592

CISH (cytokine inducible SH2 containing protein)