DDIT4L (DNA damage inducible transcript 4 like)

Gene

• Entrez ID: 115265
• Gene name: DNA damage inducible transcript 4 like
• Gene symbol: DDIT4L
• Synonyms (NCBI Gene): REDD2, Rtp801L
• Chromosome: 4
• Chromosome location: 4q24

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT929358	hsa-miR-105	CLIP-seq
MIRT929359	hsa-miR-141	CLIP-seq
MIRT929360	hsa-miR-200a	CLIP-seq
MIRT929361	hsa-miR-3190	CLIP-seq
MIRT929362	hsa-miR-33a	CLIP-seq
MIRT929363	hsa-miR-33b	CLIP-seq
MIRT929364	hsa-miR-4277	CLIP-seq
MIRT929365	hsa-miR-4495	CLIP-seq
MIRT929366	hsa-miR-450b-5p	CLIP-seq
MIRT929367	hsa-miR-4735-5p	CLIP-seq
MIRT929368	hsa-miR-4752	CLIP-seq
MIRT929369	hsa-miR-4766-5p	CLIP-seq
MIRT929370	hsa-miR-4794	CLIP-seq
MIRT929371	hsa-miR-507	CLIP-seq
MIRT929372	hsa-miR-548a-3p	CLIP-seq
MIRT929373	hsa-miR-548e	CLIP-seq
MIRT929374	hsa-miR-548f	CLIP-seq
MIRT929375	hsa-miR-557	CLIP-seq
MIRT929376	hsa-miR-570	CLIP-seq
MIRT929377	hsa-miR-600	CLIP-seq
MIRT929378	hsa-miR-892b	CLIP-seq
MIRT2210571	hsa-miR-549	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16189514, 25416956, 27107012, 31515488, 32296183, 32814053
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0009968	Process	Negative regulation of signal transduction	IEA

Other IDs

• MIM: 607730
• HGNC: 30555
• e!Ensembl: ENSG00000145358

Protein

• UniProt ID: Q96D03
• Protein name: DNA damage-inducible transcript 4-like protein (HIF-1 responsive protein RTP801-like) (Protein regulated in development and DNA damage response 2) (REDD-2)
• Protein function: Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07809	RTP801_C	65 → 183	RTP801 C-terminal region	Family

• Tissue specificity: TISSUE SPECIFICITY: Up-regulated in atherosclerotic plaques relative to healthy segments of the same artery. {ECO:0000269|PubMed:15308555}.
• Sequence:

  MVATGSLSSKNPASISELLDCGYHPESLLSDFDYWDYVVPEPNLNEVIFEESTCQNLVKM
  LENCLSKSKQTKLGCSKVLVPEKLTQRIAQDVLRLSSTEPCGLRGCVMHVNLEIENVCKK
  LDRIVCDSSVVPTFELTLVFKQENCSWTSFRDFFFSRGRFSSGFRRTLILSSGFRLVKKK
  LYSLIGTTVIEGS

• Sequence length: 193