Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
115265
Gene name Gene Name - the full gene name approved by the HGNC.
DNA damage inducible transcript 4 like
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
DDIT4L
Synonyms (NCBI Gene) Gene synonyms aliases
REDD2, Rtp801L
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q24
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT929358 hsa-miR-105 CLIP-seq
MIRT929359 hsa-miR-141 CLIP-seq
MIRT929360 hsa-miR-200a CLIP-seq
MIRT929361 hsa-miR-3190 CLIP-seq
MIRT929362 hsa-miR-33a CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 16189514, 25416956, 27107012, 31515488, 32296183, 32814053
GO:0005737 Component Cytoplasm ISS
GO:0009968 Process Negative regulation of signal transduction IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
607730 30555 ENSG00000145358
Protein
UniProt ID Q96D03
Protein name DNA damage-inducible transcript 4-like protein (HIF-1 responsive protein RTP801-like) (Protein regulated in development and DNA damage response 2) (REDD-2)
Protein function Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07809 RTP801_C 65 183 RTP801 C-terminal region Family
Tissue specificity TISSUE SPECIFICITY: Up-regulated in atherosclerotic plaques relative to healthy segments of the same artery. {ECO:0000269|PubMed:15308555}.
Sequence
Sequence length 193
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Melanoma melanoma rs121913315, rs121913323, rs137853080, rs137853081, rs121909232, rs121913388, rs104894094, rs104894095, rs104894097, rs104894098, rs104894099, rs104894109, rs137854599, rs11547328, rs104894340
View all (64 more)
16778180
Unknown
Disease term Disease name Evidence References Source
Gout Gout GWAS
Astrocytoma Astrocytoma GWAS
Eosinophilia Eosinophilia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Atrial Fibrillation Associate 33062700
Germinoma Associate 20178649
Heart Diseases Associate 38003044
Multiple Sclerosis Associate 38218802
Neoplasms Germ Cell and Embryonal Associate 20178649
Periodontitis Associate 38218802
Wounds and Injuries Associate 38003044