OSBPL7 (oxysterol binding protein like 7)

Gene

• Entrez ID: 114881
• Gene name: Oxysterol binding protein like 7
• Gene symbol: OSBPL7
• Synonyms (NCBI Gene): ORP7
• Chromosome: 17
• Chromosome location: 17q21.32
• Summary: This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like stero

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT002743	hsa-miR-1-3p	Microarray	15685193
MIRT002743	hsa-miR-1-3p	Microarray;Other	15685193
MIRT2059410	hsa-miR-3914	CLIP-seq
MIRT2059411	hsa-miR-3915	CLIP-seq
MIRT2059412	hsa-miR-3928	CLIP-seq
MIRT2059413	hsa-miR-4459	CLIP-seq
MIRT2059414	hsa-miR-4722-5p	CLIP-seq
MIRT2059415	hsa-miR-765	CLIP-seq
MIRT2287764	hsa-miR-1205	CLIP-seq
MIRT2287765	hsa-miR-1321	CLIP-seq
MIRT2287766	hsa-miR-28-5p	CLIP-seq
MIRT2287767	hsa-miR-3139	CLIP-seq
MIRT2287768	hsa-miR-3154	CLIP-seq
MIRT2287769	hsa-miR-3162-5p	CLIP-seq
MIRT2287770	hsa-miR-3179	CLIP-seq
MIRT2059410	hsa-miR-3914	CLIP-seq
MIRT2059411	hsa-miR-3915	CLIP-seq
MIRT2059412	hsa-miR-3928	CLIP-seq
MIRT2287771	hsa-miR-4434	CLIP-seq
MIRT2287772	hsa-miR-4436a	CLIP-seq
MIRT2059413	hsa-miR-4459	CLIP-seq
MIRT2287773	hsa-miR-4487	CLIP-seq
MIRT2287774	hsa-miR-450b-5p	CLIP-seq
MIRT2287775	hsa-miR-4516	CLIP-seq
MIRT2287776	hsa-miR-4713-3p	CLIP-seq
MIRT2059414	hsa-miR-4722-5p	CLIP-seq
MIRT2287777	hsa-miR-4739	CLIP-seq
MIRT2287778	hsa-miR-4756-5p	CLIP-seq
MIRT2287779	hsa-miR-507	CLIP-seq
MIRT2287780	hsa-miR-557	CLIP-seq
MIRT2287781	hsa-miR-665	CLIP-seq
MIRT2287782	hsa-miR-671-5p	CLIP-seq
MIRT2287783	hsa-miR-708	CLIP-seq
MIRT2059415	hsa-miR-765	CLIP-seq
MIRT2391973	hsa-miR-2276	CLIP-seq
MIRT2059410	hsa-miR-3914	CLIP-seq
MIRT2059411	hsa-miR-3915	CLIP-seq
MIRT2059412	hsa-miR-3928	CLIP-seq
MIRT2391974	hsa-miR-4327	CLIP-seq
MIRT2059413	hsa-miR-4459	CLIP-seq
MIRT2059414	hsa-miR-4722-5p	CLIP-seq
MIRT2391975	hsa-miR-4763-5p	CLIP-seq
MIRT2059415	hsa-miR-765	CLIP-seq
MIRT2455720	hsa-miR-1285	CLIP-seq
MIRT2455721	hsa-miR-1291	CLIP-seq
MIRT2455722	hsa-miR-3135b	CLIP-seq
MIRT2455723	hsa-miR-3144-5p	CLIP-seq
MIRT2455724	hsa-miR-3173-5p	CLIP-seq
MIRT2455725	hsa-miR-3187-5p	CLIP-seq
MIRT2455726	hsa-miR-3191	CLIP-seq
MIRT2455727	hsa-miR-4300	CLIP-seq
MIRT2287771	hsa-miR-4434	CLIP-seq
MIRT2287773	hsa-miR-4487	CLIP-seq
MIRT2455728	hsa-miR-4493	CLIP-seq
MIRT2287775	hsa-miR-4516	CLIP-seq
MIRT2455729	hsa-miR-4531	CLIP-seq
MIRT2455730	hsa-miR-4652-5p	CLIP-seq
MIRT2455731	hsa-miR-4667-5p	CLIP-seq
MIRT2455732	hsa-miR-4700-5p	CLIP-seq
MIRT2455733	hsa-miR-4731-5p	CLIP-seq
MIRT2455734	hsa-miR-612	CLIP-seq
MIRT2455735	hsa-miR-661	CLIP-seq
MIRT2455736	hsa-miR-920	CLIP-seq
MIRT2455720	hsa-miR-1285	CLIP-seq
MIRT2455721	hsa-miR-1291	CLIP-seq
MIRT2455722	hsa-miR-3135b	CLIP-seq
MIRT2455723	hsa-miR-3144-5p	CLIP-seq
MIRT2455724	hsa-miR-3173-5p	CLIP-seq
MIRT2455725	hsa-miR-3187-5p	CLIP-seq
MIRT2455726	hsa-miR-3191	CLIP-seq
MIRT2455727	hsa-miR-4300	CLIP-seq
MIRT2287771	hsa-miR-4434	CLIP-seq
MIRT2287773	hsa-miR-4487	CLIP-seq
MIRT2455728	hsa-miR-4493	CLIP-seq
MIRT2287775	hsa-miR-4516	CLIP-seq
MIRT2455729	hsa-miR-4531	CLIP-seq
MIRT2455730	hsa-miR-4652-5p	CLIP-seq
MIRT2455731	hsa-miR-4667-5p	CLIP-seq
MIRT2455732	hsa-miR-4700-5p	CLIP-seq
MIRT2455733	hsa-miR-4731-5p	CLIP-seq
MIRT2455734	hsa-miR-612	CLIP-seq
MIRT2455735	hsa-miR-661	CLIP-seq
MIRT2455736	hsa-miR-920	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	21669198
GO:0005654	Component	Nucleoplasm	IDA
GO:0005776	Component	Autophagosome	IDA	21669198
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA	14593528
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA	14593528
GO:0006699	Process	Bile acid biosynthetic process	TAS
GO:0010506	Process	Regulation of autophagy	NAS	21669198
GO:0015248	Function	Sterol transporter activity	IBA	21873635
GO:0015485	Function	Cholesterol binding	IBA	21873635
GO:0015485	Function	Cholesterol binding	IDA	17428193
GO:0015918	Process	Sterol transport	IEA
GO:0016020	Component	Membrane	IBA	21873635
GO:0032934	Function	Sterol binding	IBA	21873635
GO:0043231	Component	Intracellular membrane-bounded organelle	IBA	21873635
GO:0071397	Process	Cellular response to cholesterol	IMP	21669198
GO:0097038	Component	Perinuclear endoplasmic reticulum	IBA	21873635
GO:0097038	Component	Perinuclear endoplasmic reticulum	IDA	14593528
GO:1901800	Process	Positive regulation of proteasomal protein catabolic process	IMP	21669198

Other IDs

• MIM: 606735
• HGNC: 16387
• e!Ensembl: ENSG00000006025

Protein

• UniProt ID: Q9BZF2
• Protein name: Oxysterol-binding protein-related protein 7 (ORP-7) (OSBP-related protein 7)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15409	PH_8	52 → 141	Pleckstrin homology domain	Domain
  PF01237	Oxysterol_BP	478 → 826	Oxysterol-binding protein	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in epithelium of small and large intestines (at protein level). Expressed in stomach, duodenum, jejunum, ascending colon, spleen, thymus, lymph node, trachea and leukocytes. {ECO:0000269|PubMed:14593528}.
• Sequence:

  MDFQERDPPFLPESAQSSKPSSAQQASELWEVVEEPRVRLGTEGVMPERQEGHLLKKRKW
  PLKGWHKRYFVLEDGILHYATTRQDITKGKLHGSIDVRLSVMSINKKAQRIDLDTEDNIY
  HLKIKSQDLFQSWVAQLRAHRLAHRLDMPRGSLPSTAHRKVPGAQLPTAATASALPGLGP
  REKVSSWLRDSDGLDRCSHELSECQGKLQELHRLLQSLESLHRIPSAPVIPTHQASVTTE
  RPKKGKRTSRMWCTQSFAKDDTIGRVGRLHGSVPNLSRYLESRDSSGTRGLPPTDYAHLQ
  RSFWALAQKVHSSLSSVLAALTMERDQLRDMHQGSELSRMGVSEASTGQRRLHSLSTSSD
  TTADSFSSLNPEEQEALYMKGRELTPQLSQTSILSLADSHTEFFDACEVLLSASSSENEG
  SEEEESCTSEITTSLSEEMLDLRGAERCQKGGCVPGRPMGPPRRRCLPAASGPGADVSLW
  NILRNNIGKDLSKVSMPVQLNEPLNTLQRLCEELEYSSLLDQASRIADPCERMVYIAAFA
  VSAYSSTYHRAGCKPFNPVLGETYECERPDRGFRFISEQVSHHPPISACHAESENFAFWQ
  DMKWKNKFWGKSLEIVPVGTVNVSLPRFGDHFEWNKVTSCIHNVLSGQRWIEHYGEVLIR
  NTQDSSCHCKITFCKAKYWSSNVHEVQGAVLSRSGRVLHRLFGKWHEGLYRGPTPGGQCI
  WKPNSMPPDHERNFGFTQFALELNELTAELKRSLPSTDTRLRPDQRYLEEGNIQAAEAQK
  RRIEQLQRDRRKVMEENNIVHQARFFRRQTDSSGKEWWVTNNTYWRLRAEPGYGNMDGAV
  LW

• Sequence length: 842

Pathways

Reactome:

Synthesis of bile acids and bile salts

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs80356663, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs371977235, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	30054458

Unknown
Disease term	Disease name	Evidence	References	Source
Asthma	Asthma			GWAS
Diabetes	Diabetes			GWAS
Eczema	Eczema			GWAS
Dementia	Dementia			GWAS
Prostate cancer	Prostate cancer	Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population.		GWAS, CBGDA
Schizophrenia	Schizophrenia			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Hypercholesterolemia	Associate	36980993