Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	114881
Gene name Gene Name - the full gene name approved by the HGNC.	Oxysterol binding protein like 7
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	OSBPL7
Synonyms (NCBI Gene) Gene synonyms aliases	ORP7
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17q21.32
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like stero

Show/Hide all(83)

miRTarBase ID	miRNA	Experiments	Reference
MIRT002743	hsa-miR-1-3p	Microarray	15685193
MIRT002743	hsa-miR-1-3p	Microarray;Other	15685193
MIRT2059410	hsa-miR-3914	CLIP-seq
MIRT2059411	hsa-miR-3915	CLIP-seq
MIRT2059412	hsa-miR-3928	CLIP-seq
MIRT2059413	hsa-miR-4459	CLIP-seq
MIRT2059414	hsa-miR-4722-5p	CLIP-seq
MIRT2059415	hsa-miR-765	CLIP-seq
MIRT2287764	hsa-miR-1205	CLIP-seq
MIRT2287765	hsa-miR-1321	CLIP-seq
MIRT2287766	hsa-miR-28-5p	CLIP-seq
MIRT2287767	hsa-miR-3139	CLIP-seq
MIRT2287768	hsa-miR-3154	CLIP-seq
MIRT2287769	hsa-miR-3162-5p	CLIP-seq
MIRT2287770	hsa-miR-3179	CLIP-seq
MIRT2059410	hsa-miR-3914	CLIP-seq
MIRT2059411	hsa-miR-3915	CLIP-seq
MIRT2059412	hsa-miR-3928	CLIP-seq
MIRT2287771	hsa-miR-4434	CLIP-seq
MIRT2287772	hsa-miR-4436a	CLIP-seq
MIRT2059413	hsa-miR-4459	CLIP-seq
MIRT2287773	hsa-miR-4487	CLIP-seq
MIRT2287774	hsa-miR-450b-5p	CLIP-seq
MIRT2287775	hsa-miR-4516	CLIP-seq
MIRT2287776	hsa-miR-4713-3p	CLIP-seq
MIRT2059414	hsa-miR-4722-5p	CLIP-seq
MIRT2287777	hsa-miR-4739	CLIP-seq
MIRT2287778	hsa-miR-4756-5p	CLIP-seq
MIRT2287779	hsa-miR-507	CLIP-seq
MIRT2287780	hsa-miR-557	CLIP-seq
MIRT2287781	hsa-miR-665	CLIP-seq
MIRT2287782	hsa-miR-671-5p	CLIP-seq
MIRT2287783	hsa-miR-708	CLIP-seq
MIRT2059415	hsa-miR-765	CLIP-seq
MIRT2391973	hsa-miR-2276	CLIP-seq
MIRT2059410	hsa-miR-3914	CLIP-seq
MIRT2059411	hsa-miR-3915	CLIP-seq
MIRT2059412	hsa-miR-3928	CLIP-seq
MIRT2391974	hsa-miR-4327	CLIP-seq
MIRT2059413	hsa-miR-4459	CLIP-seq
MIRT2059414	hsa-miR-4722-5p	CLIP-seq
MIRT2391975	hsa-miR-4763-5p	CLIP-seq
MIRT2059415	hsa-miR-765	CLIP-seq
MIRT2455720	hsa-miR-1285	CLIP-seq
MIRT2455721	hsa-miR-1291	CLIP-seq
MIRT2455722	hsa-miR-3135b	CLIP-seq
MIRT2455723	hsa-miR-3144-5p	CLIP-seq
MIRT2455724	hsa-miR-3173-5p	CLIP-seq
MIRT2455725	hsa-miR-3187-5p	CLIP-seq
MIRT2455726	hsa-miR-3191	CLIP-seq
MIRT2455727	hsa-miR-4300	CLIP-seq
MIRT2287771	hsa-miR-4434	CLIP-seq
MIRT2287773	hsa-miR-4487	CLIP-seq
MIRT2455728	hsa-miR-4493	CLIP-seq
MIRT2287775	hsa-miR-4516	CLIP-seq
MIRT2455729	hsa-miR-4531	CLIP-seq
MIRT2455730	hsa-miR-4652-5p	CLIP-seq
MIRT2455731	hsa-miR-4667-5p	CLIP-seq
MIRT2455732	hsa-miR-4700-5p	CLIP-seq
MIRT2455733	hsa-miR-4731-5p	CLIP-seq
MIRT2455734	hsa-miR-612	CLIP-seq
MIRT2455735	hsa-miR-661	CLIP-seq
MIRT2455736	hsa-miR-920	CLIP-seq
MIRT2455720	hsa-miR-1285	CLIP-seq
MIRT2455721	hsa-miR-1291	CLIP-seq
MIRT2455722	hsa-miR-3135b	CLIP-seq
MIRT2455723	hsa-miR-3144-5p	CLIP-seq
MIRT2455724	hsa-miR-3173-5p	CLIP-seq
MIRT2455725	hsa-miR-3187-5p	CLIP-seq
MIRT2455726	hsa-miR-3191	CLIP-seq
MIRT2455727	hsa-miR-4300	CLIP-seq
MIRT2287771	hsa-miR-4434	CLIP-seq
MIRT2287773	hsa-miR-4487	CLIP-seq
MIRT2455728	hsa-miR-4493	CLIP-seq
MIRT2287775	hsa-miR-4516	CLIP-seq
MIRT2455729	hsa-miR-4531	CLIP-seq
MIRT2455730	hsa-miR-4652-5p	CLIP-seq
MIRT2455731	hsa-miR-4667-5p	CLIP-seq
MIRT2455732	hsa-miR-4700-5p	CLIP-seq
MIRT2455733	hsa-miR-4731-5p	CLIP-seq
MIRT2455734	hsa-miR-612	CLIP-seq
MIRT2455735	hsa-miR-661	CLIP-seq
MIRT2455736	hsa-miR-920	CLIP-seq

Show/Hide all(31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	21669198
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005776	Component	Autophagosome	IDA	21669198
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA	14593528
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	14593528
GO:0005886	Component	Plasma membrane	IEA
GO:0006699	Process	Bile acid biosynthetic process	IEA
GO:0006699	Process	Bile acid biosynthetic process	TAS
GO:0006869	Process	Lipid transport	IEA
GO:0008289	Function	Lipid binding	IEA
GO:0010506	Process	Regulation of autophagy	NAS	21669198
GO:0015485	Function	Cholesterol binding	IBA
GO:0015485	Function	Cholesterol binding	IDA	17428193
GO:0015918	Process	Sterol transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0031965	Component	Nuclear membrane	IBA
GO:0071397	Process	Cellular response to cholesterol	IMP	21669198
GO:0097038	Component	Perinuclear endoplasmic reticulum	IBA
GO:0097038	Component	Perinuclear endoplasmic reticulum	IDA	14593528
GO:0097038	Component	Perinuclear endoplasmic reticulum	IEA
GO:0120015	Function	Sterol transfer activity	IEA
GO:0120015	Function	Sterol transfer activity	TAS
GO:1901800	Process	Positive regulation of proteasomal protein catabolic process	IMP	21669198

MIM	HGNC	e!Ensembl
606735	16387	ENSG00000006025

Protein

UniProt ID

Q9BZF2

Protein name

Oxysterol-binding protein-related protein 7 (ORP-7) (OSBP-related protein 7)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15409	PH_8	52 → 141	Pleckstrin homology domain	Domain
PF01237	Oxysterol_BP	478 → 826	Oxysterol-binding protein	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in epithelium of small and large intestines (at protein level). Expressed in stomach, duodenum, jejunum, ascending colon, spleen, thymus, lymph node, trachea and leukocytes. {ECO:0000269|PubMed:14593528}.

Sequence

MDFQERDPPFLPESAQSSKPSSAQQASELWEVVEEPRVRLGTEGVMPERQEGHLLKKRKW
PLKGWHKRYFVLEDGILHYATTRQDITKGKLHGSIDVRLSVMSINKKAQRIDLDTEDNIY
HLKIKSQDLFQSWVAQLRAHRLAHRLDMPRGSLPSTAHRKVPGAQLPTAATASALPGLGP
REKVSSWLRDSDGLDRCSHELSECQGKLQELHRLLQSLESLHRIPSAPVIPTHQASVTTE
RPKKGKRTSRMWCTQSFAKDDTIGRVGRLHGSVPNLSRYLESRDSSGTRGLPPTDYAHLQ
RSFWALAQKVHSSLSSVLAALTMERDQLRDMHQGSELSRMGVSEASTGQRRLHSLSTSSD
TTADSFSSLNPEEQEALYMKGRELTPQLSQTSILSLADSHTEFFDACEVLLSASSSENEG
SEEEESCTSEITTSLSEEMLDLRGAERCQKGGCVPGRPMGPPRRRCLPAASGPGADVSLW
NILRNNIGKDLSKVSMPVQLNEPLNTLQRLCEELEYSSLLDQASRIADPCERMVYIAAFA
VSAYSSTYHRAGCKPFNPVLGETYECERPDRGFRFISEQVSHHPPISACHAESENFAFWQ
DMKWKNKFWGKSLEIVPVGTVNVSLPRFGDHFEWNKVTSCIHNVLSGQRWIEHYGEVLIR
NTQDSSCHCKITFCKAKYWSSNVHEVQGAVLSRSGRVLHRLFGKWHEGLYRGPTPGGQCI
WKPNSMPPDHERNFGFTQFALELNELTAELKRSLPSTDTRLRPDQRYLEEGNIQAAEAQK
RRIEQLQRDRRKVMEENNIVHQARFFRRQTDSSGKEWWVTNNTYWRLRAEPGYGNMDGAV
LW

Sequence length

842

Interactions

View interactions

	Reactome
			Synthesis of bile acids and bile salts

Show/Hide Unknown Diseases (7)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Asthma	Asthma, Asthma in any disease	N/A	N/A	GWAS
Dementia	Dementia	N/A	N/A	GWAS
Diabetes	Type 2 diabetes, Type 2 diabetes or prostate cancer (pleiotropy)	N/A	N/A	GWAS
Eczema	Eczema	N/A	N/A	GWAS
Encephalopathy	Encephalopathy, lethal, due to defective mitochondrial peroxisomal fission 1	N/A	N/A	ClinVar
Prostate cancer	Prostate cancer	N/A	N/A	GWAS
Schizophrenia	Schizophrenia	N/A	N/A	GWAS

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Hypercholesterolemia	Associate	36980993

OSBPL7 (oxysterol binding protein like 7)