Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
114826
Gene name Gene Name - the full gene name approved by the HGNC.
SET and MYND domain containing 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SMYD4
Synonyms (NCBI Gene) Gene synonyms aliases
ZMYND21
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17p13.3
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT037610 hsa-miR-744-5p CLASH 23622248
MIRT664253 hsa-miR-6796-3p HITS-CLIP 23824327
MIRT664252 hsa-miR-6890-3p HITS-CLIP 23824327
MIRT664251 hsa-miR-6741-3p HITS-CLIP 23824327
MIRT664250 hsa-miR-1304-3p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0008168 Function Methyltransferase activity IEA
GO:0032259 Process Methylation IEA
GO:0046872 Function Metal ion binding IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
619134 21067 ENSG00000186532
Protein
UniProt ID Q8IYR2
Protein name Protein-lysine N-methyltransferase SMYD4 (EC 2.1.1.-) (SET and MYND domain-containing protein 4)
Protein function Protein-lysine N-methyltransferase. Monomethylates PRMT5, modulating its transcriptional activity (PubMed:38438251). May also act as a histone methyltransferase (By similarity). Plays a critical role in cardiac development. Acts as a key epigene
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00856 SET 244 574 SET domain Family
PF01753 zf-MYND 296 335 MYND finger Domain
Sequence
MDLPVDEWKSYLLQKWASLPTSVQVTISTAETLRDIFLHSSSLLQPEDELFLKRLSKGYL
VGKDSDAPLFYREEGNKKFQEKDYTGAAVLYSKGVSHSRPNTEDMSLCHANRSAALFHLG
QYETCLKDINRAQTHGYPERLQPKIMLRKAECLVALGRLQEASQTISDLERNFTATPALA
DVLPQTLQRNLHRLKMKMQEKDSLTESFPAALAKTLEDAALREENEQLSNASSSIGLCVD
PLKGRCLVATKDILPGELLVQEDAFVSVLNPGELPPPHHGLDSKWDTRVTNGDLYCHRCL
KHTLATVPCDGCSYAKYCSQECLQQAWELYHRTEC
PLGGLLLTLGVFCHIALRLTLLVGF
EDVRKIITKLCDKISNKDICLPESNNQVKTLNYGLGESEKNGNIVETPIPGCDINGKYEN
NYNAVFNLLPHTENHSPEHKFLCALCVSALCRQLEAASLQAIPTERIVNSSQLKAAVTPE
LCPDVTIWGVAMLRHMLQLQCNAQAMTTIQHTGPKGSIVTDSRQVRLATGIFPVISLLNH
SCSPNTSVSFISTVATIRASQRIRKGQEILHCYG
PHKSRMGVAERQQKLRSQYFFDCACP
ACQTEAHRMAAGPRWEAFCCNSCGAPMQGDDVLRCGSRSCAESAVSRDHLVSRLQDLQQQ
VRVAQKLLRDGELERAVQRLSGCQRDAESFLWAEHAVVGEIADGLARACAALGDWQKSAT
HLQRSLYVVEVRHGPSSVEMGHELFKLAQIFFNGFAVPEALSTIQKAEEVLSLHCGPWDD
EIQELQKMKSCLLDLPPTPVGPAL
Sequence length 804
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Medulloblastoma Medulloblastoma, Childhood Medulloblastoma, Adult Medulloblastoma, Desmoplastic Medulloblastoma, Melanotic medulloblastoma rs1589970134, rs587776578, rs587776579, rs17847577, rs111033171, rs80359604, rs80358785, rs80358814, rs863224925, rs1555950011, rs1554231278, rs926177767, rs759412460, rs1564032829, rs761911009 19270706