PWWP2A (PWWP domain containing 2A)

Gene

• Entrez ID: 114825
• Gene name: PWWP domain containing 2A
• Gene symbol: PWWP2A
• Synonyms (NCBI Gene): MST101
• Chromosome: 5
• Chromosome location: 5q33.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT039973	hsa-miR-615-3p	CLASH	23622248
MIRT036570	hsa-miR-941	CLASH	23622248
MIRT641969	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT641968	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT641966	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT641967	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT641965	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT641964	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT641963	hsa-miR-7641	HITS-CLIP	23824327
MIRT641962	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT439850	hsa-miR-493-5p	HITS-CLIP	24374217
MIRT439850	hsa-miR-493-5p	HITS-CLIP	24374217
MIRT641969	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT641968	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT641966	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT641967	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT641965	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT641964	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT641963	hsa-miR-7641	HITS-CLIP	23824327
MIRT641962	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT1278678	hsa-miR-1323	CLIP-seq
MIRT1278679	hsa-miR-200b	CLIP-seq
MIRT1278680	hsa-miR-200c	CLIP-seq
MIRT1278681	hsa-miR-34b	CLIP-seq
MIRT1278682	hsa-miR-34c-3p	CLIP-seq
MIRT1278683	hsa-miR-3908	CLIP-seq
MIRT1278684	hsa-miR-3942-5p	CLIP-seq
MIRT1278685	hsa-miR-429	CLIP-seq
MIRT1278686	hsa-miR-4477a	CLIP-seq
MIRT1278687	hsa-miR-4699-3p	CLIP-seq
MIRT1278688	hsa-miR-4703-5p	CLIP-seq
MIRT1278689	hsa-miR-4705	CLIP-seq
MIRT1278690	hsa-miR-4766-3p	CLIP-seq
MIRT1278691	hsa-miR-488	CLIP-seq
MIRT1278692	hsa-miR-520d-5p	CLIP-seq
MIRT1278693	hsa-miR-524-5p	CLIP-seq
MIRT1278694	hsa-miR-548a-3p	CLIP-seq
MIRT1278695	hsa-miR-548e	CLIP-seq
MIRT1278696	hsa-miR-548f	CLIP-seq
MIRT1278697	hsa-miR-548l	CLIP-seq
MIRT1278698	hsa-miR-548o	CLIP-seq
MIRT1278699	hsa-miR-605	CLIP-seq
MIRT1278700	hsa-miR-1200	CLIP-seq
MIRT1278701	hsa-miR-1237	CLIP-seq
MIRT1278702	hsa-miR-1283	CLIP-seq
MIRT1278703	hsa-miR-129-5p	CLIP-seq
MIRT1278704	hsa-miR-1297	CLIP-seq
MIRT1278705	hsa-miR-137	CLIP-seq
MIRT1278706	hsa-miR-2053	CLIP-seq
MIRT1278707	hsa-miR-2116	CLIP-seq
MIRT1278708	hsa-miR-223	CLIP-seq
MIRT1278709	hsa-miR-23a	CLIP-seq
MIRT1278710	hsa-miR-23b	CLIP-seq
MIRT1278711	hsa-miR-23c	CLIP-seq
MIRT1278712	hsa-miR-25	CLIP-seq
MIRT1278713	hsa-miR-26a	CLIP-seq
MIRT1278714	hsa-miR-26b	CLIP-seq
MIRT1278715	hsa-miR-28-3p	CLIP-seq
MIRT1278716	hsa-miR-3064-3p	CLIP-seq
MIRT1278717	hsa-miR-3074-5p	CLIP-seq
MIRT1278718	hsa-miR-3133	CLIP-seq
MIRT1278719	hsa-miR-3161	CLIP-seq
MIRT1278720	hsa-miR-3163	CLIP-seq
MIRT1278721	hsa-miR-3174	CLIP-seq
MIRT1278722	hsa-miR-3182	CLIP-seq
MIRT1278723	hsa-miR-32	CLIP-seq
MIRT1278724	hsa-miR-3200-5p	CLIP-seq
MIRT1278725	hsa-miR-3545-3p	CLIP-seq
MIRT1278726	hsa-miR-3618	CLIP-seq
MIRT1278727	hsa-miR-363	CLIP-seq
MIRT1278728	hsa-miR-367	CLIP-seq
MIRT1278729	hsa-miR-3677-5p	CLIP-seq
MIRT1278730	hsa-miR-3688-5p	CLIP-seq
MIRT1278731	hsa-miR-380	CLIP-seq
MIRT1278732	hsa-miR-3923	CLIP-seq
MIRT1278733	hsa-miR-410	CLIP-seq
MIRT1278734	hsa-miR-4252	CLIP-seq
MIRT1278735	hsa-miR-4282	CLIP-seq
MIRT1278736	hsa-miR-4302	CLIP-seq
MIRT1278737	hsa-miR-4324	CLIP-seq
MIRT1278738	hsa-miR-4326	CLIP-seq
MIRT1278739	hsa-miR-4436b-5p	CLIP-seq
MIRT1278740	hsa-miR-4465	CLIP-seq
MIRT1278741	hsa-miR-4470	CLIP-seq
MIRT1278742	hsa-miR-4499	CLIP-seq
MIRT1278743	hsa-miR-4511	CLIP-seq
MIRT1278744	hsa-miR-4513	CLIP-seq
MIRT1278745	hsa-miR-4646-3p	CLIP-seq
MIRT1278746	hsa-miR-4652-3p	CLIP-seq
MIRT1278747	hsa-miR-4659a-3p	CLIP-seq
MIRT1278748	hsa-miR-4659b-3p	CLIP-seq
MIRT1278749	hsa-miR-4670-3p	CLIP-seq
MIRT1278750	hsa-miR-4693-5p	CLIP-seq
MIRT1278751	hsa-miR-4697-3p	CLIP-seq
MIRT1278752	hsa-miR-4698	CLIP-seq
MIRT1278753	hsa-miR-4715-3p	CLIP-seq
MIRT1278754	hsa-miR-4722-3p	CLIP-seq
MIRT1278755	hsa-miR-4766-5p	CLIP-seq
MIRT1278691	hsa-miR-488	CLIP-seq
MIRT1278756	hsa-miR-500a	CLIP-seq
MIRT1278757	hsa-miR-544b	CLIP-seq
MIRT1278758	hsa-miR-548aa	CLIP-seq
MIRT1278759	hsa-miR-548ae	CLIP-seq
MIRT1278760	hsa-miR-548ag	CLIP-seq
MIRT1278761	hsa-miR-548ai	CLIP-seq
MIRT1278762	hsa-miR-548aj	CLIP-seq
MIRT1278763	hsa-miR-548am	CLIP-seq
MIRT1278764	hsa-miR-548b-3p	CLIP-seq
MIRT1278765	hsa-miR-548m	CLIP-seq
MIRT1278766	hsa-miR-548x	CLIP-seq
MIRT1278767	hsa-miR-569	CLIP-seq
MIRT1278768	hsa-miR-577	CLIP-seq
MIRT1278769	hsa-miR-627	CLIP-seq
MIRT1278770	hsa-miR-661	CLIP-seq
MIRT1278771	hsa-miR-92a	CLIP-seq
MIRT1278772	hsa-miR-92b	CLIP-seq
MIRT2082147	hsa-miR-3941	CLIP-seq
MIRT2082148	hsa-miR-3942-3p	CLIP-seq
MIRT2082149	hsa-miR-4275	CLIP-seq
MIRT2082150	hsa-miR-466	CLIP-seq
MIRT2082151	hsa-miR-4672	CLIP-seq
MIRT2082152	hsa-miR-4731-3p	CLIP-seq
MIRT2082153	hsa-miR-4801	CLIP-seq
MIRT2307809	hsa-miR-1252	CLIP-seq
MIRT2307810	hsa-miR-1298	CLIP-seq
MIRT2307811	hsa-miR-151-3p	CLIP-seq
MIRT2307812	hsa-miR-1910	CLIP-seq
MIRT2307813	hsa-miR-2117	CLIP-seq
MIRT2307814	hsa-miR-3145-5p	CLIP-seq
MIRT2307815	hsa-miR-3194-3p	CLIP-seq
MIRT2307816	hsa-miR-3691-3p	CLIP-seq
MIRT1278733	hsa-miR-410	CLIP-seq
MIRT2307817	hsa-miR-4261	CLIP-seq
MIRT2307818	hsa-miR-4273	CLIP-seq
MIRT1278735	hsa-miR-4282	CLIP-seq
MIRT2307819	hsa-miR-4289	CLIP-seq
MIRT2307820	hsa-miR-4299	CLIP-seq
MIRT1278736	hsa-miR-4302	CLIP-seq
MIRT2307821	hsa-miR-4456	CLIP-seq
MIRT2307822	hsa-miR-4463	CLIP-seq
MIRT2307823	hsa-miR-4496	CLIP-seq
MIRT1278742	hsa-miR-4499	CLIP-seq
MIRT2307824	hsa-miR-4501	CLIP-seq
MIRT2307825	hsa-miR-455-3p	CLIP-seq
MIRT2307826	hsa-miR-4635	CLIP-seq
MIRT2307827	hsa-miR-4642	CLIP-seq
MIRT1278747	hsa-miR-4659a-3p	CLIP-seq
MIRT1278748	hsa-miR-4659b-3p	CLIP-seq
MIRT2307828	hsa-miR-4694-5p	CLIP-seq
MIRT1278751	hsa-miR-4697-3p	CLIP-seq
MIRT2307829	hsa-miR-494	CLIP-seq
MIRT2307830	hsa-miR-548q	CLIP-seq
MIRT2307831	hsa-miR-587	CLIP-seq
MIRT2307832	hsa-miR-592	CLIP-seq
MIRT2307833	hsa-miR-597	CLIP-seq
MIRT2307834	hsa-miR-616	CLIP-seq
MIRT2307809	hsa-miR-1252	CLIP-seq
MIRT2393279	hsa-miR-193a-3p	CLIP-seq
MIRT2393280	hsa-miR-193b	CLIP-seq
MIRT2307817	hsa-miR-4261	CLIP-seq
MIRT2307823	hsa-miR-4496	CLIP-seq
MIRT2307826	hsa-miR-4635	CLIP-seq
MIRT2307829	hsa-miR-494	CLIP-seq
MIRT2393281	hsa-miR-892b	CLIP-seq
MIRT2307809	hsa-miR-1252	CLIP-seq
MIRT1278704	hsa-miR-1297	CLIP-seq
MIRT2605104	hsa-miR-134	CLIP-seq
MIRT1278707	hsa-miR-2116	CLIP-seq
MIRT1278708	hsa-miR-223	CLIP-seq
MIRT1278713	hsa-miR-26a	CLIP-seq
MIRT1278714	hsa-miR-26b	CLIP-seq
MIRT2605105	hsa-miR-3118	CLIP-seq
MIRT1278720	hsa-miR-3163	CLIP-seq
MIRT2605106	hsa-miR-3164	CLIP-seq
MIRT1278721	hsa-miR-3174	CLIP-seq
MIRT1278733	hsa-miR-410	CLIP-seq
MIRT2307817	hsa-miR-4261	CLIP-seq
MIRT1278735	hsa-miR-4282	CLIP-seq
MIRT1278736	hsa-miR-4302	CLIP-seq
MIRT1278740	hsa-miR-4465	CLIP-seq
MIRT2307823	hsa-miR-4496	CLIP-seq
MIRT2307824	hsa-miR-4501	CLIP-seq
MIRT2307826	hsa-miR-4635	CLIP-seq
MIRT2307827	hsa-miR-4642	CLIP-seq
MIRT1278747	hsa-miR-4659a-3p	CLIP-seq
MIRT1278748	hsa-miR-4659b-3p	CLIP-seq
MIRT1278751	hsa-miR-4697-3p	CLIP-seq
MIRT2307829	hsa-miR-494	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001178	Process	Regulation of transcriptional start site selection at RNA polymerase II promoter	IEA
GO:0001178	Process	Regulation of transcriptional start site selection at RNA polymerase II promoter	ISS
GO:0003682	Function	Chromatin binding	IBA
GO:0003682	Function	Chromatin binding	IDA	28645917
GO:0005515	Function	Protein binding	IPI	23752268, 26496610, 30021884, 30228260, 30327463, 32296183, 33961781, 35271311
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	28645917
GO:0005634	Component	Nucleus	IEA
GO:0006338	Process	Chromatin remodeling	IEA
GO:0006338	Process	Chromatin remodeling	IMP	30327463
GO:0006338	Process	Chromatin remodeling	ISS
GO:0032968	Process	Positive regulation of transcription elongation by RNA polymerase II	IEA
GO:0032968	Process	Positive regulation of transcription elongation by RNA polymerase II	ISS
GO:0042393	Function	Histone binding	IBA
GO:0042393	Function	Histone binding	IPI	28645917
GO:0120325	Function	NuRD complex binding	IDA	30228260, 30327463
GO:0120325	Function	NuRD complex binding	IEA
GO:0140003	Function	Histone H3K36me3 reader activity	IDA	30327463

Other IDs

• MIM: 617823
• HGNC: 29406
• e!Ensembl: ENSG00000170234

Protein

• UniProt ID: Q96N64
• Protein name: PWWP domain-containing protein 2A
• Protein function: Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (Pu
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00855	PWWP	653 → 743	PWWP domain	Domain

• Sequence:

  MAAVAAEAAATAASPGEGGAGEAEPEMEPIPGSEAGTDPLPVTATEASVPDGETDGQQSA
  PQADEPPLPPPPPPPGELARSPEAVGPELEAEEKLSVRVAESAAAAPQGGPELPPSPASP
  PEQPPAPEEREEPPLPQPVAPALVPPAGGDSTVSQLIPGSEVRVTLDHIIEDALVVSFRF
  GEKLFSGVLMDLSKRFGPHGIPVTVFPKREYKDKPEAMPLQSNTFQEGTEVKCEANGAVP
  DDPSPVPHPELSLAESLWTSKPPPLFHEGAPYPPPLFIRDTYNQSIPQPPPRKIKRPKRK
  MYREEPTSIMNAIKLRPRQVLCDKCKNSVVAEKKEIRKGSSATDSSKYEDKKRRNESVTT
  VNKKLKTDHKVDGKNQNESQKRNAVVKVSNIAHSRGRVVKVSAQANTSKAQLSTKKVLQS
  KNMDHAKAREVLKIAKEKAQKKQNETSTSKNAHSKVHFTRRYQNPSSGSLPPRVRLKPQR
  YRNEENDSSLKTGLEKMRSGKMAPKPQSRCTSTRSAGEAPSENQSPSKGPEEASSEVQDT
  NEVHVPGDQDEPQTLGKKGSKNNISVYMTLNQKKSDSSSASVCSIDSTDDLKSSNSECSS
  SESFDFPPGSMHAPSTSSTSSSSKEEKKLSNSLKMKVFSKNVSKCVTPDGRTICVGDIVW
  AKIYGFPWWPARILTITVSRKDNGLLVRQEARISWFGSPTTSFLALSQLSPFLENFQSRF
  NKKRKGLYRKAITEAAKAAKQLTPEVRALLTQFET

• Sequence length: 755

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
FATTY LIVER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Diabetic Retinopathy	Associate	37681455	★☆☆☆☆ Found in Text Mining only
Nevus Epithelioid and Spindle Cell	Associate	32862201	★☆☆☆☆ Found in Text Mining only