RHPN1 (rhophilin Rho GTPase binding protein 1)

Gene

• Entrez ID: 114822
• Gene name: Rhophilin Rho GTPase binding protein 1
• Gene symbol: RHPN1
• Synonyms (NCBI Gene): ODF5, RHOPHILIN, RHPN
• Chromosome: 8
• Chromosome location: 8q24.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT040941	hsa-miR-18a-3p	CLASH	23622248
MIRT1306179	hsa-miR-10a	CLIP-seq
MIRT1306180	hsa-miR-10b	CLIP-seq
MIRT1306181	hsa-miR-1182	CLIP-seq
MIRT1306182	hsa-miR-1233	CLIP-seq
MIRT1306183	hsa-miR-1237	CLIP-seq
MIRT1306184	hsa-miR-1248	CLIP-seq
MIRT1306185	hsa-miR-1266	CLIP-seq
MIRT1306186	hsa-miR-1273e	CLIP-seq
MIRT1306187	hsa-miR-1285	CLIP-seq
MIRT1306188	hsa-miR-1290	CLIP-seq
MIRT1306189	hsa-miR-1294	CLIP-seq
MIRT1306190	hsa-miR-1343	CLIP-seq
MIRT1306191	hsa-miR-15a	CLIP-seq
MIRT1306192	hsa-miR-15b	CLIP-seq
MIRT1306193	hsa-miR-16	CLIP-seq
MIRT1306194	hsa-miR-1827	CLIP-seq
MIRT1306195	hsa-miR-1909	CLIP-seq
MIRT1306196	hsa-miR-1915	CLIP-seq
MIRT1306197	hsa-miR-195	CLIP-seq
MIRT1306198	hsa-miR-214	CLIP-seq
MIRT1306199	hsa-miR-2277-3p	CLIP-seq
MIRT1306200	hsa-miR-28-5p	CLIP-seq
MIRT1306201	hsa-miR-3126-5p	CLIP-seq
MIRT1306202	hsa-miR-3135b	CLIP-seq
MIRT1306203	hsa-miR-3136-3p	CLIP-seq
MIRT1306204	hsa-miR-3138	CLIP-seq
MIRT1306205	hsa-miR-3139	CLIP-seq
MIRT1306206	hsa-miR-3150a-3p	CLIP-seq
MIRT1306207	hsa-miR-3150b-3p	CLIP-seq
MIRT1306208	hsa-miR-3151	CLIP-seq
MIRT1306209	hsa-miR-3173-3p	CLIP-seq
MIRT1306210	hsa-miR-3175	CLIP-seq
MIRT1306211	hsa-miR-3182	CLIP-seq
MIRT1306212	hsa-miR-3187-5p	CLIP-seq
MIRT1306213	hsa-miR-3197	CLIP-seq
MIRT1306214	hsa-miR-3199	CLIP-seq
MIRT1306215	hsa-miR-331-3p	CLIP-seq
MIRT1306216	hsa-miR-338-3p	CLIP-seq
MIRT1306217	hsa-miR-3619-5p	CLIP-seq
MIRT1306218	hsa-miR-3620	CLIP-seq
MIRT1306219	hsa-miR-3660	CLIP-seq
MIRT1306220	hsa-miR-3663-3p	CLIP-seq
MIRT1306221	hsa-miR-3665	CLIP-seq
MIRT1306222	hsa-miR-3672	CLIP-seq
MIRT1306223	hsa-miR-3940-3p	CLIP-seq
MIRT1306224	hsa-miR-3940-5p	CLIP-seq
MIRT1306225	hsa-miR-424	CLIP-seq
MIRT1306226	hsa-miR-4316	CLIP-seq
MIRT1306227	hsa-miR-4323	CLIP-seq
MIRT1306228	hsa-miR-4329	CLIP-seq
MIRT1306229	hsa-miR-4428	CLIP-seq
MIRT1306230	hsa-miR-4436b-3p	CLIP-seq
MIRT1306231	hsa-miR-4446-3p	CLIP-seq
MIRT1306232	hsa-miR-4470	CLIP-seq
MIRT1306233	hsa-miR-4487	CLIP-seq
MIRT1306234	hsa-miR-4492	CLIP-seq
MIRT1306235	hsa-miR-4498	CLIP-seq
MIRT1306236	hsa-miR-4505	CLIP-seq
MIRT1306237	hsa-miR-4506	CLIP-seq
MIRT1306238	hsa-miR-4507	CLIP-seq
MIRT1306239	hsa-miR-4514	CLIP-seq
MIRT1306240	hsa-miR-4515	CLIP-seq
MIRT1306241	hsa-miR-4518	CLIP-seq
MIRT1306242	hsa-miR-4520a-3p	CLIP-seq
MIRT1306243	hsa-miR-4526	CLIP-seq
MIRT1306244	hsa-miR-4530	CLIP-seq
MIRT1306245	hsa-miR-4532	CLIP-seq
MIRT1306246	hsa-miR-4642	CLIP-seq
MIRT1306247	hsa-miR-4645-5p	CLIP-seq
MIRT1306248	hsa-miR-4663	CLIP-seq
MIRT1306249	hsa-miR-4667-5p	CLIP-seq
MIRT1306250	hsa-miR-4673	CLIP-seq
MIRT1306251	hsa-miR-4677-3p	CLIP-seq
MIRT1306252	hsa-miR-4685-5p	CLIP-seq
MIRT1306253	hsa-miR-4687-3p	CLIP-seq
MIRT1306254	hsa-miR-4687-5p	CLIP-seq
MIRT1306255	hsa-miR-4689	CLIP-seq
MIRT1306256	hsa-miR-4690-5p	CLIP-seq
MIRT1306257	hsa-miR-4692	CLIP-seq
MIRT1306258	hsa-miR-4700-5p	CLIP-seq
MIRT1306259	hsa-miR-4720-5p	CLIP-seq
MIRT1306260	hsa-miR-4721	CLIP-seq
MIRT1306261	hsa-miR-4728-5p	CLIP-seq
MIRT1306262	hsa-miR-4731-5p	CLIP-seq
MIRT1306263	hsa-miR-4733-3p	CLIP-seq
MIRT1306264	hsa-miR-4736	CLIP-seq
MIRT1306265	hsa-miR-4784	CLIP-seq
MIRT1306266	hsa-miR-4786-5p	CLIP-seq
MIRT1306267	hsa-miR-4787-5p	CLIP-seq
MIRT1306268	hsa-miR-4799-3p	CLIP-seq
MIRT1306269	hsa-miR-486-3p	CLIP-seq
MIRT1306270	hsa-miR-497	CLIP-seq
MIRT1306271	hsa-miR-563	CLIP-seq
MIRT1306272	hsa-miR-612	CLIP-seq
MIRT1306273	hsa-miR-634	CLIP-seq
MIRT1306274	hsa-miR-665	CLIP-seq
MIRT1306275	hsa-miR-708	CLIP-seq
MIRT1306276	hsa-miR-761	CLIP-seq
MIRT1306277	hsa-miR-762	CLIP-seq
MIRT1306278	hsa-miR-764	CLIP-seq
MIRT1306279	hsa-miR-766	CLIP-seq
MIRT1306280	hsa-miR-769-5p	CLIP-seq
MIRT1306281	hsa-miR-939	CLIP-seq
MIRT1306282	hsa-miR-940	CLIP-seq
MIRT2090735	hsa-miR-1207-5p	CLIP-seq
MIRT1306195	hsa-miR-1909	CLIP-seq
MIRT1306198	hsa-miR-214	CLIP-seq
MIRT1306202	hsa-miR-3135b	CLIP-seq
MIRT1306213	hsa-miR-3197	CLIP-seq
MIRT2090736	hsa-miR-3616-3p	CLIP-seq
MIRT1306217	hsa-miR-3619-5p	CLIP-seq
MIRT2090737	hsa-miR-4327	CLIP-seq
MIRT1306230	hsa-miR-4436b-3p	CLIP-seq
MIRT1306231	hsa-miR-4446-3p	CLIP-seq
MIRT1306233	hsa-miR-4487	CLIP-seq
MIRT1306252	hsa-miR-4685-5p	CLIP-seq
MIRT2090738	hsa-miR-4763-3p	CLIP-seq
MIRT2090739	hsa-miR-636	CLIP-seq
MIRT1306276	hsa-miR-761	CLIP-seq
MIRT1306181	hsa-miR-1182	CLIP-seq
MIRT2090735	hsa-miR-1207-5p	CLIP-seq
MIRT1306185	hsa-miR-1266	CLIP-seq
MIRT2315396	hsa-miR-1272	CLIP-seq
MIRT2315397	hsa-miR-1286	CLIP-seq
MIRT2315398	hsa-miR-1296	CLIP-seq
MIRT1306191	hsa-miR-15a	CLIP-seq
MIRT1306192	hsa-miR-15b	CLIP-seq
MIRT1306193	hsa-miR-16	CLIP-seq
MIRT1306194	hsa-miR-1827	CLIP-seq
MIRT1306196	hsa-miR-1915	CLIP-seq
MIRT1306197	hsa-miR-195	CLIP-seq
MIRT1306198	hsa-miR-214	CLIP-seq
MIRT2315399	hsa-miR-2278	CLIP-seq
MIRT2315400	hsa-miR-2909	CLIP-seq
MIRT2315401	hsa-miR-3120-3p	CLIP-seq
MIRT1306204	hsa-miR-3138	CLIP-seq
MIRT1306206	hsa-miR-3150a-3p	CLIP-seq
MIRT2315402	hsa-miR-3169	CLIP-seq
MIRT1306210	hsa-miR-3175	CLIP-seq
MIRT1306213	hsa-miR-3197	CLIP-seq
MIRT1306216	hsa-miR-338-3p	CLIP-seq
MIRT2315403	hsa-miR-34b	CLIP-seq
MIRT1306217	hsa-miR-3619-5p	CLIP-seq
MIRT1306225	hsa-miR-424	CLIP-seq
MIRT2315404	hsa-miR-4436a	CLIP-seq
MIRT1306230	hsa-miR-4436b-3p	CLIP-seq
MIRT1306231	hsa-miR-4446-3p	CLIP-seq
MIRT1306234	hsa-miR-4492	CLIP-seq
MIRT1306235	hsa-miR-4498	CLIP-seq
MIRT2315405	hsa-miR-4512	CLIP-seq
MIRT1306241	hsa-miR-4518	CLIP-seq
MIRT1306242	hsa-miR-4520a-3p	CLIP-seq
MIRT1306244	hsa-miR-4530	CLIP-seq
MIRT2315406	hsa-miR-4641	CLIP-seq
MIRT1306249	hsa-miR-4667-5p	CLIP-seq
MIRT1306252	hsa-miR-4685-5p	CLIP-seq
MIRT1306258	hsa-miR-4700-5p	CLIP-seq
MIRT2315407	hsa-miR-4708-3p	CLIP-seq
MIRT1306262	hsa-miR-4731-5p	CLIP-seq
MIRT1306264	hsa-miR-4736	CLIP-seq
MIRT2090738	hsa-miR-4763-3p	CLIP-seq
MIRT1306266	hsa-miR-4786-5p	CLIP-seq
MIRT1306269	hsa-miR-486-3p	CLIP-seq
MIRT1306270	hsa-miR-497	CLIP-seq
MIRT1306271	hsa-miR-563	CLIP-seq
MIRT1306273	hsa-miR-634	CLIP-seq
MIRT2315408	hsa-miR-647	CLIP-seq
MIRT1306276	hsa-miR-761	CLIP-seq
MIRT1306277	hsa-miR-762	CLIP-seq
MIRT1306279	hsa-miR-766	CLIP-seq
MIRT1306280	hsa-miR-769-5p	CLIP-seq
MIRT1306281	hsa-miR-939	CLIP-seq
MIRT1306282	hsa-miR-940	CLIP-seq
MIRT1306195	hsa-miR-1909	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 28514442, 31515488, 32296183, 32814053, 33961781
GO:0005829	Component	Cytosol	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0051497	Process	Negative regulation of stress fiber assembly	IBA

Other IDs

• MIM: 601031
• HGNC: 19973
• e!Ensembl: ENSG00000158106

Protein

• UniProt ID: Q8TCX5
• Protein name: Rhophilin-1 (GTP-Rho-binding protein 1)
• Protein function: Has no enzymatic activity. May serve as a target for Rho, and interact with some cytoskeletal component upon Rho binding or relay a Rho signal to other molecules.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02185	HR1	36 → 97	Hr1 repeat	Family
  PF03097	BRO1	109 → 510	BRO1-like domain	Domain
  PF00595	PDZ	513 → 590	PDZ domain	Domain

• Sequence:

  MILEERPDGAGAGEESPRLQGCDSLTQIQCGQLQSRRAQIHQQIDKELQMRTGAENLYRA
  TSNNRVRETVALELSYVNSNLQLLKEELEELSGGVDPGRHGSEAVTVPMIPLGLKETKEL
  DWSTPLKELISVHFGEDGASYEAEIRELEALRQAMRTPSRNESGLELLTAYYNQLCFLDA
  RFLTPARSLGLFFHWYDSLTGVPAQQRALAFEKGSVLFNIGALHTQIGARQDRSCTEGAR
  RAMEAFQRAAGAFSLLRENFSHAPSPDMSAASLCALEQLMMAQAQECVFEGLSPPASMAP
  QDCLAQLRLAQEAAQVAAEYRLVHRTMAQPPVHDYVPVSWTALVHVKAEYFRSLAHYHVA
  MALCDGSPATEGELPTHEQVFLQPPTSSKPRGPVLPQELEERRQLGKAHLKRAILGQEEA
  LRLHALCRVLREVDLLRAVISQTLQRSLAKYAELDREDDFCEAAEAPDIQPKTHQKPEAR
  MPRLSQGKGPDIFHRLGPLSVFSAKNRWRLVGPVHLTRGEGGFGLTLRGDSPVLIAAVIP
  GSQAAAAGLKEGDYIVSVNGQPCRWWRHAEVVTELKAAGEAGASLQVVSLLPSSRLPSLG
  DRRPVLLGPRGLLRSQREHGCKTPASTWASPRPLLNWSRKAQQGKTGGCPQPCAPVKPAP
  PSSLKHPGWP

• Sequence length: 670

Pathways

Reactome:

RHO GTPases Activate Rhotekin and Rhophilins

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Uterine corpus endometrial carcinoma	Uncertain significance	rs766683293	RCV005930910

Associations from Text Mining
Disease Name	Relationship Type	References
Adenocarcinoma of Lung	Associate	30896819
Breast Neoplasms	Associate	31285391
Carcinoma Hepatocellular	Associate	32910747, 34095306, 37478241
Carcinoma Ovarian Epithelial	Associate	32163372
Lymphatic Metastasis	Associate	32910747
Lymphatic Metastasis	Stimulate	39233606
Neoplasm Metastasis	Associate	32163372, 39233606
Neoplasms	Associate	31285391, 39233606
Ovarian Diseases	Associate	33907841, 34414458
Ovarian Neoplasms	Associate	32163372, 33907841, 34414458
Pancreatic Neoplasms	Associate	31285391
Precancerous Conditions	Associate	33019382
Prostatic Neoplasms	Associate	32953881
Retinoblastoma	Associate	33426053
Stomach Neoplasms	Stimulate	31982726
Urinary Bladder Neoplasms	Associate	39233606
Uveal melanoma	Associate	28124977