Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	114815
Gene name	Sortilin related VPS10 domain containing receptor 1
Gene symbol	SORCS1
Synonyms (NCBI Gene)	hSorCS
Chromosome	10
Chromosome location	10q25.1
Summary	This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many e

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miRTarBase ID	miRNA	Experiments	Reference
MIRT622145	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT622145	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT1379523	hsa-miR-1253	CLIP-seq
MIRT1379524	hsa-miR-1290	CLIP-seq
MIRT1379525	hsa-miR-1303	CLIP-seq
MIRT1379526	hsa-miR-193a-3p	CLIP-seq
MIRT1379527	hsa-miR-193b	CLIP-seq
MIRT1379528	hsa-miR-194	CLIP-seq
MIRT1379529	hsa-miR-3120-3p	CLIP-seq
MIRT1379530	hsa-miR-3148	CLIP-seq
MIRT1379531	hsa-miR-3173-3p	CLIP-seq
MIRT1379532	hsa-miR-3185	CLIP-seq
MIRT1379533	hsa-miR-361-5p	CLIP-seq
MIRT1379534	hsa-miR-383	CLIP-seq
MIRT1379535	hsa-miR-3919	CLIP-seq
MIRT1379536	hsa-miR-3929	CLIP-seq
MIRT1379537	hsa-miR-3978	CLIP-seq
MIRT1379538	hsa-miR-4257	CLIP-seq
MIRT1379539	hsa-miR-4311	CLIP-seq
MIRT1379540	hsa-miR-4419a	CLIP-seq
MIRT1379541	hsa-miR-4419b	CLIP-seq
MIRT1379542	hsa-miR-4478	CLIP-seq
MIRT1379543	hsa-miR-4510	CLIP-seq
MIRT1379544	hsa-miR-4643	CLIP-seq
MIRT1379545	hsa-miR-4663	CLIP-seq
MIRT1379546	hsa-miR-4691-5p	CLIP-seq
MIRT1379547	hsa-miR-4693-3p	CLIP-seq
MIRT1379548	hsa-miR-4695-5p	CLIP-seq
MIRT1379549	hsa-miR-4756-3p	CLIP-seq
MIRT1379550	hsa-miR-485-5p	CLIP-seq
MIRT1379551	hsa-miR-583	CLIP-seq
MIRT1379552	hsa-miR-892b	CLIP-seq
MIRT1379553	hsa-miR-1468	CLIP-seq
MIRT1379526	hsa-miR-193a-3p	CLIP-seq
MIRT1379527	hsa-miR-193b	CLIP-seq
MIRT1379554	hsa-miR-2052	CLIP-seq
MIRT1379555	hsa-miR-3591-3p	CLIP-seq
MIRT1379556	hsa-miR-4496	CLIP-seq
MIRT1379557	hsa-miR-664	CLIP-seq
MIRT1379552	hsa-miR-892b	CLIP-seq
MIRT2336419	hsa-miR-511	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	12482870, 24128306
GO:0005794	Component	Golgi apparatus	IBA
GO:0006892	Process	Post-Golgi vesicle-mediated transport	IBA
GO:0007218	Process	Neuropeptide signaling pathway	NAS	11499680
GO:0008188	Function	Neuropeptide receptor activity	NAS	11499680
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IDA	12482870
GO:0016020	Component	Membrane	IEA

MIM	HGNC	e!Ensembl
606283	16697	ENSG00000108018

Q8WY21

Protein name

VPS10 domain-containing receptor SorCS1 (hSorCS)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15902	Sortilin-Vps10	205 → 635	Sortilin, neurotensin receptor 3,	Domain
PF15901	Sortilin_C	637 → 792	Sortilin, neurotensin receptor 3, C-terminal	Domain
PF00801	PKD	803 → 880	PKD domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Detected in fetal and infant brain and in fetal retina.

Sequence

MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHI
LVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVL
VHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRRVALPSPPSPSTQPGD
SSLRLQRARHATPPSTPKRGSAGAQYAI

Sequence length

1168

Interactions

View interactions

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Alzheimer disease 6	Likely pathogenic	rs1844748933	RCV002254415

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Prostate cancer	Uncertain significance	rs193920991	RCV000149107

Show/Hide Text Mining Associations (15)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Associate	28350845
Alzheimer Disease	Associate	18830724, 19241460, 21280075, 23279143, 23595767, 23673467, 23700427, 24731980, 26166206, 36697254
Arteriolosclerosis	Associate	35156446
Carcinogenesis	Associate	28350845
Cognition Disorders	Associate	23673467
Colorectal Neoplasms	Associate	33858496
Diabetes Complications	Associate	19875614
Diabetes Mellitus	Associate	19875614
Diabetes Mellitus Type 2	Associate	23279143
Down Syndrome	Associate	26166206
Hypoglycemia	Associate	19875614
Multiple Sclerosis	Associate	36232761
Obesity	Associate	27052493, 33921825
Polycystic Ovary Syndrome	Associate	27052493
Retinal Diseases	Stimulate	19875614

SORCS1 (sortilin related VPS10 domain containing receptor 1)