FMNL2 (formin like 2)

Gene

• Entrez ID: 114793
• Gene name: Formin like 2
• Gene symbol: FMNL2
• Synonyms (NCBI Gene): FHOD2
• Chromosome: 2
• Chromosome location: 2q23.3
• Summary: This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. Alternatively spliced transcript variants encoding different isoforms have been described but their full-length natu

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT001547	hsa-miR-155-5p	pSILAC	18668040
MIRT001547	hsa-miR-155-5p	Proteomics;Other	18668040
MIRT022700	hsa-miR-124-3p	Microarray	18668037
MIRT023863	hsa-miR-1-3p	Proteomics	18668040
MIRT027997	hsa-miR-93-5p	Sequencing	20371350
MIRT036331	hsa-miR-1229-3p	CLASH	23622248
MIRT437385	hsa-miR-137	Luciferase reporter assay	23201162
MIRT719160	hsa-miR-1277-5p	HITS-CLIP	19536157
MIRT719159	hsa-miR-944	HITS-CLIP	19536157
MIRT719158	hsa-miR-5580-3p	HITS-CLIP	19536157
MIRT719157	hsa-miR-4310	HITS-CLIP	19536157
MIRT719156	hsa-miR-7157-5p	HITS-CLIP	19536157
MIRT719155	hsa-miR-889-3p	HITS-CLIP	19536157
MIRT711350	hsa-miR-96-3p	HITS-CLIP	19536157
MIRT711349	hsa-miR-4501	HITS-CLIP	19536157
MIRT711348	hsa-miR-3607-5p	HITS-CLIP	19536157
MIRT711347	hsa-miR-1237-3p	HITS-CLIP	19536157
MIRT711346	hsa-miR-1248	HITS-CLIP	19536157
MIRT711345	hsa-miR-4778-3p	HITS-CLIP	19536157
MIRT711344	hsa-miR-3124-3p	HITS-CLIP	19536157
MIRT711343	hsa-miR-134-5p	HITS-CLIP	19536157
MIRT711342	hsa-miR-3118	HITS-CLIP	19536157
MIRT711341	hsa-miR-3164	HITS-CLIP	19536157
MIRT711340	hsa-miR-6820-3p	HITS-CLIP	19536157
MIRT711338	hsa-miR-6868-3p	HITS-CLIP	19536157
MIRT711339	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT085790	hsa-miR-3609	PAR-CLIP	21572407
MIRT085792	hsa-miR-548ah-5p	PAR-CLIP	21572407
MIRT551751	hsa-miR-106a-5p	PAR-CLIP	21572407
MIRT551750	hsa-miR-106b-5p	PAR-CLIP	21572407
MIRT551749	hsa-miR-17-5p	PAR-CLIP	21572407
MIRT551748	hsa-miR-20a-5p	PAR-CLIP	21572407
MIRT551747	hsa-miR-20b-5p	PAR-CLIP	21572407
MIRT551746	hsa-miR-519d-3p	PAR-CLIP	21572407
MIRT551745	hsa-miR-526b-3p	PAR-CLIP	21572407
MIRT027997	hsa-miR-93-5p	PAR-CLIP	21572407
MIRT551744	hsa-miR-4796-3p	PAR-CLIP	21572407
MIRT551743	hsa-miR-4704-5p	PAR-CLIP	21572407
MIRT085787	hsa-miR-203a-3p	PAR-CLIP	21572407
MIRT085795	hsa-miR-4536-5p	PAR-CLIP	21572407
MIRT736979	hsa-miR-466	Luciferase reporter assay, Western blotting, qRT-PCR	34257650
MIRT719160	hsa-miR-1277-5p	HITS-CLIP	19536157
MIRT719159	hsa-miR-944	HITS-CLIP	19536157
MIRT719158	hsa-miR-5580-3p	HITS-CLIP	19536157
MIRT719157	hsa-miR-4310	HITS-CLIP	19536157
MIRT719156	hsa-miR-7157-5p	HITS-CLIP	19536157
MIRT719155	hsa-miR-889-3p	HITS-CLIP	19536157
MIRT711350	hsa-miR-96-3p	HITS-CLIP	19536157
MIRT711349	hsa-miR-4501	HITS-CLIP	19536157
MIRT711348	hsa-miR-3607-5p	HITS-CLIP	19536157
MIRT711347	hsa-miR-1237-3p	HITS-CLIP	19536157
MIRT711346	hsa-miR-1248	HITS-CLIP	19536157
MIRT711345	hsa-miR-4778-3p	HITS-CLIP	19536157
MIRT711344	hsa-miR-3124-3p	HITS-CLIP	19536157
MIRT711343	hsa-miR-134-5p	HITS-CLIP	19536157
MIRT711342	hsa-miR-3118	HITS-CLIP	19536157
MIRT711341	hsa-miR-3164	HITS-CLIP	19536157
MIRT711340	hsa-miR-6820-3p	HITS-CLIP	19536157
MIRT711338	hsa-miR-6868-3p	HITS-CLIP	19536157
MIRT711339	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT085790	hsa-miR-3609	PAR-CLIP	21572407
MIRT085792	hsa-miR-548ah-5p	PAR-CLIP	21572407
MIRT551751	hsa-miR-106a-5p	PAR-CLIP	21572407
MIRT551750	hsa-miR-106b-5p	PAR-CLIP	21572407
MIRT551749	hsa-miR-17-5p	PAR-CLIP	21572407
MIRT551748	hsa-miR-20a-5p	PAR-CLIP	21572407
MIRT551747	hsa-miR-20b-5p	PAR-CLIP	21572407
MIRT551746	hsa-miR-519d-3p	PAR-CLIP	21572407
MIRT551745	hsa-miR-526b-3p	PAR-CLIP	21572407
MIRT027997	hsa-miR-93-5p	PAR-CLIP	21572407
MIRT551744	hsa-miR-4796-3p	PAR-CLIP	21572407
MIRT551743	hsa-miR-4704-5p	PAR-CLIP	21572407
MIRT085787	hsa-miR-203a-3p	PAR-CLIP	21572407
MIRT085795	hsa-miR-4536-5p	PAR-CLIP	21572407
MIRT999525	hsa-miR-106a	CLIP-seq
MIRT999526	hsa-miR-106b	CLIP-seq
MIRT999527	hsa-miR-1227	CLIP-seq
MIRT999528	hsa-miR-1273f	CLIP-seq
MIRT999529	hsa-miR-143	CLIP-seq
MIRT999530	hsa-miR-155	CLIP-seq
MIRT999531	hsa-miR-17	CLIP-seq
MIRT999532	hsa-miR-1912	CLIP-seq
MIRT999533	hsa-miR-197	CLIP-seq
MIRT999534	hsa-miR-203	CLIP-seq
MIRT999535	hsa-miR-2053	CLIP-seq
MIRT999536	hsa-miR-20a	CLIP-seq
MIRT999537	hsa-miR-20b	CLIP-seq
MIRT999538	hsa-miR-2113	CLIP-seq
MIRT999539	hsa-miR-219-2-3p	CLIP-seq
MIRT999540	hsa-miR-23a	CLIP-seq
MIRT999541	hsa-miR-23b	CLIP-seq
MIRT999542	hsa-miR-23c	CLIP-seq
MIRT999543	hsa-miR-2964a-3p	CLIP-seq
MIRT999544	hsa-miR-302f	CLIP-seq
MIRT999545	hsa-miR-3121-3p	CLIP-seq
MIRT999546	hsa-miR-3130-5p	CLIP-seq
MIRT999547	hsa-miR-3140-3p	CLIP-seq
MIRT999548	hsa-miR-3163	CLIP-seq
MIRT999549	hsa-miR-3188	CLIP-seq
MIRT999550	hsa-miR-324-5p	CLIP-seq
MIRT999551	hsa-miR-338-5p	CLIP-seq
MIRT999552	hsa-miR-340	CLIP-seq
MIRT999553	hsa-miR-34a	CLIP-seq
MIRT999554	hsa-miR-34c-5p	CLIP-seq
MIRT999555	hsa-miR-3607-3p	CLIP-seq
MIRT999556	hsa-miR-3649	CLIP-seq
MIRT999557	hsa-miR-3653	CLIP-seq
MIRT999558	hsa-miR-3686	CLIP-seq
MIRT999559	hsa-miR-3936	CLIP-seq
MIRT999560	hsa-miR-410	CLIP-seq
MIRT999561	hsa-miR-412	CLIP-seq
MIRT999562	hsa-miR-4252	CLIP-seq
MIRT999563	hsa-miR-4418	CLIP-seq
MIRT999564	hsa-miR-4475	CLIP-seq
MIRT999565	hsa-miR-4482	CLIP-seq
MIRT999566	hsa-miR-4496	CLIP-seq
MIRT999567	hsa-miR-449a	CLIP-seq
MIRT999568	hsa-miR-449b	CLIP-seq
MIRT999569	hsa-miR-4536	CLIP-seq
MIRT999570	hsa-miR-4639-5p	CLIP-seq
MIRT999571	hsa-miR-4643	CLIP-seq
MIRT999572	hsa-miR-4652-3p	CLIP-seq
MIRT999573	hsa-miR-4690-5p	CLIP-seq
MIRT999574	hsa-miR-4699-3p	CLIP-seq
MIRT999575	hsa-miR-4708-5p	CLIP-seq
MIRT999576	hsa-miR-4770	CLIP-seq
MIRT999577	hsa-miR-4775	CLIP-seq
MIRT999578	hsa-miR-4789-3p	CLIP-seq
MIRT999579	hsa-miR-509-3-5p	CLIP-seq
MIRT999580	hsa-miR-509-5p	CLIP-seq
MIRT999581	hsa-miR-519d	CLIP-seq
MIRT999582	hsa-miR-543	CLIP-seq
MIRT999583	hsa-miR-548ah	CLIP-seq
MIRT999584	hsa-miR-556-3p	CLIP-seq
MIRT999585	hsa-miR-569	CLIP-seq
MIRT999586	hsa-miR-576-5p	CLIP-seq
MIRT999587	hsa-miR-590-3p	CLIP-seq
MIRT999588	hsa-miR-606	CLIP-seq
MIRT999589	hsa-miR-633	CLIP-seq
MIRT999590	hsa-miR-873	CLIP-seq
MIRT999591	hsa-miR-93	CLIP-seq
MIRT1996272	hsa-miR-1284	CLIP-seq
MIRT999535	hsa-miR-2053	CLIP-seq
MIRT1996273	hsa-miR-300	CLIP-seq
MIRT1996274	hsa-miR-381	CLIP-seq
MIRT999569	hsa-miR-4536	CLIP-seq
MIRT999572	hsa-miR-4652-3p	CLIP-seq
MIRT1996275	hsa-miR-4666-3p	CLIP-seq
MIRT1996276	hsa-miR-548g	CLIP-seq
MIRT999585	hsa-miR-569	CLIP-seq
MIRT2230203	hsa-miR-1	CLIP-seq
MIRT999525	hsa-miR-106a	CLIP-seq
MIRT999526	hsa-miR-106b	CLIP-seq
MIRT2230204	hsa-miR-1252	CLIP-seq
MIRT999531	hsa-miR-17	CLIP-seq
MIRT999534	hsa-miR-203	CLIP-seq
MIRT2230205	hsa-miR-206	CLIP-seq
MIRT999536	hsa-miR-20a	CLIP-seq
MIRT999537	hsa-miR-20b	CLIP-seq
MIRT999545	hsa-miR-3121-3p	CLIP-seq
MIRT2230206	hsa-miR-3125	CLIP-seq
MIRT999556	hsa-miR-3649	CLIP-seq
MIRT2230207	hsa-miR-374c	CLIP-seq
MIRT2230208	hsa-miR-3916	CLIP-seq
MIRT999560	hsa-miR-410	CLIP-seq
MIRT999564	hsa-miR-4475	CLIP-seq
MIRT2230209	hsa-miR-4476	CLIP-seq
MIRT2230210	hsa-miR-4533	CLIP-seq
MIRT999569	hsa-miR-4536	CLIP-seq
MIRT999571	hsa-miR-4643	CLIP-seq
MIRT2230211	hsa-miR-4716-5p	CLIP-seq
MIRT999578	hsa-miR-4789-3p	CLIP-seq
MIRT999581	hsa-miR-519d	CLIP-seq
MIRT999583	hsa-miR-548ah	CLIP-seq
MIRT999588	hsa-miR-606	CLIP-seq
MIRT2230212	hsa-miR-613	CLIP-seq
MIRT2230213	hsa-miR-655	CLIP-seq
MIRT999591	hsa-miR-93	CLIP-seq
MIRT999545	hsa-miR-3121-3p	CLIP-seq
MIRT2449826	hsa-miR-298	CLIP-seq
MIRT2449827	hsa-miR-411	CLIP-seq
MIRT2534001	hsa-miR-1202	CLIP-seq
MIRT999527	hsa-miR-1227	CLIP-seq
MIRT2534002	hsa-miR-124	CLIP-seq
MIRT2534003	hsa-miR-1251	CLIP-seq
MIRT2534004	hsa-miR-141	CLIP-seq
MIRT2534005	hsa-miR-200a	CLIP-seq
MIRT999538	hsa-miR-2113	CLIP-seq
MIRT2534006	hsa-miR-2117	CLIP-seq
MIRT2534007	hsa-miR-2861	CLIP-seq
MIRT2449826	hsa-miR-298	CLIP-seq
MIRT999550	hsa-miR-324-5p	CLIP-seq
MIRT2534008	hsa-miR-342-3p	CLIP-seq
MIRT2534009	hsa-miR-3664-5p	CLIP-seq
MIRT2534010	hsa-miR-3918	CLIP-seq
MIRT2534011	hsa-miR-3972	CLIP-seq
MIRT2449827	hsa-miR-411	CLIP-seq
MIRT999562	hsa-miR-4252	CLIP-seq
MIRT2534012	hsa-miR-4261	CLIP-seq
MIRT2534013	hsa-miR-4325	CLIP-seq
MIRT999563	hsa-miR-4418	CLIP-seq
MIRT2534014	hsa-miR-4512	CLIP-seq
MIRT2534015	hsa-miR-4658	CLIP-seq
MIRT2534016	hsa-miR-4684-5p	CLIP-seq
MIRT2534017	hsa-miR-4685-5p	CLIP-seq
MIRT2534018	hsa-miR-4708-3p	CLIP-seq
MIRT2534019	hsa-miR-4714-5p	CLIP-seq
MIRT2534020	hsa-miR-4738-3p	CLIP-seq
MIRT2534021	hsa-miR-4755-3p	CLIP-seq
MIRT2534022	hsa-miR-4758-5p	CLIP-seq
MIRT2534023	hsa-miR-4765	CLIP-seq
MIRT2534024	hsa-miR-4776-3p	CLIP-seq
MIRT2534025	hsa-miR-4793-5p	CLIP-seq
MIRT2534026	hsa-miR-502-5p	CLIP-seq
MIRT2534027	hsa-miR-506	CLIP-seq
MIRT2534028	hsa-miR-507	CLIP-seq
MIRT999579	hsa-miR-509-3-5p	CLIP-seq
MIRT999580	hsa-miR-509-5p	CLIP-seq
MIRT2534029	hsa-miR-557	CLIP-seq
MIRT2534030	hsa-miR-621	CLIP-seq
MIRT2534031	hsa-miR-628-3p	CLIP-seq
MIRT2534032	hsa-miR-653	CLIP-seq
MIRT2534033	hsa-miR-875-3p	CLIP-seq
MIRT2534003	hsa-miR-1251	CLIP-seq
MIRT2534006	hsa-miR-2117	CLIP-seq
MIRT2534008	hsa-miR-342-3p	CLIP-seq
MIRT2534016	hsa-miR-4684-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003779	Function	Actin binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	TAS
GO:0007010	Process	Cytoskeleton organization	IEA
GO:0007010	Process	Cytoskeleton organization	IMP	21834987
GO:0008360	Process	Regulation of cell shape	IBA
GO:0016477	Process	Cell migration	IBA
GO:0022604	Process	Regulation of cell morphogenesis	IEA
GO:0022604	Process	Regulation of cell morphogenesis	IMP	21834987
GO:0030036	Process	Actin cytoskeleton organization	IEA
GO:0030866	Process	Cortical actin cytoskeleton organization	IBA
GO:0030866	Process	Cortical actin cytoskeleton organization	IMP	21834987
GO:0031267	Function	Small GTPase binding	IEA
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0051015	Function	Actin filament binding	IBA

Other IDs

• MIM: 616285
• HGNC: 18267
• e!Ensembl: ENSG00000157827

Protein

• UniProt ID: Q96PY5
• Protein name: Formin-like protein 2 (Formin homology 2 domain-containing protein 2)
• Protein function: Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics.
• PDB: 4YC7
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF06371	Drf_GBD	23 → 159	Diaphanous GTPase-binding Domain	Family
  PF06371	Drf_GBD	202 → 275	Diaphanous GTPase-binding Domain	Family
  PF06367	Drf_FH3	278 → 475	Diaphanous FH3 Domain	Family
  PF02181	FH2	616 → 982	Formin Homology 2 Domain	Family

• Sequence:

  MGNAGSMDSQQTDFRAHNVPLKLPMPEPGELEERFAIVLNAMNLPPDKARLLRQYDNEKK
  WELICDQERFQVKNPPHTYIQKLKGYLDPAVTRKKFRRRVQESTQVLRELEISLRTNHIG
  WVREFLNEENKGLDVLVEYLSFAQYAVTFDFESVESTVESSVDKSKPWSRSIEDLHRGSN
  LPSPVGNSVSRSGRHSALRYNTLPSRRTLKNSRLVSKKDDVHVCIMCLRAIMNYQYGFNM
  VMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILSAFDNFKEVCGEKQRF
  EKLMEHFRNEDNNIDFMVASMQFINIVVHSVEDMNFRVHLQYEFTKLGLDEYLDKLKHTE
  SDKLQVQIQAYLDNVFDVGALLEDAETKNAALERVEELEENISHLSEKLQDTENEAMSKI
  VELEKQLMQRNKELDVVREIYKDANTQVHTLRKMVKEKEEAIQRQSTLEKKIHELEKQGT
  IKIQKKGDGDIAILPVVASGTLSMGSEVVAGNSVGPTMGAASSGPLPPPPPPLPPSSDTP
  ETVQNGPVTPPMPPPPPPPPPPPPPPPPPPPPPLPGPAAETVPAPPLAPPLPSAPPLPGT
  SSPTVVFNSGLAAVKIKKPIKTKFRMPVFNWVALKPNQINGTVFNEIDDERILEDLNVDE
  FEEIFKTKAQGPAIDLSSSKQKIPQKGSNKVTLLEANRAKNLAITLRKAGKTADEICKAI
  HVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDEDRFMMQFSKIERLMQ
  KMTIMAFIGNFAESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSKRGAV
  YGFKLQSLDLLLDTKSTDRKQTLLHYISNVVKEKYHQVSLFYNELHYVEKAAAVSLENVL
  LDVKELQRGMDLTKREYTMHDHNTLLKEFILNNEGKLKKLQDDAKIAQDAFDDVVKYFGE
  NPKTTPPSVFFPVFVRFVKAYKQAEEENELRKKQEQALMEKLLEQEALMEQQDPKSPSHK
  SKRQQQELIAELRRRQVKDNRHVYEGKDGAIEDIITVLKTVPFTARTAKRGSRFFCEPVL
  TEEYHY

• Sequence length: 1086

Pathways

KEGG:

Cytoskeleton in muscle cells

Reactome:

RHO GTPases Activate Formins

Associated diseases

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Crohn disease	Likely pathogenic	rs1695370663	RCV001293352

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
FMNL2-related disorder	Uncertain significance; Benign	rs377497365, rs1180261451, rs5835439	RCV003396856 RCV003404567 RCV003984502
Mycotic Aneurysm, Intracranial	Uncertain significance	rs182064759	RCV001730999

Associations from Text Mining
Disease Name	Relationship Type	References
Breast Neoplasms	Associate	34193109, 36124068
Colorectal Neoplasms	Associate	21071512, 26258642, 27058418, 30594388
COVID 19	Associate	37019895
Glaucoma Open Angle	Associate	33726755
Hypoxia	Associate	36335129
Inflammatory Bowel Diseases	Associate	34043722
Intracranial Aneurysm	Associate	35228681
Lung Neoplasms	Associate	27906963
Melanoma	Associate	20633255
Neoplasm Metastasis	Stimulate	26258642
Neoplasm Metastasis	Associate	26416600, 30594388
Neoplasms	Associate	21071512, 26258642