Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
114786
Gene name Gene Name - the full gene name approved by the HGNC.
XK related 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
XKR4
Synonyms (NCBI Gene) Gene synonyms aliases
XRG4, hXKR4
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8q12.1
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT017434 hsa-miR-335-5p Microarray 18185580
MIRT629715 hsa-miR-3173-3p HITS-CLIP 23824327
MIRT629714 hsa-miR-6891-5p HITS-CLIP 23824327
MIRT629713 hsa-miR-4779 HITS-CLIP 23824327
MIRT629712 hsa-miR-4436b-3p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 33725486
GO:0005886 Component Plasma membrane IBA
GO:0005886 Component Plasma membrane IEA
GO:0005886 Component Plasma membrane ISS
GO:0006915 Process Apoptotic process IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
HGNC N/A HGNC
Protein
UniProt ID Q5GH76
Protein name XK-related protein 4 (hXKR4) [Cleaved into: XK-related protein 4, processed form]
Protein function [XK-related protein 4, processed form]: Phospholipid scramblase that promotes phosphatidylserine exposure on apoptotic cell surface (PubMed:25231987, PubMed:33725486). Phosphatidylserine is a specific marker only present at the surface of apopto
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF09815 XK-related 113 516 XK-related protein Family
Sequence
Sequence length 650
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  Efferocytosis  
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Coronary artery disease Coronary artery disease N/A N/A GWAS
Endometriosis Endometriosis N/A N/A GWAS
Metabolic Syndrome Metabolic syndrome N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Breast Neoplasms Associate 36549768
Neoplasm Metastasis Associate 30429477
Peripheral Nervous System Diseases Associate 36549768