Gene Gene information from NCBI Gene database.
Entrez ID 114294
Gene name Lactamase beta
Gene symbol LACTB
Synonyms (NCBI Gene)
G24MRPL56
Chromosome 15
Chromosome location 15q22.2
Summary This gene encodes a mitochondrially-localized protein that has sequence similarity to prokaryotic beta-lactamases. Many of the residues responsible for beta-lactamase activity are not conserved in this protein, suggesting it may have a different enzymatic
miRNA miRNA information provided by mirtarbase database.
339
miRTarBase ID miRNA Experiments Reference
MIRT004998 hsa-miR-125b-5p Microarray 17891175
MIRT643855 hsa-miR-125a-3p HITS-CLIP 22927820
MIRT643854 hsa-miR-764 HITS-CLIP 22927820
MIRT643853 hsa-miR-3934-5p HITS-CLIP 22927820
MIRT643852 hsa-miR-1224-3p HITS-CLIP 22927820
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
18
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 28514442, 33961781
GO:0005739 Component Mitochondrion HDA 20833797
GO:0005739 Component Mitochondrion HTP 34800366
GO:0005739 Component Mitochondrion IBA
GO:0005739 Component Mitochondrion IDA 28329758
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
608440 16468 ENSG00000103642
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P83111
Protein name Serine beta-lactamase-like protein LACTB, mitochondrial (EC 3.4.-.-)
Protein function Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism (PubMed:28329758). Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (
PDB 7ULW , 7V1Y , 7V1Z , 7V21
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00144 Beta-lactamase 111 253 Beta-lactamase Domain
PF00144 Beta-lactamase 277 538 Beta-lactamase Domain
Tissue specificity TISSUE SPECIFICITY: Expressed predominantly in skeletal muscle. {ECO:0000269|PubMed:11707067}.
Sequence
Sequence length 547
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
3
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Abnormality of neuronal migration Benign rs34925488 RCV000201410
Cervical cancer Benign rs59027041 RCV005907329
Uterine corpus endometrial carcinoma Benign rs59027041 RCV005907330
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Alzheimer Disease Associate 34937778
Breast Neoplasms Inhibit 28835318, 36088805
Breast Neoplasms Associate 36282364
Carcinoma Hepatocellular Associate 38176415
Carcinoma Ovarian Epithelial Inhibit 36375842
Glioblastoma Associate 36088805
Glioma Associate 28835318
Glioma Inhibit 36088805
Neoplasms Associate 33507917
Neoplasms Inhibit 36282364, 36375842