Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
114294
Gene name Gene Name - the full gene name approved by the HGNC.
Lactamase beta
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
LACTB
Synonyms (NCBI Gene) Gene synonyms aliases
G24, MRPL56
Chromosome Chromosome number
15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
15q22.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a mitochondrially-localized protein that has sequence similarity to prokaryotic beta-lactamases. Many of the residues responsible for beta-lactamase activity are not conserved in this protein, suggesting it may have a different enzymatic
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT004998 hsa-miR-125b-5p Microarray 17891175
MIRT643855 hsa-miR-125a-3p HITS-CLIP 22927820
MIRT643854 hsa-miR-764 HITS-CLIP 22927820
MIRT643853 hsa-miR-3934-5p HITS-CLIP 22927820
MIRT643852 hsa-miR-1224-3p HITS-CLIP 22927820
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005739 Component Mitochondrion HDA 20833797
GO:0005739 Component Mitochondrion IDA 28329758
GO:0005829 Component Cytosol IDA
GO:0006508 Process Proteolysis IDA 28329758
GO:0006629 Process Lipid metabolic process IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
608440 16468 ENSG00000103642
Protein
UniProt ID P83111
Protein name Serine beta-lactamase-like protein LACTB, mitochondrial (EC 3.4.-.-)
Protein function Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism (PubMed:28329758). Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (
PDB 7ULW , 7V1Y , 7V1Z , 7V21
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00144 Beta-lactamase 111 253 Beta-lactamase Domain
PF00144 Beta-lactamase 277 538 Beta-lactamase Domain
Tissue specificity TISSUE SPECIFICITY: Expressed predominantly in skeletal muscle. {ECO:0000269|PubMed:11707067}.
Sequence
Sequence length 547
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Obesity Obesity rs74315349, rs1474810899, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562
View all (27 more)
18344982
Unknown
Disease term Disease name Evidence References Source
Dental caries Dental caries GWAS
Associations from Text Mining
Disease Name Relationship Type References
Alzheimer Disease Associate 34937778
Breast Neoplasms Inhibit 28835318, 36088805
Breast Neoplasms Associate 36282364
Carcinoma Hepatocellular Associate 38176415
Carcinoma Ovarian Epithelial Inhibit 36375842
Glioblastoma Associate 36088805
Glioma Associate 28835318
Glioma Inhibit 36088805
Neoplasms Associate 33507917
Neoplasms Inhibit 36282364, 36375842