CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit)

Gene

• Entrez ID: 1139
• Gene name: Cholinergic receptor nicotinic alpha 7 subunit
• Gene symbol: CHRNA7
• Synonyms (NCBI Gene): CHRNA7-2, NACHRA7, nAChR7
• Chromosome: 15
• Chromosome location: 15q13.3
• Summary: The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structu

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016843	hsa-miR-335-5p	Microarray	18185580
MIRT891887	hsa-miR-1827	CLIP-seq
MIRT891888	hsa-miR-186	CLIP-seq
MIRT891889	hsa-miR-3133	CLIP-seq
MIRT891890	hsa-miR-3160-3p	CLIP-seq
MIRT891891	hsa-miR-3622b-5p	CLIP-seq
MIRT891892	hsa-miR-3689d	CLIP-seq
MIRT891893	hsa-miR-3929	CLIP-seq
MIRT891894	hsa-miR-4327	CLIP-seq
MIRT891895	hsa-miR-4419b	CLIP-seq
MIRT891896	hsa-miR-4459	CLIP-seq
MIRT891897	hsa-miR-4478	CLIP-seq
MIRT891898	hsa-miR-4487	CLIP-seq
MIRT891899	hsa-miR-4633-3p	CLIP-seq
MIRT891900	hsa-miR-4649-3p	CLIP-seq
MIRT891901	hsa-miR-4695-3p	CLIP-seq
MIRT891902	hsa-miR-4722-5p	CLIP-seq
MIRT891903	hsa-miR-4723-5p	CLIP-seq
MIRT891904	hsa-miR-4768-3p	CLIP-seq
MIRT891905	hsa-miR-4787-5p	CLIP-seq
MIRT891906	hsa-miR-485-5p	CLIP-seq
MIRT891907	hsa-miR-558	CLIP-seq
MIRT891908	hsa-miR-665	CLIP-seq
MIRT891909	hsa-miR-940	CLIP-seq
MIRT891910	hsa-miR-3614-3p	CLIP-seq
MIRT891911	hsa-miR-3670	CLIP-seq
MIRT891912	hsa-miR-409-3p	CLIP-seq
MIRT891913	hsa-miR-4252	CLIP-seq
MIRT891914	hsa-miR-4452	CLIP-seq
MIRT891915	hsa-miR-4486	CLIP-seq
MIRT891916	hsa-miR-4649-5p	CLIP-seq
MIRT891917	hsa-miR-4775	CLIP-seq
MIRT891918	hsa-miR-4793-3p	CLIP-seq
MIRT891919	hsa-miR-508-5p	CLIP-seq
MIRT891920	hsa-miR-548p	CLIP-seq
MIRT891921	hsa-miR-590-3p	CLIP-seq
MIRT891922	hsa-miR-653	CLIP-seq
MIRT891923	hsa-miR-661	CLIP-seq
MIRT891924	hsa-miR-766	CLIP-seq
MIRT1964323	hsa-miR-1908	CLIP-seq
MIRT1964324	hsa-miR-3137	CLIP-seq
MIRT891891	hsa-miR-3622b-5p	CLIP-seq
MIRT1964325	hsa-miR-4645-5p	CLIP-seq
MIRT1964326	hsa-miR-4662a-5p	CLIP-seq
MIRT1964327	hsa-miR-4673	CLIP-seq
MIRT1964328	hsa-miR-4676-5p	CLIP-seq
MIRT1964329	hsa-miR-4755-3p	CLIP-seq
MIRT1964330	hsa-miR-4767	CLIP-seq
MIRT1964331	hsa-miR-566	CLIP-seq
MIRT1964332	hsa-miR-575	CLIP-seq
MIRT1964333	hsa-miR-663	CLIP-seq
MIRT2200453	hsa-miR-1184	CLIP-seq
MIRT891887	hsa-miR-1827	CLIP-seq
MIRT891890	hsa-miR-3160-3p	CLIP-seq
MIRT891891	hsa-miR-3622b-5p	CLIP-seq
MIRT2200454	hsa-miR-3668	CLIP-seq
MIRT891892	hsa-miR-3689d	CLIP-seq
MIRT891913	hsa-miR-4252	CLIP-seq
MIRT891896	hsa-miR-4459	CLIP-seq
MIRT891915	hsa-miR-4486	CLIP-seq
MIRT891898	hsa-miR-4487	CLIP-seq
MIRT891900	hsa-miR-4649-3p	CLIP-seq
MIRT891916	hsa-miR-4649-5p	CLIP-seq
MIRT891902	hsa-miR-4722-5p	CLIP-seq
MIRT891904	hsa-miR-4768-3p	CLIP-seq
MIRT891918	hsa-miR-4793-3p	CLIP-seq
MIRT891919	hsa-miR-508-5p	CLIP-seq
MIRT891920	hsa-miR-548p	CLIP-seq
MIRT891907	hsa-miR-558	CLIP-seq
MIRT2200455	hsa-miR-629	CLIP-seq
MIRT2200456	hsa-miR-642b	CLIP-seq
MIRT891923	hsa-miR-661	CLIP-seq
MIRT891908	hsa-miR-665	CLIP-seq
MIRT891924	hsa-miR-766	CLIP-seq
MIRT891909	hsa-miR-940	CLIP-seq
MIRT2503256	hsa-miR-1272	CLIP-seq
MIRT2503257	hsa-miR-3613-3p	CLIP-seq
MIRT2503258	hsa-miR-3675-3p	CLIP-seq
MIRT1964326	hsa-miR-4662a-5p	CLIP-seq
MIRT1964328	hsa-miR-4676-5p	CLIP-seq
MIRT2503259	hsa-miR-4684-5p	CLIP-seq
MIRT1964329	hsa-miR-4755-3p	CLIP-seq
MIRT2503260	hsa-miR-548c-3p	CLIP-seq
MIRT1964332	hsa-miR-575	CLIP-seq
MIRT2503256	hsa-miR-1272	CLIP-seq
MIRT2503257	hsa-miR-3613-3p	CLIP-seq
MIRT2503258	hsa-miR-3675-3p	CLIP-seq
MIRT1964326	hsa-miR-4662a-5p	CLIP-seq
MIRT1964328	hsa-miR-4676-5p	CLIP-seq
MIRT2503259	hsa-miR-4684-5p	CLIP-seq
MIRT2678154	hsa-miR-4786-5p	CLIP-seq
MIRT2678155	hsa-miR-4793-5p	CLIP-seq
MIRT2678156	hsa-miR-4794	CLIP-seq
MIRT2503260	hsa-miR-548c-3p	CLIP-seq
MIRT1964332	hsa-miR-575	CLIP-seq
MIRT2678157	hsa-miR-769-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001540	Function	Amyloid-beta binding	IPI	10681545
GO:0001666	Process	Response to hypoxia	IDA	12189247
GO:0004888	Function	Transmembrane signaling receptor activity	IDA	16968406
GO:0004888	Function	Transmembrane signaling receptor activity	IEA
GO:0005216	Function	Monoatomic ion channel activity	IDA	17898229
GO:0005216	Function	Monoatomic ion channel activity	IEA
GO:0005230	Function	Extracellular ligand-gated monoatomic ion channel activity	IEA
GO:0005262	Function	Calcium channel activity	TAS	11404397
GO:0005515	Function	Protein binding	IPI	10681545, 26905431, 27344019, 32783947, 32814053
GO:0005789	Component	Endoplasmic reticulum membrane	ISS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	16968406
GO:0005886	Component	Plasma membrane	IDA	12508119, 16280133, 27789755
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS
GO:0005892	Component	Acetylcholine-gated channel complex	IBA
GO:0005892	Component	Acetylcholine-gated channel complex	IDA	8906617, 38161283
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006811	Process	Monoatomic ion transport	NAS	8906617
GO:0006816	Process	Calcium ion transport	IBA
GO:0006816	Process	Calcium ion transport	IDA	8145738
GO:0006816	Process	Calcium ion transport	IMP	10771023
GO:0006874	Process	Intracellular calcium ion homeostasis	IMP	16280133
GO:0007165	Process	Signal transduction	IDA	8906617
GO:0007249	Process	Canonical NF-kappaB signal transduction	IDA	1406630, 9346484, 25038658, 34721373
GO:0007268	Process	Chemical synaptic transmission	IBA
GO:0007268	Process	Chemical synaptic transmission	IDA	8145738
GO:0007271	Process	Synaptic transmission, cholinergic	IEA
GO:0007611	Process	Learning or memory	ISS
GO:0007613	Process	Memory	ISS
GO:0007613	Process	Memory	NAS	10681545
GO:0007614	Process	Short-term memory	ISS
GO:0008284	Process	Positive regulation of cell population proliferation	IMP	16280133, 17498763
GO:0015464	Function	Acetylcholine receptor activity	IDA	8906617
GO:0015643	Function	Toxic substance binding	IDA	12508119
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	NAS	8145738, 8906617
GO:0017081	Function	Chloride channel regulator activity	IDA	8145738
GO:0022848	Function	Acetylcholine-gated monoatomic cation-selective channel activity	IBA
GO:0022848	Function	Acetylcholine-gated monoatomic cation-selective channel activity	IDA	8145738, 8906617, 12508119, 18387948, 21718690, 33735609
GO:0022848	Function	Acetylcholine-gated monoatomic cation-selective channel activity	IEA
GO:0022848	Function	Acetylcholine-gated monoatomic cation-selective channel activity	ISS
GO:0023019	Process	Signal transduction involved in regulation of gene expression	IDA	1406630, 9346484, 25038658, 34721373
GO:0030425	Component	Dendrite	ISS
GO:0032720	Process	Negative regulation of tumor necrosis factor production	IDA	12508119
GO:0032720	Process	Negative regulation of tumor necrosis factor production	IDA	12508119
GO:0032720	Process	Negative regulation of tumor necrosis factor production	IMP	12508119
GO:0034220	Process	Monoatomic ion transmembrane transport	IBA
GO:0034220	Process	Monoatomic ion transmembrane transport	IDA	21718690
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0034703	Component	Cation channel complex	IDA	38161283
GO:0035094	Process	Response to nicotine	IDA	8145738, 12189247
GO:0035094	Process	Response to nicotine	ISS
GO:0042166	Function	Acetylcholine binding	IDA	8145738
GO:0042391	Process	Regulation of membrane potential	IBA
GO:0042803	Function	Protein homodimerization activity	IDA	8145738
GO:0043005	Component	Neuron projection	IBA
GO:0043124	Process	Negative regulation of canonical NF-kappaB signal transduction	IDA	16968406
GO:0043124	Process	Negative regulation of canonical NF-kappaB signal transduction	ISS
GO:0043410	Process	Positive regulation of MAPK cascade	IDA	10771023
GO:0044853	Component	Plasma membrane raft	ISS
GO:0045202	Component	Synapse	IBA
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IDA	21718690
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0045766	Process	Positive regulation of angiogenesis	IMP	12189247, 16280133
GO:0050808	Process	Synapse organization	ISS
GO:0050890	Process	Cognition	IEA
GO:0050890	Process	Cognition	IMP	16754836
GO:0050890	Process	Cognition	NAS	10681545
GO:0050893	Process	Sensory processing	ISS
GO:0051247	Process	Positive regulation of protein metabolic process	ISS
GO:0060079	Process	Excitatory postsynaptic potential	IDA	21718690
GO:0060084	Process	Synaptic transmission involved in micturition	ISS
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	ISS
GO:0070588	Process	Calcium ion transmembrane transport	IEA
GO:0095500	Process	Acetylcholine receptor signaling pathway	IDA	33735609
GO:0095500	Process	Acetylcholine receptor signaling pathway	ISS
GO:0097061	Process	Dendritic spine organization	ISS
GO:0098794	Component	Postsynapse	TAS	26224839
GO:0098815	Process	Modulation of excitatory postsynaptic potential	ISS
GO:0098878	Component	Neurotransmitter receptor complex	IDA	38161283
GO:0140059	Process	Dendrite arborization	ISS
GO:1900016	Process	Negative regulation of cytokine production involved in inflammatory response	IDA	16968406, 21606497
GO:1900016	Process	Negative regulation of cytokine production involved in inflammatory response	IDA	12508119, 16968406
GO:1900016	Process	Negative regulation of cytokine production involved in inflammatory response	ISS
GO:1900016	Process	Negative regulation of cytokine production involved in inflammatory response	ISS
GO:1900273	Process	Positive regulation of long-term synaptic potentiation	ISS
GO:1902004	Process	Positive regulation of amyloid-beta formation	ISS
GO:1902430	Process	Negative regulation of amyloid-beta formation	IGI	20708605
GO:1902991	Process	Regulation of amyloid precursor protein catabolic process	IGI	20708605
GO:1904645	Process	Response to amyloid-beta	ISS
GO:1905144	Process	Response to acetylcholine	IDA	17898229
GO:1905144	Process	Response to acetylcholine	ISS
GO:1905869	Process	Negative regulation of 3'-UTR-mediated mRNA stabilization	IDA	21606497
GO:1905906	Process	Regulation of amyloid fibril formation	ISS
GO:1990806	Process	Ligand-gated ion channel signaling pathway	IDA	33735609
GO:2000463	Process	Positive regulation of excitatory postsynaptic potential	ISS

Other IDs

• MIM: 118511
• HGNC: 1960
• e!Ensembl: ENSG00000175344

Interactions View interactions

Pathways

KEGG:

Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Alzheimer disease
Pathways of neurodegeneration - multiple diseases
Nicotine addiction
Chemical carcinogenesis - receptor activation

Reactome:

Highly calcium permeable postsynaptic nicotinic acetylcholine receptors

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
CHRNA7-related disorder	Likely benign; Benign	rs771965146, rs140842241, rs200390587, rs201727782	RCV003902309 RCV003943093 RCV003920577 RCV003970385
Chromosome 15q13.3 microdeletion syndrome	Uncertain significance	rs1412812395	RCV003455887
Clear cell carcinoma of kidney	Benign	rs34476605	RCV005868201
Epilepsy, idiopathic generalized, susceptibility to, 7	no classifications from unflagged records	rs1566846736	RCV000679952
Gastric cancer	Benign	rs34476605	RCV005868202
Nonpapillary renal cell carcinoma	Benign	rs34476605	RCV005868200
Uterine corpus endometrial carcinoma	Benign	rs34476605	RCV005868203

Associations from Text Mining
Disease Name	Relationship Type	References
Acute cholinergic dysautonomia	Associate	33679766
Adenocarcinoma of Lung	Associate	27228072, 31096457
AIDS Associated Nephropathy	Associate	26567012
Alzheimer Disease	Associate	19433665, 20061627, 24391883, 24787912, 24951635, 27249957, 31707211, 32582986, 32803965
Anxiety Disorders	Associate	30029151
Arthritis Rheumatoid	Associate	19404936
Attention Deficit Disorder with Hyperactivity	Associate	22420046, 22420048, 26651393, 27853923
Autism Spectrum Disorder	Associate	27565651, 27853923, 34356041, 36750796
Autistic Disorder	Associate	21840925, 26651393, 34320968, 34356041
Autosomal Dominant Nocturnal Frontal Lobe Epilepsy	Associate	23553139
Bipolar Disorder	Associate	17192894
Breast Neoplasms	Associate	37490473
Carcinoma Non Small Cell Lung	Associate	27409670, 31096457
Carcinoma Squamous Cell	Associate	31096457
Cognition Disorders	Associate	24424125, 31707211
Colorectal Neoplasms	Inhibit	28901507
Coronary Artery Disease	Associate	37295770
Coronary Vasospasm	Associate	35096275
Dementia	Associate	27249957
Developmental Disabilities	Associate	20506139, 26968334, 27853923, 34356041
Disease	Associate	29129316
Drug Related Side Effects and Adverse Reactions	Associate	33335227
Endometriosis	Associate	33602248
Epilepsy	Associate	18278044, 24024466, 34356041
Epilepsy Idiopathic Generalized	Associate	19136953, 23553139, 24024466
Esophageal Squamous Cell Carcinoma	Associate	27610024
Glomus vagale tumors	Inhibit	33602248
Heredodegenerative Disorders Nervous System	Associate	23553139, 24024466
Hirschsprung Disease	Associate	23270508
Hyperkinesis	Associate	23454271
Inflammation	Associate	19404936, 22441542
Intellectual Disability	Associate	20506139, 24424125, 27853923
Language Development Disorders	Associate	23454271, 34356041
Lung Neoplasms	Associate	24089524, 25407004
Mental Disorders	Associate	20506139, 22420046, 25681457, 26651393, 30029151, 34320968, 34356041
Migraine Disorders	Associate	34563047
Mucocutaneous Lymph Node Syndrome	Associate	37295770
Muscle Hypotonia	Associate	20506139, 34356041
Neoplasms	Associate	27228072, 28901507
Neoplasms	Stimulate	31096457
Nerve Degeneration	Inhibit	33335227
Neurobehavioral Manifestations	Associate	20506139
Neurocognitive Disorders	Associate	33515545
Pain	Associate	36604774
Pediatric acute onset neuropsychiatric syndrome	Associate	24424125, 34356041
Personality Disorders	Associate	21812102
Prader Willi Syndrome	Associate	21840925
Precancerous Conditions	Stimulate	15807899
Psychotic Disorders	Associate	17192894
Pulmonary Disease Chronic Obstructive	Associate	25407004
Rett Syndrome	Associate	21840925
Schizophrenia	Associate	17192894, 20728875, 21979958, 23318559, 25681457, 26651393, 26968334, 31707211, 32803965
Schizophrenia Childhood	Associate	26968334
Seizures	Associate	18278044, 18805830, 24424125
Small Cell Lung Carcinoma	Associate	15807899
Stomach Neoplasms	Associate	26136123
Tobacco Use Disorder	Associate	20584212