PIK3IP1 (phosphoinositide-3-kinase interacting protein 1)

Gene

• Entrez ID: 113791
• Gene name: Phosphoinositide-3-kinase interacting protein 1
• Gene symbol: PIK3IP1
• Synonyms (NCBI Gene): HGFL, TrIP, hHGFL(S)
• Chromosome: 22
• Chromosome location: 22q12.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT020011	hsa-miR-375	Microarray	20215506
MIRT1234207	hsa-let-7a	CLIP-seq
MIRT1234208	hsa-let-7b	CLIP-seq
MIRT1234209	hsa-let-7c	CLIP-seq
MIRT1234210	hsa-let-7d	CLIP-seq
MIRT1234211	hsa-let-7e	CLIP-seq
MIRT1234212	hsa-let-7f	CLIP-seq
MIRT1234213	hsa-let-7g	CLIP-seq
MIRT1234214	hsa-let-7i	CLIP-seq
MIRT1234215	hsa-miR-105	CLIP-seq
MIRT1234216	hsa-miR-1260	CLIP-seq
MIRT1234217	hsa-miR-1260b	CLIP-seq
MIRT1234218	hsa-miR-128	CLIP-seq
MIRT1234219	hsa-miR-1299	CLIP-seq
MIRT1234220	hsa-miR-1321	CLIP-seq
MIRT1234221	hsa-miR-135a	CLIP-seq
MIRT1234222	hsa-miR-135b	CLIP-seq
MIRT1234223	hsa-miR-145	CLIP-seq
MIRT1234224	hsa-miR-148a	CLIP-seq
MIRT1234225	hsa-miR-148b	CLIP-seq
MIRT1234226	hsa-miR-152	CLIP-seq
MIRT1234227	hsa-miR-188-3p	CLIP-seq
MIRT1234228	hsa-miR-199a-3p	CLIP-seq
MIRT1234229	hsa-miR-199b-3p	CLIP-seq
MIRT1234230	hsa-miR-202	CLIP-seq
MIRT1234231	hsa-miR-224	CLIP-seq
MIRT1234232	hsa-miR-2467-3p	CLIP-seq
MIRT1234233	hsa-miR-3129-5p	CLIP-seq
MIRT1234234	hsa-miR-3156-3p	CLIP-seq
MIRT1234235	hsa-miR-3162-5p	CLIP-seq
MIRT1234236	hsa-miR-3163	CLIP-seq
MIRT1234237	hsa-miR-3180-5p	CLIP-seq
MIRT1234238	hsa-miR-3182	CLIP-seq
MIRT1234239	hsa-miR-3190	CLIP-seq
MIRT1234240	hsa-miR-3202	CLIP-seq
MIRT1234241	hsa-miR-320e	CLIP-seq
MIRT1234242	hsa-miR-34a	CLIP-seq
MIRT1234243	hsa-miR-34c-5p	CLIP-seq
MIRT1234244	hsa-miR-3591-3p	CLIP-seq
MIRT1234245	hsa-miR-3622a-3p	CLIP-seq
MIRT1234246	hsa-miR-3622b-3p	CLIP-seq
MIRT1234247	hsa-miR-3665	CLIP-seq
MIRT1234248	hsa-miR-3678-3p	CLIP-seq
MIRT1234249	hsa-miR-3686	CLIP-seq
MIRT1234250	hsa-miR-378g	CLIP-seq
MIRT1234251	hsa-miR-3934	CLIP-seq
MIRT1234252	hsa-miR-3978	CLIP-seq
MIRT1234253	hsa-miR-410	CLIP-seq
MIRT1234254	hsa-miR-4257	CLIP-seq
MIRT1234255	hsa-miR-4277	CLIP-seq
MIRT1234256	hsa-miR-4330	CLIP-seq
MIRT1234257	hsa-miR-4434	CLIP-seq
MIRT1234258	hsa-miR-4437	CLIP-seq
MIRT1234259	hsa-miR-4458	CLIP-seq
MIRT1234260	hsa-miR-449a	CLIP-seq
MIRT1234261	hsa-miR-449b	CLIP-seq
MIRT1234262	hsa-miR-4500	CLIP-seq
MIRT1234263	hsa-miR-4516	CLIP-seq
MIRT1234264	hsa-miR-4531	CLIP-seq
MIRT1234265	hsa-miR-4533	CLIP-seq
MIRT1234266	hsa-miR-4674	CLIP-seq
MIRT1234267	hsa-miR-4733-5p	CLIP-seq
MIRT1234268	hsa-miR-4739	CLIP-seq
MIRT1234269	hsa-miR-4756-5p	CLIP-seq
MIRT1234270	hsa-miR-4782-5p	CLIP-seq
MIRT1234271	hsa-miR-4786-5p	CLIP-seq
MIRT1234272	hsa-miR-516b	CLIP-seq
MIRT1234273	hsa-miR-544b	CLIP-seq
MIRT1234274	hsa-miR-558	CLIP-seq
MIRT1234275	hsa-miR-601	CLIP-seq
MIRT1234276	hsa-miR-617	CLIP-seq
MIRT1234277	hsa-miR-621	CLIP-seq
MIRT1234278	hsa-miR-657	CLIP-seq
MIRT1234279	hsa-miR-873	CLIP-seq
MIRT1234280	hsa-miR-875-3p	CLIP-seq
MIRT1234281	hsa-miR-936	CLIP-seq
MIRT1234282	hsa-miR-98	CLIP-seq
MIRT1234215	hsa-miR-105	CLIP-seq
MIRT2068999	hsa-miR-1275	CLIP-seq
MIRT2069000	hsa-miR-129-3p	CLIP-seq
MIRT1234231	hsa-miR-224	CLIP-seq
MIRT1234232	hsa-miR-2467-3p	CLIP-seq
MIRT2069001	hsa-miR-3159	CLIP-seq
MIRT1234248	hsa-miR-3678-3p	CLIP-seq
MIRT2069002	hsa-miR-4300	CLIP-seq
MIRT2069003	hsa-miR-4525	CLIP-seq
MIRT2069004	hsa-miR-4665-5p	CLIP-seq
MIRT2069005	hsa-miR-4723-5p	CLIP-seq
MIRT2069006	hsa-miR-625	CLIP-seq
MIRT2069007	hsa-miR-637	CLIP-seq
MIRT2069008	hsa-miR-661	CLIP-seq
MIRT2069009	hsa-miR-920	CLIP-seq
MIRT2069010	hsa-miR-939	CLIP-seq
MIRT1234207	hsa-let-7a	CLIP-seq
MIRT1234208	hsa-let-7b	CLIP-seq
MIRT1234209	hsa-let-7c	CLIP-seq
MIRT1234210	hsa-let-7d	CLIP-seq
MIRT1234211	hsa-let-7e	CLIP-seq
MIRT1234212	hsa-let-7f	CLIP-seq
MIRT1234213	hsa-let-7g	CLIP-seq
MIRT1234214	hsa-let-7i	CLIP-seq
MIRT2296017	hsa-miR-103a	CLIP-seq
MIRT1234215	hsa-miR-105	CLIP-seq
MIRT2296018	hsa-miR-107	CLIP-seq
MIRT2296019	hsa-miR-1202	CLIP-seq
MIRT2296020	hsa-miR-1208	CLIP-seq
MIRT2296021	hsa-miR-1236	CLIP-seq
MIRT1234216	hsa-miR-1260	CLIP-seq
MIRT1234217	hsa-miR-1260b	CLIP-seq
MIRT2068999	hsa-miR-1275	CLIP-seq
MIRT2069000	hsa-miR-129-3p	CLIP-seq
MIRT1234219	hsa-miR-1299	CLIP-seq
MIRT1234221	hsa-miR-135a	CLIP-seq
MIRT1234222	hsa-miR-135b	CLIP-seq
MIRT2296022	hsa-miR-15a	CLIP-seq
MIRT2296023	hsa-miR-15b	CLIP-seq
MIRT2296024	hsa-miR-16	CLIP-seq
MIRT1234227	hsa-miR-188-3p	CLIP-seq
MIRT2296025	hsa-miR-188-5p	CLIP-seq
MIRT2296026	hsa-miR-1914	CLIP-seq
MIRT2296027	hsa-miR-1915	CLIP-seq
MIRT2296028	hsa-miR-192	CLIP-seq
MIRT2296029	hsa-miR-195	CLIP-seq
MIRT1234230	hsa-miR-202	CLIP-seq
MIRT2296030	hsa-miR-215	CLIP-seq
MIRT1234231	hsa-miR-224	CLIP-seq
MIRT1234232	hsa-miR-2467-3p	CLIP-seq
MIRT2296031	hsa-miR-3123	CLIP-seq
MIRT1234234	hsa-miR-3156-3p	CLIP-seq
MIRT1234236	hsa-miR-3163	CLIP-seq
MIRT1234238	hsa-miR-3182	CLIP-seq
MIRT1234239	hsa-miR-3190	CLIP-seq
MIRT2296032	hsa-miR-3194-5p	CLIP-seq
MIRT1234240	hsa-miR-3202	CLIP-seq
MIRT2296033	hsa-miR-324-5p	CLIP-seq
MIRT2296034	hsa-miR-330-3p	CLIP-seq
MIRT2296035	hsa-miR-338-3p	CLIP-seq
MIRT2296036	hsa-miR-342-5p	CLIP-seq
MIRT2296037	hsa-miR-346	CLIP-seq
MIRT1234242	hsa-miR-34a	CLIP-seq
MIRT2296038	hsa-miR-34c-3p	CLIP-seq
MIRT1234243	hsa-miR-34c-5p	CLIP-seq
MIRT1234244	hsa-miR-3591-3p	CLIP-seq
MIRT1234245	hsa-miR-3622a-3p	CLIP-seq
MIRT1234246	hsa-miR-3622b-3p	CLIP-seq
MIRT2296039	hsa-miR-3646	CLIP-seq
MIRT2296040	hsa-miR-3661	CLIP-seq
MIRT2296041	hsa-miR-3662	CLIP-seq
MIRT1234247	hsa-miR-3665	CLIP-seq
MIRT1234248	hsa-miR-3678-3p	CLIP-seq
MIRT2296042	hsa-miR-3925-3p	CLIP-seq
MIRT2296043	hsa-miR-3925-5p	CLIP-seq
MIRT1234251	hsa-miR-3934	CLIP-seq
MIRT2296044	hsa-miR-3972	CLIP-seq
MIRT2296045	hsa-miR-3976	CLIP-seq
MIRT1234252	hsa-miR-3978	CLIP-seq
MIRT2296046	hsa-miR-409-3p	CLIP-seq
MIRT1234253	hsa-miR-410	CLIP-seq
MIRT2296047	hsa-miR-424	CLIP-seq
MIRT2296048	hsa-miR-4268	CLIP-seq
MIRT1234255	hsa-miR-4277	CLIP-seq
MIRT2069002	hsa-miR-4300	CLIP-seq
MIRT2296049	hsa-miR-4317	CLIP-seq
MIRT2296050	hsa-miR-4422	CLIP-seq
MIRT1234258	hsa-miR-4437	CLIP-seq
MIRT2296051	hsa-miR-4448	CLIP-seq
MIRT2296052	hsa-miR-4453	CLIP-seq
MIRT1234259	hsa-miR-4458	CLIP-seq
MIRT1234260	hsa-miR-449a	CLIP-seq
MIRT1234261	hsa-miR-449b	CLIP-seq
MIRT1234262	hsa-miR-4500	CLIP-seq
MIRT2296053	hsa-miR-4524	CLIP-seq
MIRT2069003	hsa-miR-4525	CLIP-seq
MIRT2296054	hsa-miR-4527	CLIP-seq
MIRT2296055	hsa-miR-4530	CLIP-seq
MIRT1234265	hsa-miR-4533	CLIP-seq
MIRT2296056	hsa-miR-4538	CLIP-seq
MIRT2296057	hsa-miR-4639-3p	CLIP-seq
MIRT2296058	hsa-miR-4664-5p	CLIP-seq
MIRT2069004	hsa-miR-4665-5p	CLIP-seq
MIRT1234266	hsa-miR-4674	CLIP-seq
MIRT2296059	hsa-miR-4685-5p	CLIP-seq
MIRT2296060	hsa-miR-4691-3p	CLIP-seq
MIRT2296061	hsa-miR-4695-3p	CLIP-seq
MIRT2296062	hsa-miR-4698	CLIP-seq
MIRT2296063	hsa-miR-4714-3p	CLIP-seq
MIRT2069005	hsa-miR-4723-5p	CLIP-seq
MIRT2296064	hsa-miR-4726-3p	CLIP-seq
MIRT2296065	hsa-miR-4742-5p	CLIP-seq
MIRT2296066	hsa-miR-4753-3p	CLIP-seq
MIRT1234270	hsa-miR-4782-5p	CLIP-seq
MIRT1234271	hsa-miR-4786-5p	CLIP-seq
MIRT2296067	hsa-miR-497	CLIP-seq
MIRT2296068	hsa-miR-499-3p	CLIP-seq
MIRT2296069	hsa-miR-499a-3p	CLIP-seq
MIRT2296070	hsa-miR-503	CLIP-seq
MIRT2296071	hsa-miR-515-5p	CLIP-seq
MIRT1234272	hsa-miR-516b	CLIP-seq
MIRT2296072	hsa-miR-532-5p	CLIP-seq
MIRT2296073	hsa-miR-539	CLIP-seq
MIRT1234273	hsa-miR-544b	CLIP-seq
MIRT1234275	hsa-miR-601	CLIP-seq
MIRT2069006	hsa-miR-625	CLIP-seq
MIRT2296074	hsa-miR-631	CLIP-seq
MIRT2296075	hsa-miR-634	CLIP-seq
MIRT2069007	hsa-miR-637	CLIP-seq
MIRT2296076	hsa-miR-646	CLIP-seq
MIRT1234278	hsa-miR-657	CLIP-seq
MIRT2069008	hsa-miR-661	CLIP-seq
MIRT2296077	hsa-miR-668	CLIP-seq
MIRT2296078	hsa-miR-671-5p	CLIP-seq
MIRT2296079	hsa-miR-766	CLIP-seq
MIRT2296080	hsa-miR-767-3p	CLIP-seq
MIRT1234280	hsa-miR-875-3p	CLIP-seq
MIRT2069009	hsa-miR-920	CLIP-seq
MIRT2296081	hsa-miR-938	CLIP-seq
MIRT2069010	hsa-miR-939	CLIP-seq
MIRT2296082	hsa-miR-942	CLIP-seq
MIRT1234282	hsa-miR-98	CLIP-seq
MIRT2456501	hsa-miR-18a	CLIP-seq
MIRT2456502	hsa-miR-18b	CLIP-seq
MIRT2456503	hsa-miR-3157-3p	CLIP-seq
MIRT2296040	hsa-miR-3661	CLIP-seq
MIRT2456504	hsa-miR-371b-3p	CLIP-seq
MIRT2456505	hsa-miR-4476	CLIP-seq
MIRT2456506	hsa-miR-4700-3p	CLIP-seq
MIRT2456507	hsa-miR-4735-3p	CLIP-seq
MIRT2456508	hsa-miR-628-5p	CLIP-seq
MIRT2296074	hsa-miR-631	CLIP-seq
MIRT2456501	hsa-miR-18a	CLIP-seq
MIRT2456502	hsa-miR-18b	CLIP-seq
MIRT2456503	hsa-miR-3157-3p	CLIP-seq
MIRT2296040	hsa-miR-3661	CLIP-seq
MIRT2456504	hsa-miR-371b-3p	CLIP-seq
MIRT2456505	hsa-miR-4476	CLIP-seq
MIRT2456506	hsa-miR-4700-3p	CLIP-seq
MIRT2456507	hsa-miR-4735-3p	CLIP-seq
MIRT2456508	hsa-miR-628-5p	CLIP-seq
MIRT2296074	hsa-miR-631	CLIP-seq
MIRT1234218	hsa-miR-128	CLIP-seq
MIRT2593964	hsa-miR-1291	CLIP-seq
MIRT1234224	hsa-miR-148a	CLIP-seq
MIRT1234225	hsa-miR-148b	CLIP-seq
MIRT1234226	hsa-miR-152	CLIP-seq
MIRT2593965	hsa-miR-3160-3p	CLIP-seq
MIRT2593966	hsa-miR-3173-5p	CLIP-seq
MIRT1234241	hsa-miR-320e	CLIP-seq
MIRT2593967	hsa-miR-370	CLIP-seq
MIRT1234250	hsa-miR-378g	CLIP-seq
MIRT2593968	hsa-miR-3913-3p	CLIP-seq
MIRT2296046	hsa-miR-409-3p	CLIP-seq
MIRT1234257	hsa-miR-4434	CLIP-seq
MIRT1234258	hsa-miR-4437	CLIP-seq
MIRT2593969	hsa-miR-4487	CLIP-seq
MIRT1234263	hsa-miR-4516	CLIP-seq
MIRT1234264	hsa-miR-4531	CLIP-seq
MIRT2593970	hsa-miR-4663	CLIP-seq
MIRT1234266	hsa-miR-4674	CLIP-seq
MIRT2593971	hsa-miR-489	CLIP-seq
MIRT2296068	hsa-miR-499-3p	CLIP-seq
MIRT2296069	hsa-miR-499a-3p	CLIP-seq
MIRT2593972	hsa-miR-513a-5p	CLIP-seq
MIRT2296073	hsa-miR-539	CLIP-seq
MIRT1234274	hsa-miR-558	CLIP-seq
MIRT1234277	hsa-miR-621	CLIP-seq
MIRT1234279	hsa-miR-873	CLIP-seq
MIRT2593973	hsa-miR-877	CLIP-seq
MIRT1234218	hsa-miR-128	CLIP-seq
MIRT2593964	hsa-miR-1291	CLIP-seq
MIRT1234224	hsa-miR-148a	CLIP-seq
MIRT1234225	hsa-miR-148b	CLIP-seq
MIRT1234226	hsa-miR-152	CLIP-seq
MIRT2593965	hsa-miR-3160-3p	CLIP-seq
MIRT2593966	hsa-miR-3173-5p	CLIP-seq
MIRT2593967	hsa-miR-370	CLIP-seq
MIRT2593969	hsa-miR-4487	CLIP-seq
MIRT2593970	hsa-miR-4663	CLIP-seq
MIRT1234274	hsa-miR-558	CLIP-seq
MIRT1234277	hsa-miR-621	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004175	Function	Endopeptidase activity	IBA
GO:0005102	Function	Signaling receptor binding	IBA
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005615	Component	Extracellular space	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0051898	Process	Negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA
GO:0051898	Process	Negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA	17475214
GO:0141039	Function	Phosphatidylinositol 3-kinase inhibitor activity	IEA
GO:0141039	Function	Phosphatidylinositol 3-kinase inhibitor activity	IPI	17475214
GO:0141039	Function	Phosphatidylinositol 3-kinase inhibitor activity	ISS

Other IDs

• MIM: 619158
• HGNC: 24942
• e!Ensembl: ENSG00000100100

Protein

• UniProt ID: Q96FE7
• Protein name: Phosphoinositide-3-kinase-interacting protein 1 (PI3K-interacting protein 1) (Kringle domain-containing protein HGFL)
• Protein function: Negative regulator of hepatic phosphatidylinositol 3-kinase (PI3K) activity.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00051	Kringle	25 → 101	Kringle domain	Domain

• Sequence:

  MLLAWVQAFLVSNMLLAEAYGSGGCFWDNGHLYREDQTSPAPGLRCLNWLDAQSGLASAP
  VSGAGNHSYCRNPDEDPRGPWCYVSGEAGVPEKRPCEDLRCPETTSQALPAFTTEIQEAS
  EGPGADEVQVFAPANALPARSEAAAVQPVIGISQRVRMNSKEKKDLGTLGYVLGITMMVI
  IIAIGAGIILGYSYKRGKDLKEQHDQKVCEREMQRITLPLSAFTNPTCEIVDEKTVVVHT
  SQTPVDPQEGTTPLMGQAGTPGA

• Sequence length: 263

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	rs866587054	RCV004557887

Associations from Text Mining
Disease Name	Relationship Type	References
Brain Edema	Associate	24056404
Brain Ischemia	Associate	36077416
Breast Neoplasms	Associate	36549768
Carcinogenesis	Associate	36701842
Carcinoma Hepatocellular	Associate	38049860
Hashimoto Disease	Stimulate	34867951
Inflammation	Associate	30679758
Leukemia Myeloid Acute	Associate	36232694
Lymphoma	Associate	23676220
Lymphoma Mantle Cell	Associate	23676220
Microvascular Angina	Associate	38049860
Neoplasm Metastasis	Associate	36701842
Osteosarcoma	Associate	28549102
Retinal Neovascularization	Associate	37550343