TMEM106A (transmembrane protein 106A)

Gene

• Entrez ID: 113277
• Gene name: Transmembrane protein 106A
• Gene symbol: TMEM106A
• Synonyms (NCBI Gene): -
• Chromosome: 17
• Chromosome location: 17q21.31

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024549	hsa-miR-215-5p	Microarray	19074876
MIRT026644	hsa-miR-192-5p	Microarray	19074876
MIRT1429548	hsa-miR-1185	CLIP-seq
MIRT1429549	hsa-miR-1207-5p	CLIP-seq
MIRT1429550	hsa-miR-122	CLIP-seq
MIRT1429551	hsa-miR-1225-3p	CLIP-seq
MIRT1429552	hsa-miR-1226	CLIP-seq
MIRT1429553	hsa-miR-1233	CLIP-seq
MIRT1429554	hsa-miR-1254	CLIP-seq
MIRT1429555	hsa-miR-1271	CLIP-seq
MIRT1429556	hsa-miR-1278	CLIP-seq
MIRT1429557	hsa-miR-1321	CLIP-seq
MIRT1429558	hsa-miR-1323	CLIP-seq
MIRT1429559	hsa-miR-182	CLIP-seq
MIRT1429560	hsa-miR-1827	CLIP-seq
MIRT1429561	hsa-miR-1914	CLIP-seq
MIRT1429562	hsa-miR-1976	CLIP-seq
MIRT1429563	hsa-miR-2467-5p	CLIP-seq
MIRT1429564	hsa-miR-3116	CLIP-seq
MIRT1429565	hsa-miR-3121-5p	CLIP-seq
MIRT1429566	hsa-miR-3130-3p	CLIP-seq
MIRT1429567	hsa-miR-3135b	CLIP-seq
MIRT1429568	hsa-miR-3137	CLIP-seq
MIRT1429569	hsa-miR-3140-5p	CLIP-seq
MIRT1429570	hsa-miR-3154	CLIP-seq
MIRT1429571	hsa-miR-3158-3p	CLIP-seq
MIRT1429572	hsa-miR-3184	CLIP-seq
MIRT1429573	hsa-miR-3201	CLIP-seq
MIRT1429574	hsa-miR-330-3p	CLIP-seq
MIRT1429575	hsa-miR-3652	CLIP-seq
MIRT1429576	hsa-miR-3659	CLIP-seq
MIRT1429577	hsa-miR-3665	CLIP-seq
MIRT1429578	hsa-miR-3667-3p	CLIP-seq
MIRT1429579	hsa-miR-3667-5p	CLIP-seq
MIRT1429580	hsa-miR-3679-5p	CLIP-seq
MIRT1429581	hsa-miR-3689a-3p	CLIP-seq
MIRT1429582	hsa-miR-3689c	CLIP-seq
MIRT1429583	hsa-miR-3934	CLIP-seq
MIRT1429584	hsa-miR-3973	CLIP-seq
MIRT1429585	hsa-miR-423-5p	CLIP-seq
MIRT1429586	hsa-miR-4254	CLIP-seq
MIRT1429587	hsa-miR-4265	CLIP-seq
MIRT1429588	hsa-miR-4270	CLIP-seq
MIRT1429589	hsa-miR-4279	CLIP-seq
MIRT1429590	hsa-miR-4296	CLIP-seq
MIRT1429591	hsa-miR-4322	CLIP-seq
MIRT1429592	hsa-miR-4430	CLIP-seq
MIRT1429593	hsa-miR-4433	CLIP-seq
MIRT1429594	hsa-miR-4441	CLIP-seq
MIRT1429595	hsa-miR-4455	CLIP-seq
MIRT1429596	hsa-miR-4470	CLIP-seq
MIRT1429597	hsa-miR-4493	CLIP-seq
MIRT1429598	hsa-miR-4540	CLIP-seq
MIRT1429599	hsa-miR-4648	CLIP-seq
MIRT1429600	hsa-miR-4651	CLIP-seq
MIRT1429601	hsa-miR-4654	CLIP-seq
MIRT1429602	hsa-miR-4658	CLIP-seq
MIRT1429603	hsa-miR-4663	CLIP-seq
MIRT1429604	hsa-miR-4670-3p	CLIP-seq
MIRT1429605	hsa-miR-4728-5p	CLIP-seq
MIRT1429606	hsa-miR-4733-3p	CLIP-seq
MIRT1429607	hsa-miR-4738-3p	CLIP-seq
MIRT1429608	hsa-miR-4739	CLIP-seq
MIRT1429609	hsa-miR-4756-5p	CLIP-seq
MIRT1429610	hsa-miR-4763-3p	CLIP-seq
MIRT1429611	hsa-miR-4769-5p	CLIP-seq
MIRT1429612	hsa-miR-4791	CLIP-seq
MIRT1429613	hsa-miR-5095	CLIP-seq
MIRT1429614	hsa-miR-516a-3p	CLIP-seq
MIRT1429615	hsa-miR-548k	CLIP-seq
MIRT1429616	hsa-miR-548o	CLIP-seq
MIRT1429617	hsa-miR-550a	CLIP-seq
MIRT1429618	hsa-miR-552	CLIP-seq
MIRT1429619	hsa-miR-574-5p	CLIP-seq
MIRT1429620	hsa-miR-608	CLIP-seq
MIRT1429621	hsa-miR-625	CLIP-seq
MIRT1429622	hsa-miR-661	CLIP-seq
MIRT1429623	hsa-miR-665	CLIP-seq
MIRT1429624	hsa-miR-764	CLIP-seq
MIRT1429625	hsa-miR-765	CLIP-seq
MIRT1429626	hsa-miR-877	CLIP-seq
MIRT1429627	hsa-miR-940	CLIP-seq
MIRT1429628	hsa-miR-96	CLIP-seq
MIRT1429549	hsa-miR-1207-5p	CLIP-seq
MIRT1429554	hsa-miR-1254	CLIP-seq
MIRT1429555	hsa-miR-1271	CLIP-seq
MIRT1429559	hsa-miR-182	CLIP-seq
MIRT2128745	hsa-miR-28-5p	CLIP-seq
MIRT1429564	hsa-miR-3116	CLIP-seq
MIRT1429565	hsa-miR-3121-5p	CLIP-seq
MIRT2128746	hsa-miR-3139	CLIP-seq
MIRT1429570	hsa-miR-3154	CLIP-seq
MIRT1429571	hsa-miR-3158-3p	CLIP-seq
MIRT1429574	hsa-miR-330-3p	CLIP-seq
MIRT2128747	hsa-miR-409-3p	CLIP-seq
MIRT1429586	hsa-miR-4254	CLIP-seq
MIRT1429589	hsa-miR-4279	CLIP-seq
MIRT2128748	hsa-miR-4438	CLIP-seq
MIRT1429596	hsa-miR-4470	CLIP-seq
MIRT2128749	hsa-miR-4676-5p	CLIP-seq
MIRT2128750	hsa-miR-4715-3p	CLIP-seq
MIRT2128751	hsa-miR-4740-3p	CLIP-seq
MIRT1429610	hsa-miR-4763-3p	CLIP-seq
MIRT1429613	hsa-miR-5095	CLIP-seq
MIRT1429617	hsa-miR-550a	CLIP-seq
MIRT1429618	hsa-miR-552	CLIP-seq
MIRT2128752	hsa-miR-575	CLIP-seq
MIRT1429622	hsa-miR-661	CLIP-seq
MIRT2128753	hsa-miR-708	CLIP-seq
MIRT1429624	hsa-miR-764	CLIP-seq
MIRT2128754	hsa-miR-767-3p	CLIP-seq
MIRT1429628	hsa-miR-96	CLIP-seq
MIRT2350230	hsa-miR-1200	CLIP-seq
MIRT1429550	hsa-miR-122	CLIP-seq
MIRT1429552	hsa-miR-1226	CLIP-seq
MIRT1429554	hsa-miR-1254	CLIP-seq
MIRT2350231	hsa-miR-143	CLIP-seq
MIRT2350232	hsa-miR-185	CLIP-seq
MIRT2350233	hsa-miR-197	CLIP-seq
MIRT1429564	hsa-miR-3116	CLIP-seq
MIRT1429567	hsa-miR-3135b	CLIP-seq
MIRT2350234	hsa-miR-3149	CLIP-seq
MIRT2350235	hsa-miR-3199	CLIP-seq
MIRT1429574	hsa-miR-330-3p	CLIP-seq
MIRT2350236	hsa-miR-3622a-5p	CLIP-seq
MIRT1429575	hsa-miR-3652	CLIP-seq
MIRT2350237	hsa-miR-411	CLIP-seq
MIRT1429586	hsa-miR-4254	CLIP-seq
MIRT2350238	hsa-miR-4306	CLIP-seq
MIRT2350239	hsa-miR-4324	CLIP-seq
MIRT2350240	hsa-miR-4423-3p	CLIP-seq
MIRT1429592	hsa-miR-4430	CLIP-seq
MIRT2128748	hsa-miR-4438	CLIP-seq
MIRT2350241	hsa-miR-4644	CLIP-seq
MIRT2350242	hsa-miR-4716-5p	CLIP-seq
MIRT1429606	hsa-miR-4733-3p	CLIP-seq
MIRT2350243	hsa-miR-4770	CLIP-seq
MIRT1429613	hsa-miR-5095	CLIP-seq
MIRT2350244	hsa-miR-5096	CLIP-seq
MIRT1429614	hsa-miR-516a-3p	CLIP-seq
MIRT2350245	hsa-miR-544b	CLIP-seq
MIRT1429617	hsa-miR-550a	CLIP-seq
MIRT1429618	hsa-miR-552	CLIP-seq
MIRT2350246	hsa-miR-624	CLIP-seq
MIRT1429622	hsa-miR-661	CLIP-seq
MIRT2350247	hsa-miR-760	CLIP-seq
MIRT1429624	hsa-miR-764	CLIP-seq
MIRT1429550	hsa-miR-122	CLIP-seq
MIRT1429567	hsa-miR-3135b	CLIP-seq
MIRT1429575	hsa-miR-3652	CLIP-seq
MIRT1429592	hsa-miR-4430	CLIP-seq
MIRT1429604	hsa-miR-4670-3p	CLIP-seq
MIRT2128748	hsa-miR-4438	CLIP-seq
MIRT2128750	hsa-miR-4715-3p	CLIP-seq
MIRT2461614	hsa-miR-4735-5p	CLIP-seq
MIRT1429613	hsa-miR-5095	CLIP-seq
MIRT2350230	hsa-miR-1200	CLIP-seq
MIRT1429549	hsa-miR-1207-5p	CLIP-seq
MIRT2643848	hsa-miR-1229	CLIP-seq
MIRT1429555	hsa-miR-1271	CLIP-seq
MIRT1429559	hsa-miR-182	CLIP-seq
MIRT1429560	hsa-miR-1827	CLIP-seq
MIRT2643849	hsa-miR-302a	CLIP-seq
MIRT2643850	hsa-miR-302b	CLIP-seq
MIRT2643851	hsa-miR-302c	CLIP-seq
MIRT2643852	hsa-miR-302d	CLIP-seq
MIRT2643853	hsa-miR-302e	CLIP-seq
MIRT1429565	hsa-miR-3121-5p	CLIP-seq
MIRT2643854	hsa-miR-3122	CLIP-seq
MIRT2350234	hsa-miR-3149	CLIP-seq
MIRT1429571	hsa-miR-3158-3p	CLIP-seq
MIRT2643855	hsa-miR-3607-3p	CLIP-seq
MIRT2643856	hsa-miR-3686	CLIP-seq
MIRT1429581	hsa-miR-3689a-3p	CLIP-seq
MIRT1429582	hsa-miR-3689c	CLIP-seq
MIRT2643857	hsa-miR-3691-3p	CLIP-seq
MIRT2643858	hsa-miR-372	CLIP-seq
MIRT2643859	hsa-miR-373	CLIP-seq
MIRT2643860	hsa-miR-3913-5p	CLIP-seq
MIRT1429589	hsa-miR-4279	CLIP-seq
MIRT2350239	hsa-miR-4324	CLIP-seq
MIRT2128748	hsa-miR-4438	CLIP-seq
MIRT1429596	hsa-miR-4470	CLIP-seq
MIRT2128750	hsa-miR-4715-3p	CLIP-seq
MIRT1429605	hsa-miR-4728-5p	CLIP-seq
MIRT2461614	hsa-miR-4735-5p	CLIP-seq
MIRT1429610	hsa-miR-4763-3p	CLIP-seq
MIRT2643861	hsa-miR-4775	CLIP-seq
MIRT1429613	hsa-miR-5095	CLIP-seq
MIRT1429614	hsa-miR-516a-3p	CLIP-seq
MIRT2643862	hsa-miR-520a-3p	CLIP-seq
MIRT2643863	hsa-miR-520b	CLIP-seq
MIRT2643864	hsa-miR-520c-3p	CLIP-seq
MIRT2643865	hsa-miR-520d-3p	CLIP-seq
MIRT2643866	hsa-miR-520e	CLIP-seq
MIRT2643867	hsa-miR-520f	CLIP-seq
MIRT2350245	hsa-miR-544b	CLIP-seq
MIRT2643868	hsa-miR-590-3p	CLIP-seq
MIRT1429627	hsa-miR-940	CLIP-seq
MIRT1429628	hsa-miR-96	CLIP-seq
MIRT1429549	hsa-miR-1207-5p	CLIP-seq
MIRT1429555	hsa-miR-1271	CLIP-seq
MIRT2693337	hsa-miR-1297	CLIP-seq
MIRT1429559	hsa-miR-182	CLIP-seq
MIRT1429560	hsa-miR-1827	CLIP-seq
MIRT2693338	hsa-miR-26a	CLIP-seq
MIRT2693339	hsa-miR-26b	CLIP-seq
MIRT2643849	hsa-miR-302a	CLIP-seq
MIRT2643850	hsa-miR-302b	CLIP-seq
MIRT2643851	hsa-miR-302c	CLIP-seq
MIRT2643852	hsa-miR-302d	CLIP-seq
MIRT2643853	hsa-miR-302e	CLIP-seq
MIRT1429565	hsa-miR-3121-5p	CLIP-seq
MIRT2643854	hsa-miR-3122	CLIP-seq
MIRT2350234	hsa-miR-3149	CLIP-seq
MIRT1429571	hsa-miR-3158-3p	CLIP-seq
MIRT2643855	hsa-miR-3607-3p	CLIP-seq
MIRT2643856	hsa-miR-3686	CLIP-seq
MIRT1429581	hsa-miR-3689a-3p	CLIP-seq
MIRT1429582	hsa-miR-3689c	CLIP-seq
MIRT2643857	hsa-miR-3691-3p	CLIP-seq
MIRT2643858	hsa-miR-372	CLIP-seq
MIRT2643859	hsa-miR-373	CLIP-seq
MIRT2643860	hsa-miR-3913-5p	CLIP-seq
MIRT1429589	hsa-miR-4279	CLIP-seq
MIRT2693340	hsa-miR-4297	CLIP-seq
MIRT2128748	hsa-miR-4438	CLIP-seq
MIRT2693341	hsa-miR-4465	CLIP-seq
MIRT1429596	hsa-miR-4470	CLIP-seq
MIRT2693342	hsa-miR-4664-3p	CLIP-seq
MIRT2128750	hsa-miR-4715-3p	CLIP-seq
MIRT1429605	hsa-miR-4728-5p	CLIP-seq
MIRT2461614	hsa-miR-4735-5p	CLIP-seq
MIRT1429610	hsa-miR-4763-3p	CLIP-seq
MIRT2643861	hsa-miR-4775	CLIP-seq
MIRT2693343	hsa-miR-498	CLIP-seq
MIRT1429613	hsa-miR-5095	CLIP-seq
MIRT2643862	hsa-miR-520a-3p	CLIP-seq
MIRT2643863	hsa-miR-520b	CLIP-seq
MIRT2643864	hsa-miR-520c-3p	CLIP-seq
MIRT2643865	hsa-miR-520d-3p	CLIP-seq
MIRT2643866	hsa-miR-520e	CLIP-seq
MIRT2643867	hsa-miR-520f	CLIP-seq
MIRT2643868	hsa-miR-590-3p	CLIP-seq
MIRT2693344	hsa-miR-671-3p	CLIP-seq
MIRT1429627	hsa-miR-940	CLIP-seq
MIRT1429628	hsa-miR-96	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002376	Process	Immune system process	IEA
GO:0005515	Function	Protein binding	IPI	32296183, 33961781
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0009101	Process	Glycoprotein biosynthetic process	IEA
GO:0009101	Process	Glycoprotein biosynthetic process	ISS
GO:0016020	Component	Membrane	IEA
GO:0032731	Process	Positive regulation of interleukin-1 beta production	IEA
GO:0032731	Process	Positive regulation of interleukin-1 beta production	ISS
GO:0032755	Process	Positive regulation of interleukin-6 production	IEA
GO:0032755	Process	Positive regulation of interleukin-6 production	ISS
GO:0032760	Process	Positive regulation of tumor necrosis factor production	IEA
GO:0032760	Process	Positive regulation of tumor necrosis factor production	ISS
GO:0042116	Process	Macrophage activation	IEA
GO:0042116	Process	Macrophage activation	ISS
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IEA
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	ISS
GO:0043410	Process	Positive regulation of MAPK cascade	IEA
GO:0043410	Process	Positive regulation of MAPK cascade	ISS
GO:0045087	Process	Innate immune response	IEA
GO:0045348	Process	Positive regulation of MHC class II biosynthetic process	IEA
GO:0045348	Process	Positive regulation of MHC class II biosynthetic process	ISS
GO:1904407	Process	Positive regulation of nitric oxide metabolic process	IEA
GO:1904407	Process	Positive regulation of nitric oxide metabolic process	ISS

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q96A25
• Protein name: Transmembrane protein 106A
• Protein function: Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, up-regulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the rel
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07092	DUF1356	25 → 252	Protein of unknown function (DUF1356)	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in renal cells (at protein level) (PubMed:29131025). Expressed in epithelial cells (PubMed:30456879). {ECO:0000269|PubMed:29131025, ECO:0000269|PubMed:30456879}.
• Sequence:

  MGKTFSQLGSWREDENKSILSSKPAIGSKAVNYSSTGSSKSFCSCVPCEGTADASFVTCP
  TCQGSGKIPQELEKQLVALIPYGDQRLKPKHTKLFVFLAVLICLVTSSFIVFFLFPRSVI
  VQPAGLNSSTVAFDEADIYLNITNILNISNGNYYPIMVTQLTLEVLHLSLVVGQVSNNLL
  LHIGPLASEQMFYAVATKIRDENTYKICTWLEIKVHHVLLHIQGTLTCSYLSHSEQLVFQ
  SYEYVDCRGNASVPHQLTPHPP

• Sequence length: 262

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
LIVER CIRRHOSIS, EXPERIMENTAL	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROMUSCULAR DISEASES	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Carcinoma Hepatocellular	Inhibit	35713314	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Associate	36345721	★☆☆☆☆ Found in Text Mining only
Coxsackievirus Infections	Inhibit	35359978	★☆☆☆☆ Found in Text Mining only
Epilepsy Generalized	Associate	40495522	★☆☆☆☆ Found in Text Mining only
Hand Foot and Mouth Disease	Associate	35359978	★☆☆☆☆ Found in Text Mining only
Kidney Neoplasms	Inhibit	29131025	★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Inhibit	35713314	★☆☆☆☆ Found in Text Mining only
Neoplasms	Inhibit	29131025	★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	35713314	★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Inhibit	29131025	★☆☆☆☆ Found in Text Mining only
Urethral Neoplasms	Associate	39875053	★☆☆☆☆ Found in Text Mining only