Gene Gene information from NCBI Gene database.
Entrez ID 113263
Gene name Glucocorticoid induced 1
Gene symbol GLCCI1
Synonyms (NCBI Gene)
FAM117CGCTRGIG18TSSN1
Chromosome 7
Chromosome location 7p21.3
Summary This gene encodes a protein of unknown function. Expression of this gene is induced by glucocorticoids and may be an early marker for glucocorticoid-induced apoptosis. Single nucleotide polymorphisms in this gene are associated with a decreased response t
miRNA miRNA information provided by mirtarbase database.
469
miRTarBase ID miRNA Experiments Reference
MIRT017656 hsa-miR-335-5p Microarray 18185580
MIRT026406 hsa-miR-192-5p Microarray 19074876
MIRT002411 hsa-miR-21-5p Sequencing 20371350
MIRT002411 hsa-miR-21-5p Microarray 18591254
MIRT612230 hsa-miR-8485 HITS-CLIP 22927820
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
2
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 28514442, 33961781
GO:0005737 Component Cytoplasm IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
614283 18713 ENSG00000106415
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q86VQ1
Protein name Glucocorticoid-induced transcript 1 protein
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15388 FAM117 167 477 Protein Family FAM117 Family
Tissue specificity TISSUE SPECIFICITY: Predominantly expressed in lung, spleen, thymus and testis and, at lower levels, in brain, bone marrow, peripheral leukocytes, skin and trachea. {ECO:0000269|PubMed:12557054, ECO:0000269|PubMed:21991891}.
Sequence
MSTASSSSSSSSSQTPHPPSQRMRRSAAGSPPAVAAAGSGNGAGGGGGVGCAPAAGAGRL
LQPIRATVPYQLLRGSQHSPTRPPVAAAAASLGSLPGPGAARGPSPSSPTPPAAAAPAEQ
APRAKGRPRRSPESHRRSSSPERRSPGSPVCRADKAKSQQVRTSSTIRRTSSLDTITGPY
LTGQWPRDPHVHYPSCMKDKATQTPSCWAEEGAEKRSHQRSASWGSADQLKEQIAKLRQQ
LQRSKQSSRHSKEKDRQSPLHGNHITISHTQATGSRSVPMPLSNISVPKSSVSRVPCNVE
GISPELEKVFIKENNGKEEVSKPLDIPDGRRAPLPAHYRSSSTRSIDTQTPSVQERSSSC
SSHSPCVSPFCPPESQDGSPCSTEDLLYDRDKDSGSSSPLPKYASSPKPNNSYMFKREPP
EGCERVKVFEEMASRQPISAPLFSCPDKNKVNFIPTGSAFCPVKLLGPLLPASDLML
KNS
PNSGQSSALATLTVEQLSSRVSFTSLSDDTSTAGSMEASVQQPSQQQQLLQELQGEDHIS
AQNYVII
Sequence length 547
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
7
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Glucocorticoid therapy, response to drug response ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Adenocarcinoma Associate 23301059
★☆☆☆☆
Found in Text Mining only
Adenoma Associate 23301059
★☆☆☆☆
Found in Text Mining only
Arthritis Rheumatoid Associate 25724472
★☆☆☆☆
Found in Text Mining only
Asthma Associate 21991891, 27852250, 29224020, 29345236, 29384926, 31391381
★☆☆☆☆
Found in Text Mining only
Behcet Syndrome Associate 39278467
★☆☆☆☆
Found in Text Mining only
Bipolar and Related Disorders Associate 39278467
★☆☆☆☆
Found in Text Mining only
Bipolar Disorder Associate 39278467
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Associate 23301059
★☆☆☆☆
Found in Text Mining only
Glaucoma Associate 23836780
★☆☆☆☆
Found in Text Mining only
Glaucoma Open Angle Associate 23836780
★☆☆☆☆
Found in Text Mining only