CHRM4 (cholinergic receptor muscarinic 4)

Gene
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1132
Gene name Gene Name - the full gene name approved by the HGNC.
Cholinergic receptor muscarinic 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CHRM4
Synonyms (NCBI Gene) Gene synonyms aliases
HM4, M4R
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11p11.2
Summary Summary of gene provided in NCBI Entrez Gene.
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, pho
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(18)
GO ID Ontology Definition Evidence Reference
GO:0004993 Function G protein-coupled serotonin receptor activity IBA 21873635
GO:0005515 Function Protein binding IPI 15518545
GO:0005886 Component Plasma membrane TAS
GO:0005887 Component Integral component of plasma membrane IBA 21873635
GO:0007165 Process Signal transduction TAS 9603968
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
118495 1953 ENSG00000180720
Protein
Gene Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P08173
Protein name Muscarinic acetylcholine receptor M4
Protein function The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effec
PDB 5DSG , 6D9H , 6KP6 , 7LD3 , 7LD4 , 7TRK , 7TRP , 7TRQ , 7TRS , 7V68 , 7V69 , 7V6A , 8E9X , 8FX5 , 8IYH , 8IYW , 8JER , 8JHN
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 49 → 453 7 transmembrane receptor (rhodopsin family) Family
Sequence
Sequence length 479
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Neuroactive ligand-receptor interaction
Cholinergic synapse
Regulation of actin cytoskeleton 		  Muscarinic acetylcholine receptors
G alpha (i) signalling events
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)		 21747397, 23490763
Show/Hide Text Mining Associations (13)
Associations from Text Mining
Disease Name Relationship Type References
Cardiovascular Diseases Associate 30466987
Cognitive Dysfunction Associate 30466987
Dyslipidemias Associate 30466987
Emergence Delirium Associate 34674705
Hypertension Associate 30466987
Hypertensive Retinopathy Associate 30466987
Inflammation Associate 30466987
Intellectual Disability Associate 30466987
Metabolic Diseases Associate 30466987
Neoplasms Associate 30466987, 37142586