Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	11317
Gene name Gene Name - the full gene name approved by the HGNC.	Recombination signal binding protein for immunoglobulin kappa J region like
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	RBPJL
Synonyms (NCBI Gene) Gene synonyms aliases	RBPL, RBPSUHL, SUHL
Chromosome Chromosome number	20
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	20q13.12
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the suppressor of hairless protein family. A similar protein in mouse is a transcription factor that binds to DNA sequences almost identical to that bound by the Notch receptor signaling pathway transcription factor recombini

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SNP ID	Visualize variation	Clinical significance	Consequence
rs200998587	C>T	Risk-factor	Missense variant, coding sequence variant, non coding transcript variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT499193	hsa-miR-6758-5p	PAR-CLIP	24398324
MIRT499191	hsa-miR-6856-5p	PAR-CLIP	24398324
MIRT499192	hsa-miR-6760-5p	PAR-CLIP	24398324
MIRT499190	hsa-miR-4716-3p	PAR-CLIP	24398324
MIRT499189	hsa-miR-6794-5p	PAR-CLIP	24398324
MIRT499188	hsa-miR-7515	PAR-CLIP	24398324
MIRT499187	hsa-miR-3184-5p	PAR-CLIP	24398324
MIRT499186	hsa-miR-423-5p	PAR-CLIP	24398324
MIRT499185	hsa-miR-1914-3p	PAR-CLIP	24398324
MIRT499184	hsa-miR-5194	PAR-CLIP	24398324
MIRT499183	hsa-miR-6738-5p	PAR-CLIP	24398324
MIRT499182	hsa-miR-3202	PAR-CLIP	24398324
MIRT499181	hsa-miR-185-5p	PAR-CLIP	24398324
MIRT499180	hsa-miR-4306	PAR-CLIP	24398324
MIRT499179	hsa-miR-4644	PAR-CLIP	24398324
MIRT499178	hsa-miR-4747-5p	PAR-CLIP	24398324
MIRT499177	hsa-miR-5196-5p	PAR-CLIP	24398324
MIRT499176	hsa-miR-6731-5p	PAR-CLIP	24398324
MIRT499174	hsa-miR-8085	PAR-CLIP	24398324
MIRT499175	hsa-miR-4271	PAR-CLIP	24398324
MIRT499173	hsa-miR-4725-3p	PAR-CLIP	24398324
MIRT499172	hsa-miR-6780b-5p	PAR-CLIP	24398324
MIRT499171	hsa-miR-625-5p	PAR-CLIP	24398324
MIRT499170	hsa-miR-6734-5p	PAR-CLIP	24398324
MIRT499169	hsa-miR-1303	PAR-CLIP	24398324
MIRT499193	hsa-miR-6758-5p	PAR-CLIP	24398324
MIRT499191	hsa-miR-6856-5p	PAR-CLIP	24398324
MIRT499192	hsa-miR-6760-5p	PAR-CLIP	24398324
MIRT499190	hsa-miR-4716-3p	PAR-CLIP	24398324
MIRT499189	hsa-miR-6794-5p	PAR-CLIP	24398324
MIRT499188	hsa-miR-7515	PAR-CLIP	24398324
MIRT499187	hsa-miR-3184-5p	PAR-CLIP	24398324
MIRT499186	hsa-miR-423-5p	PAR-CLIP	24398324
MIRT499185	hsa-miR-1914-3p	PAR-CLIP	24398324
MIRT499184	hsa-miR-5194	PAR-CLIP	24398324
MIRT499183	hsa-miR-6738-5p	PAR-CLIP	24398324
MIRT499182	hsa-miR-3202	PAR-CLIP	24398324
MIRT499181	hsa-miR-185-5p	PAR-CLIP	24398324
MIRT499180	hsa-miR-4306	PAR-CLIP	24398324
MIRT499179	hsa-miR-4644	PAR-CLIP	24398324
MIRT499178	hsa-miR-4747-5p	PAR-CLIP	24398324
MIRT499177	hsa-miR-5196-5p	PAR-CLIP	24398324
MIRT499176	hsa-miR-6731-5p	PAR-CLIP	24398324
MIRT499174	hsa-miR-8085	PAR-CLIP	24398324
MIRT499175	hsa-miR-4271	PAR-CLIP	24398324
MIRT499173	hsa-miR-4725-3p	PAR-CLIP	24398324
MIRT499172	hsa-miR-6780b-5p	PAR-CLIP	24398324
MIRT499171	hsa-miR-625-5p	PAR-CLIP	24398324
MIRT499170	hsa-miR-6734-5p	PAR-CLIP	24398324
MIRT499169	hsa-miR-1303	PAR-CLIP	24398324
MIRT1297401	hsa-miR-1253	CLIP-seq
MIRT1297402	hsa-miR-134	CLIP-seq
MIRT1297403	hsa-miR-1912	CLIP-seq
MIRT1297404	hsa-miR-3118	CLIP-seq
MIRT1297405	hsa-miR-3165	CLIP-seq
MIRT1297406	hsa-miR-3189-5p	CLIP-seq
MIRT1297407	hsa-miR-3646	CLIP-seq
MIRT1297408	hsa-miR-3649	CLIP-seq
MIRT1297409	hsa-miR-4434	CLIP-seq
MIRT1297410	hsa-miR-4471	CLIP-seq
MIRT1297411	hsa-miR-4476	CLIP-seq
MIRT1297412	hsa-miR-4516	CLIP-seq
MIRT1297413	hsa-miR-4533	CLIP-seq
MIRT1297414	hsa-miR-4648	CLIP-seq
MIRT1297415	hsa-miR-4726-3p	CLIP-seq
MIRT1297416	hsa-miR-4758-3p	CLIP-seq
MIRT1297417	hsa-miR-524-3p	CLIP-seq
MIRT1297418	hsa-miR-525-3p	CLIP-seq
MIRT1297419	hsa-miR-548q	CLIP-seq
MIRT1297420	hsa-miR-582-3p	CLIP-seq
MIRT1297421	hsa-miR-637	CLIP-seq
MIRT1297422	hsa-miR-665	CLIP-seq
MIRT1297423	hsa-miR-759	CLIP-seq
MIRT1297406	hsa-miR-3189-5p	CLIP-seq
MIRT1297408	hsa-miR-3649	CLIP-seq
MIRT2088396	hsa-miR-3907	CLIP-seq
MIRT1297410	hsa-miR-4471	CLIP-seq
MIRT1297414	hsa-miR-4648	CLIP-seq
MIRT2088397	hsa-miR-4685-5p	CLIP-seq
MIRT1297415	hsa-miR-4726-3p	CLIP-seq
MIRT1297416	hsa-miR-4758-3p	CLIP-seq
MIRT1297419	hsa-miR-548q	CLIP-seq
MIRT1297420	hsa-miR-582-3p	CLIP-seq
MIRT1297406	hsa-miR-3189-5p	CLIP-seq
MIRT1297408	hsa-miR-3649	CLIP-seq
MIRT2088396	hsa-miR-3907	CLIP-seq
MIRT1297410	hsa-miR-4471	CLIP-seq
MIRT1297414	hsa-miR-4648	CLIP-seq
MIRT2088397	hsa-miR-4685-5p	CLIP-seq
MIRT1297415	hsa-miR-4726-3p	CLIP-seq
MIRT1297416	hsa-miR-4758-3p	CLIP-seq
MIRT1297419	hsa-miR-548q	CLIP-seq
MIRT1297420	hsa-miR-582-3p	CLIP-seq
MIRT1297406	hsa-miR-3189-5p	CLIP-seq
MIRT1297408	hsa-miR-3649	CLIP-seq
MIRT2088396	hsa-miR-3907	CLIP-seq
MIRT1297410	hsa-miR-4471	CLIP-seq
MIRT1297414	hsa-miR-4648	CLIP-seq
MIRT2088397	hsa-miR-4685-5p	CLIP-seq
MIRT1297415	hsa-miR-4726-3p	CLIP-seq
MIRT1297416	hsa-miR-4758-3p	CLIP-seq
MIRT1297419	hsa-miR-548q	CLIP-seq
MIRT1297420	hsa-miR-582-3p	CLIP-seq
MIRT2457964	hsa-miR-1207-5p	CLIP-seq
MIRT2457965	hsa-miR-1827	CLIP-seq
MIRT2457966	hsa-miR-3160-3p	CLIP-seq
MIRT2457967	hsa-miR-4270	CLIP-seq
MIRT2457968	hsa-miR-4441	CLIP-seq
MIRT2457969	hsa-miR-4709-3p	CLIP-seq
MIRT2457970	hsa-miR-4763-3p	CLIP-seq
MIRT2457971	hsa-miR-940	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003682	Function	Chromatin binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0003700	Function	DNA-binding transcription factor activity	TAS	9929984
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IEA
GO:0005667	Component	Transcription regulator complex	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0007165	Process	Signal transduction	TAS	9929984
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA

MIM	HGNC	e!Ensembl
616104	13761	ENSG00000124232

Protein

UniProt ID

Q9UBG7

Protein name

Recombining binding protein suppressor of hairless-like protein (Transcription factor RBP-L)

Protein function

Putative transcription factor, which cooperates with EBNA2 to activate transcription.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF09271	LAG1-DNAbind	69 → 206	LAG1, DNA binding	Domain
PF09270	BTD	234 → 359	Beta-trefoil DNA-binding domain	Domain

Sequence

MDPAGAADPSVPPNPLTHLSLQDRSEMQLQSEADRRSLPGTWTRSSPEHTTILRGGVRRC
LQQQCEQTVRILHAKVAQKSYGNEKRFFCPPPCVYLSGPGWRVKPGQDQAHQAGETGPTV
CGYMGLDSASGSATETQKLNFEQQPDSREFGCAKTLYISDADKRKHFRLVLRLVLRGGRE
LGTFHSRLIKVISKPSQKKQSLKNTDLCISSGSKVSLFNRLRSQTVSTRYLSVEDGAFVA
SARQWAAFTLHLADGHSAQGDFPPREGYVRYGSLVQLVCTVTGITLPPMIIRKVAKQCAL
LDVDEPISQLHKCAFQFPGSPPGGGGTYLCLATEKVVQFQASPCPKEANRALLNDSSCWT
IIGTESVEFSFSTSLACTLEPVTPVPLISTLELSGGGDVATLELHGENFHAGLKVWFGDV
EAETMYRSPRSLVCVVPDVAAFCSDWRWLRAPITIPMSLVRADGLFYPSAFSFTYTPEYS
VRPGHPGVPEPATDADALLESIHQEFTRTNFHLFIQT

Sequence length

517

Interactions

View interactions

	KEGG
	Notch signaling pathway Th1 and Th2 cell differentiation Spinocerebellar ataxia Human papillomavirus infection Epstein-Barr virus infection Viral carcinogenesis

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Bipolar Disorder	Bipolar disorder, Bipolar I disorder	N/A	N/A	GWAS
Diabetes Mellitus	Type 2 diabetes mellitus	N/A	N/A	ClinVar

RBPJL (recombination signal binding protein for immunoglobulin kappa J region like)