GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000785 |
Component |
Chromatin |
IDA |
16731528 |
GO:0001046 |
Function |
Core promoter sequence-specific DNA binding |
IC |
15790595 |
GO:0001933 |
Process |
Negative regulation of protein phosphorylation |
IGI |
15983381 |
GO:0002866 |
Process |
Positive regulation of acute inflammatory response to antigenic stimulus |
ISS |
|
GO:0003690 |
Function |
Double-stranded DNA binding |
IDA |
22683601 |
GO:0003697 |
Function |
Single-stranded DNA binding |
IDA |
22683601 |
GO:0003713 |
Function |
Transcription coactivator activity |
IGI |
15790595 |
GO:0003713 |
Function |
Transcription coactivator activity |
TAS |
16731528 |
GO:0003729 |
Function |
MRNA binding |
IDA |
18626009 |
GO:0005102 |
Function |
Signaling receptor binding |
IPI |
21785459 |
GO:0005507 |
Function |
Copper ion binding |
IDA |
23792957 |
GO:0005515 |
Function |
Protein binding |
IPI |
11477070, 15790595, 15983381, 16632486, 17510388, 18000879, 19229105, 19822128, 20127688, 21097510, 21785459, 22683601, 23743200, 24899725, 24947010, 25416956, 26752685, 31536960, 32814053 |
GO:0005634 |
Component |
Nucleus |
HDA |
21630459 |
GO:0005634 |
Component |
Nucleus |
IBA |
21873635 |
GO:0005634 |
Component |
Nucleus |
IDA |
11477070, 12446870, 14662519, 15790595, 15983381, 18711745, 19822128, 22683601 |
GO:0005654 |
Component |
Nucleoplasm |
IDA |
|
GO:0005654 |
Component |
Nucleoplasm |
TAS |
|
GO:0005737 |
Component |
Cytoplasm |
IDA |
12446870, 15983381, 17510388, 18711745, 19822128 |
GO:0005739 |
Component |
Mitochondrion |
IDA |
15790595, 15944198, 18711745, 19229105, 19822128, 23743200, 31536960 |
GO:0005739 |
Component |
Mitochondrion |
IMP |
21785459 |
GO:0005758 |
Component |
Mitochondrial intermembrane space |
IEA |
|
GO:0005759 |
Component |
Mitochondrial matrix |
IEA |
|
GO:0005783 |
Component |
Endoplasmic reticulum |
IDA |
31536960 |
GO:0005829 |
Component |
Cytosol |
IBA |
21873635 |
GO:0005829 |
Component |
Cytosol |
IDA |
14662519, 15944198, 19229105, 22683601 |
GO:0005829 |
Component |
Cytosol |
IMP |
21785459 |
GO:0005886 |
Component |
Plasma membrane |
IEA |
|
GO:0005912 |
Component |
Adherens junction |
HDA |
25468996 |
GO:0006281 |
Process |
DNA repair |
IDA |
28596309 |
GO:0006469 |
Process |
Negative regulation of protein kinase activity |
IGI |
15983381 |
GO:0006508 |
Process |
Proteolysis |
IEA |
|
GO:0006517 |
Process |
Protein deglycosylation |
IDA |
25416785 |
GO:0006517 |
Process |
Protein deglycosylation |
IDA |
27903648 |
GO:0006517 |
Process |
Protein deglycosylation |
IMP |
26995087, 30894531 |
GO:0006914 |
Process |
Autophagy |
IEA |
|
GO:0006954 |
Process |
Inflammatory response |
IEA |
|
GO:0007005 |
Process |
Mitochondrion organization |
ISS |
|
GO:0007265 |
Process |
Ras protein signal transduction |
TAS |
14662519 |
GO:0007338 |
Process |
Single fertilization |
IEA |
|
GO:0008134 |
Function |
Transcription factor binding |
IPI |
21097510 |
GO:0008233 |
Function |
Peptidase activity |
IDA |
20304780 |
GO:0008344 |
Process |
Adult locomotory behavior |
IEA |
|
GO:0009438 |
Process |
Methylglyoxal metabolic process |
IDA |
22523093 |
GO:0009438 |
Process |
Methylglyoxal metabolic process |
IDA |
27903648 |
GO:0010273 |
Process |
Detoxification of copper ion |
IMP |
23792957 |
GO:0010628 |
Process |
Positive regulation of gene expression |
TAS |
24252804 |
GO:0010629 |
Process |
Negative regulation of gene expression |
IDA |
22683601 |
GO:0016532 |
Function |
Superoxide dismutase copper chaperone activity |
IDA |
24567322 |
GO:0016570 |
Process |
Histone modification |
IMP |
30150385, 30894531 |
GO:0016605 |
Component |
PML body |
IDA |
22683601 |
GO:0016684 |
Function |
Oxidoreductase activity, acting on peroxide as acceptor |
IDA |
24567322 |
GO:0019249 |
Process |
Lactate biosynthetic process |
IDA |
22523093 |
GO:0019826 |
Function |
Oxygen sensor activity |
IEA |
|
GO:0019899 |
Function |
Enzyme binding |
IPI |
19703902, 19822128, 23743200 |
GO:0019900 |
Function |
Kinase binding |
IPI |
19229105 |
GO:0019955 |
Function |
Cytokine binding |
IPI |
21097510 |
GO:0030073 |
Process |
Insulin secretion |
ISS |
|
GO:0030424 |
Component |
Axon |
ISS |
|
GO:0031334 |
Process |
Positive regulation of protein-containing complex assembly |
IDA |
24947010 |
GO:0031397 |
Process |
Negative regulation of protein ubiquitination |
IDA |
17015834, 24899725 |
GO:0032091 |
Process |
Negative regulation of protein binding |
IDA |
11477070, 16731528, 17015834, 24899725 |
GO:0032091 |
Process |
Negative regulation of protein binding |
IGI |
15983381 |
GO:0032091 |
Process |
Negative regulation of protein binding |
IMP |
21785459 |
GO:0032148 |
Process |
Activation of protein kinase B activity |
IC |
22492997 |
GO:0032435 |
Process |
Negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
IDA |
17015834 |
GO:0032679 |
Process |
Regulation of TRAIL production |
IMP |
21785459 |
GO:0032757 |
Process |
Positive regulation of interleukin-8 production |
IDA |
21097510 |
GO:0033138 |
Process |
Positive regulation of peptidyl-serine phosphorylation |
IMP |
22492997 |
GO:0033182 |
Process |
Regulation of histone ubiquitination |
IMP |
30150385 |
GO:0033234 |
Process |
Negative regulation of protein sumoylation |
IDA |
16731528 |
GO:0033864 |
Process |
Positive regulation of NAD(P)H oxidase activity |
ISS |
|
GO:0034599 |
Process |
Cellular response to oxidative stress |
IDA |
15983381, 19703902, 20969476, 22683601 |
GO:0034599 |
Process |
Cellular response to oxidative stress |
IMP |
24899725 |
GO:0035065 |
Process |
Regulation of histone acetylation |
IMP |
30150385 |
GO:0036470 |
Function |
Tyrosine 3-monooxygenase activator activity |
IDA |
19703902 |
GO:0036471 |
Process |
Cellular response to glyoxal |
IDA |
22523093 |
GO:0036478 |
Function |
L-dopa decarboxylase activator activity |
IDA |
19703902 |
GO:0036524 |
Function |
Protein deglycase activity |
IBA |
21873635 |
GO:0036524 |
Function |
Protein deglycase activity |
IDA |
25416785 |
GO:0036524 |
Function |
Protein deglycase activity |
IDA |
31653696 |
GO:0036526 |
Process |
Peptidyl-cysteine deglycation |
IDA |
25416785 |
GO:0036527 |
Process |
Peptidyl-arginine deglycation |
IDA |
25416785 |
GO:0036527 |
Process |
Peptidyl-arginine deglycation |
IMP |
30150385 |
GO:0036528 |
Process |
Peptidyl-lysine deglycation |
IDA |
25416785 |
GO:0036529 |
Process |
Protein deglycation, glyoxal removal |
IBA |
21873635 |
GO:0036529 |
Process |
Protein deglycation, glyoxal removal |
IDA |
25416785 |
GO:0036530 |
Process |
Protein deglycation, methylglyoxal removal |
IDA |
25416785 |
GO:0036530 |
Process |
Protein deglycation, methylglyoxal removal |
IDA |
27903648 |
GO:0036530 |
Process |
Protein deglycation, methylglyoxal removal |
IMP |
30150385 |
GO:0036531 |
Process |
Glutathione deglycation |
IDA |
25416785 |
GO:0042593 |
Process |
Glucose homeostasis |
ISS |
|
GO:0042743 |
Process |
Hydrogen peroxide metabolic process |
IDA |
20969476, 24567322 |
GO:0042802 |
Function |
Identical protein binding |
IPI |
15502874, 15983381, 24947010 |
GO:0042803 |
Function |
Protein homodimerization activity |
IDA |
18711745, 24144264, 24567322 |
GO:0043066 |
Process |
Negative regulation of apoptotic process |
IDA |
22523093 |
GO:0043523 |
Process |
Regulation of neuron apoptotic process |
IDA |
18711745, 20304780 |
GO:0043524 |
Process |
Negative regulation of neuron apoptotic process |
IDA |
22511790 |
GO:0044297 |
Component |
Cell body |
IEA |
|
GO:0044388 |
Function |
Small protein activating enzyme binding |
IPI |
15983381 |
GO:0044390 |
Function |
Ubiquitin-like protein conjugating enzyme binding |
IPI |
15983381 |
GO:0044877 |
Function |
Protein-containing complex binding |
IDA |
19822128 |
GO:0045121 |
Component |
Membrane raft |
IEA |
|
GO:0045296 |
Function |
Cadherin binding |
HDA |
25468996 |
GO:0045340 |
Function |
Mercury ion binding |
IDA |
23792957 |
GO:0045944 |
Process |
Positive regulation of transcription by RNA polymerase II |
IDA |
21097510 |
GO:0045944 |
Process |
Positive regulation of transcription by RNA polymerase II |
IGI |
15790595, 17015834 |
GO:0045944 |
Process |
Positive regulation of transcription by RNA polymerase II |
IMP |
16731528, 19703902, 22492997 |
GO:0046295 |
Process |
Glycolate biosynthetic process |
IDA |
22523093 |
GO:0046826 |
Process |
Negative regulation of protein export from nucleus |
IGI |
15983381 |
GO:0048471 |
Component |
Perinuclear region of cytoplasm |
IDA |
25468996 |
GO:0050681 |
Function |
Androgen receptor binding |
IPI |
17510388 |
GO:0050727 |
Process |
Regulation of inflammatory response |
ISS |
|
GO:0050787 |
Process |
Detoxification of mercury ion |
IMP |
23792957 |
GO:0050821 |
Process |
Protein stabilization |
IDA |
24947010 |
GO:0050821 |
Process |
Protein stabilization |
IMP |
17015834, 19229105 |
GO:0051091 |
Process |
Positive regulation of DNA-binding transcription factor activity |
IMP |
17015834 |
GO:0051091 |
Process |
Positive regulation of DNA-binding transcription factor activity |
TAS |
22492997 |
GO:0051444 |
Process |
Negative regulation of ubiquitin-protein transferase activity |
IDA |
24899725 |
GO:0051583 |
Process |
Dopamine uptake involved in synaptic transmission |
IEA |
|
GO:0051881 |
Process |
Regulation of mitochondrial membrane potential |
IMP |
23743200 |
GO:0051897 |
Process |
Positive regulation of protein kinase B signaling |
IC |
22492997 |
GO:0051899 |
Process |
Membrane depolarization |
IEA |
|
GO:0051920 |
Function |
Peroxiredoxin activity |
IEA |
|
GO:0060081 |
Process |
Membrane hyperpolarization |
IEA |
|
GO:0060548 |
Process |
Negative regulation of cell death |
IDA |
14749723 |
GO:0060765 |
Process |
Regulation of androgen receptor signaling pathway |
IDA |
11477070 |
GO:0061727 |
Process |
Methylglyoxal catabolic process to lactate |
IDA |
28993701 |
GO:0070062 |
Component |
Extracellular exosome |
HDA |
19056867, 19199708, 20458337, 23533145 |
GO:0070301 |
Process |
Cellular response to hydrogen peroxide |
IDA |
14749723 |
GO:0070491 |
Function |
Repressing transcription factor binding |
IPI |
15790595, 16731528 |
GO:0070994 |
Process |
Detection of oxidative stress |
IEA |
|
GO:0097110 |
Function |
Scaffold protein binding |
IPI |
21785459 |
GO:0098793 |
Component |
Presynapse |
IEA |
|
GO:0098869 |
Process |
Cellular oxidant detoxification |
IEA |
|
GO:0106044 |
Process |
Guanine deglycation |
IDA |
28596309 |
GO:0106045 |
Process |
Guanine deglycation, methylglyoxal removal |
IDA |
28596309 |
GO:0106046 |
Process |
Guanine deglycation, glyoxal removal |
IBA |
21873635 |
GO:0106046 |
Process |
Guanine deglycation, glyoxal removal |
IDA |
28596309 |
GO:0110095 |
Process |
Cellular detoxification of aldehyde |
IDA |
28993701 |
GO:0140041 |
Process |
Cellular detoxification of methylglyoxal |
IDA |
28993701 |
GO:1900182 |
Process |
Positive regulation of protein localization to nucleus |
IDA |
21097510 |
GO:1900182 |
Process |
Positive regulation of protein localization to nucleus |
IMP |
22492997 |
GO:1901215 |
Process |
Negative regulation of neuron death |
IDA |
22683601 |
GO:1901671 |
Process |
Positive regulation of superoxide dismutase activity |
IDA |
24567322 |
GO:1901984 |
Process |
Negative regulation of protein acetylation |
IDA |
22683601 |
GO:1902177 |
Process |
Positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
IEA |
|
GO:1902236 |
Process |
Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway |
IGI |
14652021 |
GO:1902903 |
Process |
Regulation of supramolecular fiber organization |
TAS |
23626584 |
GO:1902958 |
Process |
Positive regulation of mitochondrial electron transport, NADH to ubiquinone |
IMP |
19822128 |
GO:1903073 |
Process |
Negative regulation of death-inducing signaling complex assembly |
IC |
21785459 |
GO:1903094 |
Process |
Negative regulation of protein K48-linked deubiquitination |
IDA |
21097510 |
GO:1903122 |
Process |
Negative regulation of TRAIL-activated apoptotic signaling pathway |
IMP |
21785459 |
GO:1903135 |
Function |
Cupric ion binding |
IDA |
24567322 |
GO:1903136 |
Function |
Cuprous ion binding |
IDA |
24144264, 24567322 |
GO:1903168 |
Process |
Positive regulation of pyrroline-5-carboxylate reductase activity |
IDA |
23743200 |
GO:1903178 |
Process |
Positive regulation of tyrosine 3-monooxygenase activity |
IDA |
19703902 |
GO:1903181 |
Process |
Positive regulation of dopamine biosynthetic process |
IC |
16731528 |
GO:1903181 |
Process |
Positive regulation of dopamine biosynthetic process |
IDA |
19703902 |
GO:1903189 |
Process |
Glyoxal metabolic process |
IDA |
22523093 |
GO:1903190 |
Process |
Glyoxal catabolic process |
IEA |
|
GO:1903197 |
Process |
Positive regulation of L-dopa biosynthetic process |
IMP |
16731528 |
GO:1903200 |
Process |
Positive regulation of L-dopa decarboxylase activity |
IDA |
19703902 |
GO:1903202 |
Process |
Negative regulation of oxidative stress-induced cell death |
IDA |
16632486 |
GO:1903206 |
Process |
Negative regulation of hydrogen peroxide-induced cell death |
IMP |
22492997, 23743200 |
GO:1903208 |
Process |
Negative regulation of hydrogen peroxide-induced neuron death |
IDA |
15983381, 24947010 |
GO:1903377 |
Process |
Negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway |
IDA |
15790595 |
GO:1903384 |
Process |
Negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway |
IGI |
14652021 |
GO:1903427 |
Process |
Negative regulation of reactive oxygen species biosynthetic process |
ISS |
|
GO:1903428 |
Process |
Positive regulation of reactive oxygen species biosynthetic process |
IEA |
|
GO:1903599 |
Process |
Positive regulation of autophagy of mitochondrion |
NAS |
24531622 |
GO:1905259 |
Process |
Negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway |
IDA |
14752510 |
GO:1990381 |
Function |
Ubiquitin-specific protease binding |
IPI |
21097510 |
GO:1990422 |
Function |
Glyoxalase (glycolic acid-forming) activity |
IDA |
31653696 |
GO:2000157 |
Process |
Negative regulation of ubiquitin-specific protease activity |
IDA |
21097510 |
GO:2000277 |
Process |
Positive regulation of oxidative phosphorylation uncoupler activity |
IEA |
|
GO:2000679 |
Process |
Positive regulation of transcription regulatory region DNA binding |
IMP |
22492997 |
GO:2000825 |
Process |
Positive regulation of androgen receptor activity |
IMP |
17510388 |
GO:2001237 |
Process |
Negative regulation of extrinsic apoptotic signaling pathway |
IMP |
21785459 |
GO:2001268 |
Process |
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
IMP |
21785459 |