Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	1131
Gene name Gene Name - the full gene name approved by the HGNC.	Cholinergic receptor muscarinic 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CHRM3
Synonyms (NCBI Gene) Gene synonyms aliases	EGBRS, HM3, PBS, m3AChR
Disease Acronyms (UniProt) Disease acronyms from UniProt database	PBS
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1q43
Summary Summary of gene provided in NCBI Entrez Gene.	The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, pho

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SNP ID	Visualize variation	Clinical significance	Consequence
rs587776862	GCCTGAGGAGGA>T	Pathogenic	Genic downstream transcript variant, coding sequence variant, frameshift variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT018504	hsa-miR-335-5p	Microarray	18185580
MIRT038434	hsa-miR-296-3p	CLASH	23622248
MIRT524478	hsa-miR-4789-3p	HITS-CLIP	21572407
MIRT524477	hsa-miR-4643	HITS-CLIP	21572407
MIRT524476	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT524475	hsa-miR-466	HITS-CLIP	21572407
MIRT524474	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT524473	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT524472	hsa-miR-5590-5p	HITS-CLIP	21572407
MIRT524471	hsa-miR-4659a-5p	HITS-CLIP	21572407
MIRT524470	hsa-miR-4659b-5p	HITS-CLIP	21572407
MIRT524469	hsa-miR-4776-3p	HITS-CLIP	21572407
MIRT524468	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT612111	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612110	hsa-miR-508-3p	HITS-CLIP	23824327
MIRT612109	hsa-miR-219a-5p	HITS-CLIP	23824327
MIRT612108	hsa-miR-4782-3p	HITS-CLIP	23824327
MIRT612107	hsa-miR-6766-3p	HITS-CLIP	23824327
MIRT612106	hsa-miR-4445-5p	HITS-CLIP	23824327
MIRT612105	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT612104	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT612103	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT612102	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612111	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612110	hsa-miR-508-3p	HITS-CLIP	23824327
MIRT612109	hsa-miR-219a-5p	HITS-CLIP	23824327
MIRT612108	hsa-miR-4782-3p	HITS-CLIP	23824327
MIRT612107	hsa-miR-6766-3p	HITS-CLIP	23824327
MIRT612106	hsa-miR-4445-5p	HITS-CLIP	23824327
MIRT612105	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT612104	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT612103	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT612102	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612111	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612110	hsa-miR-508-3p	HITS-CLIP	23824327
MIRT612109	hsa-miR-219a-5p	HITS-CLIP	23824327
MIRT612108	hsa-miR-4782-3p	HITS-CLIP	23824327
MIRT612107	hsa-miR-6766-3p	HITS-CLIP	23824327
MIRT612106	hsa-miR-4445-5p	HITS-CLIP	23824327
MIRT612105	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT612104	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT612103	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT612102	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612111	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612110	hsa-miR-508-3p	HITS-CLIP	23824327
MIRT612109	hsa-miR-219a-5p	HITS-CLIP	23824327
MIRT612108	hsa-miR-4782-3p	HITS-CLIP	23824327
MIRT612107	hsa-miR-6766-3p	HITS-CLIP	23824327
MIRT612106	hsa-miR-4445-5p	HITS-CLIP	23824327
MIRT612105	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT612104	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT612103	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT612102	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612111	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612110	hsa-miR-508-3p	HITS-CLIP	23824327
MIRT612109	hsa-miR-219a-5p	HITS-CLIP	23824327
MIRT612108	hsa-miR-4782-3p	HITS-CLIP	23824327
MIRT612107	hsa-miR-6766-3p	HITS-CLIP	23824327
MIRT612106	hsa-miR-4445-5p	HITS-CLIP	23824327
MIRT612105	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT612104	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT612103	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT612102	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612111	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612110	hsa-miR-508-3p	HITS-CLIP	23824327
MIRT612109	hsa-miR-219a-5p	HITS-CLIP	23824327
MIRT612108	hsa-miR-4782-3p	HITS-CLIP	23824327
MIRT612107	hsa-miR-6766-3p	HITS-CLIP	23824327
MIRT612106	hsa-miR-4445-5p	HITS-CLIP	23824327
MIRT612105	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT612104	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT612103	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT612102	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612111	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612110	hsa-miR-508-3p	HITS-CLIP	23824327
MIRT612109	hsa-miR-219a-5p	HITS-CLIP	23824327
MIRT612108	hsa-miR-4782-3p	HITS-CLIP	23824327
MIRT612107	hsa-miR-6766-3p	HITS-CLIP	23824327
MIRT612106	hsa-miR-4445-5p	HITS-CLIP	23824327
MIRT612105	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT612104	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT612103	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT612102	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT624359	hsa-miR-4728-3p	HITS-CLIP	23824327
MIRT612111	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612110	hsa-miR-508-3p	HITS-CLIP	23824327
MIRT612109	hsa-miR-219a-5p	HITS-CLIP	23824327
MIRT612108	hsa-miR-4782-3p	HITS-CLIP	23824327
MIRT612107	hsa-miR-6766-3p	HITS-CLIP	23824327
MIRT612106	hsa-miR-4445-5p	HITS-CLIP	23824327
MIRT624358	hsa-miR-8075	HITS-CLIP	23824327
MIRT612105	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT612104	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT612103	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT612102	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT624357	hsa-miR-4428	HITS-CLIP	23824327
MIRT624356	hsa-miR-148a-5p	HITS-CLIP	23824327
MIRT624355	hsa-miR-6888-5p	HITS-CLIP	23824327
MIRT624354	hsa-miR-3973	HITS-CLIP	23824327
MIRT624353	hsa-miR-520g-3p	HITS-CLIP	23824327
MIRT624352	hsa-miR-520h	HITS-CLIP	23824327
MIRT624351	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT624350	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT624349	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT624348	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT624347	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT624346	hsa-miR-4522	HITS-CLIP	23824327
MIRT624345	hsa-miR-5186	HITS-CLIP	23824327
MIRT624344	hsa-miR-6079	HITS-CLIP	23824327
MIRT612111	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612106	hsa-miR-4445-5p	HITS-CLIP	23824327
MIRT612105	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT612104	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT612103	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT612102	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612111	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612106	hsa-miR-4445-5p	HITS-CLIP	23824327
MIRT612105	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT612104	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT612103	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT612102	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612111	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612110	hsa-miR-508-3p	HITS-CLIP	23824327
MIRT612109	hsa-miR-219a-5p	HITS-CLIP	23824327
MIRT612108	hsa-miR-4782-3p	HITS-CLIP	23824327
MIRT612107	hsa-miR-6766-3p	HITS-CLIP	23824327
MIRT612106	hsa-miR-4445-5p	HITS-CLIP	23824327
MIRT612105	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT612104	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT612103	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT612102	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT524479	hsa-miR-137	PAR-CLIP	21572407
MIRT524478	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT524477	hsa-miR-4643	PAR-CLIP	21572407
MIRT524476	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT524475	hsa-miR-466	PAR-CLIP	21572407
MIRT524474	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT524473	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT524472	hsa-miR-5590-5p	PAR-CLIP	21572407
MIRT524471	hsa-miR-4659a-5p	PAR-CLIP	21572407
MIRT524470	hsa-miR-4659b-5p	PAR-CLIP	21572407
MIRT524469	hsa-miR-4776-3p	PAR-CLIP	21572407
MIRT524468	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT524479	hsa-miR-137	PAR-CLIP	23446348
MIRT524478	hsa-miR-4789-3p	PAR-CLIP	23446348
MIRT524477	hsa-miR-4643	PAR-CLIP	23446348
MIRT524476	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT524475	hsa-miR-466	PAR-CLIP	23446348
MIRT524474	hsa-miR-4789-5p	PAR-CLIP	23446348
MIRT524473	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT524472	hsa-miR-5590-5p	PAR-CLIP	23446348
MIRT524471	hsa-miR-4659a-5p	PAR-CLIP	23446348
MIRT524470	hsa-miR-4659b-5p	PAR-CLIP	23446348
MIRT524469	hsa-miR-4776-3p	PAR-CLIP	23446348
MIRT524468	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT500184	hsa-miR-4311	PAR-CLIP	24398324
MIRT500182	hsa-miR-5197-3p	PAR-CLIP	24398324
MIRT500183	hsa-miR-6758-5p	PAR-CLIP	24398324
MIRT500181	hsa-miR-6856-5p	PAR-CLIP	24398324
MIRT500180	hsa-miR-6873-5p	PAR-CLIP	24398324
MIRT500179	hsa-miR-6760-5p	PAR-CLIP	24398324
MIRT500178	hsa-miR-4419a	PAR-CLIP	24398324
MIRT500177	hsa-miR-4510	PAR-CLIP	24398324
MIRT500176	hsa-miR-6127	PAR-CLIP	24398324
MIRT500175	hsa-miR-6129	PAR-CLIP	24398324
MIRT500173	hsa-miR-6130	PAR-CLIP	24398324
MIRT500174	hsa-miR-6133	PAR-CLIP	24398324
MIRT500172	hsa-miR-6878-5p	PAR-CLIP	24398324
MIRT500171	hsa-miR-2467-3p	PAR-CLIP	24398324
MIRT524478	hsa-miR-4789-3p	HITS-CLIP	21572407
MIRT524477	hsa-miR-4643	HITS-CLIP	21572407
MIRT524476	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT524475	hsa-miR-466	HITS-CLIP	21572407
MIRT524474	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT524473	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT524472	hsa-miR-5590-5p	HITS-CLIP	21572407
MIRT524471	hsa-miR-4659a-5p	HITS-CLIP	21572407
MIRT524470	hsa-miR-4659b-5p	HITS-CLIP	21572407
MIRT524469	hsa-miR-4776-3p	HITS-CLIP	21572407
MIRT524468	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT612111	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612110	hsa-miR-508-3p	HITS-CLIP	23824327
MIRT612109	hsa-miR-219a-5p	HITS-CLIP	23824327
MIRT612108	hsa-miR-4782-3p	HITS-CLIP	23824327
MIRT612107	hsa-miR-6766-3p	HITS-CLIP	23824327
MIRT612106	hsa-miR-4445-5p	HITS-CLIP	23824327
MIRT612105	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT612104	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT612103	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT612102	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612111	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612110	hsa-miR-508-3p	HITS-CLIP	23824327
MIRT612109	hsa-miR-219a-5p	HITS-CLIP	23824327
MIRT612108	hsa-miR-4782-3p	HITS-CLIP	23824327
MIRT612107	hsa-miR-6766-3p	HITS-CLIP	23824327
MIRT612106	hsa-miR-4445-5p	HITS-CLIP	23824327
MIRT612105	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT612104	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT612103	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT612102	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612111	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612110	hsa-miR-508-3p	HITS-CLIP	23824327
MIRT612109	hsa-miR-219a-5p	HITS-CLIP	23824327
MIRT612108	hsa-miR-4782-3p	HITS-CLIP	23824327
MIRT612107	hsa-miR-6766-3p	HITS-CLIP	23824327
MIRT612106	hsa-miR-4445-5p	HITS-CLIP	23824327
MIRT612105	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT612104	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT612103	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT612102	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612111	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612110	hsa-miR-508-3p	HITS-CLIP	23824327
MIRT612109	hsa-miR-219a-5p	HITS-CLIP	23824327
MIRT612108	hsa-miR-4782-3p	HITS-CLIP	23824327
MIRT612107	hsa-miR-6766-3p	HITS-CLIP	23824327
MIRT612106	hsa-miR-4445-5p	HITS-CLIP	23824327
MIRT612105	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT612104	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT612103	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT612102	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612111	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612110	hsa-miR-508-3p	HITS-CLIP	23824327
MIRT612109	hsa-miR-219a-5p	HITS-CLIP	23824327
MIRT612108	hsa-miR-4782-3p	HITS-CLIP	23824327
MIRT612107	hsa-miR-6766-3p	HITS-CLIP	23824327
MIRT612106	hsa-miR-4445-5p	HITS-CLIP	23824327
MIRT612105	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT612104	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT612103	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT612102	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612111	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612110	hsa-miR-508-3p	HITS-CLIP	23824327
MIRT612109	hsa-miR-219a-5p	HITS-CLIP	23824327
MIRT612108	hsa-miR-4782-3p	HITS-CLIP	23824327
MIRT612107	hsa-miR-6766-3p	HITS-CLIP	23824327
MIRT612106	hsa-miR-4445-5p	HITS-CLIP	23824327
MIRT612105	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT612104	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT612103	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT612102	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612111	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612110	hsa-miR-508-3p	HITS-CLIP	23824327
MIRT612109	hsa-miR-219a-5p	HITS-CLIP	23824327
MIRT612108	hsa-miR-4782-3p	HITS-CLIP	23824327
MIRT612107	hsa-miR-6766-3p	HITS-CLIP	23824327
MIRT612106	hsa-miR-4445-5p	HITS-CLIP	23824327
MIRT612105	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT612104	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT612103	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT612102	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT624359	hsa-miR-4728-3p	HITS-CLIP	23824327
MIRT612111	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612110	hsa-miR-508-3p	HITS-CLIP	23824327
MIRT612109	hsa-miR-219a-5p	HITS-CLIP	23824327
MIRT612108	hsa-miR-4782-3p	HITS-CLIP	23824327
MIRT612107	hsa-miR-6766-3p	HITS-CLIP	23824327
MIRT612106	hsa-miR-4445-5p	HITS-CLIP	23824327
MIRT624358	hsa-miR-8075	HITS-CLIP	23824327
MIRT612105	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT612104	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT612103	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT612102	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT624357	hsa-miR-4428	HITS-CLIP	23824327
MIRT624356	hsa-miR-148a-5p	HITS-CLIP	23824327
MIRT624355	hsa-miR-6888-5p	HITS-CLIP	23824327
MIRT624354	hsa-miR-3973	HITS-CLIP	23824327
MIRT624353	hsa-miR-520g-3p	HITS-CLIP	23824327
MIRT624352	hsa-miR-520h	HITS-CLIP	23824327
MIRT624351	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT624350	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT624349	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT624348	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT624347	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT624346	hsa-miR-4522	HITS-CLIP	23824327
MIRT624345	hsa-miR-5186	HITS-CLIP	23824327
MIRT624344	hsa-miR-6079	HITS-CLIP	23824327
MIRT612111	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612106	hsa-miR-4445-5p	HITS-CLIP	23824327
MIRT612105	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT612104	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT612103	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT612102	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612111	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612106	hsa-miR-4445-5p	HITS-CLIP	23824327
MIRT612105	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT612104	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT612103	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT612102	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612111	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612110	hsa-miR-508-3p	HITS-CLIP	23824327
MIRT612109	hsa-miR-219a-5p	HITS-CLIP	23824327
MIRT612108	hsa-miR-4782-3p	HITS-CLIP	23824327
MIRT612107	hsa-miR-6766-3p	HITS-CLIP	23824327
MIRT612106	hsa-miR-4445-5p	HITS-CLIP	23824327
MIRT612105	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT612104	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT612103	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT612102	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT524479	hsa-miR-137	PAR-CLIP	21572407
MIRT524478	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT524477	hsa-miR-4643	PAR-CLIP	21572407
MIRT524476	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT524475	hsa-miR-466	PAR-CLIP	21572407
MIRT524474	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT524473	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT524472	hsa-miR-5590-5p	PAR-CLIP	21572407
MIRT524471	hsa-miR-4659a-5p	PAR-CLIP	21572407
MIRT524470	hsa-miR-4659b-5p	PAR-CLIP	21572407
MIRT524469	hsa-miR-4776-3p	PAR-CLIP	21572407
MIRT524468	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT524479	hsa-miR-137	PAR-CLIP	23446348
MIRT524478	hsa-miR-4789-3p	PAR-CLIP	23446348
MIRT524477	hsa-miR-4643	PAR-CLIP	23446348
MIRT524476	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT524475	hsa-miR-466	PAR-CLIP	23446348
MIRT524474	hsa-miR-4789-5p	PAR-CLIP	23446348
MIRT524473	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT524472	hsa-miR-5590-5p	PAR-CLIP	23446348
MIRT524471	hsa-miR-4659a-5p	PAR-CLIP	23446348
MIRT524470	hsa-miR-4659b-5p	PAR-CLIP	23446348
MIRT524469	hsa-miR-4776-3p	PAR-CLIP	23446348
MIRT524468	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT500184	hsa-miR-4311	PAR-CLIP	24398324
MIRT500182	hsa-miR-5197-3p	PAR-CLIP	24398324
MIRT500183	hsa-miR-6758-5p	PAR-CLIP	24398324
MIRT500181	hsa-miR-6856-5p	PAR-CLIP	24398324
MIRT500180	hsa-miR-6873-5p	PAR-CLIP	24398324
MIRT500179	hsa-miR-6760-5p	PAR-CLIP	24398324
MIRT500178	hsa-miR-4419a	PAR-CLIP	24398324
MIRT500177	hsa-miR-4510	PAR-CLIP	24398324
MIRT500176	hsa-miR-6127	PAR-CLIP	24398324
MIRT500175	hsa-miR-6129	PAR-CLIP	24398324
MIRT500173	hsa-miR-6130	PAR-CLIP	24398324
MIRT500174	hsa-miR-6133	PAR-CLIP	24398324
MIRT500172	hsa-miR-6878-5p	PAR-CLIP	24398324
MIRT500171	hsa-miR-2467-3p	PAR-CLIP	24398324
MIRT891653	hsa-miR-30a	CLIP-seq
MIRT891654	hsa-miR-30b	CLIP-seq
MIRT891655	hsa-miR-30c	CLIP-seq
MIRT891656	hsa-miR-30d	CLIP-seq
MIRT891657	hsa-miR-30e	CLIP-seq
MIRT891658	hsa-miR-4514	CLIP-seq
MIRT891659	hsa-miR-4692	CLIP-seq
MIRT1964266	hsa-miR-668	CLIP-seq

Show/Hide all(32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003056	Process	Regulation of vascular associated smooth muscle contraction	IBA	21873635
GO:0004435	Function	Phosphatidylinositol phospholipase C activity	TAS	1905013
GO:0004993	Function	G protein-coupled serotonin receptor activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	19575010, 20398705, 21056967
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005886	Component	Plasma membrane	IDA	21056967
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0005887	Component	Integral component of plasma membrane	ISS
GO:0006464	Process	Cellular protein modification process	TAS	10051746
GO:0007165	Process	Signal transduction	TAS	10940357
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA	21873635
GO:0007197	Process	Adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	IBA	21873635
GO:0007213	Process	G protein-coupled acetylcholine receptor signaling pathway	ISS
GO:0007268	Process	Chemical synaptic transmission	IBA	21873635
GO:0007399	Process	Nervous system development	TAS	2739737
GO:0009925	Component	Basal plasma membrane	IDA	17478539
GO:0016907	Function	G protein-coupled acetylcholine receptor activity	IBA	21873635
GO:0016907	Function	G protein-coupled acetylcholine receptor activity	ISS
GO:0019722	Process	Calcium-mediated signaling	IDA	17478539
GO:0030425	Component	Dendrite	IBA	21873635
GO:0030594	Function	Neurotransmitter receptor activity	IBA	21873635
GO:0032412	Process	Regulation of ion transmembrane transporter activity	IDA	17478539
GO:0038023	Function	Signaling receptor activity	TAS	10940357
GO:0042166	Function	Acetylcholine binding	ISS
GO:0045202	Component	Synapse	IBA	21873635
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0045987	Process	Positive regulation of smooth muscle contraction	IEA
GO:0046541	Process	Saliva secretion	IEA
GO:0095500	Process	Acetylcholine receptor signaling pathway	IDA	17478539
GO:0098664	Process	G protein-coupled serotonin receptor signaling pathway	IEA

MIM	HGNC	e!Ensembl
118494	1952	ENSG00000133019

Protein

UniProt ID

P20309

Protein name

Muscarinic acetylcholine receptor M3

Protein function

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effec

PDB

2CSA , 8E9W , 8E9Y , 8E9Z , 8EA0

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	85 → 544	7 transmembrane receptor (rhodopsin family)	Family

Sequence

MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPL
GGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVI
SMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKR
TTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAF
YMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSM
KRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSE
TRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSF
PKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKR
MSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVN
PVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL

Sequence length

590

Interactions

View interactions

	KEGG		Reactome
	Calcium signaling pathway Neuroactive ligand-receptor interaction Cholinergic synapse Taste transduction Regulation of actin cytoskeleton Insulin secretion Salivary secretion Gastric acid secretion Pancreatic secretion Alzheimer disease Pathways of neurodegeneration - multiple diseases		Muscarinic acetylcholine receptors G alpha (q) signalling events

Show/Hide Causal Diseases (11)

Disease term	Disease name	dbSNP ID	References
Causal
Atrial septal defect	Atrial Septal Defects	rs137852951, rs137852953, rs137852955, rs267607106, rs104893900, rs104893901, rs104893903, rs606231358, rs606231359, rs137852683, rs606231360, rs104893907, rs104894073, rs1585703301, rs104894074 View all (25 more)
Congenital heart defects	Congenital Heart Defects	rs267607101, rs121434422, rs387906498, rs397509416, rs587777371, rs587777372, rs587777374, rs367537998, rs797044882, rs886041730, rs768027510, rs1064793873, rs1555447012, rs1554263268, rs1554263321 View all (13 more)
Cryptorchidism	Cryptorchidism, Bilateral Cryptorchidism, Unilateral Cryptorchidism, Abdominal Cryptorchidism	rs121912555, rs104894697, rs104894698, rs398122886	22077972
Epilepsy	Epilepsy	rs113994140, rs28937874, rs1589762127, rs104894166, rs28939075, rs2134001459, rs104894167, rs119488099, rs119488100, rs387906420, rs121917752, rs121918622, rs281865564, rs387907313, rs397514670 View all (165 more)	22949513
Patent ductus arteriosus	Patent ductus arteriosus	rs80338911, rs879253870, rs879253871, rs879255278, rs879255279, rs879253872
Prune belly syndrome	Prune Belly Syndrome, Prune belly syndrome	rs587776862, rs1597782599, rs1597802479, rs1603359205, rs1603359091	22077972
Renal insufficiency	Renal Insufficiency	rs1596536873
Scoliosis	Scoliosis, unspecified	rs1057518828, rs147296805, rs758163506, rs1555613564, rs1596852902, rs1596853067, rs1596853085
Tetralogy of fallot	Tetralogy of Fallot	rs28939668, rs727504412, rs864321649, rs774966208, rs876660981, rs886044220, rs1114167357, rs1569484126, rs1569484164, rs1569484122, rs1569484124, rs1569484042, rs1569484120, rs1569484299, rs1569484301, rs1569484288 View all (1 more)
Ventricular septal defect	Ventricular Septal Defects	rs104894073, rs387906775
Vesicoureteral reflux	Vesico-Ureteral Reflux	rs587777684, rs148731211

Show/Hide Unknown Diseases (9)

Disease term	Disease name	Evidence	References	Source
Unknown
Chronic obstructive pulmonary disease	Chronic Obstructive Airway Disease		30804561	ClinVar
Mental depression	Major Depressive Disorder		30219690	ClinVar
Schizophrenia	Schizophrenia			GWAS
Hypertension	Hypertension			GWAS
Colorectal Cancer	Colorectal Cancer	In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1.		GWAS, CBGDA
Dementia	Dementia			GWAS
Pulmonary Fibrosis	Pulmonary Fibrosis			GWAS
Oligodendroglioma	Oligodendroglioma			GWAS
Eosinophilia	Eosinophilia			GWAS

Show/Hide Text Mining Associations (35)

Disease Name	Relationship Type	References
Associations from Text Mining
Acute cholinergic dysautonomia	Inhibit	35967390
Alzheimer Disease	Inhibit	36475335
Asthma	Associate	28166213
Astrocytoma	Associate	16280122
Calcinosis Cutis	Stimulate	28416748
Carcinogenesis	Associate	25964092, 36919835
Carcinoma Non Small Cell Lung	Associate	25964092
Carcinoma Renal Cell	Inhibit	31862408
Colorectal Neoplasms	Associate	21273532, 28416748, 36919835
Depressive Disorder	Associate	30219690
Epilepsy	Associate	22022585
Epilepsy Familial Mesial Temporal Lobe	Associate	22022585
Hypertension	Associate	38010846
Hypoxia	Associate	31862408
Lipodystrophy Congenital Generalized	Associate	32349771
Liver Failure	Associate	36111745
Multiple Sclerosis	Associate	21346779
Mydriasis	Associate	31441039
Neoplasm Metastasis	Associate	26919111
Neoplasms	Associate	25964092, 28053981, 28416748, 32060041
Nerve Degeneration	Stimulate	39684851
Ovarian Neoplasms	Associate	33997040, 39355254
Prostatic Neoplasms	Associate	30483762, 32205868, 36754848
Prostatic Neoplasms Castration Resistant	Associate	36754848
Prune Belly Syndrome	Associate	31441039
Pulmonary Disease Chronic Obstructive	Associate	28166213, 30214182
REM Sleep Parasomnias	Associate	36475335
Sjogren's Syndrome	Associate	36017844
Sleep Bruxism	Associate	39684851
Sleep Wake Disorders	Associate	36475335
Small Cell Lung Carcinoma	Associate	2153134
Stomach Neoplasms	Associate	26919111, 35673819
Sweat Gland Diseases	Associate	35967390
Urinary Bladder Diseases	Associate	31441039
Urinary Bladder Neoplasms	Associate	28053981

CHRM3 (cholinergic receptor muscarinic 3)