ADCY7 (adenylate cyclase 7)

Gene

• Entrez ID: 113
• Gene name: Adenylate cyclase 7
• Gene symbol: ADCY7
• Synonyms (NCBI Gene): AC7
• Chromosome: 16
• Chromosome location: 16q12.1
• Summary: This gene encodes a membrane-bound adenylate cyclase that catalyses the formation of cyclic AMP from ATP and is inhibitable by calcium. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme family that is characteriz

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018909	hsa-miR-335-5p	Microarray	18185580
MIRT527570	hsa-miR-302f	PAR-CLIP	22012620
MIRT527571	hsa-miR-634	PAR-CLIP	22012620
MIRT527569	hsa-miR-4310	PAR-CLIP	22012620
MIRT527568	hsa-miR-7157-5p	PAR-CLIP	22012620
MIRT527567	hsa-miR-338-3p	PAR-CLIP	22012620
MIRT527566	hsa-miR-938	PAR-CLIP	22012620
MIRT527565	hsa-miR-6886-3p	PAR-CLIP	22012620
MIRT527564	hsa-miR-6501-5p	PAR-CLIP	22012620
MIRT527563	hsa-miR-4423-5p	PAR-CLIP	22012620
MIRT527562	hsa-miR-5590-5p	PAR-CLIP	22012620
MIRT527560	hsa-miR-4659a-5p	PAR-CLIP	22012620
MIRT527561	hsa-miR-4659b-5p	PAR-CLIP	22012620
MIRT527559	hsa-miR-3157-3p	PAR-CLIP	22012620
MIRT527558	hsa-miR-874-3p	PAR-CLIP	22012620
MIRT527557	hsa-miR-744-3p	PAR-CLIP	22012620
MIRT527556	hsa-miR-4776-3p	PAR-CLIP	22012620
MIRT527570	hsa-miR-302f	PAR-CLIP	22012620
MIRT527571	hsa-miR-634	PAR-CLIP	22012620
MIRT527569	hsa-miR-4310	PAR-CLIP	22012620
MIRT527568	hsa-miR-7157-5p	PAR-CLIP	22012620
MIRT527567	hsa-miR-338-3p	PAR-CLIP	22012620
MIRT527566	hsa-miR-938	PAR-CLIP	22012620
MIRT527565	hsa-miR-6886-3p	PAR-CLIP	22012620
MIRT527564	hsa-miR-6501-5p	PAR-CLIP	22012620
MIRT527563	hsa-miR-4423-5p	PAR-CLIP	22012620
MIRT527562	hsa-miR-5590-5p	PAR-CLIP	22012620
MIRT527560	hsa-miR-4659a-5p	PAR-CLIP	22012620
MIRT527561	hsa-miR-4659b-5p	PAR-CLIP	22012620
MIRT527559	hsa-miR-3157-3p	PAR-CLIP	22012620
MIRT527558	hsa-miR-874-3p	PAR-CLIP	22012620
MIRT527557	hsa-miR-744-3p	PAR-CLIP	22012620
MIRT527556	hsa-miR-4776-3p	PAR-CLIP	22012620
MIRT768122	hsa-miR-103a	CLIP-seq
MIRT768123	hsa-miR-107	CLIP-seq
MIRT768124	hsa-miR-1202	CLIP-seq
MIRT768125	hsa-miR-1207-5p	CLIP-seq
MIRT768126	hsa-miR-1225-3p	CLIP-seq
MIRT768127	hsa-miR-127-5p	CLIP-seq
MIRT768128	hsa-miR-1279	CLIP-seq
MIRT768129	hsa-miR-135a	CLIP-seq
MIRT768130	hsa-miR-135b	CLIP-seq
MIRT768131	hsa-miR-147b	CLIP-seq
MIRT768132	hsa-miR-1539	CLIP-seq
MIRT768133	hsa-miR-1909	CLIP-seq
MIRT768134	hsa-miR-210	CLIP-seq
MIRT768135	hsa-miR-24	CLIP-seq
MIRT768136	hsa-miR-3120-3p	CLIP-seq
MIRT768137	hsa-miR-3175	CLIP-seq
MIRT768138	hsa-miR-3614-5p	CLIP-seq
MIRT768139	hsa-miR-3617	CLIP-seq
MIRT768140	hsa-miR-3669	CLIP-seq
MIRT768141	hsa-miR-3943	CLIP-seq
MIRT768142	hsa-miR-3944-5p	CLIP-seq
MIRT768143	hsa-miR-3972	CLIP-seq
MIRT768144	hsa-miR-3978	CLIP-seq
MIRT768145	hsa-miR-4284	CLIP-seq
MIRT768146	hsa-miR-4436b-5p	CLIP-seq
MIRT768147	hsa-miR-4530	CLIP-seq
MIRT768148	hsa-miR-455-5p	CLIP-seq
MIRT768149	hsa-miR-4659a-3p	CLIP-seq
MIRT768150	hsa-miR-4659b-3p	CLIP-seq
MIRT768151	hsa-miR-4712-3p	CLIP-seq
MIRT768152	hsa-miR-4729	CLIP-seq
MIRT768153	hsa-miR-4755-3p	CLIP-seq
MIRT768154	hsa-miR-4762-5p	CLIP-seq
MIRT768155	hsa-miR-4763-3p	CLIP-seq
MIRT768156	hsa-miR-4768-3p	CLIP-seq
MIRT768157	hsa-miR-4789-5p	CLIP-seq
MIRT768158	hsa-miR-520f	CLIP-seq
MIRT768159	hsa-miR-548ac	CLIP-seq
MIRT768160	hsa-miR-548ae	CLIP-seq
MIRT768161	hsa-miR-548aj	CLIP-seq
MIRT768162	hsa-miR-548am	CLIP-seq
MIRT768163	hsa-miR-548d-3p	CLIP-seq
MIRT768164	hsa-miR-548x	CLIP-seq
MIRT768165	hsa-miR-548z	CLIP-seq
MIRT768166	hsa-miR-558	CLIP-seq
MIRT768167	hsa-miR-579	CLIP-seq
MIRT768168	hsa-miR-604	CLIP-seq
MIRT768169	hsa-miR-641	CLIP-seq
MIRT768170	hsa-miR-642b	CLIP-seq
MIRT768171	hsa-miR-647	CLIP-seq
MIRT768172	hsa-miR-665	CLIP-seq
MIRT768144	hsa-miR-3978	CLIP-seq
MIRT768158	hsa-miR-520f	CLIP-seq
MIRT768144	hsa-miR-3978	CLIP-seq
MIRT768158	hsa-miR-520f	CLIP-seq
MIRT768144	hsa-miR-3978	CLIP-seq
MIRT768158	hsa-miR-520f	CLIP-seq
MIRT768144	hsa-miR-3978	CLIP-seq
MIRT768158	hsa-miR-520f	CLIP-seq
MIRT1926578	hsa-miR-539	CLIP-seq
MIRT2167569	hsa-miR-128	CLIP-seq
MIRT2167570	hsa-miR-3144-5p	CLIP-seq
MIRT2167571	hsa-miR-3191	CLIP-seq
MIRT2167572	hsa-miR-3200-5p	CLIP-seq
MIRT2167573	hsa-miR-3663-3p	CLIP-seq
MIRT768144	hsa-miR-3978	CLIP-seq
MIRT2167574	hsa-miR-4269	CLIP-seq
MIRT2167575	hsa-miR-4303	CLIP-seq
MIRT2167576	hsa-miR-4645-5p	CLIP-seq
MIRT2167577	hsa-miR-4652-5p	CLIP-seq
MIRT2167578	hsa-miR-4673	CLIP-seq
MIRT768158	hsa-miR-520f	CLIP-seq
MIRT2443241	hsa-miR-10a	CLIP-seq
MIRT2443242	hsa-miR-10b	CLIP-seq
MIRT2443243	hsa-miR-2276	CLIP-seq
MIRT2443244	hsa-miR-4704-3p	CLIP-seq
MIRT2443245	hsa-miR-4772-3p	CLIP-seq
MIRT2470134	hsa-miR-1207-3p	CLIP-seq
MIRT2470135	hsa-miR-1254	CLIP-seq
MIRT2470136	hsa-miR-1266	CLIP-seq
MIRT2470137	hsa-miR-129-3p	CLIP-seq
MIRT2470138	hsa-miR-1912	CLIP-seq
MIRT2470139	hsa-miR-1915	CLIP-seq
MIRT2470140	hsa-miR-19a	CLIP-seq
MIRT2470141	hsa-miR-19b	CLIP-seq
MIRT2470142	hsa-miR-205	CLIP-seq
MIRT2470143	hsa-miR-2113	CLIP-seq
MIRT768135	hsa-miR-24	CLIP-seq
MIRT2470144	hsa-miR-3065-3p	CLIP-seq
MIRT2470145	hsa-miR-3116	CLIP-seq
MIRT2470146	hsa-miR-3130-5p	CLIP-seq
MIRT2470147	hsa-miR-3156-5p	CLIP-seq
MIRT2470148	hsa-miR-3176	CLIP-seq
MIRT2470149	hsa-miR-337-5p	CLIP-seq
MIRT2470150	hsa-miR-3650	CLIP-seq
MIRT2470151	hsa-miR-371-5p	CLIP-seq
MIRT2470152	hsa-miR-371b-5p	CLIP-seq
MIRT2470153	hsa-miR-3922-3p	CLIP-seq
MIRT2470154	hsa-miR-3925-3p	CLIP-seq
MIRT2470155	hsa-miR-3942-3p	CLIP-seq
MIRT2470156	hsa-miR-3973	CLIP-seq
MIRT2470157	hsa-miR-4252	CLIP-seq
MIRT2470158	hsa-miR-4261	CLIP-seq
MIRT2470159	hsa-miR-4267	CLIP-seq
MIRT2167574	hsa-miR-4269	CLIP-seq
MIRT2470160	hsa-miR-4270	CLIP-seq
MIRT2470161	hsa-miR-4441	CLIP-seq
MIRT2470162	hsa-miR-4482	CLIP-seq
MIRT2470163	hsa-miR-4495	CLIP-seq
MIRT2470164	hsa-miR-4518	CLIP-seq
MIRT2470165	hsa-miR-451b	CLIP-seq
MIRT2167576	hsa-miR-4645-5p	CLIP-seq
MIRT2167578	hsa-miR-4673	CLIP-seq
MIRT2470166	hsa-miR-4690-3p	CLIP-seq
MIRT2470167	hsa-miR-4695-3p	CLIP-seq
MIRT2470168	hsa-miR-4726-3p	CLIP-seq
MIRT2470169	hsa-miR-4738-3p	CLIP-seq
MIRT2470170	hsa-miR-515-5p	CLIP-seq
MIRT2470171	hsa-miR-520g	CLIP-seq
MIRT2470172	hsa-miR-520h	CLIP-seq
MIRT2470173	hsa-miR-543	CLIP-seq
MIRT2470174	hsa-miR-548g	CLIP-seq
MIRT2470175	hsa-miR-561	CLIP-seq
MIRT2470176	hsa-miR-766	CLIP-seq
MIRT2470177	hsa-miR-875-3p	CLIP-seq
MIRT2470136	hsa-miR-1266	CLIP-seq
MIRT2674541	hsa-miR-1294	CLIP-seq
MIRT2470139	hsa-miR-1915	CLIP-seq
MIRT768135	hsa-miR-24	CLIP-seq
MIRT2470147	hsa-miR-3156-5p	CLIP-seq
MIRT2674542	hsa-miR-3180	CLIP-seq
MIRT2674543	hsa-miR-3180-3p	CLIP-seq
MIRT2674544	hsa-miR-3184	CLIP-seq
MIRT2674545	hsa-miR-3196	CLIP-seq
MIRT2470149	hsa-miR-337-5p	CLIP-seq
MIRT2470151	hsa-miR-371-5p	CLIP-seq
MIRT2470152	hsa-miR-371b-5p	CLIP-seq
MIRT2470155	hsa-miR-3942-3p	CLIP-seq
MIRT2470156	hsa-miR-3973	CLIP-seq
MIRT2674546	hsa-miR-423-5p	CLIP-seq
MIRT2470160	hsa-miR-4270	CLIP-seq
MIRT2674547	hsa-miR-4316	CLIP-seq
MIRT2470161	hsa-miR-4441	CLIP-seq
MIRT2674548	hsa-miR-4488	CLIP-seq
MIRT2470164	hsa-miR-4518	CLIP-seq
MIRT2470165	hsa-miR-451b	CLIP-seq
MIRT2470166	hsa-miR-4690-3p	CLIP-seq
MIRT2470167	hsa-miR-4695-3p	CLIP-seq
MIRT2674549	hsa-miR-4697-5p	CLIP-seq
MIRT2470168	hsa-miR-4726-3p	CLIP-seq
MIRT2470171	hsa-miR-520g	CLIP-seq
MIRT2470172	hsa-miR-520h	CLIP-seq
MIRT768159	hsa-miR-548ac	CLIP-seq
MIRT768160	hsa-miR-548ae	CLIP-seq
MIRT768161	hsa-miR-548aj	CLIP-seq
MIRT768162	hsa-miR-548am	CLIP-seq
MIRT768163	hsa-miR-548d-3p	CLIP-seq
MIRT768164	hsa-miR-548x	CLIP-seq
MIRT768165	hsa-miR-548z	CLIP-seq
MIRT768172	hsa-miR-665	CLIP-seq
MIRT2674550	hsa-miR-758	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0002819	Process	Regulation of adaptive immune response	IEA
GO:0002819	Process	Regulation of adaptive immune response	ISS
GO:0004016	Function	Adenylate cyclase activity	IBA
GO:0004016	Function	Adenylate cyclase activity	IDA	11113152, 17760784
GO:0004016	Function	Adenylate cyclase activity	IEA
GO:0004016	Function	Adenylate cyclase activity	IMP	18541530, 23178822, 23229509, 23842570
GO:0005524	Function	ATP binding	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS
GO:0006171	Process	CAMP biosynthetic process	IBA
GO:0006171	Process	CAMP biosynthetic process	IDA	11113152, 17760784
GO:0006171	Process	CAMP biosynthetic process	IEA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA
GO:0009190	Process	Cyclic nucleotide biosynthetic process	IEA
GO:0016020	Component	Membrane	IDA	11113152
GO:0016020	Component	Membrane	IEA
GO:0016829	Function	Lyase activity	IEA
GO:0016849	Function	Phosphorus-oxygen lyase activity	IEA
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0060135	Process	Maternal process involved in female pregnancy	IEA
GO:0071285	Process	Cellular response to lithium ion	IEA
GO:0071285	Process	Cellular response to lithium ion	ISS
GO:0071361	Process	Cellular response to ethanol	IDA	12454008, 17760784
GO:1900016	Process	Negative regulation of cytokine production involved in inflammatory response	IEA
GO:1900016	Process	Negative regulation of cytokine production involved in inflammatory response	ISS

Other IDs

• MIM: 600385
• HGNC: 238
• e!Ensembl: ENSG00000121281

Protein

• UniProt ID: P51828
• Protein name: Adenylate cyclase type 7 (EC 4.6.1.1) (ATP pyrophosphate-lyase 7) (Adenylate cyclase type VII) (Adenylyl cyclase 7)
• Protein function: Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors (Probable). Functions in signaling cascades activated namely by thrombin and sphingosine 1-phosphate and mediates regulation of cAMP synthesis through syner
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF16214	AC_N	15 → 256	Adenylyl cyclase N-terminal extracellular and transmembrane region	Family
  PF00211	Guanylate_cyc	270 → 447	Adenylate and Guanylate cyclase catalytic domain	Domain
  PF06327	DUF1053	485 → 593	Domain of Unknown Function (DUF1053)	Family
  PF00211	Guanylate_cyc	870 → 1069	Adenylate and Guanylate cyclase catalytic domain	Domain

• Sequence:

  MPAKGRYFLNEGEEGPDQDALYEKYQLTSQHGPLLLTLLLVAATACVALIIIAFSQGDPS
  RHQAILGMAFLVLAVFAALSVLMYVECLLRRWLRALALLTWACLVALGYVLVFDAWTKAA
  CAWEQVPFFLFIVFVVYTLLPFSMRGAVAVGAVSTASHLLVLGSLMGGFTTPSVRVGLQL
  LANAVIFLCGNLTGAFHKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPAH
  ISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDCSPKEL
  VVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDMCQAIKQ
  VREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEAT
  LKHLDKAYEVEDGHGQQRDPYLKEMNIRTYLVIDPRSQQPPPPSQHLPRPKGDAALKMRA
  SVRMTRYLESWGAARPFAHLNHRESVSSGETHVPNGRRPKSVPQRHRRTPDRSMSPKGRS
  EDDSYDDEMLSAIEGLSSTRPCCSKSDDFYTFGSIFLEKGFEREYRLAPIPRARHDFACA
  SLIFVCILLVHVLLMPRTAALGVSFGLVACVLGLVLGLCFATKFSRCCPARGTLCTISER
  VETQPLLRLTLAVLTIGSLLTVAIINLPLMPFQVPELPVGNETGLLAASSKTRALCEPLP
  YYTCSCVLGFIACSVFLRMSLEPKVVLLTVALVAYLVLFNLSPCWQWDCCGQGLGNLTKP
  NGTTSGTPSCSWKDLKTMTNFYLVLFYITLLTLSRQIDYYCRLDCLWKKKFKKEHEEFET
  MENVNRLLLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKE
  GLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVASGHENQELERQHAH
  IGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVAS
  RMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGELRTYFVCTDTAKFQGLGLN
  

• Sequence length: 1080

Pathways

KEGG:

Purine metabolism
Metabolic pathways
Endocrine resistance
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
Phospholipase D signaling pathway
Hormone signaling
Oocyte meiosis
Longevity regulating pathway
Longevity regulating pathway - multiple species
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Apelin signaling pathway
Gap junction
Platelet activation
Circadian entrainment
Thermogenesis
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
GABAergic synapse
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Ovarian steroidogenesis
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Oxytocin signaling pathway
Regulation of lipolysis in adipocytes
Aldosterone synthesis and secretion
Relaxin signaling pathway
Cortisol synthesis and secretion
Parathyroid hormone synthesis, secretion and action
Cushing syndrome
Growth hormone synthesis, secretion and action
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Bile secretion
Morphine addiction
Human cytomegalovirus infection
Human T-cell leukemia virus 1 infection
Pathways in cancer
Chemical carcinogenesis - receptor activation
Dilated cardiomyopathy

Reactome:

Glucagon signaling in metabolic regulation
PKA activation
PKA activation in glucagon signalling
Adenylate cyclase activating pathway
Adenylate cyclase inhibitory pathway
G alpha (s) signalling events
G alpha (z) signalling events
Vasopressin regulates renal water homeostasis via Aquaporins
Hedgehog 'off' state
ADORA2B mediated anti-inflammatory cytokines production
FCGR3A-mediated IL10 synthesis

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Thyroid cancer, nonmedullary, 1	Uncertain significance	rs777013802	RCV005932420

Associations from Text Mining
Disease Name	Relationship Type	References
Aortic Aneurysm Abdominal	Associate	22797469
Colitis Ulcerative	Associate	28067910
Epilepsy	Associate	34555062
Inflammatory Bowel Diseases	Associate	28067910
Leukemia	Associate	26220344
Leukemia Myeloid Acute	Associate	26220344
Neoplasms Adipose Tissue	Associate	32901515