Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	112950
Gene name	Mediator complex subunit 8
Gene symbol	MED8
Synonyms (NCBI Gene)	ARC32
Chromosome	1
Chromosome location	1p34.2
Summary	This gene encodes a protein component of the mediator complex, which aids in transcriptional activation through interaction with RNA polymerase II and gene-specific transcription factors. The encoded protein may also function in ubiquitin ligation and pro

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Show/Hide all (214)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019689	hsa-miR-375	Microarray	20215506
MIRT027422	hsa-miR-98-5p	Microarray	19088304
MIRT045059	hsa-miR-186-5p	CLASH	23622248
MIRT040043	hsa-miR-615-3p	CLASH	23622248
MIRT713642	hsa-miR-519a-3p	HITS-CLIP	19536157
MIRT713641	hsa-miR-519b-3p	HITS-CLIP	19536157
MIRT713640	hsa-miR-519c-3p	HITS-CLIP	19536157
MIRT713639	hsa-miR-130a-3p	HITS-CLIP	19536157
MIRT713638	hsa-miR-130b-3p	HITS-CLIP	19536157
MIRT713637	hsa-miR-301a-3p	HITS-CLIP	19536157
MIRT713636	hsa-miR-301b-3p	HITS-CLIP	19536157
MIRT713635	hsa-miR-3666	HITS-CLIP	19536157
MIRT713634	hsa-miR-4295	HITS-CLIP	19536157
MIRT713633	hsa-miR-454-3p	HITS-CLIP	19536157
MIRT713632	hsa-miR-3938	HITS-CLIP	19536157
MIRT713631	hsa-miR-5088-3p	HITS-CLIP	19536157
MIRT713630	hsa-miR-4469	HITS-CLIP	19536157
MIRT713629	hsa-miR-7113-3p	HITS-CLIP	19536157
MIRT713628	hsa-miR-4287	HITS-CLIP	19536157
MIRT713627	hsa-miR-4685-3p	HITS-CLIP	19536157
MIRT713626	hsa-miR-4795-5p	HITS-CLIP	19536157
MIRT713625	hsa-miR-623	HITS-CLIP	19536157
MIRT713624	hsa-miR-204-5p	HITS-CLIP	19536157
MIRT713623	hsa-miR-211-5p	HITS-CLIP	19536157
MIRT713622	hsa-miR-4713-5p	HITS-CLIP	19536157
MIRT713621	hsa-miR-6867-3p	HITS-CLIP	19536157
MIRT713620	hsa-miR-3616-5p	HITS-CLIP	19536157
MIRT713619	hsa-miR-573	HITS-CLIP	19536157
MIRT713618	hsa-miR-3611	HITS-CLIP	19536157
MIRT713617	hsa-miR-4755-5p	HITS-CLIP	19536157
MIRT713616	hsa-miR-5006-3p	HITS-CLIP	19536157
MIRT713615	hsa-miR-629-3p	HITS-CLIP	19536157
MIRT713614	hsa-miR-877-3p	HITS-CLIP	19536157
MIRT713642	hsa-miR-519a-3p	HITS-CLIP	19536157
MIRT713641	hsa-miR-519b-3p	HITS-CLIP	19536157
MIRT713640	hsa-miR-519c-3p	HITS-CLIP	19536157
MIRT713639	hsa-miR-130a-3p	HITS-CLIP	19536157
MIRT713638	hsa-miR-130b-3p	HITS-CLIP	19536157
MIRT713637	hsa-miR-301a-3p	HITS-CLIP	19536157
MIRT713636	hsa-miR-301b-3p	HITS-CLIP	19536157
MIRT713635	hsa-miR-3666	HITS-CLIP	19536157
MIRT713634	hsa-miR-4295	HITS-CLIP	19536157
MIRT713633	hsa-miR-454-3p	HITS-CLIP	19536157
MIRT713632	hsa-miR-3938	HITS-CLIP	19536157
MIRT713631	hsa-miR-5088-3p	HITS-CLIP	19536157
MIRT713630	hsa-miR-4469	HITS-CLIP	19536157
MIRT713629	hsa-miR-7113-3p	HITS-CLIP	19536157
MIRT713628	hsa-miR-4287	HITS-CLIP	19536157
MIRT713627	hsa-miR-4685-3p	HITS-CLIP	19536157
MIRT713626	hsa-miR-4795-5p	HITS-CLIP	19536157
MIRT713625	hsa-miR-623	HITS-CLIP	19536157
MIRT713624	hsa-miR-204-5p	HITS-CLIP	19536157
MIRT713623	hsa-miR-211-5p	HITS-CLIP	19536157
MIRT713622	hsa-miR-4713-5p	HITS-CLIP	19536157
MIRT713621	hsa-miR-6867-3p	HITS-CLIP	19536157
MIRT713620	hsa-miR-3616-5p	HITS-CLIP	19536157
MIRT713619	hsa-miR-573	HITS-CLIP	19536157
MIRT713618	hsa-miR-3611	HITS-CLIP	19536157
MIRT713617	hsa-miR-4755-5p	HITS-CLIP	19536157
MIRT713616	hsa-miR-5006-3p	HITS-CLIP	19536157
MIRT713615	hsa-miR-629-3p	HITS-CLIP	19536157
MIRT713614	hsa-miR-877-3p	HITS-CLIP	19536157
MIRT1141908	hsa-miR-4480	CLIP-seq
MIRT1141909	hsa-miR-4715-5p	CLIP-seq
MIRT1141910	hsa-miR-514	CLIP-seq
MIRT1141911	hsa-miR-514b-3p	CLIP-seq
MIRT1141912	hsa-let-7a	CLIP-seq
MIRT1141913	hsa-let-7b	CLIP-seq
MIRT1141914	hsa-let-7c	CLIP-seq
MIRT1141915	hsa-let-7d	CLIP-seq
MIRT1141916	hsa-let-7e	CLIP-seq
MIRT1141917	hsa-let-7f	CLIP-seq
MIRT1141918	hsa-let-7g	CLIP-seq
MIRT1141919	hsa-let-7i	CLIP-seq
MIRT1141920	hsa-miR-1202	CLIP-seq
MIRT1141921	hsa-miR-1231	CLIP-seq
MIRT1141922	hsa-miR-1238	CLIP-seq
MIRT1141923	hsa-miR-181a	CLIP-seq
MIRT1141924	hsa-miR-181b	CLIP-seq
MIRT1141925	hsa-miR-181c	CLIP-seq
MIRT1141926	hsa-miR-181d	CLIP-seq
MIRT1141927	hsa-miR-202	CLIP-seq
MIRT1141928	hsa-miR-29a	CLIP-seq
MIRT1141929	hsa-miR-29b	CLIP-seq
MIRT1141930	hsa-miR-29c	CLIP-seq
MIRT1141931	hsa-miR-302a	CLIP-seq
MIRT1141932	hsa-miR-302b	CLIP-seq
MIRT1141933	hsa-miR-302c	CLIP-seq
MIRT1141934	hsa-miR-302d	CLIP-seq
MIRT1141935	hsa-miR-302e	CLIP-seq
MIRT1141936	hsa-miR-3194-5p	CLIP-seq
MIRT1141937	hsa-miR-331-5p	CLIP-seq
MIRT1141938	hsa-miR-346	CLIP-seq
MIRT1141939	hsa-miR-3663-3p	CLIP-seq
MIRT1141940	hsa-miR-372	CLIP-seq
MIRT1141941	hsa-miR-373	CLIP-seq
MIRT1141942	hsa-miR-3972	CLIP-seq
MIRT1141943	hsa-miR-4262	CLIP-seq
MIRT1141944	hsa-miR-4270	CLIP-seq
MIRT1141945	hsa-miR-4288	CLIP-seq
MIRT1141946	hsa-miR-4441	CLIP-seq
MIRT1141947	hsa-miR-4458	CLIP-seq
MIRT1141948	hsa-miR-4500	CLIP-seq
MIRT1141949	hsa-miR-4654	CLIP-seq
MIRT1141950	hsa-miR-4678	CLIP-seq
MIRT1141951	hsa-miR-4733-3p	CLIP-seq
MIRT1141952	hsa-miR-4766-5p	CLIP-seq
MIRT1141953	hsa-miR-4769-5p	CLIP-seq
MIRT1141954	hsa-miR-519a	CLIP-seq
MIRT1141955	hsa-miR-520a-3p	CLIP-seq
MIRT1141956	hsa-miR-520b	CLIP-seq
MIRT1141957	hsa-miR-520c-3p	CLIP-seq
MIRT1141958	hsa-miR-520d-3p	CLIP-seq
MIRT1141959	hsa-miR-520e	CLIP-seq
MIRT1141960	hsa-miR-520f	CLIP-seq
MIRT1141961	hsa-miR-579	CLIP-seq
MIRT1141962	hsa-miR-632	CLIP-seq
MIRT1141963	hsa-miR-664	CLIP-seq
MIRT1141964	hsa-miR-98	CLIP-seq
MIRT1141912	hsa-let-7a	CLIP-seq
MIRT1141913	hsa-let-7b	CLIP-seq
MIRT1141914	hsa-let-7c	CLIP-seq
MIRT1141915	hsa-let-7d	CLIP-seq
MIRT1141916	hsa-let-7e	CLIP-seq
MIRT1141917	hsa-let-7f	CLIP-seq
MIRT1141918	hsa-let-7g	CLIP-seq
MIRT1141919	hsa-let-7i	CLIP-seq
MIRT1141927	hsa-miR-202	CLIP-seq
MIRT1141937	hsa-miR-331-5p	CLIP-seq
MIRT1141947	hsa-miR-4458	CLIP-seq
MIRT1141948	hsa-miR-4500	CLIP-seq
MIRT1141950	hsa-miR-4678	CLIP-seq
MIRT1141964	hsa-miR-98	CLIP-seq
MIRT2270113	hsa-miR-1183	CLIP-seq
MIRT1141923	hsa-miR-181a	CLIP-seq
MIRT1141924	hsa-miR-181b	CLIP-seq
MIRT1141925	hsa-miR-181c	CLIP-seq
MIRT1141926	hsa-miR-181d	CLIP-seq
MIRT1141931	hsa-miR-302a	CLIP-seq
MIRT1141932	hsa-miR-302b	CLIP-seq
MIRT1141933	hsa-miR-302c	CLIP-seq
MIRT1141934	hsa-miR-302d	CLIP-seq
MIRT1141935	hsa-miR-302e	CLIP-seq
MIRT2270114	hsa-miR-3614-5p	CLIP-seq
MIRT1141940	hsa-miR-372	CLIP-seq
MIRT1141941	hsa-miR-373	CLIP-seq
MIRT2270115	hsa-miR-377	CLIP-seq
MIRT2270116	hsa-miR-3974	CLIP-seq
MIRT1141943	hsa-miR-4262	CLIP-seq
MIRT2270117	hsa-miR-4697-3p	CLIP-seq
MIRT2270118	hsa-miR-500a	CLIP-seq
MIRT1141954	hsa-miR-519a	CLIP-seq
MIRT1141955	hsa-miR-520a-3p	CLIP-seq
MIRT1141956	hsa-miR-520b	CLIP-seq
MIRT1141957	hsa-miR-520c-3p	CLIP-seq
MIRT1141958	hsa-miR-520d-3p	CLIP-seq
MIRT1141959	hsa-miR-520e	CLIP-seq
MIRT1141960	hsa-miR-520f	CLIP-seq
MIRT2270119	hsa-miR-548ag	CLIP-seq
MIRT2270120	hsa-miR-548ai	CLIP-seq
MIRT1141961	hsa-miR-579	CLIP-seq
MIRT1141963	hsa-miR-664	CLIP-seq
MIRT2270113	hsa-miR-1183	CLIP-seq
MIRT1141923	hsa-miR-181a	CLIP-seq
MIRT1141924	hsa-miR-181b	CLIP-seq
MIRT1141925	hsa-miR-181c	CLIP-seq
MIRT1141926	hsa-miR-181d	CLIP-seq
MIRT1141931	hsa-miR-302a	CLIP-seq
MIRT1141932	hsa-miR-302b	CLIP-seq
MIRT1141933	hsa-miR-302c	CLIP-seq
MIRT1141934	hsa-miR-302d	CLIP-seq
MIRT1141935	hsa-miR-302e	CLIP-seq
MIRT2390795	hsa-miR-3165	CLIP-seq
MIRT2390796	hsa-miR-3190	CLIP-seq
MIRT1141940	hsa-miR-372	CLIP-seq
MIRT1141941	hsa-miR-373	CLIP-seq
MIRT1141943	hsa-miR-4262	CLIP-seq
MIRT1141949	hsa-miR-4654	CLIP-seq
MIRT2270117	hsa-miR-4697-3p	CLIP-seq
MIRT1141953	hsa-miR-4769-5p	CLIP-seq
MIRT1141954	hsa-miR-519a	CLIP-seq
MIRT1141955	hsa-miR-520a-3p	CLIP-seq
MIRT1141956	hsa-miR-520b	CLIP-seq
MIRT1141957	hsa-miR-520c-3p	CLIP-seq
MIRT1141958	hsa-miR-520d-3p	CLIP-seq
MIRT1141959	hsa-miR-520e	CLIP-seq
MIRT1141960	hsa-miR-520f	CLIP-seq
MIRT1141961	hsa-miR-579	CLIP-seq
MIRT1141963	hsa-miR-664	CLIP-seq
MIRT2569170	hsa-miR-3065-5p	CLIP-seq
MIRT2569171	hsa-miR-3140-5p	CLIP-seq
MIRT2569172	hsa-miR-3714	CLIP-seq
MIRT2569173	hsa-miR-4293	CLIP-seq
MIRT2569174	hsa-miR-4641	CLIP-seq
MIRT2569175	hsa-miR-4736	CLIP-seq
MIRT2569176	hsa-miR-4799-5p	CLIP-seq
MIRT2569177	hsa-miR-548an	CLIP-seq
MIRT2569178	hsa-miR-596	CLIP-seq
MIRT2569179	hsa-miR-657	CLIP-seq
MIRT2569180	hsa-miR-940	CLIP-seq
MIRT2569170	hsa-miR-3065-5p	CLIP-seq
MIRT2569171	hsa-miR-3140-5p	CLIP-seq
MIRT2684802	hsa-miR-3163	CLIP-seq
MIRT2684803	hsa-miR-340	CLIP-seq
MIRT2569172	hsa-miR-3714	CLIP-seq
MIRT2569173	hsa-miR-4293	CLIP-seq
MIRT2569174	hsa-miR-4641	CLIP-seq
MIRT2684804	hsa-miR-4690-5p	CLIP-seq
MIRT2569175	hsa-miR-4736	CLIP-seq
MIRT2569176	hsa-miR-4799-5p	CLIP-seq
MIRT2569177	hsa-miR-548an	CLIP-seq
MIRT2569178	hsa-miR-596	CLIP-seq
MIRT2569179	hsa-miR-657	CLIP-seq
MIRT2569180	hsa-miR-940	CLIP-seq

Show/Hide all (20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000151	Component	Ubiquitin ligase complex	IEA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0003712	Function	Transcription coregulator activity	IBA
GO:0003712	Function	Transcription coregulator activity	IEA
GO:0005515	Function	Protein binding	IPI	12149480, 25416956, 30021884, 32296183, 35271311
GO:0005634	Component	Nucleus	IDA	24882805
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016592	Component	Mediator complex	IBA
GO:0016592	Component	Mediator complex	IDA	14638676
GO:0016592	Component	Mediator complex	IEA
GO:0032968	Process	Positive regulation of transcription elongation by RNA polymerase II	NAS	11559591
GO:0051123	Process	RNA polymerase II preinitiation complex assembly	NAS	11559591
GO:0060261	Process	Positive regulation of transcription initiation by RNA polymerase II	NAS	11559591
GO:0061630	Function	Ubiquitin protein ligase activity	IEA
GO:0070847	Component	Core mediator complex	IBA
GO:0070847	Component	Core mediator complex	IPI	24882805

MIM	HGNC	e!Ensembl
607956	19971	ENSG00000159479

Q96G25

Protein name

Mediator of RNA polymerase II transcription subunit 8 (Activator-recruited cofactor 32 kDa component) (ARC32) (Mediator complex subunit 8)

Protein function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RN

PDB

7EMF , 7ENA , 7ENC , 7ENJ , 7LBM , 7NVR , 8GXQ , 8GXS , 8T9D , 8TQW , 8TRH

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10232	Med8	1 → 265	Mediator of RNA polymerase II transcription complex subunit 8	Family

Sequence

MQREEKQLEASLDALLSQVADLKNSLGSFICKLENEYGRLTWPSVLDSFALLSGQLNTLN
KVLKHEKTPLFRNQVIIPLVLSPDRDEDLMRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQ
EKQLTTDAARIGADAAQKQIQSLNKMCSNLLEKISKEERESESGGLRPNKQTFNPTDTNA
LVAAVAFGKGLSNWRPSGSSGPGQAGQPGAGTILAGTSGLQQVQMAGAPSQQQPMLSGVQ
MAQAGQPGKMPSGIKTNIKSASMHPYQR

Sequence length

268

Interactions

View interactions

	Reactome
			PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Carcinoma Hepatocellular	Associate	35069777, 38238845	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Associate	27050271	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Associate	21209843	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leiomyoma	Associate	27889101	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	27050271	★★★★★ ★☆☆☆☆ Found in Text Mining only
Non alcoholic Fatty Liver Disease	Associate	38238845	★★★★★ ★☆☆☆☆ Found in Text Mining only

MED8 (mediator complex subunit 8)