Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	1129
Gene name Gene Name - the full gene name approved by the HGNC.	Cholinergic receptor muscarinic 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CHRM2
Synonyms (NCBI Gene) Gene synonyms aliases	HM2
Chromosome Chromosome number	7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	7q33
Summary Summary of gene provided in NCBI Entrez Gene.	The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cycl

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miRTarBase ID	miRNA	Experiments	Reference
MIRT017560	hsa-miR-335-5p	Microarray	18185580
MIRT617798	hsa-miR-3140-3p	HITS-CLIP	23824327
MIRT617797	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT617796	hsa-miR-29b-2-5p	HITS-CLIP	23824327
MIRT617795	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT617794	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT617793	hsa-miR-659-3p	HITS-CLIP	23824327
MIRT617797	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT617796	hsa-miR-29b-2-5p	HITS-CLIP	23824327
MIRT617795	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT617794	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT617793	hsa-miR-659-3p	HITS-CLIP	23824327
MIRT617792	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT617798	hsa-miR-3140-3p	HITS-CLIP	23824327
MIRT617797	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT617796	hsa-miR-29b-2-5p	HITS-CLIP	23824327
MIRT617795	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT617794	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT617793	hsa-miR-659-3p	HITS-CLIP	23824327
MIRT617792	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT617791	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT735110	hsa-miR-17-5p	qRT-PCR	31776299
MIRT735112	hsa-miR-582-3p	qRT-PCR	31776299
MIRT735121	hsa-miR-378a-5p	qRT-PCR	31776299
MIRT617798	hsa-miR-3140-3p	HITS-CLIP	23824327
MIRT617797	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT617796	hsa-miR-29b-2-5p	HITS-CLIP	23824327
MIRT617795	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT617794	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT617793	hsa-miR-659-3p	HITS-CLIP	23824327
MIRT617797	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT617796	hsa-miR-29b-2-5p	HITS-CLIP	23824327
MIRT617795	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT617794	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT617793	hsa-miR-659-3p	HITS-CLIP	23824327
MIRT617792	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT617798	hsa-miR-3140-3p	HITS-CLIP	23824327
MIRT617797	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT617796	hsa-miR-29b-2-5p	HITS-CLIP	23824327
MIRT617795	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT617794	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT617793	hsa-miR-659-3p	HITS-CLIP	23824327
MIRT617792	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT617791	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT891626	hsa-miR-18a	CLIP-seq
MIRT891627	hsa-miR-18b	CLIP-seq
MIRT891628	hsa-miR-200b	CLIP-seq
MIRT891629	hsa-miR-200c	CLIP-seq
MIRT891630	hsa-miR-3140-5p	CLIP-seq
MIRT891631	hsa-miR-335	CLIP-seq
MIRT891632	hsa-miR-3660	CLIP-seq
MIRT891633	hsa-miR-378g	CLIP-seq
MIRT891634	hsa-miR-4268	CLIP-seq
MIRT891635	hsa-miR-429	CLIP-seq
MIRT891636	hsa-miR-4437	CLIP-seq
MIRT891637	hsa-miR-4448	CLIP-seq
MIRT891638	hsa-miR-450b-5p	CLIP-seq
MIRT891639	hsa-miR-4526	CLIP-seq
MIRT891640	hsa-miR-4645-3p	CLIP-seq
MIRT891641	hsa-miR-4674	CLIP-seq
MIRT891642	hsa-miR-4712-3p	CLIP-seq
MIRT891643	hsa-miR-4731-5p	CLIP-seq
MIRT891644	hsa-miR-4735-3p	CLIP-seq
MIRT891645	hsa-miR-4778-3p	CLIP-seq
MIRT891646	hsa-miR-507	CLIP-seq
MIRT891647	hsa-miR-539	CLIP-seq
MIRT891648	hsa-miR-557	CLIP-seq
MIRT891649	hsa-miR-592	CLIP-seq
MIRT891650	hsa-miR-595	CLIP-seq
MIRT891651	hsa-miR-597	CLIP-seq
MIRT891652	hsa-miR-668	CLIP-seq

Show/Hide all(27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004993	Function	G protein-coupled serotonin receptor activity	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0005887	Component	Integral component of plasma membrane	IDA	24256733
GO:0006940	Process	Regulation of smooth muscle contraction	IBA	21873635
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA	21873635
GO:0007188	Process	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway	TAS	8139539
GO:0007197	Process	Adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	IBA	21873635
GO:0007207	Process	Phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	TAS	2739737
GO:0007213	Process	G protein-coupled acetylcholine receptor signaling pathway	IDA	24256733
GO:0007268	Process	Chemical synaptic transmission	IBA	21873635
GO:0007399	Process	Nervous system development	TAS	2739737
GO:0008016	Process	Regulation of heart contraction	IEA
GO:0009615	Process	Response to virus	IEP	16548883
GO:0016021	Component	Integral component of membrane	IDA	11566136
GO:0016907	Function	G protein-coupled acetylcholine receptor activity	IBA	21873635
GO:0016907	Function	G protein-coupled acetylcholine receptor activity	IDA	24256733
GO:0030425	Component	Dendrite	IBA	21873635
GO:0030594	Function	Neurotransmitter receptor activity	IBA	21873635
GO:0030665	Component	Clathrin-coated vesicle membrane	TAS
GO:0045202	Component	Synapse	IBA	21873635
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0061024	Process	Membrane organization	TAS
GO:0098664	Process	G protein-coupled serotonin receptor signaling pathway	IEA
GO:1990763	Function	Arrestin family protein binding	IPI	11566136

MIM	HGNC	e!Ensembl
118493	1951	ENSG00000181072

Protein

UniProt ID

P08172

Protein name

Muscarinic acetylcholine receptor M2

Protein function

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effec

PDB

3UON , 4MQS , 4MQT , 5YC8 , 5ZK3 , 5ZK8 , 5ZKB , 5ZKC , 6OIK , 6U1N , 7T8X , 7T90 , 7T94 , 7T96 , 8J8R , 8J97 , 8JAF

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	40 → 440	7 transmembrane receptor (rhodopsin family)	Family

Sequence

MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI
VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE
ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI
VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR

Sequence length

466

Interactions

View interactions

	KEGG		Reactome
	Calcium signaling pathway cAMP signaling pathway Neuroactive ligand-receptor interaction PI3K-Akt signaling pathway Cholinergic synapse Regulation of actin cytoskeleton		Muscarinic acetylcholine receptors G alpha (i) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis

Show/Hide Causal Diseases (4)

Disease term	Disease name	dbSNP ID	References
Causal
Diabetes mellitus	Diabetes Mellitus, Insulin-Dependent, Diabetes Mellitus, Ketosis-Prone, Diabetes Mellitus, Sudden-Onset	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237 View all (293 more)	18603373
Epilepsy	Epilepsy, Epilepsy, Cryptogenic, Awakening Epilepsy	rs113994140, rs28937874, rs1589762127, rs104894166, rs28939075, rs2134001459, rs104894167, rs119488099, rs119488100, rs387906420, rs121917752, rs121918622, rs281865564, rs387907313, rs397514670 View all (165 more)	18333967
Esophagus neoplasm	Malignant neoplasm of esophagus	rs28934578, rs121918714, rs1567556006, rs1575166666	21642993
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	20691427

Show/Hide Unknown Diseases (2)

Disease term	Disease name	References	Source
Unknown
Mental depression	Mental Depression, Depressive disorder	20351719, 15229186, 12116189, 19181679	ClinVar
Migraine with Aura	Migraine with Aura		GWAS

Show/Hide Text Mining Associations (27)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma	Associate	34133324
Alzheimer Disease	Associate	16181410
Antisocial Personality Disorder	Associate	21883161
Arrhythmias Cardiac	Associate	18451336
Asthma	Associate	11325793, 22370858, 24430298
Atrial Fibrillation	Associate	21617318
Atrioventricular Block	Associate	18451336
Bipolar Disorder	Associate	20351719
Carcinoma Renal Cell	Inhibit	31862408
Cardiomyopathy Dilated	Associate	18451336
Colorectal Neoplasms	Associate	35545337
Cutaneous Fistula	Associate	21883161
Death Sudden	Associate	18451336
Depressive Disorder	Associate	20351719
Dyskinesia Drug Induced	Associate	30623717
Emergence Delirium	Associate	34674705
familial dilated cardiomyopathy	Associate	18451336
Heart Failure	Associate	18451336
Hypoxia	Associate	31862408
Leiomyoma	Associate	34440356
Myopia	Associate	31776299
Obesity	Associate	25155933
Postoperative Cognitive Complications	Associate	34674705
Precancerous Conditions	Associate	22377736
Status Asthmaticus	Associate	11325793
Stomach Neoplasms	Associate	22377736
Temporomandibular Joint Disorders	Associate	22074755

CHRM2 (cholinergic receptor muscarinic 2)