Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	1129
Gene name	Cholinergic receptor muscarinic 2
Gene symbol	CHRM2
Synonyms (NCBI Gene)	HM2
Chromosome	7
Chromosome location	7q33
Summary	The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cycl

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miRTarBase ID	miRNA	Experiments	Reference
MIRT017560	hsa-miR-335-5p	Microarray	18185580
MIRT617798	hsa-miR-3140-3p	HITS-CLIP	23824327
MIRT617797	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT617796	hsa-miR-29b-2-5p	HITS-CLIP	23824327
MIRT617795	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT617794	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT617793	hsa-miR-659-3p	HITS-CLIP	23824327
MIRT617797	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT617796	hsa-miR-29b-2-5p	HITS-CLIP	23824327
MIRT617795	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT617794	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT617793	hsa-miR-659-3p	HITS-CLIP	23824327
MIRT617792	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT617798	hsa-miR-3140-3p	HITS-CLIP	23824327
MIRT617797	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT617796	hsa-miR-29b-2-5p	HITS-CLIP	23824327
MIRT617795	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT617794	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT617793	hsa-miR-659-3p	HITS-CLIP	23824327
MIRT617792	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT617791	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT735110	hsa-miR-17-5p	qRT-PCR	31776299
MIRT735112	hsa-miR-582-3p	qRT-PCR	31776299
MIRT735121	hsa-miR-378a-5p	qRT-PCR	31776299
MIRT617798	hsa-miR-3140-3p	HITS-CLIP	23824327
MIRT617797	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT617796	hsa-miR-29b-2-5p	HITS-CLIP	23824327
MIRT617795	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT617794	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT617793	hsa-miR-659-3p	HITS-CLIP	23824327
MIRT617797	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT617796	hsa-miR-29b-2-5p	HITS-CLIP	23824327
MIRT617795	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT617794	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT617793	hsa-miR-659-3p	HITS-CLIP	23824327
MIRT617792	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT617798	hsa-miR-3140-3p	HITS-CLIP	23824327
MIRT617797	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT617796	hsa-miR-29b-2-5p	HITS-CLIP	23824327
MIRT617795	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT617794	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT617793	hsa-miR-659-3p	HITS-CLIP	23824327
MIRT617792	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT617791	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT891626	hsa-miR-18a	CLIP-seq
MIRT891627	hsa-miR-18b	CLIP-seq
MIRT891628	hsa-miR-200b	CLIP-seq
MIRT891629	hsa-miR-200c	CLIP-seq
MIRT891630	hsa-miR-3140-5p	CLIP-seq
MIRT891631	hsa-miR-335	CLIP-seq
MIRT891632	hsa-miR-3660	CLIP-seq
MIRT891633	hsa-miR-378g	CLIP-seq
MIRT891634	hsa-miR-4268	CLIP-seq
MIRT891635	hsa-miR-429	CLIP-seq
MIRT891636	hsa-miR-4437	CLIP-seq
MIRT891637	hsa-miR-4448	CLIP-seq
MIRT891638	hsa-miR-450b-5p	CLIP-seq
MIRT891639	hsa-miR-4526	CLIP-seq
MIRT891640	hsa-miR-4645-3p	CLIP-seq
MIRT891641	hsa-miR-4674	CLIP-seq
MIRT891642	hsa-miR-4712-3p	CLIP-seq
MIRT891643	hsa-miR-4731-5p	CLIP-seq
MIRT891644	hsa-miR-4735-3p	CLIP-seq
MIRT891645	hsa-miR-4778-3p	CLIP-seq
MIRT891646	hsa-miR-507	CLIP-seq
MIRT891647	hsa-miR-539	CLIP-seq
MIRT891648	hsa-miR-557	CLIP-seq
MIRT891649	hsa-miR-592	CLIP-seq
MIRT891650	hsa-miR-595	CLIP-seq
MIRT891651	hsa-miR-597	CLIP-seq
MIRT891652	hsa-miR-668	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0005730	Component	Nucleolus	IDA
GO:0005794	Component	Golgi apparatus	IDA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	24256733
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	3037705, 3443095
GO:0005929	Component	Cilium	IDA
GO:0006940	Process	Regulation of smooth muscle contraction	IBA
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS	9603968
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS	10895079
GO:0007188	Process	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway	TAS	8139539
GO:0007197	Process	Adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	IBA
GO:0007197	Process	Adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	IDA	36690613
GO:0007207	Process	Phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	TAS	2739737
GO:0007213	Process	G protein-coupled acetylcholine receptor signaling pathway	IDA	24256733, 36690613
GO:0007213	Process	G protein-coupled acetylcholine receptor signaling pathway	IEA
GO:0007213	Process	G protein-coupled acetylcholine receptor signaling pathway	IEA
GO:0007268	Process	Chemical synaptic transmission	IBA
GO:0007399	Process	Nervous system development	TAS	2739737
GO:0008016	Process	Regulation of heart contraction	IEA
GO:0008016	Process	Regulation of heart contraction	TAS	10544184
GO:0009615	Process	Response to virus	IEP	16548883
GO:0016020	Component	Membrane	IDA	11566136
GO:0016020	Component	Membrane	IEA
GO:0016907	Function	G protein-coupled acetylcholine receptor activity	IBA
GO:0016907	Function	G protein-coupled acetylcholine receptor activity	IDA	24256733, 36690613
GO:0016907	Function	G protein-coupled acetylcholine receptor activity	IEA
GO:0016907	Function	G protein-coupled acetylcholine receptor activity	TAS	9603968
GO:0030425	Component	Dendrite	IBA
GO:0030669	Component	Clathrin-coated endocytic vesicle membrane	TAS
GO:0036064	Component	Ciliary basal body	IDA
GO:0045202	Component	Synapse	IBA
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0098793	Component	Presynapse	IEA
GO:0098981	Component	Cholinergic synapse	IEA
GO:0099171	Process	Presynaptic modulation of chemical synaptic transmission	IEA
GO:1990763	Function	Arrestin family protein binding	IPI	11566136

MIM	HGNC	e!Ensembl
118493	1951	ENSG00000181072

P08172

Protein name

Muscarinic acetylcholine receptor M2

Protein function

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effec

PDB

3UON , 4MQS , 4MQT , 5YC8 , 5ZK3 , 5ZK8 , 5ZKB , 5ZKC , 6OIK , 6U1N , 7T8X , 7T90 , 7T94 , 7T96 , 8J8R , 8J97 , 8JAF

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	40 → 440	7 transmembrane receptor (rhodopsin family)	Family

Sequence

MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI
VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE
ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI
VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR

Sequence length

466

Interactions

View interactions

	KEGG		Reactome
	Calcium signaling pathway cAMP signaling pathway Neuroactive ligand-receptor interaction PI3K-Akt signaling pathway Cholinergic synapse Regulation of actin cytoskeleton		Muscarinic acetylcholine receptors G alpha (i) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis

157

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Cardiomyopathy	Uncertain significance	rs745902607	RCV000203522
CHRM2-related disorder	Benign; Likely benign	rs142006633	RCV003929885
Dilated Cardiomyopathy, Dominant	Uncertain significance; Likely benign; Benign; Conflicting classifications of pathogenicity	rs1440850408, rs762688022, rs139037603, rs1237014805, rs774760812, rs760821552, rs200017653, rs2131132962, rs747925877, rs375980850, rs531986911, rs1443103188, rs573795503, rs1481148988, rs781736829 View all (127 more)	RCV001315040 RCV001312250 RCV001317198 RCV001316597 RCV001344501 RCV001340481 RCV001348953 RCV001363618 RCV001368000 RCV001402402 RCV001402841 RCV001392704 RCV001400150 RCV001443945 RCV001436419 RCV001451124 RCV001460824 RCV001491422 RCV001490656 RCV001479634 RCV001523439 RCV002039128 RCV001948970 RCV002017930 RCV001933012 RCV001947659 RCV002008548 RCV001898352 RCV001883472 RCV001910477 RCV002022915 RCV002050872 RCV001985549 RCV001974692 RCV001886556 RCV002021128 RCV001917158 RCV001917190 RCV002003959 RCV002131222 RCV002136445 RCV002131830 RCV002142906 RCV002133939 RCV002155657 RCV002214797 RCV002210252 RCV002124107 RCV002172447 RCV002163498 RCV003071386 RCV003093327 RCV003084457 RCV003080667 RCV002648092 RCV003110701 RCV003118147 RCV003118164 RCV002572685 RCV002590674 RCV002608855 RCV002647162 RCV002711951 RCV002756835 RCV002781094 RCV002838678 RCV002835317 RCV002900121 RCV002895200 RCV002947625 RCV002938335 RCV002958257 RCV002975335 RCV003002603 RCV002996107 RCV002972194 RCV003018846 RCV003014582 RCV003045875 RCV000554962 RCV000543439 RCV000555863 RCV000548560 RCV000542120 RCV000554571 RCV003592595 RCV003592585 RCV003592847 RCV003592653 RCV003591485 RCV003592084 RCV003592146 RCV003592211 RCV003755072 RCV003755409 RCV003755492 RCV003755705 RCV003755755 RCV003755782 RCV003755837 RCV003755928 RCV003755923 RCV003756233 RCV003756275 RCV003756435 RCV003756383 RCV003756530 RCV003756519 RCV003824365 RCV003874223 RCV003878798 RCV001409902 RCV001086960 RCV001858049 RCV000528194 RCV000524568 RCV000526071 RCV000532481 RCV000536065 RCV000538497 RCV003591757 RCV005091711 RCV000874607 RCV001476825 RCV000691247 RCV000706849 RCV000805214 RCV000807718 RCV000792415 RCV000817634 RCV000793624 RCV000877725 RCV001522458 RCV002066259 RCV000960743 RCV001398409 RCV001408680 RCV000934828 RCV001484789 RCV001036347 RCV001055269 RCV001051194 RCV001045589 RCV001064642 RCV001220749 RCV001211521 RCV001236002 RCV001237090 RCV001246558
Gastric cancer	Benign	rs324651	RCV005902200
Hepatocellular carcinoma	Benign	rs74662321	RCV005920702
Ovarian serous cystadenocarcinoma	Benign	rs324651	RCV005902201

Show/Hide Text Mining Associations (27)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Associate	34133324
Alzheimer Disease	Associate	16181410
Antisocial Personality Disorder	Associate	21883161
Arrhythmias Cardiac	Associate	18451336
Asthma	Associate	11325793, 22370858, 24430298
Atrial Fibrillation	Associate	21617318
Atrioventricular Block	Associate	18451336
Bipolar Disorder	Associate	20351719
Carcinoma Renal Cell	Inhibit	31862408
Cardiomyopathy Dilated	Associate	18451336
Colorectal Neoplasms	Associate	35545337
Cutaneous Fistula	Associate	21883161
Death Sudden	Associate	18451336
Depressive Disorder	Associate	20351719
Dyskinesia Drug Induced	Associate	30623717
Emergence Delirium	Associate	34674705
familial dilated cardiomyopathy	Associate	18451336
Heart Failure	Associate	18451336
Hypoxia	Associate	31862408
Leiomyoma	Associate	34440356
Myopia	Associate	31776299
Obesity	Associate	25155933
Postoperative Cognitive Complications	Associate	34674705
Precancerous Conditions	Associate	22377736
Status Asthmaticus	Associate	11325793
Stomach Neoplasms	Associate	22377736
Temporomandibular Joint Disorders	Associate	22074755

CHRM2 (cholinergic receptor muscarinic 2)