KLF8 (KLF transcription factor 8)
| Gene | |
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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11279 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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KLF transcription factor 8 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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KLF8 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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BKLF3, ZNF741 |
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Chromosome
Chromosome number
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X |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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Xp11.21 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a protein which is a member of the Sp/KLF family of transcription factors. Members of this family contain a C-terminal DNA-binding domain with three Kruppel-like zinc fingers. The encoded protein is thought to play an important role in t |
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miRNA
miRNA information provided by mirtarbase database.
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| Transcription factors | |||||||
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | |||||||||||||||||||||
| UniProt ID | O95600 | ||||||||||||||||||||
| Protein name | Krueppel-like factor 8 (Basic krueppel-like factor 3) (Zinc finger protein 741) | ||||||||||||||||||||
| Protein function | Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK). {ECO:0000269|Pu | ||||||||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:10756197}. | ||||||||||||||||||||
| Sequence |
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| Sequence length | 359 | ||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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